{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:39:42Z","timestamp":1788565182856,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573857"],"award-info":[{"award-number":["82573857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004433","name":"Chinese Pharmaceutical Association","doi-asserted-by":"publisher","award":["CPA-Z05-2C-2024-003"],"award-info":[{"award-number":["CPA-Z05-2C-2024-003"]}],"id":[{"id":"10.13039\/501100004433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LHDMZ26H160001"],"award-info":[{"award-number":["LHDMZ26H160001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbadis.2026.168303","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:02:52Z","timestamp":1779688972000},"page":"168303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["HN1\/CEBPB\/CCL2 signaling shapes VSIG4+ tumor-associated macrophages in anaplastic thyroid carcinoma"],"prefix":"10.1016","volume":"1872","author":[{"given":"Ziwen","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixue","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168303_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113826","article-title":"The genomic and evolutionary landscapes of anaplastic thyroid carcinoma","volume":"43","author":"Zeng","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168303_bb0010","article-title":"Clinical trials in management of anaplastic thyroid carcinoma; progressions and set backs: a systematic review","volume":"17","author":"Salehian","year":"2019","journal-title":"Int. J. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2026.168303_bb0015","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12022-024-09832-1","article-title":"Unravelling the reasons behind limited response to anti-PD therapy in ATC: a comprehensive evaluation of tumor-infiltrating immune cells and checkpoints","volume":"35","author":"Boruah","year":"2024","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0020","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1200\/JCO.19.02727","article-title":"PD-1 blockade in anaplastic thyroid carcinoma","volume":"38","author":"Capdevila","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0025","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1038\/s41467-025-58910-3","article-title":"Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers","volume":"16","author":"Pan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2026.168303_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022567","article-title":"Tumor-associated macrophages (TAMs) form an interconnected cellular supportive network in anaplastic thyroid carcinoma","volume":"6","author":"Caillou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2026.168303_bb0035","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3803\/EnM.2016.31.3.469","article-title":"Macrophage densities correlated with CXC chemokine receptor 4 expression and related with poor survival in anaplastic thyroid Cancer","volume":"31","author":"Kim","year":"2016","journal-title":"Endocrinol Metab (Seoul)"},{"key":"10.1016\/j.bbadis.2026.168303_bb0040","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccell.2026.01.020","article-title":"Macrophages: targets for next-generation cancer immunotherapy","volume":"44","author":"Sun","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbadis.2026.168303_bb0045","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/labinvest.2014.73","article-title":"VSIG4 expression on macrophages facilitates lung cancer development","volume":"94","author":"Liao","year":"2014","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbadis.2026.168303_bb0050","article-title":"V-set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116160","article-title":"Antibodies targeting human or mouse VSIG4 repolarize tumor-associated macrophages providing the potential of potent and specific clinical anti-tumor response induced across multiple cancer types","volume":"25","author":"Sazinsky","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168303_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166591","article-title":"IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer","volume":"1869","author":"Pan","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbadis.2026.168303_bb0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13046-025-03303-z","article-title":"VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1","volume":"44","author":"Pan","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168303_bb0070","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2019.00333","article-title":"Chemokines modulate immune surveillance in tumorigenesis, metastasis, and response to immunotherapy","volume":"10","author":"Vilgelm","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2796.2001.00867.x","article-title":"Chemokines in pathology and medicine","volume":"250","author":"Baggiolini","year":"2001","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbadis.2026.168303_bb0080","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/cas.15671","article-title":"Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin","volume":"114","author":"Kawaguchi","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbadis.2026.168303_bb0085","doi-asserted-by":"crossref","first-page":"963","DOI":"10.7150\/thno.65411","article-title":"HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment","volume":"12","author":"Wang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2026.168303_bb0090","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.18632\/oncotarget.2207","article-title":"Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4\/CXCL12 axis and promote their polarization toward the M2 phenotype","volume":"5","author":"Beider","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2026.168303_bb0095","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.3390\/ijms21217955","article-title":"CCL18 in the progression of Cancer","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168303_bb0100","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-013027","article-title":"Macrophage CCL7 promotes resistance to immunotherapy for colorectal cancer by regulating the infiltration of macrophages and CD8+ T