{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:41Z","timestamp":1791204761042,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304628"],"award-info":[{"award-number":["82304628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505091"],"award-info":[{"award-number":["82505091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbadis.2026.168229","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T22:58:58Z","timestamp":1774220338000},"page":"168229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress"],"prefix":"10.1016","volume":"1872","author":[{"given":"Mengyao","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbadis.2026.168229_bb0005","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","article-title":"Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors","volume":"18","author":"Klein","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"9791","key":"10.1016\/j.bbadis.2026.168229_bb0010","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0140-6736(10)62307-0","article-title":"Pancreatic cancer","volume":"378","author":"Vincent","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168229_bb0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41575-023-00856-2","article-title":"Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer","volume":"21","author":"Stoop","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168229_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156789","article-title":"Mori folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT\/GSK3\u03b2\/NRF2 axis","volume":"142","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2026.168229_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117759","article-title":"Screening of anti-melanoma compounds from Morus alba L.: sanggenon C promotes melanoma cell apoptosis by disrupting intracellular ca(2+) homeostasis","volume":"324","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2026.168229_bb0030","doi-asserted-by":"crossref","first-page":"1007279","DOI":"10.3389\/fphar.2022.1007279","article-title":"Cortex Mori extracts induce apoptosis and inhibit tumor invasion via blockage of the PI3K\/AKT signaling in melanoma cells","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168229_bb0035","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.biotechadv.2018.02.002","article-title":"Plants as sources of natural and recombinant anti-cancer agents","volume":"36","author":"Buyel","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bbadis.2026.168229_bb0040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopha.2017.01.104","article-title":"Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells","volume":"88","author":"Chen","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"19","key":"10.1016\/j.bbadis.2026.168229_bb0045","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1021\/acschemneuro.1c00381","article-title":"Securinine promotes neuronal development and exhibits antidepressant-like effects via mTOR activation","volume":"12","author":"Xiao","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168229_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155735","article-title":"Securinine inhibits carcinogenesis in gastric cancer by targeting AURKA-\u03b2-catenin\/Akt\/STAT3 and the cell cycle pathway","volume":"130","author":"Lv","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2026.168229_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120105","article-title":"Securinine induces mitotic block in cancer cells by binding to tubulin and inhibiting microtubule assembly: a possible mechanistic basis for its anticancer activity","volume":"287","author":"Ashraf","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2026.168229_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116125","article-title":"Securinine inhibits the tumor growth of human bladder cancer cells by suppressing Wnt\/\u03b2-catenin signaling pathway and activating p38 and JNK signaling pathways","volume":"223","author":"Xie","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168229_bb0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168229_bb0070","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2016.03.007","article-title":"Endoplasmic reticulum stress and the hallmarks of Cancer","volume":"2","author":"Urra","year":"2016","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbadis.2026.168229_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155935","article-title":"Targeting MCL1 with sanggenon C overcomes MCL1-driven adaptive chemoresistance via dysregulation of autophagy and endoplasmic reticulum stress in cervical cancer","volume":"133","author":"Sun","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168229_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020999","article-title":"Gastrointestinal Cancer therapeutics via triggering unfolded protein response and endoplasmic reticulum stress by 2-Arylbenzofuran","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168229_bb0085","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"37","key":"10.1016\/j.bbadis.2026.168229_bb0090","doi-asserted-by":"crossref","first-page":"13768","DOI":"10.1021\/acs.jafc.3c02257","article-title":"Kuwanon H inhibits melanoma growth through cytotoxic endoplasmic reticulum stress and impaired autophagy flux","volume":"71","author":"Hu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbadis.2026.168229_bb0095","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.phrs.2017.04.003","article-title":"Targeting the unfolded protein response in cancer","volume":"120","author":"Ojha","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168229_bb0100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","article-title":"p38(MAPK): stress responses from molecular mechanisms to therapeutics","volume":"15","author":"Coulthard","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168229_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102452","article-title":"Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization","volume":"56","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168229_bb0110","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"issue":"1\u20133","key":"10.1016\/j.bbadis.2026.168229_bb0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2011.12.035","article-title":"Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization","volume":"677","author":"Zhang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"30","key":"10.1016\/j.bbadis.2026.168229_bb0120","doi-asserted-by":"crossref","first-page":"21353","DOI":"10.1074\/jbc.M511052200","article-title":"Bcl-2 phosphorylation by p38 MAPK: identification of target sites and biologic consequences","volume":"281","author":"De Chiara","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5.5","key":"10.1016\/j.bbadis.2026.168229_bb0125","first-page":"603","article-title":"NCCN guidelines updates: pancreatic Cancer","volume":"17","author":"Tempero","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168229_bb0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12943-024-02135-3","article-title":"Chinese herbal medicine for the treatment of intestinal cancer: preclinical studies and potential clinical applications","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"31","key":"10.1016\/j.bbadis.2026.168229_bb0135","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1200\/JCO.24.00020","article-title":"Open-label, multicenter, phase I\/II, first-in-human trial of TK216: a first-generation EWS::FLI1 fusion protein antagonist in Ewing sarcoma","volume":"42","author":"Meyers","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2026.168229_bb0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-019-0164-y","article-title":"Progress in research on paclitaxel and tumor immunotherapy","volume":"24","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168229_bb0145","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc1977","article-title":"Topoisomerase I inhibitors: camptothecins and beyond","volume":"6","author":"Pommier","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.bbadis.2026.168229_bb0150","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41422-019-0195-y","article-title":"Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma","volume":"29","author":"Peng","year":"2019","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168229_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41575-019-0109-y","article-title":"Molecular subtypes of pancreatic cancer","volume":"16","author":"Collisson","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168229_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.824907","article-title":"Neuroinflammation and neutrophils: modulation by Ouabain","volume":"13","author":"Leite","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168229_bb0165","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41417-023-00622-1","article-title":"P38 kinase in gastrointestinal cancers","volume":"30","author":"Phan","year":"2023","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168229_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-06386-0","article-title":"Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging","volume":"7","author":"Odawara","year":"2024","journal-title":"Commun Biol"},{"issue":"Pt 1","key":"10.1016\/j.bbadis.2026.168229_bb0175","article-title":"S100A9 promotes renal calcium oxalate stone formation via activating the TLR4-p38\/MAPK-LCN2 signaling pathway","volume":"281","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbadis.2026.168229_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114225","article-title":"Targeting the S100A9\/P38 MAPK\/HSPB1 axis as a novel approach for aortic dissection therapy","volume":"149","author":"Ma","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168229_bb0185","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12964-023-01112-5","article-title":"Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signal"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392600092X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392600092X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:08:44Z","timestamp":1791202124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392600092X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S092544392600092X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168229","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168229"}}