{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:21:03Z","timestamp":1783153263275,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2023ZJ1124"],"award-info":[{"award-number":["2023ZJ1124"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40411"],"award-info":[{"award-number":["2023JJ40411"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ81962"],"award-info":[{"award-number":["2026JJ81962"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ81653"],"award-info":[{"award-number":["2026JJ81653"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80872"],"award-info":[{"award-number":["2025JJ80872"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbadis.2026.168276","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:47:41Z","timestamp":1776959261000},"page":"168276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Succinylation modification on NFS1 ameliorates the glucose starvation-induced ferroptosis through maintaining mitochondrial iron homeostasis in oral squamous cell carcinoma cells"],"prefix":"10.1016","volume":"1872","author":[{"given":"Hang","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","article-title":"Oral squamous cell carcinomas: state of the field and emerging directions","volume":"15","author":"Tan","year":"2023","journal-title":"Int. J. Oral Sci."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168276_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11102718","article-title":"Identification of SEC61G as a diagnostic and prognostic biomarker in oral squamous cell carcinoma","volume":"11","author":"Zhang","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbadis.2026.168276_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216833","article-title":"IL-1alpha facilitates GSH synthesis to counteract oxidative stress in oral squamous cell carcinoma under glucose-deprivation","volume":"589","author":"Ji","year":"2024","journal-title":"Cancer Lett."},{"issue":"16","key":"10.1016\/j.bbadis.2026.168276_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29163964","article-title":"Cascade hydroxyl radical-generating and ferroptosis-inducing nanofiber system for the therapy of oral squamous cell carcinoma","volume":"29","author":"Park","year":"2024","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168276_bb0025","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1111\/odi.14774","article-title":"System Xc(\u2212) exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma","volume":"30","author":"Wang","year":"2024","journal-title":"Oral Dis."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168276_bb0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbadis.2026.168276_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111176","article-title":"Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma","volume":"119","author":"Zhou","year":"2024","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168276_bb0040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7682","key":"10.1016\/j.bbadis.2026.168276_bb0045","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nature24637","article-title":"NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis","volume":"551","author":"Alvarez","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2026.168276_bb0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020518-114742","article-title":"Mitochondrial iron in human health and disease","volume":"81","author":"Ward","year":"2019","journal-title":"Annu. Rev. Physiol."},{"issue":"43","key":"10.1016\/j.bbadis.2026.168276_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202209136","article-title":"An anticancer Rhenium Tricarbonyl targets Fe-S cluster biogenesis in ovarian cancer cells","volume":"61","author":"Neuditschko","year":"2022","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168276_bb0060","doi-asserted-by":"crossref","first-page":"e70051","DOI":"10.1002\/jbt.70051","article-title":"Overexpression of Nfs1 cysteine desulphurase relieves Sevoflurane-induced neurotoxicity and cognitive dysfunction in neonatal mice via suppressing oxidative stress and ferroptosis","volume":"38","author":"Zhang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168276_bb0065","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10863-024-10038-7","article-title":"NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway","volume":"56","author":"Jiang","year":"2024","journal-title":"J. Bioenerg. Biomembr."},{"issue":"37","key":"10.1016\/j.bbadis.2026.168276_bb0070","doi-asserted-by":"crossref","first-page":"eabm9427","DOI":"10.1126\/sciadv.abm9427","article-title":"Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction","volume":"8","author":"Fujihara","year":"2022","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168276_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and cancer: Mitochondria meet the \u201cIron Maiden\u201d cell death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: Two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168276_bb0085","doi-asserted-by":"crossref","first-page":"1414301","DOI":"10.3389\/fimmu.2024.1414301","article-title":"Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168276_bb0090","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2026.168276_bb0095","doi-asserted-by":"crossref","first-page":"103553","DOI":"10.1016\/j.redox.2025.103553","article-title":"Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation","volume":"81","author":"Huang","year":"2025","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168276_bb0100","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1080\/15548627.2018.1503146","article-title":"Activation of ferritinophagy is required for the RNA-binding protein ELAVL1\/HuR to regulate ferroptosis in hepatic stellate cells","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0105","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13046-020-01681-0","article-title":"Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer","volume":"39","author":"Li","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168276_bb0110","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.7150\/thno.71102","article-title":"Cardiomyocytic FoxP3 is involved in Parkin-mediated mitophagy during cardiac remodeling