cells","volume":"13","author":"Chen","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbadis.2026.168303_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-014043","article-title":"Targeting AKR1B1 reprograms tumor-associated macrophages to enhance antitumor immunity","volume":"14","author":"Liu","year":"2026","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbadis.2026.168303_bb0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41417-023-00704-0","article-title":"SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma","volume":"31","author":"Wu","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbadis.2026.168303_bb0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.canlet.2017.10.037","article-title":"Metabolic changes in tumor cells and tumor-associated macrophages: a mutual relationship","volume":"413","author":"Netea-Maier","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2026.168303_bb0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2020.12.026","article-title":"HN1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by interacting with STMN1","volume":"501","author":"Pan","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2026.168303_bb0125","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3390\/cells14181458","article-title":"Tumor-associated macrophages in glioblastoma: mechanisms of tumor progression and therapeutic strategies","volume":"14","author":"Chen","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168303_bb0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12943-024-02064-1","article-title":"Decoding the spatiotemporal heterogeneity of tumor-associated macrophages","volume":"23","author":"Chu","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbadis.2026.168303_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142415","article-title":"Single-cell and spatial analyses reveal the effect of VSIG4+S100A10+TAMs on the immunosuppression of glioblastoma and anti-PD-1 immunotherapy","volume":"308","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70340","article-title":"VSIG4 promotes tumour-associated macrophage M2 polarization and immune escape in colorectal Cancer via fatty acid oxidation pathway","volume":"15","author":"Liu","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168303_bb0145","article-title":"Deciphering the performance of macrophages in tumour microenvironment: A call for precision immunotherapy","volume":"17","author":"B","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0150","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-025-02325-5","article-title":"Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168303_bb0155","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1158\/0008-5472.CAN-25-0235","article-title":"ChREBP-mediated choline deprivation and chemokine secretion shape tumor-associated macrophages to promote immune evasion","volume":"85","author":"Zhao","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168303_bb0160","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/HEP.0000000000001393","article-title":"Hepatocyte-specific C-C motif chemokine ligand 9 signaling promotes liver fibrosis progression in mice","volume":"83","author":"Wang","year":"2026","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2026.168303_bb0165","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.4049\/jimmunol.1302821","article-title":"CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2\/CCR2-dependent gene expression profile","volume":"192","author":"Sierra-Filardi","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0170","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.diff.2009.04.001","article-title":"Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest","volume":"78","author":"Laughlin","year":"2009","journal-title":"Differentiation"},{"key":"10.1016\/j.bbadis.2026.168303_bb0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.gene.2004.02.025","article-title":"Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family","volume":"331","author":"Zhou","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.bbadis.2026.168303_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216496","article-title":"Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer","volume":"580","author":"Pan","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2026.168303_bb0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11010-020-03897-2","article-title":"Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p\/ROCK2 axis","volume":"476","author":"Wang","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2026.168303_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.30569","article-title":"HN1 is a novel dedifferentiation factor involved in regulating the cell cycle and microtubules in SH-SY5Y neuroblastoma cells","volume":"126","author":"\u00d6zar","year":"2025","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2026.168303_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.15010","article-title":"hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p","volume":"28","author":"Pu","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168303_bb0200","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-017-0656-1","article-title":"HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbadis.2026.168303_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104446","article-title":"Role of hematological and neurological expressed 1 (HN1) in human cancers","volume":"201","author":"Li","year":"2024","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0210","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1172\/JCI25673","article-title":"VSIG4, a B7 family-related protein, is a negative regulator of T cell activation","volume":"116","author":"Vogt","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2026.168303_bb0215","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41420-024-01990-9","article-title":"CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling","volume":"10","author":"Ma","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2026.168303_bb0220","doi-asserted-by":"crossref","DOI":"10.1093\/g3journal\/jkad207","article-title":"CRISPR screen identifies CEBPB as contributor to dyskeratosis congenita fibroblast senescence via augmented inflammatory