{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:57:48Z","timestamp":1790891868668,"version":"4.1.0"},"reference-count":172,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bbadis.2026.168477","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:22:15Z","timestamp":1790576535000},"page":"168477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid-autophagy crosstalk in glioblastoma: A context-dependent stress-adaptation interface under temozolomide pressure"],"prefix":"10.1016","volume":"1873","author":[{"given":"Mehdi","family":"Eshraghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Iurchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Barzegar Behrooz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0010","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12032-025-02830-1","article-title":"Unlocking glioblastoma: breakthroughs in molecular mechanisms and next-generation therapies","volume":"42","author":"Rizwani","year":"2025","journal-title":"Med. Oncol."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168477_bb0015","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.bbadis.2026.168477_bb0020","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.3390\/jcm14186550","article-title":"Evaluation of clinical outcome and survival under application of various therapies at first recurrence in patients with glioblastoma","volume":"14","author":"Rapp","year":"2025","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s40478-025-02046-4","article-title":"Overcoming temozolomide resistance in glioma: recent advances and mechanistic insights","volume":"13","author":"Li","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0030","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s12672-025-02567-3","article-title":"Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance","volume":"16","author":"Pu","year":"2025","journal-title":"Discov. Oncol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0035","article-title":"MGMT in TMZ-based glioma therapy: multifaceted insights and clinical trial perspectives. Biochimica et Biophysica Acta (BBA) - molecular","volume":"1871","author":"Shaw","year":"2024","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0040","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1186\/s12885-025-15225-2","article-title":"Optimal qMSP cutoff value for MGMT promoter methylation in glioblastoma and its validation for clinical significance","volume":"25","author":"Huseyinoglu","year":"2025","journal-title":"BMC Cancer"},{"issue":"11","key":"10.1016\/j.bbadis.2026.168477_bb0045","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/cancers16112121","article-title":"Genetic prognostic factors in adult diffuse gliomas: a 10-year experience at a single institution","volume":"16","author":"Barzegar Behrooz","year":"2024","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0050","doi-asserted-by":"crossref","DOI":"10.1172\/JCI195189","article-title":"Mismatch repair deficiency drives malignant progression and alters the tumor immune microenvironment in glioblastoma models","volume":"136","author":"Puigdelloses Vallcorba","year":"2026","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0055","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/s41467-024-45979-5","article-title":"Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0060","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1470-2045(24)00640-5","article-title":"The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study","volume":"26","author":"Negm","year":"2025","journal-title":"Lancet Oncol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0065","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/neuonc\/nor011","article-title":"N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide","volume":"13","author":"Tang","year":"2011","journal-title":"Neuro-Oncology"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031353","article-title":"Wnt and PI3K\/Akt\/mTOR survival pathways as therapeutic targets in glioblastoma","volume":"23","author":"Barzegar Behrooz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168477_bb0075","article-title":"Targeting metabolic reprogramming in glioblastoma as a new strategy to overcome therapy resistance","volume":"13\u20132025","author":"D\u2019Aprile","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0080","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.1009044","article-title":"Targeting metabolic mechanisms to overcome temozolomide resistance in glioblastoma","volume":"17","author":"Yan","year":"2026","journal-title":"Discov. Oncol."},{"issue":"18","key":"10.1016\/j.bbadis.2026.168477_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells13181574","article-title":"Metabolic reprogramming in glioblastoma Multiforme: a review of pathways and therapeutic targets","volume":"13","author":"Cortes Ballen","year":"2024","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16020397","article-title":"Emerging lipid targets in glioblastoma","volume":"16","author":"Darwish","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12944-023-01881-5","article-title":"Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities","volume":"22","author":"Kao","year":"2023","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0100","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41419-025-07993-3","article-title":"Cut the fat: targeting cholesterol and lipid metabolism in glioblastoma","volume":"16","author":"Zekanovic","year":"2025","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/1878-0261.13571","article-title":"Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance","volume":"19","author":"Zarzuela","year":"2025","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bbadis.2026.168477_bb0110","article-title":"Targeting glycolysis: exploring a new frontier in glioblastoma therapy","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0115","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s42255-023-00863-2","article-title":"The pentose phosphate pathway in health and disease","volume":"5","author":"TeSlaa","year":"2023","journal-title":"Nat. Metab."