and the regulatory role of triptolide","volume":"12","author":"Pan","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0115","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41392-025-02458-7","article-title":"KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma","volume":"10","author":"Wu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168276_bb0120","doi-asserted-by":"crossref","first-page":"106554","DOI":"10.1016\/j.biocel.2024.106554","article-title":"PLA inhibits TNF-alpha-induced PANoptosis of prostate cancer cells through metabolic reprogramming","volume":"169","author":"Hao","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41392-022-00889-0","article-title":"Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis","volume":"7","author":"Lin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168276_bb0130","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.molcel.2020.10.016","article-title":"Hyperactive CDK2 activity in basal-like breast cancer imposes a genome integrity liability that can be exploited by targeting DNA polymerase epsilon","volume":"80","author":"Sviderskiy","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2026.168276_bb0135","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.2147\/IJGM.S444443","article-title":"NFS1 as a candidate prognostic biomarker for gastric cancer correlated with immune infiltrates","volume":"17","author":"Jiang","year":"2024","journal-title":"Int. J. Gen. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"13","key":"10.1016\/j.bbadis.2026.168276_bb0145","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.7150\/ijbs.61441","article-title":"Multi-omics analysis of ferroptosis regulation patterns and characterization of tumor microenvironment in patients with oral squamous cell carcinoma","volume":"17","author":"Gu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13073-024-01357-w","article-title":"Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers","volume":"16","author":"Krieg","year":"2024","journal-title":"Genome Med."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168276_bb0155","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168276_bb0160","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168276_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168276_bb0170","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1016\/j.gendis.2022.10.028","article-title":"Lysine succinylation, the metabolic bridge between cancer and immunity","volume":"10","author":"Shen","year":"2023","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168276_bb0175","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41588-025-02077-6","article-title":"Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma","volume":"57","author":"Liang","year":"2025","journal-title":"Nat. Genet."},{"issue":"7684","key":"10.1016\/j.bbadis.2026.168276_bb0180","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature25003","article-title":"KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase","volume":"552","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2026.168276_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.09.015","article-title":"KAT2A succinyltransferase activity-mediated 14-3-3zeta upregulation promotes beta-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells","volume":"469","author":"Tong","year":"2020","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0190","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/CS20200986","article-title":"The GCN5: its biological functions and therapeutic potentials","volume":"135","author":"Haque","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168276_bb0195","doi-asserted-by":"crossref","first-page":"20251135","DOI":"10.1515\/biol-2025-1135","article-title":"Overexpression of the ferroptosis-related gene, NFS1, corresponds to gastric cancer growth and tumor immune infiltration","volume":"20","author":"Mao","year":"2025","journal-title":"Open Life Sci."},{"issue":"17","key":"10.1016\/j.bbadis.2026.168276_bb0200","doi-asserted-by":"crossref","first-page":"e2100381","DOI":"10.1002\/pmic.202100381","article-title":"Global profiling of lysine succinylation in human lungs","volume":"22","author":"Yang","year":"2022","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.bbadis.2026.168276_bb0205","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1161\/STROKEAHA.121.034850","article-title":"Sirtuin 5-mediated lysine desuccinylation protects mitochondrial metabolism following subarachnoid hemorrhage in mice","volume":"52","author":"Xiao","year":"2021","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168276_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032479","article-title":"The journey of mitochondrial protein import and the roadmap to follow","volume":"24","author":"Haastrup","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168276_bb2000","first-page":"11","article-title":"Current situation and unmet demands of supportive care for cancer patients in China.Holistic","volume":"5","author":"Xie","year":"2026","journal-title":"Integrative Oncol."},{"key":"10.1016\/j.bbadis.2026.168276_bb2005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s44178-025-00201-4","article-title":"CACA guidelines for holistic integrative management of older adults with cancer","volume":"5","author":"Shi","year":"2026","journal-title":"Holist. Integr. Oncol."},{"key":"10.1016\/j.bbadis.2026.168276_bb2010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s44178-025-00164-6","article-title":"CACA clinical guideline of holistic psychosocial care for cancer patients","volume":"4","author":"Tang","year":"2025","journal-title":"Holist. Integr. Oncol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:13:57Z","timestamp":1783152837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926001390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0925443926001390"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168276","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Succinylation modification on NFS1 ameliorates the glucose starvation-induced ferroptosis through maintaining mitochondrial iron homeostasis in oral squamous cell carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168276"}}