{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:57:22Z","timestamp":1790989042945,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012576","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2025A1515012031"],"award-info":[{"award-number":["2025A1515012031"]}],"id":[{"id":"10.13039\/501100012576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Xinjiang Uygur Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2025D01D44"],"award-info":[{"award-number":["2025D01D44"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Xinjiang Uygur Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2021D01C012"],"award-info":[{"award-number":["2021D01C012"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070708"],"award-info":[{"award-number":["82070708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015308","name":"Xinjiang Uygur Autonomous Region Department of Science and Technology","doi-asserted-by":"publisher","award":["TSYC202401B202"],"award-info":[{"award-number":["TSYC202401B202"]}],"id":[{"id":"10.13039\/501100015308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbadis.2026.168388","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:06:06Z","timestamp":1785251166000},"page":"168388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway"],"prefix":"10.1016","volume":"1873","author":[{"given":"Jiaqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbadis.2026.168388_bb0005","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168388_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"issue":"7983","key":"10.1016\/j.bbadis.2026.168388_bb0015","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.bbadis.2026.168388_bb0020","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168388_bb0025","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1038\/s41467-025-63152-4","article-title":"Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168388_bb0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrm3479","article-title":"Mitochondria: master regulators of danger signalling","volume":"13","author":"Galluzzi","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168388_bb0035","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168388_bb0040","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen","year":"2012","journal-title":"Cell. Signal."},{"issue":"7973","key":"10.1016\/j.bbadis.2026.168388_bb0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbadis.2026.168388_bb0050","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tcb.2022.11.001","article-title":"Cellular functions of cGAS-STING signaling","volume":"33","author":"Chen","year":"2023","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168388_bb0055","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41556-024-01419-6","article-title":"TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA","volume":"26","author":"Liu","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168388_bb0060","first-page":"201","article-title":"Efficient elimination of mtDNA from mammalian cells with 2\u2032,3\u2032-dideoxycytidine","volume":"4","author":"Kozhukhar","year":"2024","journal-title":"DNA (Basel)"},{"issue":"11","key":"10.1016\/j.bbadis.2026.168388_bb0065","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6378","key":"10.1016\/j.bbadis.2026.168388_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.bbadis.2026.168388_bb0075","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1016\/j.lfs.2004.12.012","article-title":"The permeability transition pore as a pathway for the release of mitochondrial DNA","volume":"76","author":"Garc\u00eda","year":"2005","journal-title":"Life Sci."},{"issue":"6472","key":"10.1016\/j.bbadis.2026.168388_bb0080","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168388_bb0085","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41589-018-0223-0","article-title":"Small-molecule allosteric inhibitors of BAX","volume":"15","author":"Garner","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"7317","key":"10.1016\/j.bbadis.2026.168388_bb0090","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168388_bb0095","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00125-021-05418-2","article-title":"High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice","volume":"64","author":"Jorquera","year":"2021","journal-title":"Diabetologia"},{"issue":"9","key":"10.1016\/j.bbadis.2026.168388_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7676","key":"10.1016\/j.bbadis.2026.168388_bb0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic chromatin triggers inflammation in senescence and cancer","volume":"550","author":"Dou","year":"2017","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bbadis.2026.168388_bb0110","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.tcb.2025.06.005","article-title":"Mitochondrial DNA: how does it leave mitochondria?","volume":"35","author":"Gogvadze","year":"2025","journal-title":"Trends Cell Biol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168388_bb0115","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"issue":"17","key":"10.1016\/j.bbadis.2026.168388_bb0120","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899238","article-title":"Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis","volume":"37","author":"Riley","year":"2018","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168388_bb0125","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1096\/fj.01-0269fje","article-title":"The permeability transition pore signals apoptosis by directing Bax translocation and multimerization","volume":"16","author":"De Giorgi","year":"2002","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168388_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091273","article-title":"The mitochondrial permeability transition pore-current knowledge of its structure, function, and regulation, and optimized methods for evaluating its functional state","volume":"12","author":"Endlicher","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168388_bb0135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.freeradbiomed.2026.03.036","article-title":"cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation","volume":"249","author":"Wang","year":"2026","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168388_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24033029","article-title":"How the innate immune DNA sensing cGAS-STING pathway is involved in apoptosis","volume":"24","author":"Zheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168388_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116203","article-title":"Crosstalk between cGAS-STING and pyroptosis: from molecular mechanisms to therapeutic strategies","volume":"172","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168388_bb0150","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1007\/s00204-025-04150-9","article-title":"Interplay of cGAS-STING and ferroptosis: crosstalk, molecular mechanisms, and therapeutic prospects","volume":"99","author":"Wang","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168388_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107137","article-title":"cGAS-STING targeting offers a novel therapeutic paradigm in cardiovascular diseases","volume":"211","author":"Wang","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bbadis.2026.168388_bb0160","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.2147\/DDDT.S521397","article-title":"cGAS-STING targeting offers novel therapeutic opportunities in liver diseases","volume":"19","author":"Wang","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168388_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10565-025-10051-5","article-title":"cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction","volume":"41","author":"Yu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168388_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102691","article-title":"cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases","volume":"105","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168388_bb0175","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12974-025-03563-8","article-title":"cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives","volume":"22","author":"Li","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168388_bb0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00204-025-04206-w","article-title":"cGAS-STING and autophagy: crosstalk, molecular mechanisms, and targeted therapy","volume":"100","author":"Wang","year":"2026","journal-title":"Arch. Toxicol."},{"issue":"Suppl","key":"10.1016\/j.bbadis.2026.168388_bb0185","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: choreographing the social lives of cells","volume":"109","author":"Crabtree","year":"2002","journal-title":"Cell"},{"issue":"5011","key":"10.1016\/j.bbadis.2026.168388_bb0190","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.1646483","article-title":"CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases","volume":"252","author":"Sheng","year":"1991","journal-title":"Science"},{"issue":"27","key":"10.1016\/j.bbadis.2026.168388_bb0195","doi-asserted-by":"crossref","first-page":"18859","DOI":"10.1074\/jbc.M512543200","article-title":"Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation","volume":"281","author":"Xin","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:23:32Z","timestamp":1790987012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0925443926002516"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168388","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168388"}}