{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:27:16Z","timestamp":1787430436140,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470192"],"award-info":[{"award-number":["82470192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["GSPJS202501"],"award-info":[{"award-number":["GSPJS202501"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["XYFY202314"],"award-info":[{"award-number":["XYFY202314"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241768"],"award-info":[{"award-number":["BK20241768"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2024062"],"award-info":[{"award-number":["Z2024062"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbadis.2026.168382","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:55:45Z","timestamp":1784908545000},"page":"168382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["RRx-001 induces apoptosis through reactive oxygen species and endoplasmic reticulum stress in Burkitt lymphoma cells by acting as CD47 and c-Myc regulator"],"prefix":"10.1016","volume":"1872","author":[{"given":"Linyan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianzhu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168382_bb0005","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0140-6736(11)61177-X","article-title":"Burkitt\u2019s lymphoma","volume":"379","author":"Molyneux","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2026.168382_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3026(24)00351-X","article-title":"Diagnosis and treatment of Burkitt lymphoma in adults: clinical practice guidelines from ERN-EuroBloodNet","volume":"12","author":"Ribrag","year":"2025","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41408-024-01138-z","article-title":"Global, regional, and national burden of Burkitt lymphoma from 1990 to 2021 and predictions to 2030: a systematic analysis for the Global Burden of Disease Study 2021","volume":"14","author":"Wang","year":"2024","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.bbadis.2026.168382_bb0020","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00432-020-03269-9","article-title":"Sequential anti-CD19, 22, and 20 autologous chimeric antigen receptor T-cell (CAR-T) treatments of a child with relapsed refractory Burkitt lymphoma: a case report and literature review (vol 146, pg 1575, 2020)","volume":"146","author":"Du","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0025","first-page":"1124","article-title":"Progressive or relapsed Burkitt lymphoma or leukemia in children and adolescents after BFM-type first-line therapy","volume":"135","author":"Woessmann","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2026.168382_bb0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10555-025-10269-z","article-title":"Novel immunotherapy for gastric cancer: targeting the CD47-SIRPalpha axis","volume":"44","author":"Ooki","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbadis.2026.168382_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189294","article-title":"CD47 as a potent target in cancer immunotherapy: a review","volume":"1880","author":"Ahvati","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbadis.2026.168382_bb0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/08820139.2024.2415409","article-title":"The physiological and therapeutic role of CD47 in macrophage function and cancer","volume":"54","author":"Bess","year":"2025","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.bbadis.2026.168382_bb0045","article-title":"Targeting the CD47\/SIRPalpha pathway in malignancies: recent progress, difficulties and future perspectives","volume":"14","author":"Jiang","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.seminoncol.2020.05.009","article-title":"Just eat it: a review of CD47 and SIRP-\u03b1 antagonism","volume":"47","author":"Oronsky","year":"2020","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0055","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gendis.2022.12.008","article-title":"Targeting CD47-SIRPalpha axis for Hodgkin and non-Hodgkin lymphoma immunotherapy","volume":"11","author":"Zhao","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbadis.2026.168382_bb0060","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-011550","article-title":"Oncolytic viruses targeting CD47: a new road to success?","volume":"13","author":"Takimoto C.","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbadis.2026.168382_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114576","article-title":"Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc\/CD47 axis","volume":"188","author":"Ren","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0070","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1021\/acs.jmedchem.1c00599","article-title":"Discovery of RRx-001, a Myc and CD47 downregulating small molecule with tumor targeted cytotoxicity and healthy tissue cytoprotective properties in clinical development","volume":"64","author":"Oronsky","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2026.168382_bb0075","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1746172","article-title":"RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an \u201cerythrophagoimmunotherapeutic\u201d","volume":"9","author":"Oronsky","year":"2020","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.bbadis.2026.168382_bb0080","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ijrobp.2022.12.031","article-title":"PREVLAR: phase 2a randomized trial to assess the safety and efficacy of RRx-001 in the attenuation of oral mucositis in patients receiving head and neck chemoradiotherapy","volume":"116","author":"Bonomi","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbadis.2026.168382_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1469825","article-title":"Anti-tumor and anti-metastatic effects of RRx-001 on hepatocellular carcinoma: mechanisms of action and therapeutic potential","volume":"15","author":"Yan","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1176448","article-title":"A multicenter, phase 1, dose escalation clinical trial (G-FORCE-1) of XRT, RRx-001 and temozolomide followed by temozolomide +\/\u2212 RRx-001 in newly diagnosed glioblastoma","volume":"13","author":"Fine","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0095","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.2217\/fon-2019-0317","article-title":"REPLATINUM phase III randomized study: RRx-001 + platinum doublet versus platinum doublet in third-line small cell lung cancer","volume":"15","author":"Oronsky","year":"2019","journal-title":"Future Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/17425255.2021.1876025","article-title":"RRx-001, a downregulator of the CD47- SIRPalpha checkpoint pathway, does not