{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:26:31Z","timestamp":1787430391910,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025J011545"],"award-info":[{"award-number":["2025J011545"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J011488"],"award-info":[{"award-number":["2024J011488"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J011745"],"award-info":[{"award-number":["2023J011745"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbadis.2026.168375","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:58:08Z","timestamp":1784645888000},"page":"168375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["LINC02207 suppresses breast cancer progression by promoting cuproptosis through NFAT5 regulation"],"prefix":"10.1016","volume":"1872","author":[{"given":"JiCheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binglin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10074","key":"10.1016\/j.bbadis.2026.168375_bb0005","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","article-title":"Breast cancer","volume":"389","author":"Harbeck","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168375_bb0010","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.16947","article-title":"Breast cancer incidence trends in older US women by race, ethnicity, geography, and stage","volume":"8","author":"Lee Argov","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168375_bb0020","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.bbadis.2026.168375_bb0025","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.tibs.2023.03.007","article-title":"LncRNAs: the missing link to senescence nuclear architecture","volume":"48","author":"Han","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2026.168375_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215798","article-title":"LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling","volume":"543","author":"Yang","year":"2022","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168375_bb0035","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.7150\/ijbs.40769","article-title":"LncRNAs regulate metabolism in cancer","volume":"16","author":"Lin","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2026.168375_bb0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ncrna.2025.05.014","article-title":"LncRNA MEG3\/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration","volume":"14","author":"Elhassan","year":"2025","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.bbadis.2026.168375_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106418","article-title":"Long non-coding RNA (lncRNA) H19 in human cancer: from proliferation and metastasis to therapy","volume":"184","author":"Hashemi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2026.168375_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1194300","article-title":"The current advances of lncRNAs in breast cancer immunobiology research","volume":"14","author":"Fonseca-Monta\u00f1o","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168375_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112963","article-title":"Long non-coding RNAs and exosomal lncRNAs: potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling","volume":"150","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168375_bb0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/cac2.12108","article-title":"LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer","volume":"41","author":"Tan","year":"2021","journal-title":"Cancer Commun. (Lond.)"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168375_bb0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: a copper-triggered modality of mitochondrial cell death","volume":"32","author":"Tang","year":"2022","journal-title":"Cell Res."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168375_bb0075","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41423-022-00866-1","article-title":"Cuproptosis: a new form of programmed cell death","volume":"19","author":"Wang","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168375_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202213644","article-title":"Metalloallostery and transition metal signaling: bioinorganic copper chemistry beyond active sites","volume":"62","author":"Pham","year":"2023","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168375_bb0085","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","article-title":"Cuproptosis: cellular and molecular mechanisms underlying copper-induced cell death","volume":"82","author":"Cobine","year":"2022","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168375_bb0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168375_bb0095","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The cancer genome atlas pan-cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2026.168375_bb0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13073-015-0226-3","article-title":"The cancer genome atlas clinical explorer: a web and mobile interface for identifying clinical-genomic driver associations","volume":"7","author":"Lee","year":"2015","journal-title":"Genome Med."},{"issue":"24","key":"10.1016\/j.bbadis.2026.168375_bb0105","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1111\/jcmm.17985","article-title":"Contribution of cuproptosis and Cu metabolism-associated genes to chronic obstructive pulmonary disease","volume":"27","author":"Qi","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168375_bb0110","article-title":"Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168375_bb0115","first-page":"4074","article-title":"Pan-cancer profiles of the cuproptosis gene set","volume":"12","author":"Liu","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168375_bb0120","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41580-023-00694-9","article-title":"Transcription regulation by long non-coding RNAs: mechanisms and disease relevance","volume":"25","author":"Ferrer","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2026.168375_bb0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.gde.2021.11.005","article-title":"Understanding lncRNA-protein assemblies with imaging and single-molecule approaches","volume":"72","author":"Liu","year":"2022","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13048-023-01099-0","article-title":"Development and verification of a 7-lncRNA prognostic model based on tumor immunity for patients with ovarian cancer","volume":"16","author":"Feng","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.bbadis.2026.168375_bb0135","article-title":"Screening and identification of an immune-associated lncRNA prognostic signature in ovarian carcinoma: evidence from bioinformatic analysis","volume":"2021","author":"Li","year":"2021","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168375_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2019.04.005","article-title":"Non-coding RNAs as potential therapeutic targets in breast cancer","volume":"1863","author":"Tomar","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.bbadis.2026.168375_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcancer.2020.06.019","article-title":"Emerging roles of long non-coding RNAs in breast cancer biology and management","volume":"72","author":"Amelio","year":"2021","journal-title":"Semin. Cancer Biol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168375_bb0150","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/ijc.30546","article-title":"Potential of long non-coding RNAs in cancer patients: from biomarkers to therapeutic targets","volume":"140","author":"Chandra Gupta","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2026.168375_bb0155","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-981-10-5203-3_7","article-title":"Long noncoding RNAs in cancer and therapeutic potential","volume":"1008","author":"Renganathan","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbadis.2026.168375_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101910","article-title":"The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p\/Mfn1 axis-mediated mitochondrial dynamics","volume":"41","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-023-01765-3","article-title":"HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer","volume":"22","author":"Raju","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbadis.2026.168375_bb0170","doi-asserted-by":"crossref","unstructured":"Zhang Y, Luo M, Cui X, O'Connell D, Yang Y: Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p\/MIOX axis as a ceRNA. Cell Death Differ. 2022, 29(9):1850\u20131863.","DOI":"10.1038\/s41418-022-00970-9"},{"issue":"22","key":"10.1016\/j.bbadis.2026.168375_bb0175","article-title":"Cuproptosis induced by ROS responsive nanoparticles with Elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0180","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168375_bb0185","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.freeradbiomed.2012.03.017","article-title":"The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells","volume":"52","author":"Nagai","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168375_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005245","article-title":"The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress","volume":"4","author":"Drews-Elger","year":"2009","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168375_bb0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.kint.2023.03.030","article-title":"Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways","volume":"104","author":"Yoo","year":"2023","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168375_bb0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gutjnl-2017-315348","article-title":"Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis","volume":"68","author":"Lee","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2026.168375_bb0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jss.2017.12.036","article-title":"Prognostic significance of nuclear factor of activated T-cells 5 expression in non-small cell lung cancer patients who underwent surgical resection","volume":"226","author":"Cho","year":"2018","journal-title":"J. Surg. Res."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168375_bb0210","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/s41590-023-01614-x","article-title":"Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion","volume":"24","author":"Till\u00e9","year":"2023","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168375_bb0215","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240766","article-title":"NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer","volume":"221","author":"Deng","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2026.168375_bb0220","doi-asserted-by":"crossref","DOI":"10.1177\/15330338241255585","article-title":"LncRNA AP000842.3 triggers the malignant progression of prostate cancer by regulating cuproptosis related gene NFAT5","volume":"23","author":"Zhou","year":"2024","journal-title":"Technol. Cancer Res. Treat."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168375_bb0225","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-14-0001","article-title":"Patient-derived xenograft models: an emerging platform for translational cancer research","volume":"4","author":"Hidalgo","year":"2014","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168375_bb0230","doi-asserted-by":"crossref","first-page":"T259","DOI":"10.1530\/ERC-16-0251","article-title":"Patient-derived tumour xenografts for breast cancer drug discovery","volume":"23","author":"Cassidy","year":"2016","journal-title":"Endocr. Relat. Cancer"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:19:24Z","timestamp":1787429964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0925443926002383"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168375","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LINC02207 suppresses breast cancer progression by promoting cuproptosis through NFAT5 regulation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168375"}}