{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:57:43Z","timestamp":1790989063773,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYGD20008"],"award-info":[{"award-number":["ZYGD20008"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300451"],"award-info":[{"award-number":["32300451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20721"],"award-info":[{"award-number":["U24A20721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273168"],"award-info":[{"award-number":["82273168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbadis.2026.168424","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:07:12Z","timestamp":1786774032000},"page":"168424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["IGF2BP3 promotes esophageal squamous cell carcinoma progression by regulating global protein translation"],"prefix":"10.1016","volume":"1873","author":[{"given":"Gu-Ha","family":"A-Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Dan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbadis.2026.168424_bb0005","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"27","key":"10.1016\/j.bbadis.2026.168424_bb0010","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1200\/JCO.2018.79.1483","article-title":"Neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced squamous cell carcinoma of the esophagus (NEOCRTEC5010): a phase III multicenter, randomized, open-label clinical trial","volume":"36","author":"Yang","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168424_bb0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/SLA.0000000000004436","article-title":"Distribution of residual disease and recurrence patterns in pathological responders after neoadjuvant chemotherapy for esophageal squamous cell carcinoma","volume":"276","author":"Matsuda","year":"2022","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbadis.2026.168424_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.104115","article-title":"Combine radiotherapy and immunotherapy inesophageal squamous cell carcinoma","volume":"190","author":"Chen","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbadis.2026.168424_bb0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-074962","article-title":"Advances in diagnosis and management of cancer of the esophagus","volume":"385","author":"Deboever","year":"2024","journal-title":"BMJ"},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2026.168424_bb0030","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.semcancer.2022.03.018","article-title":"RNA-binding proteins and cancer metastasis","volume":"86","author":"Wang","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-020-00927-w","article-title":"RNA-binding proteins in tumor progression","volume":"13","author":"Qin","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"Pt 3","key":"10.1016\/j.bbadis.2026.168424_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.semcancer.2022.05.009","article-title":"The IGF2BP family of RNA binding proteins linksepitranscriptomics to cancer","volume":"86","author":"Kumar","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40364-023-00499-0","article-title":"Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential","volume":"11","author":"Zhu","year":"2023","journal-title":"Biomark. Res."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168424_bb0050","article-title":"Targeting IGF2BP3 in cancer","volume":"24","author":"Xin Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168424_bb0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2014.07.006","article-title":"The role of the oncofetal IGF2 mRNA-bindingprotein 3 (IGF2BP3) in cancer","volume":"29","author":"Lederer","year":"2014","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168424_bb0060","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.gendis.2023.06.017","article-title":"IGF2BPs as novel m6A readers: diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment","volume":"11","author":"Duan","year":"2023","journal-title":"Genes Dis."},{"issue":"13","key":"10.1016\/j.bbadis.2026.168424_bb0065","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1158\/0008-5472.CAN-22-3059","article-title":"Metabolic reprogramming driven by IGF2BP3 promotes acquired resistance to EGFR inhibitors in non-small cell lung cancer","volume":"83","author":"Lin","year":"2023","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168424_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41419-024-06520-0","article-title":"IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD","volume":"15","author":"Han","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168424_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","article-title":"Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP","volume":"141","author":"Hafner","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2026.168424_bb0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N (6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168424_bb0085","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.str.2025.01.022","article-title":"Structural basis for the RNA binding properties of mouse IGF2BP3","volume":"33","author":"Li","year":"2025","journal-title":"Structure"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0090","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12935-024-03349-7","article-title":"The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation","volume":"24","author":"Li","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168424_bb0095","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41419-023-06099-y","article-title":"IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12943-025-02442-3","article-title":"A circRNA promotes esophageal squamous cell carcinoma progression by inhibiting TRIM25-mediated degradation of IGF2BP family members","volume":"24","author":"Tan","year":"2025","journal-title":"Mol. Cancer"},{"issue":"15","key":"10.1016\/j.bbadis.2026.168424_bb0105","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","article-title":"Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?","volume":"70","author":"Bell","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"D1","key":"10.1016\/j.bbadis.2026.168424_bb0110","doi-asserted-by":"crossref","first-page":"D287","DOI":"10.1093\/nar\/gkab702","article-title":"POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins","volume":"50","author":"Zhao","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168424_bb0115","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1172\/JCI80046","article-title":"RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation","volume":"126","author":"Palanichamy","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2026.168424_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217944","article-title":"Dual regulation of FZD1\/7 by IGF2BP3 enhances stem-like properties and carboplatin resistance in triple-negative breast cancer","volume":"632","author":"Cai","year":"2025","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-024-02013-y","article-title":"N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2","volume":"23","author":"Wen","year":"2024","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168424_bb0130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cncr.35048","article-title":"Association of the m6 A reader IGF2BP3 with tumor progression and brain-specific metastasis in breast cancer","volume":"130","author":"Li","year":"2024","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12943-017-0647-2","article-title":"IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168424_bb0140","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/hep.22459","article-title":"RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma","volume":"48","author":"Jeng","year":"2008","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0145","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1186\/s12967-024-05685-8","article-title":"Multi-omics analysis unveils the predictive value of IGF2BP3\/SPHK1 signaling in cancer stem cells for prognosis and immunotherapeutic response in muscle-invasive bladder cancer","volume":"22","author":"Wang","year":"2024","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0150","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41375-021-01346-7","article-title":"The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis","volume":"36","author":"Tran","year":"2022","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168424_bb0155","first-page":"1495","article-title":"LL22NC03-N14H11.1 regulates the m6A modification of MYC and promotes glycolytic activity in hepatocellular carcinoma cells by inhibiting IGF2BP3 ubiquitination degradation","volume":"126","author":"Yi","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2026.168424_bb0160","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1038\/s41388-022-02464-x","article-title":"A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC","volume":"41","author":"Gao","year":"2022","journal-title":"Oncogene"},{"issue":"41","key":"10.1016\/j.bbadis.2026.168424_bb0165","article-title":"m6A-modified circRAPGEF1 interaction with IGF2BP3 promotes hepatocellular carcinoma progression via reprogramming aspartate metabolism","volume":"12","author":"Shi","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbadis.2026.168424_bb0170","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41467-023-42571-1","article-title":"A circular RNA activated by TGF\u03b2 promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168424_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114111","article-title":"Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome","volume":"43","author":"Wu","year":"2024","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168424_bb0180","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41419-022-04950-2","article-title":"m6A methylated EphA2 and VEGFA through IGF2BP2\/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K\/AKT and ERK1\/2 signaling","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0185","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41392-023-01428-1","article-title":"RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168424_bb0190","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1007\/s12035-024-04450-8","article-title":"Monosome stalls the translation process mediated by IGF2BP in arcuate nucleus for puberty onset delay","volume":"62","author":"Shen","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168424_bb0195","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.ccell.2022.10.004","article-title":"The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia","volume":"40","author":"Weng","year":"2022","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0200","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1038\/s41467-025-58966-1","article-title":"m6A\/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"46","key":"10.1016\/j.bbadis.2026.168424_bb0205","article-title":"Lactylation-driven IGF2BP3-mediated serine metabolism reprogramming and RNA m6A-modification promotes lenvatinib resistance in HCC","volume":"11","author":"Lu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168424_bb0210","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/s41467-020-16306-5","article-title":"N6-methyladenosine regulates glycolysis of cancer cells through PDK4","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926002875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:25:42Z","timestamp":1790987142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926002875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0925443926002875"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168424","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF2BP3 promotes esophageal squamous cell carcinoma progression by regulating global protein translation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168424"}}