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci15080884","article-title":"Redox-regulated pathways in glioblastoma stem-like cells: mechanistic insights and therapeutic implications","volume":"15","author":"Esteban-Rom\u00e1n","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbadis.2026.168477_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3292704","article-title":"Metabolic heterogeneity evidenced by MRS among patient-derived glioblastoma multiforme stem-like cells accounts for cell clustering and different responses to drugs","volume":"2018","author":"Grande","year":"2018","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-021-00491-w","article-title":"The adaptive transition of glioblastoma stem cells and its implications on treatments","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0135","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s42255-025-01293-y","article-title":"Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of (13)C-labelled glucose metabolism","volume":"7","author":"Tsyben","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbadis.2026.168477_bb0140","article-title":"Integrated single cell spatial multi-omics landscape of WHO grades 2\u20134 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth","author":"Ma","year":"2025","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1186\/s12967-025-06706-w","article-title":"Single-cell and spatial transcriptome analyses reveal MAZ(+) NPC-like clusters as key role contributing to glioma recurrence and drug resistance","volume":"23","author":"Gu","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/neuonc\/noaf248","article-title":"Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment","volume":"28","author":"Savani","year":"2026","journal-title":"Neuro-Oncology"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0155","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/neuonc\/noaf294","article-title":"Metabolic profiling defines glioblastoma subtypes with distinct prognoses and therapeutic vulnerabilities","volume":"28","author":"Wu","year":"2026","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbadis.2026.168477_bb0160","article-title":"Metabolic remodeling and immune evasion in glioblastoma: a focus on serine and lipid networks","volume":"16\u20132026","author":"Jiang","year":"2026","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0165","doi-asserted-by":"crossref","first-page":"14161","DOI":"10.1038\/s41598-021-93663-1","article-title":"Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide","volume":"11","author":"Lorenz","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030214","article-title":"Hypoxia-inducible factors and the regulation of lipid metabolism","volume":"8","author":"Mylonis","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0175","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41392-025-02506-2","article-title":"Repartitioning brain glucose: serine-nucleotide dependency sensitizes glioblastoma therapy","volume":"10","author":"Hong","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0180","doi-asserted-by":"crossref","first-page":"16277","DOI":"10.1038\/s41598-022-20613-w","article-title":"Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma","volume":"12","author":"Nakamizo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168477_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.00535","article-title":"Radiation induced metabolic alterations associate with tumor aggressiveness and poor outcome in glioblastoma","volume":"10","author":"Gupta","year":"2020","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-022-05044-9","article-title":"High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1\/MRP1 upregulation","volume":"13","author":"de Souza","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0195","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41419-025-07667-0","article-title":"Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment","volume":"16","author":"D\u2019Aprile","year":"2025","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0200","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/jcmm.17147","article-title":"Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy","volume":"26","author":"Wang","year":"2022","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168477_bb0205","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263459","article-title":"Fis1 regulates mitochondrial morphology, bioenergetics and removal of mitochondrial DNA damage in irradiated glioblastoma cells","volume":"138","author":"Buckley","year":"2025","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2026.168477_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.933746","article-title":"Cyclooxygenase-2 upregulated by Temozolomide in glioblastoma cells is shuttled in extracellular vesicles modifying recipient cell phenotype","volume":"12","author":"Lombardi","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0215","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12915-024-02075-w","article-title":"The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies","volume":"22","author":"Bou-Gharios","year":"2024","journal-title":"BMC Biol."},{"key":"10.1016\/j.bbadis.2026.168477_bb0220","article-title":"A key pathway to cancer resilience: the role of autophagy in glioblastomas","volume":"11\u20132021","author":"Jandrey","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0225","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00018-017-2608-8","article-title":"Developmentally regulated signaling pathways in glioma invasion","volume":"75","author":"Mehta","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10081943","article-title":"Lipid metabolism in glioblastoma: from De novo synthesis to storage","volume":"10","author":"Kou","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-025-02357-x","article-title":"Lipid metabolism in homeostasis and disease","volume":"11","author":"Li","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0240","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163448","article-title":"Targeting fatty acid metabolism in glioblastoma","volume":"133","author":"Miska","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0245","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ccell.2021.01.006","article-title":"Proteogenomic and metabolomic characterization of human glioblastoma","volume":"39","author":"Wang","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbadis.2026.168477_bb0250","article-title":"Treatment-resilient lipid remodeling defines temozolomide resistance and failure of simvastatin sensitization in