{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:47:30Z","timestamp":1791956850626,"version":"4.3.4"},"reference-count":162,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT190238"],"award-info":[{"award-number":["PJT190238"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bbadis.2026.168496","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:53Z","timestamp":1791216413000},"page":"168496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["iPSC-derived cardiomyocytes for personalized medicine- promises and challenges"],"prefix":"10.1016","volume":"1873","author":[{"given":"Keshav Narayan","family":"Alagarsamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilee","family":"Bueckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehak","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Allison","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168496_bb0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ceb.2019.07.005","article-title":"Leading progress in heart regeneration and repair","volume":"61","author":"Deshmukh","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0010","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.clinthera.2023.09.020","article-title":"Global trends in atherosclerotic cardiovascular disease","volume":"45","author":"Nedkoff","year":"2023","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0015","doi-asserted-by":"crossref","DOI":"10.2174\/011573403X299265240405080030","article-title":"Review on emerging therapeutic strategies for managing cardiovascular disease","volume":"20","author":"Narkhede","year":"2024","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.bbadis.2026.168496_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/HCG.0000000000000043","article-title":"Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine","volume":"11","author":"Musunuru","year":"2018","journal-title":"Circ. Genom. Precis. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123483","article-title":"Human induced pluripotent stem cell as a disease modeling and drug development platform\u2014a cardiac perspective","volume":"10","author":"Bekhite","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168496_bb0030","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s12015-020-10061-2","article-title":"A concise review on induced pluripotent stem cell-derived cardiomyocytes for personalized regenerative medicine","volume":"17","author":"Pushp","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2478\/jtim-2020-0004","article-title":"Concise review: harnessing iPSC-derived cells for ischemic heart disease treatment","volume":"8","author":"Duan","year":"2020","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.925777","article-title":"Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification","volume":"9","author":"Atkins","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0045","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/CIRCRESAHA.115.307523","article-title":"Murine \u201cmodel\u201d monotheism","volume":"117","author":"Libby","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrcardio.2016.36","article-title":"Induced pluripotent stem cells: at the heart of cardiovascular precision medicine","volume":"13","author":"Chen","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chembiol.2021.02.016","article-title":"Human iPSC modeling of heart disease for drug development","volume":"28","author":"Hnatiuk","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00368","article-title":"Advances in stem cell modeling of dystrophin-associated disease: implications for the wider world of dilated cardiomyopathy","volume":"11","author":"Pioner","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113251","article-title":"Searching for an experimental rodent model of heart failure with preserved ejection fraction: re-visited","volume":"152","author":"Jasi\u0144ska-Stroschein","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2026.168496_bb0070","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95867","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient","volume":"13","author":"Tatekoshi","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.bbadis.2026.168496_bb0075","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1161\/RES.0000000000000291","article-title":"Use of human induced pluripotent stem cell\u2013derived cardiomyocytes in preclinical cancer drug cardiotoxicity testing","volume":"125","author":"Gintant","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0080","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8960236","article-title":"The impact of CRISPR\/Cas9 technology on cardiac research: from disease modelling to therapeutic approaches","volume":"2017","author":"Motta","year":"2017","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bbadis.2026.168496_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-03690-8","article-title":"Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patch","volume":"15","author":"Miyagawa","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0090","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev-pharmtox-010919-023309","article-title":"Unlocking personalized biomedicine and drug discovery with human induced pluripotent stem cell\u2013derived cardiomyocytes: fit for purpose or forever elusive?","volume":"60","author":"de Korte","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0095","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90% of clinical drug development fails and how to improve it?","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbadis.2026.168496_bb0100","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrd1470","article-title":"Can the pharmaceutical industry reduce attrition rates?","volume":"3","author":"Kola","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2026.168496_bb0105","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.stem.2020.08.003","article-title":"Reengineering an antiarrhythmic drug using patient hiPSC cardiomyocytes to improve therapeutic potential and reduce toxicity","volume":"27","author":"McKeithan","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0110","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.celrep.2014.09.055","article-title":"Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells","volume":"9","author":"Drawnel","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0115","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.stem.2019.01.013","article-title":"MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo","volume":"24","author":"Fiedler","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0120","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1093\/eurheartj\/ehy249","article-title":"CRISPR\/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy","volume":"39","author":"Mosqueira","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbadis.2026.168496_bb0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd3078","article-title":"How to improve R&D productivity: the pharmaceutical industry\u2019s grand