{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:57:12Z","timestamp":1790989032210,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2026ZZTS0100"],"award-info":[{"award-number":["2026ZZTS0100"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200775"],"award-info":[{"award-number":["82200775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170707"],"award-info":[{"award-number":["82170707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbadis.2026.168467","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:29:39Z","timestamp":1790195379000},"page":"168467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anp32e mediates histone variant H2A.Z-regulated TGF-\u03b21 involvement in renal interstitial fibrosis"],"prefix":"10.1016","volume":"1873","author":[{"given":"Dong","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168467_bb0005","doi-asserted-by":"crossref","first-page":"17088","DOI":"10.1038\/nrdp.2017.88","article-title":"Chronic kidney disease","volume":"3","author":"Romagnani","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.bbadis.2026.168467_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00284","article-title":"Editorial: advances in mechanisms of renal fibrosis","volume":"9","author":"Lan","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168467_bb0015","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1038\/s41467-020-18821-x","article-title":"Genome-wide chromatin accessibility is restricted by ANP32E","volume":"11","author":"Murphy","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168467_bb0020","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/1878-0261.12202","article-title":"ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1","volume":"12","author":"Xiong","year":"2018","journal-title":"Mol. Oncol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168467_bb0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbagrm.2018.03.002","article-title":"Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A","volume":"1861","author":"Shin","year":"2018","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168467_bb0030","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/cam4.1024","article-title":"Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting","volume":"6","author":"Li","year":"2017","journal-title":"Cancer Med."},{"issue":"15","key":"10.1016\/j.bbadis.2026.168467_bb0035","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.7150\/ijbs.74431","article-title":"Anp32e promotes renal interstitial fibrosis by upregulating the expression of fibrosis-related proteins","volume":"18","author":"Wei","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"32","key":"10.1016\/j.bbadis.2026.168467_bb0040","doi-asserted-by":"crossref","first-page":"eadg2699","DOI":"10.1126\/sciadv.adg2699","article-title":"DDM1-mediated R-loop resolution and H2A.Z exclusion facilitates heterochromatin formation in Arabidopsis","volume":"9","author":"Zhou","year":"2023","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168467_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade8312","article-title":"The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy","volume":"9","author":"Li","year":"2023","journal-title":"Sci. Adv."},{"issue":"15","key":"10.1016\/j.bbadis.2026.168467_bb0050","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1093\/nar\/gkaa552","article-title":"NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition","volume":"48","author":"Cui","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168467_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/biom14080993","article-title":"The function of H2A histone variants and their roles in diseases","volume":"14","author":"Yin","year":"2024","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168467_bb0060","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/cr.2014.30","article-title":"Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z","volume":"24","author":"Mao","year":"2014","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168467_bb0065","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.celrep.2017.09.086","article-title":"The histone variant H2A.Z is a master regulator of the epithelial-mesenchymal transition","volume":"21","author":"Domaschenz","year":"2017","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168467_bb0070","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.beha.2017.09.001","article-title":"Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting","volume":"30","author":"Ciechanover","year":"2017","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.bbadis.2026.168467_bb0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and autophagic degradation systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"10225","key":"10.1016\/j.bbadis.2026.168467_bb0080","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2026.168467_bb0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mam.2018.06.002","article-title":"Cellular and molecular mechanisms of kidney fibrosis","volume":"65","author":"Djudjaj","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2026.168467_bb0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"24","key":"10.1016\/j.bbadis.2026.168467_bb0095","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1073\/pnas.1504868112","article-title":"Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair","volume":"112","author":"Gursoy-Yuzugullu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3\u20134","key":"10.1016\/j.bbadis.2026.168467_bb0100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/gad.351278.123","article-title":"Coordination of histone chaperones for parental histone segregation and epigenetic inheritance","volume":"38","author":"Fang","year":"2024","journal-title":"Genes Dev."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168467_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109551","article-title":"The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons","volume":"36","author":"Stefanelli","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168467_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/s13072-019-0274-9","article-title":"The histone variant H2A.Z in gene regulation","volume":"12","author":"Giaimo","year":"2019","journal-title":"Epigenetics Chromatin"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168467_bb0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tig.2021.10.003","article-title":"The H2A.Z-nuclesome code in mammals: emerging functions","volume":"38","author":"Colino-Sanguino","year":"2022","journal-title":"Trends Genet."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168467_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/jdb10030028","article-title":"The role of the histone variant H2A.Z in metazoan development","volume":"10","author":"Dijkwel","year":"2022","journal-title":"J. Dev. Biol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168467_bb0125","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.2893","article-title":"Multigenerational epigenetic adaptation of the hepatic wound-healing response","volume":"18","author":"Zeybel","year":"2012","journal-title":"Nat. Med."},{"issue":"14","key":"10.1016\/j.bbadis.2026.168467_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.166876","article-title":"Collaboration through chromatin: motors of transcription and chromatin structure","volume":"433","author":"Gamarra","year":"2021","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168467_bb0135","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/acs.accounts.2c00041","article-title":"Participation of histones in DNA damage and repair within nucleosome core particles: mechanism and applications","volume":"55","author":"Ren","year":"2022","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168467_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2020.10.012","article-title":"Contributions of histone variants in nucleosome structure and function","volume":"433","author":"Kurumizaka","year":"2021","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168467_bb0145","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2020.07.020","article-title":"Primary role of the nucleosome","volume":"79","author":"Kornberg","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2026.168467_bb0150","article-title":"Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation","author":"Halblander","year":"2023","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168467_bb0155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/10985549.2024.2319731","article-title":"ANP32e binds histone H2A.Z in a cell cycle-dependent manner and regulates its protein stability in the cytoplasm","volume":"44","author":"Dijkwel","year":"2024","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2026.168467_bb0160","doi-asserted-by":"crossref","first-page":"e922673","DOI":"10.12659\/MSM.922673","article-title":"Autophagy inhibition sensitizes renal tubular epithelial cell to G1 arrest induced by transforming growth factor beta (TGF-beta)","volume":"26","author":"Yang","year":"2020","journal-title":"Med. Sci. Monit."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:22:42Z","timestamp":1790986962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926003339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0925443926003339"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168467","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anp32e mediates histone variant H2A.Z-regulated TGF-\u03b21 involvement in renal interstitial fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168467"}}