glioblastoma","author":"Naghibzadeh","year":"2026","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12929-022-00804-3","article-title":"Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation","volume":"29","author":"Tsai","year":"2022","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147717","article-title":"Inhibition of fatty acid synthase decreases expression of Stemness markers in glioma stem cells","volume":"11","author":"Yasumoto","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2026.168477_bb0265","article-title":"Corrigendum: SCD1 confers temozolomide resistance to human glioma cells via the Akt\/GSK3\u03b2\/\u03b2-catenin signaling axis","volume":"10\u20132019","author":"Dai","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168477_bb0270","article-title":"SCD1 confers Temozolomide resistance to human glioma cells via the Akt\/GSK3\u03b2\/\u03b2-catenin signaling axis","volume":"8","author":"Dai","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0275","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.31","article-title":"Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma","volume":"6","author":"Chuang","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.bbadis.2026.168477_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101413","article-title":"AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-mediated redox homeostasis","volume":"30","author":"Chen","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2026.168477_bb0285","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.freeradbiomed.2021.06.028","article-title":"17\u03b2-estradiol induces temozolomide resistance through NRF2-mediated redox homeostasis in glioblastoma","volume":"172","author":"Lin","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031318","article-title":"Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma","volume":"22","author":"Khan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0295","first-page":"217","article-title":"The interplay of mitochondrial dysfunction and altered metabolic pathways in glioblastoma","volume":"29","author":"Baharuddin","year":"2025","journal-title":"Contemp Oncol (Pozn)"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0300","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/EBC20240007","article-title":"New developments in AMPK and mTORC1 cross-talk","volume":"68","author":"Smiles","year":"2024","journal-title":"Essays Biochem."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0305","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0310","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4161\/auto.7.6.15123","article-title":"The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR","volume":"7","author":"Egan","year":"2011","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0315","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1748-1716.2009.01972.x","article-title":"LKB1 and AMP-activated protein kinase control of mTOR signalling and growth","volume":"196","author":"Shaw","year":"2009","journal-title":"Acta Physiol (Oxf.)"},{"key":"10.1016\/j.bbadis.2026.168477_bb0320","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-biochem-061516-044820","article-title":"Mechanisms of autophagy initiation","volume":"86","author":"Hurley","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0325","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jmb.2019.07.027","article-title":"Recruitment and activation of the ULK1\/Atg1 kinase complex in selective autophagy","volume":"432","author":"Turco","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbadis.2026.168477_bb0330","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/7651_2024_571","article-title":"Assessing autophagy flux in glioblastoma Temozolomide resistant cells","volume":"2879","author":"Clark","year":"2025","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0335","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3892\/ol.2017.6107","article-title":"Temozolomide induces autophagy in primary and established glioblastoma cells in an EGFR independent manner","volume":"14","author":"W\u00fcrstle","year":"2017","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines14030656","article-title":"The time-dependent effects of Temozolomide on autophagy gene expression in glioblastoma cells","volume":"14","author":"Kiraz","year":"2026","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.bbadis.2026.168477_bb0345","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.3390\/cimb45110546","article-title":"Autophagy modulation and its implications on glioblastoma treatment","volume":"45","author":"Chen","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"16","key":"10.1016\/j.bbadis.2026.168477_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/cells13161332","article-title":"Importance of autophagy regulation in glioblastoma with Temozolomide resistance","volume":"13","author":"Hwang","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168477_bb0355","first-page":"66","article-title":"Role of autophagy in therapeutic resistance of glioblastoma","volume":"5","author":"Chien","year":"2019","journal-title":"J. Cancer Metastasis Treat."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188616","article-title":"Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance","volume":"1876","author":"Tomar","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0365","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12967-024-06063-0","article-title":"Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168477_bb0370","article-title":"Tumor suppressing subtransferable candidate 4 expression prevents autophagy-induced cell death following Temozolomide treatment in glioblastoma cells","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0375","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14020339","article-title":"STAT3 enhances sensitivity of glioblastoma to drug-induced autophagy-dependent cell death","volume":"14","author":"Remy","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06352","article-title":"Nutrient starvation induces apoptosis and autophagy in C6 glioma stem-like cells","volume":"7","author":"Sa-Nongdej","year":"2021","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0385","doi-asserted-by":"crossref","first-page":"19731","DOI":"10.1038\/s41598-025-04862-z","article-title":"Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma","volume":"15","author":"Xu","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0390","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1186\/s12967-025-07034-9","article-title":"Phenotypic