gene response","volume":"13","author":"Westin","year":"2023","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.bbadis.2026.168303_bb0225","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.7150\/thno.93473","article-title":"The CEBPB+ glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growth","volume":"14","author":"Yang","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2026.168303_bb0230","article-title":"Neutrophil membrane-camouflaged polyprodrug nanomedicine for inflammation suppression in ischemic stroke therapy","volume":"36","author":"Zhao","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bbadis.2026.168303_bb0235","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13046-024-03135-3","article-title":"Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA\/RXRA\/ANGPT1 pathway in lung adenocarcinoma","volume":"43","author":"Chen","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168303_bb0240","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.3390\/ijms25179612","article-title":"Downregulation of IL-8 and IL-10 by LRRC8A inhibition through the NOX2-Nrf2-CEBPB transcriptional Axis in THP-1-derived M2 macrophages","volume":"25","author":"Matsui","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168303_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1111522","article-title":"Emerging functions of C\/EBP\u03b2 in breast cancer","volume":"13","author":"Matherne","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0250","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2018.04.022","article-title":"Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast Cancer","volume":"28","author":"Li","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2026.168303_bb0255","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12929-023-00991-7","article-title":"Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer","volume":"31","author":"Chen","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2026.168303_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.991797","article-title":"CEBPB is associated with active tumor immune environment and favorable prognosis of metastatic skin cutaneous melanoma","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0265","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13805","article-title":"HN1 functions in protein synthesis regulation via mTOR-RPS6 axis and maintains nucleolar integrity","volume":"58","author":"\u00d6zduman","year":"2025","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbadis.2026.168303_bb0270","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1080\/15384101.2021.1962624","article-title":"HN1 interacts with \u03b3-tubulin to regulate centrosomes in advanced prostate cancer cells","volume":"20","author":"Varisli","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbadis.2026.168303_bb0275","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cbin.11957","article-title":"Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma","volume":"47","author":"Feng","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbadis.2026.168303_bb0280","article-title":"Relationship between PTEN and angiogenesis of esophageal squamous cell carcinoma and the underlying mechanism","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0285","doi-asserted-by":"crossref","DOI":"10.1177\/1533033819849068","article-title":"Colon Cancer cell secretes EGF to promote M2 polarization of TAM through EGFR\/PI3K\/AKT\/mTOR pathway","volume":"18","author":"Lian","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.bbadis.2026.168303_bb0290","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2025.2535824","article-title":"Cooperative CCL2\/CCR2 and HGF\/MET signaling enhances breast cancer growth and invasion associated with metabolic reprogramming","volume":"26","author":"Fang","year":"2025","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbadis.2026.168303_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176076","article-title":"Honokiol prevents lung metastasis of triple-negative breast cancer by regulating polarization and recruitment of macrophages","volume":"959","author":"Mei","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168303_bb0300","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s42255-025-01281-2","article-title":"Neuronal CCL2 responds to hyperglycaemia and contributes to anxiety disorders in the context of diabetes","volume":"7","author":"Pan","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbadis.2026.168303_bb0305","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41392-025-02455-w","article-title":"Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop","volume":"10","author":"Wang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168303_bb0310","doi-asserted-by":"crossref","first-page":"E1600","DOI":"10.1073\/pnas.1404357111","article-title":"p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer","volume":"111","author":"McFadden","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2026.168303_bb0315","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9734576","article-title":"Integrated bioinformatics analysis of master regulators in anaplastic thyroid carcinoma","volume":"2019","author":"Pan","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbadis.2026.168303_bb0320","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12943-022-01658-x","article-title":"CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment","volume":"21","author":"Pan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbadis.2026.168303_bb0325","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1038\/s41598-024-58943-6","article-title":"Comprehensive bioinformatics analysis unveils THEMIS2 as a carcinogenic indicator related to immune infiltration and prognosis of thyroid cancer","volume":"14","author":"Liu","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:25:01Z","timestamp":1783412701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0925443926001663"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168303","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HN1\/CEBPB\/CCL2 signaling shapes VSIG4+ tumor-associated macrophages in anaplastic thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168303"}}