cause anemia or thrombocytopenia","volume":"17","author":"Oronsky","year":"2021","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0105","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/jpet.123.001583","article-title":"Chidamide induces Epstein-Barr virus (EBV) lytic infection and acts synergistically with Tenofovir to eliminate EBV-positive Burkitt lymphoma","volume":"387","author":"Xu","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2026.168382_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23117","article-title":"L-Asparaginase synergizes with etoposide via the PI3K\/Akt\/mTOR pathway in Epstein-Barr virus-positive Burkitt lymphoma","volume":"36","author":"Sang","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.ircmb.2021.04.001","article-title":"Reactive oxygen species and DNA damage response in cancer","volume":"364","author":"Renaudin","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.7150\/ijms.84952","article-title":"Anlotinib suppresses the DNA damage response by disrupting SETD1A and inducing p53-dependent apoptosis in Transformed Follicular Lymphoma","volume":"21","author":"Zhuang X.","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bbadis.2026.168382_bb0125","doi-asserted-by":"crossref","first-page":"153707","DOI":"10.1016\/j.tox.2023.153707","article-title":"DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells","volume":"501","author":"Hou","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.bbadis.2026.168382_bb0130","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1007\/s00018-014-1666-4","article-title":"Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress","volume":"71","author":"Yan","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2026.168382_bb0135","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2026.168382_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.120","article-title":"AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation","volume":"3","author":"Baritaud","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168382_bb0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3892\/mmr.2015.3404","article-title":"Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit\u2019s lymphoma cells","volume":"12","author":"Hu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbadis.2026.168382_bb0150","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.actbio.2025.01.015","article-title":"Promotion of triple negative breast cancer immunotherapy by combining bioactive radicals with immune checkpoint blockade","volume":"194","author":"Chen","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbadis.2026.168382_bb0155","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/leu.2016.96","article-title":"A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells","volume":"30","author":"Das","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.bbadis.2026.168382_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304476","article-title":"An \u201call-in-one\u201d immunomodulator-engineered clinical translatable immunotherapy of advanced hepatocellular carcinoma","volume":"13","author":"Xie","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbadis.2026.168382_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.879204","article-title":"ROS and endoplasmic reticulum stress in pulmonary disease","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0170","article-title":"Unfolding the interactions between endoplasmic reticulum stress and oxidative stress","volume":"12","author":"Ong","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.bbadis.2026.168382_bb0175","article-title":"Mechanisms of the JNK\/p38 MAPK signaling pathway in drug resistance in ovarian cancer","volume":"15","author":"Ma","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0180","doi-asserted-by":"crossref","DOI":"10.31083\/FBL31317","article-title":"Role of ERK1\/2 and p38 protein kinases in tumors: biological insights and clinical implications","volume":"30","author":"Emelyanova","year":"2025","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2026.168382_bb0185","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbadis.2026.168382_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.179","article-title":"Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism","volume":"5","author":"Dixit","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168382_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102154","article-title":"MYC as a target for cancer treatment","volume":"94","author":"Duffy M.","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bbadis.2026.168382_bb0200","doi-asserted-by":"crossref","first-page":"23439","DOI":"10.18632\/oncotarget.25211","article-title":"Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells","volume":"9","author":"Oronsky","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2026.168382_bb0205","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.7150\/ijbs.60782","article-title":"CD47\/SIRP\u03b1 pathway mediates cancer immune escape and immunotherapy","volume":"17","author":"Jia","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2026.168382_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110255","article-title":"The CD47-SIRP\u03b1 axis is a promising target for cancer immunotherapies","volume":"120","author":"Hao","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2026.168382_bb0215","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1182\/blood-2017-11-742577","article-title":"The MYC oncogene is a global regulator of the immune response","volume":"131","author":"Casey","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2026.168382_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04667-6","article-title":"Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-\u03b3 production via activating the JAK\/STAT3 pathway during HIV infection","volume":"21","author":"Lang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168382_bb0225","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tranon.2018.12.001","article-title":"RRx-001 acts as a dual small molecule checkpoint inhibitor by downregulating CD47 on cancer cells and SIRP-alpha on monocytes\/macrophages","volume":"12","author":"Cabrales","year":"2019","journal-title":"Transl. Oncol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:20:35Z","timestamp":1787430035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0925443926002450"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168382","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RRx-001 induces apoptosis through reactive oxygen species and endoplasmic reticulum stress in Burkitt lymphoma cells by acting as CD47 and c-Myc regulator","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168382"}}