variations in glioma stem cells: regulatory mechanisms and implications for therapeutic strategies","volume":"23","author":"Tian","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168477_bb0395","article-title":"Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations","volume":"16","author":"Fu","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0400","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41467-025-67783-5","article-title":"Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations","volume":"17","author":"Suter","year":"2026","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0405","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/ptr.70210","article-title":"Mitophagy and mitochondrial function regulation by traditional Chinese medicine small molecules in Cancer therapy: mechanisms, challenges, and translational opportunities","volume":"40","author":"Shi","year":"2026","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bbadis.2026.168477_bb0410","article-title":"Mitophagy receptors in tumor biology","volume":"8\u20132020","author":"Xie","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0415","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168477_bb0420","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/2211-5463.13307","article-title":"A brief overview of BNIP3L\/NIX receptor-mediated mitophagy","volume":"11","author":"Marinkovi\u0107","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0425","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.7150\/jca.93189","article-title":"Erratum: FAM72A promotes glioma progression by regulating mitophagy through the Pink1\/Parkin signaling pathway: erratum","volume":"15","author":"Zeng","year":"2024","journal-title":"J. Cancer"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0430","doi-asserted-by":"crossref","first-page":"903","DOI":"10.7150\/jca.82949","article-title":"FAM72A promotes glioma progression by regulating mitophagy through the Pink1\/Parkin signaling pathway","volume":"14","author":"Zeng","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbadis.2026.168477_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.111184","article-title":"Deciphering glioblastoma pathogenesis: insights from mitophagy dysregulation and SNX7 as a therapeutic target","volume":"220","author":"Zhang","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0440","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1139\/bcb-2023-0221","article-title":"The role of BCL2L13 in glioblastoma: turning a need into a target","volume":"102","author":"Jacobs","year":"2024","journal-title":"Biochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168477_bb0445","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41419-023-06112-4","article-title":"BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bbadis.2026.168477_bb0450","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113126","article-title":"Temozolomide treatment increases fatty acid uptake in glioblastoma stem cells","volume":"12","author":"Caragher","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0455","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","article-title":"The constitutive lipid droplet protein PLIN2 regulates autophagy in liver","volume":"13","author":"Tsai","year":"2017","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0460","doi-asserted-by":"crossref","first-page":"19593","DOI":"10.1038\/s41598-019-55985-z","article-title":"Lipid accumulation and oxidation in glioblastoma multiforme","volume":"9","author":"Ta\u00efb","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0465","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-020-2449-5","article-title":"Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment","volume":"11","author":"Kant","year":"2020","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168477_bb0470","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/s41416-021-01294-0","article-title":"Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis","volume":"124","author":"Wang","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0475","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202002085","article-title":"Autophagosome biogenesis: from membrane growth to closure","volume":"219","author":"Melia","year":"2020","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23062949","article-title":"Polyunsaturated fatty acid-enriched lipid fingerprint of glioblastoma proliferative regions is differentially regulated according to glioblastoma molecular subtype","volume":"23","author":"Maim\u00f3-Barcel\u00f3","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0485","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1080\/15548627.2019.1659608","article-title":"De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy","volume":"16","author":"Andrejeva","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0490","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13046-025-03445-0","article-title":"Correction: SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma","volume":"44","author":"Chien","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0495","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4062\/biomolther.2024.094","article-title":"Regulatory mechanisms governing the autophagy-initiating VPS34 complex and its inhibitors","volume":"32","author":"Lee","year":"2024","journal-title":"Biomol Ther (Seoul)"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0500","first-page":"190","article-title":"WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1","volume":"11","author":"Dooley","year":"2015","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0505","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4161\/auto.5.4.8390","article-title":"Ceramide-induced autophagy: to junk or to protect cells?","volume":"5","author":"Pattingre","year":"2009","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0510","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1096\/fj.10-167502","article-title":"Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration","volume":"25","author":"Strub","year":"2011","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0515","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41420-023-01681-x","article-title":"The role of sphingosine-1-phosphate in autophagy and related