challenge","volume":"9","author":"Paul","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2026.168496_bb0130","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014092","article-title":"Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company","volume":"4","author":"Gromo","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0135","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrd4609","article-title":"An analysis of the attrition of drug candidates from four major pharmaceutical companies","volume":"14","author":"Waring","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2026.168496_bb0140","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrd.2015.34","article-title":"Evolution of strategies to improve preclinical cardiac safety testing","volume":"15","author":"Gintant","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2026.168496_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147215","article-title":"When quality beats quantity: decision theory, drug discovery, and the reproducibility crisis","volume":"11","author":"Scannell","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2026.168496_bb0150","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.bbamcr.2016.03.003","article-title":"High throughput physiological screening of iPSC-derived cardiomyocytes for drug development","volume":"1863","author":"del \u00c1lamo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2026.168496_bb0155","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.vascn.2012.08.167","article-title":"High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry","volume":"66","author":"Cerignoli","year":"2012","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.bbadis.2026.168496_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00766","article-title":"An automated platform for assessment of congenital and drug-induced arrhythmia with hiPSC-derived cardiomyocytes","volume":"8","author":"McKeithan","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0165","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1161\/CIRCRESAHA.117.312067","article-title":"MUSCLEMOTION","volume":"122","author":"Sala","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0170","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s12551-019-00589-0","article-title":"Recent technological advancements in traction force microscopy","volume":"11","author":"Ferrari","year":"2019","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.bbadis.2026.168496_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111331","article-title":"HiPSCs derived cardiac cells for drug and toxicity screening and disease modeling: what micro- electrode-array analyses can tell us","volume":"8","author":"Kussauer","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168496_bb0180","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/acs.chemrestox.0c00382","article-title":"High-throughput screening to identify chemical Cardiotoxic potential","volume":"34","author":"Krishna","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0185","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/17425255.2023.2273378","article-title":"In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes","volume":"20","author":"Rosell-Hidalgo","year":"2024","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0190","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/01.RES.84.9.989","article-title":"Mechanism of Block and identification of the verapamil binding domain to HERG potassium channels","volume":"84","author":"Zhang","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0195","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1038\/s41598-020-62344-w","article-title":"Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells","volume":"10","author":"Kramer","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0200","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12859-019-2814-5","article-title":"Computational determination of hERG-related cardiotoxicity of drug candidates","volume":"20","author":"Lee","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bbadis.2026.168496_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.838435","article-title":"Identifying acute cardiac Hazard in early drug discovery using a calcium transient high-throughput assay in human-induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14071313","article-title":"Assessing drug-induced mitochondrial toxicity in cardiomyocytes: implications for preclinical cardiac safety evaluation","volume":"14","author":"Tang","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbadis.2026.168496_bb0215","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/stcltm\/szae029","article-title":"Promotion of maturation of human pluripotent stem cell-derived cardiomyocytes via treatment with the peroxisome proliferator-activated receptor alpha agonist Fenofibrate","volume":"13","author":"Lee","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0220","doi-asserted-by":"crossref","first-page":"17409","DOI":"10.1038\/s41598-022-22225-w","article-title":"Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture","volume":"12","author":"Ergir","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/life14111370","article-title":"Investigating inherited heart diseases using human induced pluripotent stem cell-based models","volume":"14","author":"Wang","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.bbadis.2026.168496_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020334","article-title":"IPSC-derived cardiomyocytes in inherited cardiac arrhythmias: pathomechanistic discovery and drug development","volume":"11","author":"Simons","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbadis.2026.168496_bb0235","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/s41598-024-52871-1","article-title":"Modeling mutation-specific arrhythmogenic phenotypes in isogenic human iPSC-derived cardiac tissues","volume":"14","author":"Maurissen","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0240","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/CIRCRESAHA.122.321951","article-title":"iPSC-based modeling of variable clinical presentation in hypertrophic cardiomyopathy","volume":"133","author":"Escrib\u00e1","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310510","article-title":"An update on MYBPC3 gene mutation in hypertrophic cardiomyopathy","volume":"24","author":"Tudurachi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168496_bb0250","article-title":"Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0255","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11936-014-0320-7","article-title":"hiPSC MODELING OF INHERITED CARDIOMYOPATHIES","volume":"16","author":"Jung","year":"2014","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0260","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/cvr\/cvy208","article-title":"Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential","volume":"114","author":"van Mil","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0265","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCRESAHA.116.309283","article-title":"A precision medicine approach to the Rescue of Function on malignant Calmodulinopathic long QT