{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:26:32Z","timestamp":1787430392074,"version":"build-2736575974"},"reference-count":13,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbadis.2026.168386","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:12:52Z","timestamp":1785132772000},"page":"168386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ozone-driven NRF2 activation boosts osteoblast activity: Implications for skeletal diseases"],"prefix":"10.1016","volume":"1872","author":[{"given":"Alessandra","family":"Sala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Dominoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsenio","family":"Spinillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Forlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Besio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbadis.2026.168386_bb0005","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949211","article-title":"N-acetyl-L-tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals","volume":"21","author":"Matsumura","year":"2020","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168386_bb0010","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050340","article-title":"Endogenous metabolites promote stress resistance through induction of mitohormesis","volume":"21","author":"Fischer","year":"2020","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168386_bb0015","article-title":"Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"21","key":"10.1016\/j.bbadis.2026.168386_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115747","article-title":"Ozone as redox bioregulator in preventive medicine: the molecular and pharmacological basis of the low-dose ozone concept-a review","volume":"24","author":"Viebahn-Haensler","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168386_bb0025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2018.05.093","article-title":"Mild ozonisation activates antioxidant cell response by the Keap1\/Nrf2 dependent pathway","volume":"124","author":"Gali\u00e8","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168386_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-026-01475-8","article-title":"Impact of oxygen-ozone mixture on cellular functions: a biochemical perspective across cell types","volume":"32","author":"Khalid","year":"2026","journal-title":"Mol. Med."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168386_bb0035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168386_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ejo\/cjv045","article-title":"The effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats","volume":"38","author":"Buyuk","year":"2016","journal-title":"Eur. J. Orthod."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168386_bb0045","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s00784-024-05961-3","article-title":"Systemic ozone therapy as an adjunctive treatment in guided bone regeneration: a histomorphometrical and immunohistochemical study in rats","volume":"28","author":"Baggio","year":"2024","journal-title":"Clin. Oral Investig."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168386_bb0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0041-1731886","article-title":"Preliminary histological evaluation of the application of ozone in the first days of orthodontic force induction in animal model","volume":"16","author":"Faccini","year":"2022","journal-title":"Eur J Dent"},{"key":"10.1016\/j.bbadis.2026.168386_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2021.03.001","article-title":"Targeting cellular stress in vitro improves osteoblast homeostasis, matrix collagen content and mineralization in two murine models of osteogenesis imperfecta","volume":"98","author":"Garibaldi","year":"2021","journal-title":"Matrix Biol."},{"issue":"53","key":"10.1016\/j.bbadis.2026.168386_bb0060","doi-asserted-by":"crossref","first-page":"37923","DOI":"10.1074\/jbc.274.53.37923","article-title":"Use of the Cre\/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice","volume":"274","author":"Forlino","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168386_bb0065","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jbmr\/zjae088","article-title":"The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion","volume":"39","author":"Suh","year":"2024","journal-title":"J. Bone Miner. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:20:57Z","timestamp":1787430057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0925443926002498"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168386","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ozone-driven NRF2 activation boosts osteoblast activity: Implications for skeletal diseases","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"168386"}}