disorders","volume":"9","author":"Xiao","year":"2023","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0520","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41419-019-1805-9","article-title":"TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ","volume":"10","author":"Lu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0525","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3892\/mmr.2014.2151","article-title":"Temozolomide induces autophagy via ATM-AMPK-ULK1 pathways in glioma","volume":"10","author":"Zou","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0530","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1074\/jbc.TM118.004165","article-title":"NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes","volume":"294","author":"Pfeffer","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0535","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13046-022-02429-8","article-title":"SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma","volume":"41","author":"Chien","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0540","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1194\/jlr.M700555-JLR200","article-title":"The Niemann-pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts","volume":"49","author":"Garver","year":"2008","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0545","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41401-022-00984-6","article-title":"Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide","volume":"44","author":"Choo","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0550","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2012.63","article-title":"Regulation of lipid stores and metabolism by lipophagy","volume":"20","author":"Liu","year":"2013","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0555","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/ATVBAHA.119.312136","article-title":"Lysosomal acid lipase in lipid metabolism and beyond","volume":"39","author":"Li","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0560","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11041009","article-title":"Integrative analysis of the predictive value of Perilipin family on clinical significance, prognosis and immunotherapy of glioma","volume":"11","author":"Li","year":"2023","journal-title":"Biomedicines"},{"issue":"10","key":"10.1016\/j.bbadis.2026.168477_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101569","article-title":"Lipid droplets maintain energy homeostasis and glioblastoma growth via Autophagic release of stored fatty acids","volume":"23","author":"Wu","year":"2020","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0570","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/ncb1854","article-title":"Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex","volume":"11","author":"Zhong","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0575","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213670120","article-title":"A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB","volume":"120","author":"Lin","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"52","key":"10.1016\/j.bbadis.2026.168477_bb0580","doi-asserted-by":"crossref","first-page":"40461","DOI":"10.1074\/jbc.M110.164046","article-title":"Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.bbadis.2026.168477_bb0585","doi-asserted-by":"crossref","first-page":"43820","DOI":"10.18632\/oncotarget.9907","article-title":"ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis","volume":"7","author":"Weatherbee","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0590","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40164-025-00603-0","article-title":"Targeting secretory autophagy in solid cancers: mechanisms, immune regulation and clinical insights","volume":"14","author":"Li","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0595","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-08313-5","article-title":"Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling","volume":"17","author":"Xie","year":"2025","journal-title":"Cell Death Dis."},{"issue":"14","key":"10.1016\/j.bbadis.2026.168477_bb0600","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/jcs.199521","article-title":"TRAPPC13 modulates autophagy and the response to Golgi stress","volume":"130","author":"Ram\u00edrez-Peinado","year":"2017","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102219","article-title":"GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin","volume":"298","author":"Ahat","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0610","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ijc.34991","article-title":"Autophagy in glioblastoma: a mechanistic perspective","volume":"155","author":"Meena","year":"2024","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0615","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41420-024-02224-8","article-title":"Lipids associated with autophagy: mechanisms and therapeutic targets","volume":"10","author":"Jarocki","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2026.168477_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108023","article-title":"Crosstalk between lipid droplets and autophagy in cancer: a nexus for therapeutic targeting","volume":"222","author":"Li","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2026.168477_bb0625","article-title":"GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide","volume":"12\u20132022","author":"Parik","year":"2022","journal-title":"Front. Oncol."},{"issue":"679","key":"10.1016\/j.bbadis.2026.168477_bb0630","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq6288","article-title":"Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models","volume":"15","author":"Eyme","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169566","article-title":"Inhibition of acetyl-CoA carboxylase 1 (ACC1) and 2 (ACC2) reduces proliferation and De novo lipogenesis of EGFRvIII human glioblastoma cells","volume":"12","author":"Jones","year":"2017","journal-title":"PloS One"},{"issue":"17","key":"10.1016\/j.bbadis.2026.168477_bb0640","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1158\/1078-0432.CCR-19-4055","article-title":"Phosphorylated acetyl-CoA carboxylase is associated with clinical benefit with Regorafenib in relapsed glioblastoma: REGOMA trial biomarker analysis","volume":"26","author":"Indraccolo","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0645","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.bjc.6603350","article-title":"Fatty