syndrome","volume":"120","author":"Limpitikul","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0270","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10557-017-6735-0","article-title":"Human iPSC-derived cardiomyocytes for investigation of disease mechanisms and therapeutic strategies in inherited arrhythmia syndromes: strengths and limitations","volume":"31","author":"Casini","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0275","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1093\/cvr\/cvad155","article-title":"Targeted activation of human ether-\u00e0-go-go-related gene channels rescues electrical instability induced by the R56Q+\/\u2212 long QT syndrome variant","volume":"119","author":"Venkateshappa","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0280","doi-asserted-by":"crossref","first-page":"f46","DOI":"10.1093\/europace\/euy042","article-title":"Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy","volume":"20","author":"El-Battrawy","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.bbadis.2026.168496_bb0285","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00395-022-00912-z","article-title":"Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy","volume":"117","author":"Jung","year":"2022","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0290","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.stemcr.2023.07.005","article-title":"Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy","volume":"18","author":"Kim","year":"2023","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.bbadis.2026.168496_bb0295","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155640","article-title":"Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC\u2013derived atrial fibrillation model","volume":"7","author":"Ly","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2026.168496_bb0300","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.122.061864","article-title":"Studying long QT syndrome caused by NAA10 genetic variants using patient-derived induced pluripotent stem cells","volume":"148","author":"Belbachir","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0305","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s44161-025-00669-3","article-title":"Maturation of human cardiac organoids enables complex disease modeling and drug discovery","volume":"4","author":"Pocock","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0310","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.stem.2020.05.004","article-title":"Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease","volume":"26","author":"Giacomelli","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0315","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ymthe.2018.02.026","article-title":"Pluripotent stem cell-derived cardiomyocytes as a platform for cell therapy applications: Progress and hurdles for clinical translation","volume":"26","author":"Oikonomopoulos","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0320","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.stem.2024.01.007","article-title":"Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes","volume":"31","author":"Raniga","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0325","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2023.12.001","article-title":"Pluripotent stem cell-based cardiac regenerative therapy for heart failure","volume":"187","author":"Soma","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.794690","article-title":"Co-transplantation of mesenchymal stromal cells and induced pluripotent stem cell-derived cardiomyocytes improves cardiac function after myocardial damage","volume":"8","author":"Neef","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2023.12.009","article-title":"Stem cell-based therapy in cardiac repair after myocardial infarction: promise, challenges, and future directions","volume":"188","author":"Yan","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0340","first-page":"533","article-title":"Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction","volume":"37","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0345","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb5067","article-title":"4D physiologically adaptable cardiac patch: a 4-month in vivo study for the treatment of myocardial infarction","volume":"6","author":"Cui","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2026.168496_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/jcdd8120172","article-title":"Designing a 3D printing based auxetic cardiac patch with hiPSC-CMs for heart repair","volume":"8","author":"Brazhkina","year":"2021","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.bbadis.2026.168496_bb0355","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/CIRCULATIONAHA.121.053563","article-title":"In vitro matured human pluripotent stem cell\u2013derived cardiomyocytes form grafts with enhanced structure and function in injured hearts","volume":"145","author":"Dhahri","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1182209","article-title":"Safety confirmation of induced pluripotent stem cell-derived cardiomyocyte patch transplantation for ischemic cardiomyopathy: first three case reports","volume":"10","author":"Kawamura","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0365","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/CIRCULATIONAHA.122.061736","article-title":"Combined treatment of human iPSC-derived cardiomyocytes and endothelial cells regenerate the infarcted heart in mice and non-human primates","volume":"148","author":"Cheng","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0370","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13287-020-01602-0","article-title":"Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts","volume":"11","author":"Guan","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0375","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ymthe.2022.08.012","article-title":"Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI","volume":"31","author":"Ai","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0380","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.7150\/thno.56757","article-title":"Thymosin \u03b24 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction","volume":"11","author":"Tan","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2026.168496_bb0385","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/cvr\/cvad004","article-title":"Cardiac muscle patches containing four types of cardiac cells derived from human pluripotent stem cells improve recovery from cardiac injury in mice","volume":"119","author":"Lou","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2020.03.003","article-title":"CHIR99021 and fibroblast growth factor 1 enhance the regenerative potency of human cardiac muscle patch after myocardial infarction in mice","volume":"141","author":"Fan","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0395","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.CIR.90.2.713","article-title":"Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium","volume":"90","author":"Peters","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0400","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2026.168496_bb0405","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCRESAHA.114.300558","article-title":"Engineering