{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:43:37Z","timestamp":1787697817149,"version":"build-2784847793"},"reference-count":69,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["ZR2025MS1258"],"award-info":[{"award-number":["ZR2025MS1258"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbadis.2026.168320","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:30:52Z","timestamp":1781022652000},"page":"168320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ajugol attenuates acute gouty arthritis by enhancing mitophagy to suppress chondrocyte pyroptosis"],"prefix":"10.1016","volume":"1872","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbadis.2026.168320_bb0005","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168320_bb0010","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s10067-020-04947-2","article-title":"Risk factors of ultrasound-detected tophi in patients with gout","volume":"39","author":"Lu","year":"2020","journal-title":"Clin. Rheumatol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168320_bb0015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.berh.2016.10.010","article-title":"Imaging of gout: new tools and biomarkers?","volume":"30","author":"Araujo","year":"2016","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"21","key":"10.1016\/j.bbadis.2026.168320_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015819","article-title":"The association between serum uric acid level and changes of MRI findings in knee osteoarthritis: a retrospective study (a STROBE-compliant article)","volume":"98","author":"Xiao","year":"2019","journal-title":"Medicine"},{"issue":"12","key":"10.1016\/j.bbadis.2026.168320_bb0025","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.3899\/jrheum.130708","article-title":"The effects of monosodium urate monohydrate crystals on chondrocyte viability and function: implications for development of cartilage damage in gout","volume":"40","author":"Chhana","year":"2013","journal-title":"J. Rheumatol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168320_bb0030","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1136\/ard-2023-224154","article-title":"Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink","volume":"82","author":"Roddy","year":"2023","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168320_bb0035","article-title":"Non-steroidal anti-inflammatory drugs for acute gout","volume":"12","author":"van Durme","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168320_bb0040","doi-asserted-by":"crossref","first-page":"9605","DOI":"10.1097\/JS9.0000000000004619","article-title":"3,4-Dimethoxychalcone-induced caloric restriction inhibits PANoptosis to promote ischemic and diabetic skin flap survival: experimental studies","volume":"112","author":"Yu","year":"2026","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.bbadis.2026.168320_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101387","article-title":"Programmed cell death network in cancer drug resistance: a framework for therapeutic intervention","volume":"86","author":"Guo","year":"2026","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bbadis.2026.168320_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102707","article-title":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","volume":"62","author":"Zhu","year":"2023","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168320_bb0055","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2024.03.012","article-title":"The NLR family of innate immune and cell death sensors","volume":"57","author":"Sundaram","year":"2024","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.bbadis.2026.168320_bb0060","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbadis.2026.168320_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115439","article-title":"Cyclic helix B peptide alleviates liver fibrosis via attenuating ROS-mediated pyroptosis","volume":"165","author":"Yuan","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168320_bb0070","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/s41418-021-00755-6","article-title":"GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy","volume":"28","author":"Li","year":"2021","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168320_bb0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-020-2476-2","article-title":"Chemotherapy-induced pyroptosis is mediated by BAK\/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"16","key":"10.1016\/j.bbadis.2026.168320_bb0080","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.7150\/ijbs.46153","article-title":"Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis","volume":"16","author":"Hao","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s10020-024-00831-w","article-title":"BRD4 promotes gouty arthritis through MDM2-mediated PPAR\u03b3 degradation and pyroptosis","volume":"30","author":"Xu","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168320_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111656","article-title":"Geraniin restricts inflammasome activation and macrophage pyroptosis by preventing the interaction between ASC and NLRP3 to exert anti-inflammatory effects","volume":"129","author":"Zhou","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0095","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41420-022-00969-8","article-title":"HIF-1\u03b1-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2026.168320_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116142","article-title":"PLCE1 enhances mitochondrial dysfunction to promote GSDME-mediated pyroptosis in doxorubicin-induced cardiotoxicity","volume":"223","author":"Tuersuntuoheti","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0105","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12931-024-03028-1","article-title":"Research progress of mitochondrial dysfunction induced pyroptosis in acute lung injury","volume":"25","author":"Yang","year":"2024","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12974-025-03606-0","article-title":"SIK2 mediated mitochondrial homeostasis in spinal cord injury: modulating oxidative stress and the AIM2 inflammasome via CRTC1\/CREB