acid synthase: a novel target for antiglioma therapy","volume":"95","author":"Zhao","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"13","key":"10.1016\/j.bbadis.2026.168477_bb0650","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1158\/1078-0432.CCR-22-2807","article-title":"Phase II investigation of TVB-2640 (Denifanstat) with bevacizumab in patients with first relapse high-grade astrocytoma","volume":"29","author":"Kelly","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"21","key":"10.1016\/j.bbadis.2026.168477_bb0655","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1158\/1078-0432.CCR-15-2973","article-title":"Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1\u2013mediated lipogenesis","volume":"22","author":"Geng","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0660","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1158\/1078-0432.CCR-17-0063","article-title":"Correction: inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis","volume":"23","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0665","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1046\/j.1471-4159.1996.66020710.x","article-title":"Lipid metabolism as a target for brain Cancer therapy: synergistic activity of lovastatin and sodium Phenylacetate against human glioma cells","volume":"66","author":"Prasanna","year":"1996","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0670","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ccell.2016.09.008","article-title":"An LXR-cholesterol Axis creates a metabolic co-dependency for brain cancers","volume":"30","author":"Villa","year":"2016","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.bbadis.2026.168477_bb0675","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910769","article-title":"Activation of LXR\u03b2 inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition","volume":"11","author":"Nguyen","year":"2019","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0680","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cmet.2020.06.002","article-title":"Targeting DGAT1 ameliorates glioblastoma by increasing fat catabolism and oxidative stress","volume":"32","author":"Cheng","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0685","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12935-022-02731-7","article-title":"Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres","volume":"22","author":"Shim","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0690","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4143\/crt.2017.466","article-title":"High-dose metformin plus Temozolomide shows increased anti-tumor effects in glioblastoma in vitro and in vivo compared with monotherapy","volume":"50","author":"Lee","year":"2018","journal-title":"Cancer Res. Treat."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0695","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/cncr.31811","article-title":"Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma","volume":"125","author":"Maraka","year":"2019","journal-title":"Cancer"},{"issue":"17","key":"10.1016\/j.bbadis.2026.168477_bb0700","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14174222","article-title":"Metformin with temozolomide for newly diagnosed glioblastoma: results of phase I study and a brief review of relevant studies","volume":"14","author":"Ohno","year":"2022","journal-title":"Cancers"},{"issue":"16_suppl","key":"10.1016\/j.bbadis.2026.168477_bb0705","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1200\/JCO.2025.43.16_suppl.2064","article-title":"Phase II propensity-matched controlled trial evaluating metformin as an adjunct to neo-adjuvant, concomitant, and adjuvant temozolomide and hypofractionated-accelerated radiotherapy (M-HART) in glioblastoma patients (NCT02780024)","volume":"43","author":"Shenouda","year":"2025","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0710","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12672-023-00678-3","article-title":"Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)","volume":"14","author":"Yoon","year":"2023","journal-title":"Discov. Oncol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0715","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00280-009-1063-0","article-title":"A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells","volume":"64","author":"Bektas","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0720","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063527","article-title":"Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway","volume":"8","author":"Gramatzki","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0725","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s10637-020-00992-5","article-title":"Atorvastatin in combination with radiotherapy and temozolomide for glioblastoma: a prospective phase II study","volume":"39","author":"Altwairgi","year":"2021","journal-title":"Investig. New Drugs"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0730","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1215\/15228517-2008-005","article-title":"Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults","volume":"10","author":"Kesari","year":"2008","journal-title":"Neuro-Oncology"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0735","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12032-025-02697-2","article-title":"Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K\/AKT\/NF-\u03baB axis","volume":"42","author":"Pekmez","year":"2025","journal-title":"Med. Oncol."