adolescence: maturation of human pluripotent stem cell\u2013derived cardiomyocytes","volume":"114","author":"Yang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0410","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00178","article-title":"A brief review of current maturation methods for human induced pluripotent stem cells-derived cardiomyocytes","volume":"8","author":"Ahmed","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0415","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1111\/j.1582-4934.2011.01417.x","article-title":"Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure","volume":"15","author":"Gherghiceanu","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0420","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1113\/jphysiol.2013.256495","article-title":"Calcium signalling of human pluripotent stem cell-derived cardiomyocytes","volume":"591","author":"Li","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0425","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yjmcc.2015.05.003","article-title":"Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories","volume":"85","author":"Hwang","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0430","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.devcel.2016.10.001","article-title":"Single-cell resolution of temporal gene expression during heart development","volume":"39","author":"DeLaughter","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0435","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.gpb.2016.04.004","article-title":"Comparative gene expression analysis of mouse and human cardiac maturation","volume":"14","author":"Uosaki","year":"2016","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.bbadis.2026.168496_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2015.00059","article-title":"Excitation\u2013contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes","volume":"3","author":"Kane","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0445","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell\u2013derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00080","article-title":"Structural immaturity of human iPSC-derived cardiomyocytes: in silico investigation of effects on function and disease modeling","volume":"9","author":"Koivum\u00e4ki","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0455","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbadis.2014.11.003","article-title":"Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure","volume":"1852","author":"Yin","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbadis.2026.168496_bb0460","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.bbamcr.2015.10.014","article-title":"Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform","volume":"1863","author":"Denning","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0465","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0002-8703(68)90168-3","article-title":"Metabolism of the heart in health and disease. Part I","volume":"76","author":"Opie","year":"1968","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbadis.2026.168496_bb0470","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s13287-024-03961-4","article-title":"Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects","volume":"15","author":"Jiang","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0475","doi-asserted-by":"crossref","first-page":"H1698","DOI":"10.1152\/ajpheart.1991.261.6.H1698","article-title":"Glycolysis is predominant source of myocardial ATP production immediately after birth","volume":"261","author":"Lopaschuk","year":"1991","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0480","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/bit.26504","article-title":"3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes","volume":"115","author":"Correia","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bbadis.2026.168496_bb0485","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2018.06.089","article-title":"Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: functional assessment using in vitro radionuclide uptake assay","volume":"269","author":"Nose","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0490","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.stemcr.2018.01.039","article-title":"Contractile work contributes to maturation of energy metabolism in hiPSC-derived cardiomyocytes","volume":"10","author":"Ulmer","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.bbadis.2026.168496_bb0495","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200833","article-title":"Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes","volume":"41","author":"Wu","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0500","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation\u2013contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2026.168496_bb0505","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2602","article-title":"Phenotypic assays for analyses of pluripotent stem cell\u2013derived cardiomyocytes","volume":"30","author":"Pesl","year":"2017","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.bbadis.2026.168496_bb0510","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005135","article-title":"Switch from fetal to adult SCN5A isoform in human induced pluripotent stem cell\u2013derived cardiomyocytes unmasks the cellular phenotype of a conduction disease\u2013causing mutation","volume":"6","author":"Veerman","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbadis.2026.168496_bb0515","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-3495(78)85489-7","article-title":"Ionic channels in excitable membranes. Current problems and biophysical approaches","volume":"22","author":"Hille","year":"1978","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbadis.2026.168496_bb0520","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0735-1097(98)00330-1","article-title":"Amiodarone reduces transmural heterogeneity of repolarization in the human heart","volume":"32","author":"Drouin","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0525","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.joa.2015.11.003","article-title":"Mechanisms of cardiac arrhythmias","volume":"32","author":"Tse","year":"2016","journal-title":"J. Arrhythm."