signaling","volume":"22","author":"Fang","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbadis.2026.168320_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110104","article-title":"4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS\/STING pathway","volume":"118","author":"Wu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168320_bb0120","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.7150\/ijbs.57825","article-title":"Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway","volume":"17","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2026.168320_bb0125","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jare.2025.05.017","article-title":"PTPN22 as a therapeutic target in intervertebral disc degeneration: modulating mitophagy and pyroptosis through the PI3K\/AKT\/mTOR axis","volume":"80","author":"Liang","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbadis.2026.168320_bb0130","first-page":"1","article-title":"Sipeimine ameliorates osteoarthritis progression by suppression of NLRP3 inflammasome-mediated pyroptosis through inhibition of PI3K\/AKT\/NF-\u03baB pathway: an in vitro and in vivo study","volume":"46","author":"Fang","year":"2024","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bbadis.2026.168320_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.797855","article-title":"Mechanical stimulation protects against chondrocyte pyroptosis through Irisin-induced suppression of PI3K\/Akt\/NF-\u03baB signal pathway in osteoarthritis","volume":"10","author":"Jia","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2026.168320_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116131","article-title":"Exploring the quality markers and mechanism of Bushen Huoxue prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy","volume":"306","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2026.168320_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105964","article-title":"Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease","volume":"174","author":"Zhang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2026.168320_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154345","article-title":"A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine\/chemokine activity in OVA-induced asthmatic mice","volume":"105","author":"Yi","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2026.168320_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1644847","article-title":"Systems pharmacology identifies ajugol-mediated NF-\u03baB\/caspase-3 inhibition and isoacteoside-driven p62\/mTOR-mediated autophagy as key mechanisms of Rehmanniae Radix and its processed form in Alzheimer\u2019s treatment","volume":"16","author":"Han","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168320_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111406","article-title":"Harpagide inhibits the TNF-\u03b1-induced inflammatory response in rat articular chondrocytes by the glycolytic pathways for alleviating osteoarthritis","volume":"127","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168320_bb0165","article-title":"Irisin mitigates oxidative stress, chondrocyte dysfunction and osteoarthritis development through regulating mitochondrial integrity and autophagy","volume":"9","author":"Wang","year":"2020","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.bbadis.2026.168320_bb0170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2017.09.140","article-title":"A standardized extract of Butea monosperma (lam.) flowers suppresses the IL-1\u03b2-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes","volume":"96","author":"Ansari","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2026.168320_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580593","article-title":"Gallic acid alleviates gouty arthritis by inhibiting NLRP3 Inflammasome activation and Pyroptosis through enhancing Nrf2 signaling","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Immunol."},{"issue":"0","key":"10.1016\/j.bbadis.2026.168320_bb0180","article-title":"Motherwort regulates PI3K\/Akt pathway in the treatment of spinal tuberculosis through miR-432-5p","volume":"0","author":"Zhang","year":"2025","journal-title":"Pharmacogn. Mag."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168320_bb0185","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168320_bb0190","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","article-title":"Gout: an old disease in new perspective - a review","volume":"8","author":"Ragab","year":"2017","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168320_bb0195","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.rdc.2022.03.001","article-title":"Management and cure of gouty arthritis","volume":"48","author":"Keller","year":"2022","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"19","key":"10.1016\/j.bbadis.2026.168320_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910853","article-title":"Advances in gouty arthritis management: integration of established therapies, emerging treatments, and lifestyle interventions","volume":"25","author":"Yao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168320_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168320_bb0210","article-title":"Colchicine for acute gout","volume":"8","author":"McKenzie","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbadis.2026.168320_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122817","article-title":"Collagen hydrogel-driven pyroptosis suppression and combined microfracture technique delay osteoarthritis progression","volume":"314","author":"Meng","year":"2025","journal-title":"Biomaterials"},{"issue":"7081","key":"10.1016\/j.bbadis.2026.168320_bb0220","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2026.168320_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101523","article-title":"NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy","volume":"34","author":"Zeng","year":"2020","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168320_bb0230","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","article-title":"Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy","volume":"17","author":"Lin","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168320_bb0235","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2026.168320_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0245","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s13018-025-06033-2","article-title":"VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1\/Parkin-mediated