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0740","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/0091270009335768","article-title":"Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants","volume":"49","author":"Katz","year":"2009","journal-title":"J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0745","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.cdd.4402030","article-title":"DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells","volume":"14","author":"Katayama","year":"2007","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0750","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040535","article-title":"Is autophagy inhibition in combination with Temozolomide a therapeutically viable strategy?","volume":"12","author":"Elshazly","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0755","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055665","article-title":"Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of Temozolomide-induced DNA damage","volume":"8","author":"Knizhnik","year":"2013","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168477_bb0760","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.18632\/aging.202539","article-title":"Nicardipine sensitizes temozolomide by inhibiting autophagy and promoting cell apoptosis in glioma stem cells","volume":"13","author":"Shi","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbadis.2026.168477_bb0765","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2021.12.113","article-title":"JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells","volume":"591","author":"Ando","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0770","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.3171\/2014.9.FOCUS14504","article-title":"Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy","volume":"37","author":"Golden","year":"2014","journal-title":"Neurosurg. Focus"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168477_bb0775","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.cdd.4401359","article-title":"Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells","volume":"11","author":"Kanzawa","year":"2004","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0780","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.4161\/auto.28984","article-title":"A phase I\/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme","volume":"10","author":"Rosenfeld","year":"2014","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.bbadis.2026.168477_bb0785","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1080\/15548627.2020.1816343","article-title":"Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial","volume":"17","author":"Compter","year":"2021","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.bbadis.2026.168477_bb0790","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4161\/auto.29118","article-title":"Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma","volume":"10","author":"Rangwala","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2026.168477_bb0795","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13046-016-0303-5","article-title":"Targeting autophagy to sensitive glioma to temozolomide treatment","volume":"35","author":"Yan","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0800","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.canlet.2015.02.012","article-title":"The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells","volume":"360","author":"Lee","year":"2015","journal-title":"Cancer Lett."},{"issue":"43","key":"10.1016\/j.bbadis.2026.168477_bb0805","doi-asserted-by":"crossref","first-page":"10458","DOI":"10.1021\/jf501234b","article-title":"Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression","volume":"62","author":"Liao","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0810","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.freeradbiomed.2011.10.487","article-title":"Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy","volume":"52","author":"Lin","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0815","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.3892\/mmr.2015.3293","article-title":"MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma","volume":"11","author":"Zou","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0820","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3892\/ol.2011.406","article-title":"Effect of temozolomide on the U-118 glioma cell line","volume":"2","author":"Carmo","year":"2011","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.bbadis.2026.168477_bb0825","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038706","article-title":"Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells","volume":"7","author":"Lin","year":"2012","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.bbadis.2026.168477_bb0830","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081345","article-title":"Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma","volume":"8","author":"Liu","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168477_bb0835","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.canlet.2014.12.044","article-title":"Autophagy inhibition improves the efficacy of curcumin\/temozolomide combination therapy in glioblastomas","volume":"358","author":"Zanotto-Filho","year":"2015","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0840","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/neuonc\/nou219","article-title":"VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells","volume":"17","author":"Chen","year":"2015","journal-title":"Neuro-Oncology"},{"issue":"3","key":"10.1016\/j.bbadis.2026.168477_bb0845","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.3171\/2014.12.FOCUS14748","article-title":"Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors","volume":"38","author":"Golden","year":"2015","journal-title":"Neurosurg. Focus"},{"issue":"10","key":"10.1016\/j.bbadis.2026.168477_bb0850","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1158\/2159-8290.CD-14-0157","article-title":"ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents","volume":"4","author":"Agnihotri","year":"2014","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168477_bb0855","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1158\/1535-7163.MCT-10-0688","article-title":"A combined preclinical therapy of cannabinoids and temozolomide against glioma","volume":"10","author":"Torres","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"7","key":"10.1016\/j.bbadis.2026.168477_bb0860","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/sj.bjc.6604969","article-title":"Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo","volume":"100","author":"Ulasov","year":"2009","journal-title":"Br. J. Cancer"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:22:55Z","timestamp":1790889775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926003431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":172,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2027,2]]}},"alternative-id":["S0925443926003431"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168477","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid-autophagy crosstalk in glioblastoma: A context-dependent stress-adaptation interface under temozolomide pressure","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"168477"}}