{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:56:56Z","timestamp":1790989016233,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373056"],"award-info":[{"award-number":["82373056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023AFB1059"],"award-info":[{"award-number":["2023AFB1059"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025AFD780"],"award-info":[{"award-number":["2025AFD780"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbadis.2026.168464","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:01:44Z","timestamp":1789365704000},"page":"168464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detachment-induced ETS1 drives anoikis resistance and metastasis through STX3-mediated PTEN ubiquitination in gastric cancer"],"prefix":"10.1016","volume":"1873","author":[{"given":"Pengbo","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168464_bb0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1001\/jama.2025.20034","article-title":"Gastric cancer: a review","volume":"335","author":"Patel","year":"2026","journal-title":"JAMA"},{"key":"10.1016\/j.bbadis.2026.168464_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1533544","article-title":"The burden and trends of gastric cancer from 1990 to 2021 in China and globally: a cross-sectional study","volume":"12","author":"Yin","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.bbadis.2026.168464_bb0015","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","article-title":"Gastric cancer","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbadis.2026.168464_bb0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.6004\/jnccn.2025.0022","article-title":"Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines in Oncology","volume":"23","author":"Ajani","year":"2025","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.bbadis.2026.168464_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.soc.2024.12.009","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer peritoneal metastases","volume":"34","author":"Ruff","year":"2025","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"10.1016\/j.bbadis.2026.168464_bb0030","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1056\/NEJMoa2503119","article-title":"Trastuzumab deruxtecan or ramucirumab plus paclitaxel in gastric cancer","volume":"393","author":"Shitara","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2026.168464_bb0035","article-title":"Intraperitoneal chemotherapy for gastric cancer","volume":"10","author":"Mu","year":"2025","journal-title":"The Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbadis.2026.168464_bb0040","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1186\/s12885-025-15178-6","article-title":"Anoikis resistance and cancer","volume":"25","author":"Frisch","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10555-025-10265-3","article-title":"Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma","volume":"44","author":"Ng","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbadis.2026.168464_bb0050","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41419-025-07860-1","article-title":"Anoikis resistance in gastric cancer: a comprehensive review","volume":"16","author":"D'Amore","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168464_bb0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10120-025-01602-0","article-title":"FERMT2 drives anoikis resistance and peritoneal metastasis by enhancing extracellular matrix deposition in gastric cancer","volume":"28","author":"He","year":"2025","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0060","article-title":"SERPINE1 facilitates metastasis in gastric cancer through anoikis resistance and tumor microenvironment remodeling","volume":"21","author":"Wang","year":"2025","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"key":"10.1016\/j.bbadis.2026.168464_bb0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.semcancer.2015.09.010","article-title":"The role of the transcription factor Ets1 in carcinoma","volume":"35","author":"Dittmer","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbadis.2026.168464_bb0070","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.canlet.2017.11.012","article-title":"ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase","volume":"414","author":"Tomar","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2026.168464_bb0075","article-title":"ETS-1 in tumor immunology: implications for novel anti-cancer strategies","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2026.168464_bb0080","article-title":"ETS transcription factors: Multifaceted players from cancer progression to tumor immunity, Biochimica et biophysica acta","volume":"1878","author":"Wang","year":"2023","journal-title":"Reviews on Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0085","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/ijc.22870","article-title":"Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer","volume":"121","author":"Taniguchi","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0090","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1038\/s41388-018-0302-4","article-title":"Ets-1 promoter-associated noncoding RNA regulates the NONO\/ERG\/Ets-1 axis to drive gastric cancer progression","volume":"37","author":"Li","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2026.168464_bb0095","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1016\/j.ajpath.2015.05.017","article-title":"miR-506 inhibits epithelial-to-mesenchymal transition and angiogenesis in gastric cancer","volume":"185","author":"Li","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2026.168464_bb0100","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.7150\/ijbs.69933","article-title":"TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2026.168464_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113446","article-title":"Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencing","volume":"42","author":"Craig","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168464_bb0110","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1158\/2159-8290.CD-21-0248","article-title":"Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung","volume":"12","author":"Concepcion","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbadis.2026.168464_bb0115","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1038\/s41388-026-03778-w","article-title":"SAMD4 represses VGLL4 mRNA to activate TEAD and promote cancer progression","volume":"45","author":"Otani","year":"2026","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2026.168464_bb0120","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.7150\/ijbs.93815","article-title":"ETS1-mediated regulation of SOAT1 enhances the malignant phenotype of oral squamous cell carcinoma and induces tumor-associated macrophages M2-like polarization","volume":"20","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2026.168464_bb0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41523-025-00782-3","article-title":"Enhanced ETS1 stability by DNAPKcs orchestrates transcriptional changes during chemoresistance in triple negative breast cancer","volume":"11","author":"Dhara","year":"2025","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12943-019-1053-8","article-title":"WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbadis.2026.168464_bb0135","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1038\/s41467-025-61551-1","article-title":"Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor","volume":"16","author":"Martinez-Marin","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2026.168464_bb0140","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41419-024-07091-w","article-title":"LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expression","volume":"15","author":"Liao","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168464_bb0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41388-024-03201-2","article-title":"Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in fusion-positive rhabdomyosarcoma","volume":"44","author":"Hsieh","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2026.168464_bb0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1158\/1541-7786.MCR-23-1090","article-title":"ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3","volume":"22","author":"Ebegboni","year":"2024","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbadis.2026.168464_bb0155","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.bbadis.2018.01.031","article-title":"STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells","volume":"1864","author":"Nan","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2026.168464_bb0160","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ymthe.2021.08.027","article-title":"circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma","volume":"30","author":"Li","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2026.168464_bb0165","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00432-024-05899-9","article-title":"Establishment of a prognostic risk model for prostate cancer based on Gleason grading and cuprotosis related genes","volume":"150","author":"Wang","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2026.168464_bb0170","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/1878-0261.70108","article-title":"Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer","volume":"20","author":"Sambath","year":"2026","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bbadis.2026.168464_bb0175","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ng.556","article-title":"Subtle variations in Pten dose determine cancer susceptibility","volume":"42","author":"Alimonti","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2026.168464_bb0180","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","volume":"1833","author":"Paoli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2026.168464_bb0185","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:20:48Z","timestamp":1790986848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926003303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0925443926003303"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168464","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detachment-induced ETS1 drives anoikis resistance and metastasis through STX3-mediated PTEN ubiquitination in gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168464"}}