mitophagy pathway","volume":"20","author":"Zhang","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bbadis.2026.168320_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113974","article-title":"CREG1 attenuates intervertebral disc degeneration by alleviating nucleus pulposus cell pyroptosis via the PINK1\/Parkin-related mitophagy pathway","volume":"147","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168320_bb0255","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1016\/j.ymthe.2023.10.016","article-title":"FUNDC1\/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis","volume":"31","author":"Fang","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2026.168320_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102663","article-title":"The physiological metabolite \u03b1-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress","volume":"62","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"issue":"32","key":"10.1016\/j.bbadis.2026.168320_bb0265","article-title":"Retuning mitochondrial apoptosis\/mitophagy balance via SIRT3-energized and microenvironment-modulated hydrogel microspheres to impede osteoarthritis","volume":"12","author":"Xia","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbadis.2026.168320_bb0270","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.actbio.2024.05.014","article-title":"Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles","volume":"181","author":"Qi","year":"2024","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168320_bb0275","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14294","article-title":"\u03b2-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2\/AMPK\/PINK1\/Parkin pathway","volume":"23","author":"Zhuang","year":"2024","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0280","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41413-025-00413-4","article-title":"SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch","volume":"13","author":"Deng","year":"2025","journal-title":"Bone Res."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168320_bb0285","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.joca.2018.05.018","article-title":"Mitochondria and mitophagy: biosensors for cartilage degradation and osteoarthritis","volume":"26","author":"Blanco","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbadis.2026.168320_bb0290","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.2147\/JIR.S320912","article-title":"Resveratrol relieves gouty arthritis by promoting mitophagy to inhibit activation of NLRP3 inflammasomes","volume":"14","author":"Fan","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbadis.2026.168320_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110756","article-title":"Autophagy induced by PP121 alleviates MSU crystal-induced acute gouty arthritis via inhibition of the NLRP3 inflammasome","volume":"123","author":"Yuan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0300","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12967-024-04870-z","article-title":"Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K\/AKT\/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms","volume":"22","author":"Gu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168320_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109895","article-title":"Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS\/P38\/Nrf2 axis and PI3K\/AKT\/mTOR pathway in macrophages","volume":"125","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2026.168320_bb0310","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.02.029","article-title":"SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K\/Akt\/mTOR pathway","volume":"175","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168320_bb0315","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.7150\/thno.96038","article-title":"Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K\/AKT\/mTOR signaling pathway to alleviate ulcerative colitis","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2026.168320_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109746","article-title":"Synergic effect of PD-1 blockade and endostar on the PI3K\/AKT\/mTOR-mediated autophagy and angiogenesis in Lewis lung carcinoma mouse model","volume":"125","author":"Wu","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"Pt A","key":"10.1016\/j.bbadis.2026.168320_bb0325","article-title":"Qingre Huazhuo Jiangsuan decoction promotes autophagy by inhibiting PI3K\/AKT\/mTOR signaling pathway to relieve acute gouty arthritis","volume":"302","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2026.168320_bb0330","article-title":"The interplay between NLRP3 inflammasome and metabolic signals in gouty arthritis","volume":"17","author":"Cao","year":"2026","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0335","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-026-01379-z","article-title":"The IL-17 pathway mediated by m6A-modified lncRNA H19: a new mechanism for Jianpi Qingre Tongluo prescription in repressing inflammation and improving lipid metabolism in gout arthritis","volume":"21","author":"Zhang","year":"2026","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168320_bb0340","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13075-023-03095-7","article-title":"Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168320_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1764497","article-title":"Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation","volume":"17","author":"Xiao","year":"2026","journal-title":"Front. Immunol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926001833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:26:56Z","timestamp":1783412816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926001833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0925443926001833"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168320","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ajugol attenuates acute gouty arthritis by enhancing mitophagy to suppress chondrocyte pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168320"}}