{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:56:52Z","timestamp":1790989012331,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202501AY070001-188"],"award-info":[{"award-number":["202501AY070001-188"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018FH001-074"],"award-info":[{"award-number":["2018FH001-074"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202205AF150064"],"award-info":[{"award-number":["202205AF150064"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007846","name":"Yunnan Province Department of Education","doi-asserted-by":"publisher","award":["2026Y0433"],"award-info":[{"award-number":["2026Y0433"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbadis.2026.168452","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:50:34Z","timestamp":1789073434000},"page":"168452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PXDN knockdown alleviates hepatic stellate cell activation by regulating GPX1"],"prefix":"10.1016","volume":"1873","author":[{"given":"Gang","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168452_bb0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile acid metabolism and signalling in liver disease","volume":"82","author":"Fuchs","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0010","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/HEP.0000000000001341","article-title":"Epidemiological and economical burden of cholestatic liver disease","volume":"82","author":"Mol","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2026.168452_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cells13231997","article-title":"Molecular mechanisms of fibrosis in cholestatic liver diseases and regenerative medicine-based therapies","volume":"13","author":"Wang","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168452_bb0020","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/HEP.0000000000001093","article-title":"Central role for cholangiocyte pathobiology in cholestatic liver diseases","volume":"82","author":"Jalan-Sakrikar","year":"2025","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.bbadis.2026.168452_bb0025","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.cgh.2023.02.005","article-title":"New treatment paradigms in primary biliary cholangitis","volume":"21","author":"Levy","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14309\/ajg.0000000000003174","article-title":"Primary biliary cholangitis and primary Sclerosing cholangitis therapy landscape","volume":"120","author":"Bhushan","year":"2025","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0035","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/HEP.0000000000001268","article-title":"Liver transplantation for cholestatic liver diseases: timing and disease recurrence","volume":"82","author":"Can\u00e7ado","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2026.168452_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051107","article-title":"Fibrotic events in the progression of Cholestatic liver disease","volume":"10","author":"Wu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168452_bb0045","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jcmgh.2024.01.005","article-title":"Cellular interactions and crosstalk facilitating biliary fibrosis in cholestasis","volume":"17","author":"Ceci","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0050","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jcp.30582","article-title":"Hepatic stellate cells in the injured liver: perspectives beyond hepatic fibrosis","volume":"237","author":"Ezhilarasan","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0055","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1113\/JP281061","article-title":"Hepatic stellate cells in physiology and pathology","volume":"600","author":"Kamm","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147873","article-title":"Liver fibrosis: from basic science towards clinical Progress, focusing on the central role of hepatic stellate cells","volume":"25","author":"Akk\u0131z","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168452_bb0065","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/hep.31418","article-title":"Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells","volume":"73","author":"Zhang","year":"2021","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.bbadis.2026.168452_bb0070","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400733R","article-title":"GSK805 inhibits alpha-smooth muscle expression and modulates liver inflammation without impairing the well-being of mice","volume":"38","author":"Nierath","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2026.168452_bb0075","article-title":"TGF-\u03b2 inhibitors: the future for prevention and treatment of liver fibrosis?","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0080","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000893","article-title":"Hepatocyte-hepatic stellate cell interactions in liver fibrosis: mechanisms and therapeutic implications","volume":"10","author":"Wang","year":"2026","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbadis.2026.168452_bb0085","article-title":"Present and future perspectives in the treatment of liver fibrosis","volume":"18","author":"Cerrito","year":"2025","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"10.1016\/j.bbadis.2026.168452_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000612","article-title":"PPAR agonists for the treatment of cholestatic liver diseases: over a decade of clinical progress","volume":"9","author":"Hayes","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbadis.2026.168452_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13287-023-03276-w","article-title":"BM-MSCs overexpressing the numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction","volume":"14","author":"Xu","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168452_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118910","article-title":"Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K\/AKT signaling pathway","volume":"337","author":"Cui","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.J."},{"key":"10.1016\/j.bbadis.2026.168452_bb0110","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-019-1910-1","article-title":"Transcriptome assembly from long-read RNA-seq alignments with StringTie2","volume":"20","author":"Kovaka","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0120","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0125","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2026.168452_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174447","article-title":"Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review","volume":"910","author":"He","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118854","article-title":"Xenobiotic-induced liver injury: molecular mechanisms and disease progression","volume":"303","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbadis.2026.168452_bb0140","article-title":"Advances in pharmacological interventions for hepatic fibrosis: from pathogenic mechanisms to novel therapeutic targets","volume":"58","author":"Zhang","year":"2026","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbadis.2026.168452_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23788","article-title":"Hepatoprotective effect of astaxanthin against cholestasis liver fibrosis induced by bile duct ligation in adult Wistar rats","volume":"38","author":"Laderian","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0150","article-title":"REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K\/AKT\/mTOR pathway","volume":"12","author":"Li","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.bbadis.2026.168452_bb0155","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.advms.2024.08.001","article-title":"Evolution of splenomegaly in liver cirrhosis: simulation using an electronic circuit","volume":"69","author":"Jung","year":"2024","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.bbadis.2026.168452_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2024.101577","article-title":"Clinically significant portal hypertension in patients with primary biliary cholangitis: Clinicopathological features and prognostic value","volume":"30","author":"Zhang","year":"2025","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0165","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2022.02.026","article-title":"Mammalian peroxidasin (PXDN): from physiology to pathology","volume":"182","author":"Cheng","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2026.168452_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110155","article-title":"Exploring mammalian heme peroxidases: a comprehensive review on the structure and function of myeloperoxidase, lactoperoxidase, eosinophil peroxidase, thyroid peroxidase and peroxidasin","volume":"761","author":"Singh","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2026.168452_bb0175","doi-asserted-by":"crossref","first-page":"F360","DOI":"10.1152\/ajprenal.00291.2018","article-title":"Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model","volume":"316","author":"Colon","year":"2019","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0180","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.jcmgh.2022.01.015","article-title":"Peroxidasin deficiency re-programs macrophages toward pro-fibrolysis function and promotes collagen resolution in liver","volume":"13","author":"Sojoodi","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121824","article-title":"Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells","volume":"328","author":"Guo","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2026.168452_bb0190","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2022.06.004","article-title":"The role of glutathione peroxidase-1 in health and disease","volume":"188","author":"Handy","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2026.168452_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1147414","article-title":"Research progress of glutathione peroxidase family (GPX) in redoxidation","volume":"14","author":"Pei","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168452_bb0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0378-4274(03)00258-3","article-title":"Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice","volume":"144","author":"Li","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbadis.2026.168452_bb0205","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/2211-5463.12961","article-title":"PGC-1\u03b1 is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis","volume":"11","author":"Park","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbadis.2026.168452_bb0210","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1007\/s00125-016-4084-3","article-title":"Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice","volume":"59","author":"Merry","year":"2016","journal-title":"Diabetologia"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:20:26Z","timestamp":1790986826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926003182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0925443926003182"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168452","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PXDN knockdown alleviates hepatic stellate cell activation by regulating GPX1","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"168452"}}