{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:26:31Z","timestamp":1787430391865,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbadis.2026.168370","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:32:32Z","timestamp":1784179952000},"page":"168370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SERPING1 facilitates colorectal liver metastasis by modulating epithelial-mesenchymal transition and tumor microenvironment remodeling"],"prefix":"10.1016","volume":"1872","author":[{"given":"Wenhao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168370_bb0005","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbadis.2026.168370_bb0010","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1136\/gutjnl-2019-319511","article-title":"Global patterns and trends in colorectal cancer incidence in young adults","volume":"68","author":"Siegel","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2026.168370_bb0015","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbadis.2026.168370_bb0020","article-title":"Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells","volume":"6","author":"Testa","year":"2018","journal-title":"Med Sci (Basel)."},{"key":"10.1016\/j.bbadis.2026.168370_bb0025","article-title":"The 150 most important questions in cancer research and clinical oncology series: questions 6\u201314: edited by Chinese Journal of Cancer","volume":"36","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.bbadis.2026.168370_bb0030","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5306\/wjco.v11.i10.761","article-title":"Colorectal liver metastases: current management and future perspectives","volume":"11","author":"Martin","year":"2020","journal-title":"World J Clin Oncol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0035","first-page":"1","article-title":"Mechanisms of metastatic colorectal cancer","author":"Ca\u00f1ellas-Socias","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics."},{"key":"10.1016\/j.bbadis.2026.168370_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106779","article-title":"Identification of key genes in colorectal cancer diagnosis by co-expression analysis weighted gene co-expression network analysis","volume":"157","author":"Mortezapour","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.bbadis.2026.168370_bb0050","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","article-title":"The tumor microenvironment innately modulates cancer progression","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168370_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133212","article-title":"Tumor microenvironment as a \u201cgame changer\u201d in cancer radiotherapy","volume":"20","author":"Jarosz-Biej","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168370_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13058-016-0740-2","article-title":"Tumor-associated stromal cells as key contributors to the tumor microenvironment","volume":"18","author":"Bussard","year":"2016","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168370_bb0065","article-title":"CX3CR1 acts as a protective biomarker in the tumor microenvironment of colorectal cancer","volume":"12","author":"Yue","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0070","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41581-018-0021-7","article-title":"Single-cell RNA sequencing for the study of development, physiology and disease","volume":"14","author":"Potter","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0075","article-title":"Specific extracellular matrix remodeling signature of colon hepatic metastases","volume":"8","author":"Rio","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2026.168370_bb0080","doi-asserted-by":"crossref","first-page":"72908","DOI":"10.18632\/oncotarget.12140","article-title":"Genomic characterization of liver metastases from colorectal cancer patients","volume":"7","author":"Sayagu\u00e9s","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2026.168370_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001453","article-title":"Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value","volume":"10","author":"Marisa","year":"2013","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbadis.2026.168370_bb0090","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/ijc.22975","article-title":"Whole genome analysis for liver metastasis gene signatures in colorectal cancer","volume":"121","author":"Ki","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2026.168370_bb0095","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1073\/pnas.0902232106","article-title":"Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer","volume":"106","author":"Sheffer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2026.168370_bb0100","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2026.168370_bb0105","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152616","article-title":"Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing","volume":"7","author":"Guo","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2026.168370_bb0110","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2015.08.026","article-title":"Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice","volume":"64","author":"Lei","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0115","first-page":"93","article-title":"The eighth edition AJCC Cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbadis.2026.168370_bb0120","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/14712598.2017.1315405","article-title":"Immunotherapy for colorectal cancer: where are we heading?","volume":"17","author":"Basile","year":"2017","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bbadis.2026.168370_bb0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00384-018-3202-8","article-title":"Current status of immunotherapy in metastatic colorectal cancer","volume":"34","author":"Wrobel","year":"2019","journal-title":"Int. J. Color. Dis."},{"key":"10.1016\/j.bbadis.2026.168370_bb0130","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1101\/gr.147800","article-title":"Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function","volume":"10","author":"Irving","year":"2000","journal-title":"Genome Res."},{"key":"10.1016\/j.bbadis.2026.168370_bb0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1432-1033.1991.tb15911.x","article-title":"Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements","volume":"197","author":"Carter","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbadis.2026.168370_bb0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12016-016-8543-x","article-title":"Genetics of hereditary angioedema revisited","volume":"51","author":"Germenis","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12016-016-8561-8","article-title":"HAE pathophysiology and underlying mechanisms","volume":"51","author":"Zuraw","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0150","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.148.3672.957","article-title":"Hereditary angioneurotic edema: two genetic variants","volume":"148","author":"Rosen","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2026.168370_bb0155","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.18632\/oncotarget.27191","article-title":"Upregulation of C1-inhibitor in pancreatic cancer","volume":"10","author":"Osther","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2026.168370_bb0160","first-page":"116","article-title":"Genetic secrets of long-term glioblastoma survivors","volume":"19","author":"Jov\u010devska","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.bbadis.2026.168370_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1018639","article-title":"Identification of hub genes for early detection of bone metastasis in breast cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbadis.2026.168370_bb0170","doi-asserted-by":"crossref","first-page":"366.e1","DOI":"10.1016\/j.urolonc.2018.05.021","article-title":"Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression","volume":"36","author":"Peng","year":"2018","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0175","article-title":"Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration","volume":"10","author":"Javanmardi","year":"2023","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.bbadis.2026.168370_bb0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","article-title":"Extracellular matrix and its therapeutic potential for cancer treatment","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168370_bb0185","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.091744","article-title":"Cdks, cyclins and CKIs: roles beyond cell cycle regulation","volume":"140","author":"Lim","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.bbadis.2026.168370_bb0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-019-0054-9","article-title":"Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis","volume":"4","author":"Lyu","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168370_bb0195","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.semcancer.2022.09.004","article-title":"TGF-\u03b2 in developmental and fibrogenic EMTs","volume":"86","author":"Lee","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0200","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12935-025-03973-x","article-title":"Breast neoplasm epithelial-mesenchymal transition and cytokines: a systematic review","volume":"25","author":"Chen","year":"2025","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbadis.2026.168370_bb0205","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3892\/ijo.2014.2310","article-title":"JAK\/STAT3 signaling is required for TGF-\u03b2-induced epithelial-mesenchymal transition in lung cancer cells","volume":"44","author":"Liu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1375543","article-title":"The role of cancer-associated fibroblasts in the invasion and metastasis of colorectal cancer","volume":"12","author":"Yin","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2026.168370_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-022-03510-8","article-title":"Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer","volume":"20","author":"Peng","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168370_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45144-w","article-title":"Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations","volume":"13","author":"Abbas","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:20:54Z","timestamp":1787430054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0925443926002334"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168370","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERPING1 facilitates colorectal liver metastasis by modulating epithelial-mesenchymal transition and tumor microenvironment remodeling","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168370"}}