},{"key":"10.1016\/j.bbadis.2026.168496_bb0530","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0535","doi-asserted-by":"crossref","first-page":"H2006","DOI":"10.1152\/ajpheart.00694.2011","article-title":"High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents","volume":"301","author":"Ma","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0540","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2012.00346","article-title":"Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias","volume":"3","author":"Hoekstra","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0545","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIRCEP.111.973420","article-title":"Mechanism-based facilitated maturation of human pluripotent stem cell\u2013derived cardiomyocytes","volume":"6","author":"Lieu","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0550","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2009.08.018","article-title":"Cardiac connexins and impulse propagation","volume":"48","author":"Jansen","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0555","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/CIRCRESAHA.111.262535","article-title":"Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell\u2013derived cardiac myocyte monolayers","volume":"110","author":"Lee","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0560","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/CIRCULATIONAHA.109.868885","article-title":"Cardiomyocyte differentiation of human induced pluripotent stem cells","volume":"120","author":"Zwi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0565","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.105.565804","article-title":"Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration","volume":"113","author":"Wiegerinck","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2026.168496_bb0570","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1152\/physrev.00025.2003","article-title":"Basic mechanisms of cardiac impulse propagation and associated arrhythmias","volume":"84","author":"Kl\u00e9ber","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2026.168496_bb0575","doi-asserted-by":"crossref","DOI":"10.31083\/j.rcm2403069","article-title":"Research progress towards the effects of fatty acids on the differentiation and maturation of human induced pluripotent stem cells into cardiomyocytes","volume":"24","author":"Gao","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0580","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.stemcr.2019.08.013","article-title":"Fatty acids enhance the maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"13","author":"Yang","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.bbadis.2026.168496_bb0585","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00253","article-title":"Culture in glucose-depleted medium supplemented with fatty acid and 3,3\u2032,5-Triiodo-l-Thyronine facilitates purification and maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"8","author":"Lin","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0590","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-023-06585-5","article-title":"Inhibition of fatty acid oxidation enables heart regeneration in adult mice","volume":"622","author":"Li","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2026.168496_bb0595","first-page":"1","article-title":"Promotion of maturation in CDM3-induced embryonic stem cell-derived cardiomyocytes by palmitic acid","author":"Mu","year":"2024","journal-title":"Bio-Med. Mater. Eng. Preprint"},{"key":"10.1016\/j.bbadis.2026.168496_bb0600","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08713-4","article-title":"Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"7","author":"Correia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107925","article-title":"Metabolic maturation media improve physiological function of human iPSC-derived cardiomyocytes","volume":"32","author":"Feyen","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0610","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.32604\/biocell.2023.028186","article-title":"Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells","volume":"47","author":"Yano","year":"2023","journal-title":"Biocell"},{"key":"10.1016\/j.bbadis.2026.168496_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114160","article-title":"Independent compartmentalization of functional, metabolic, and transcriptional maturation of hiPSC-derived cardiomyocytes","volume":"43","author":"Fetterman","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0620","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1038\/s41467-019-12482-1","article-title":"TFPa\/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes","volume":"10","author":"Miklas","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2026.168496_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165881","article-title":"Metabolic environment in vivo as a blueprint for differentiation and maturation of human stem cell-derived cardiomyocytes","volume":"1866","author":"Slaats","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbadis.2026.168496_bb0630","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s13287-022-03209-z","article-title":"Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Chirico","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0635","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098112","article-title":"AKAP1 regulates mitochondrial dynamics during the fatty-acid-promoted maturation of human-induced pluripotent stem cell-derived cardiomyocytes as indicated by proteomics sequencing","volume":"24","author":"Xiang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168496_bb0640","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.606931","article-title":"Thyroid hormone plays an important role in cardiac function: from bench to bedside","volume":"12","author":"Yamakawa","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0645","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13287-023-03470-w","article-title":"Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes","volume":"14","author":"Yang","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168496_bb0650","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.scr.2014.07.001","article-title":"Thyroid hormone action in postnatal heart development","volume":"13","author":"Li","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0655","doi-asserted-by":"crossref","first-page":"T145","DOI":"10.1530\/JOE-18-0704","article-title":"Thyroid hormone SIGNALLING and consequences for cardiac development","volume":"242","author":"Chattergoon","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0660","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yjmcc.2014.04.005","article-title":"Tri-iodo-L-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells","volume":"72","author":"Yang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0665","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2015.03.009","article-title":"Glucocorticoid signaling in the heart: a cardiomyocyte perspective","volume":"153","author":"Oakley","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0670","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101227","article-title":"The glucocorticoid receptor in cardiovascular health and disease","volume":"8","author":"Liu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168496_bb0675","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/cdd.2014.181","article-title":"Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1\u03b1","volume":"22","author":"Rog-Zielinska","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2026.168496_bb0680","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.117.311920","article-title":"Thyroid and glucocorticoid hormones promote functional T-tubule development in human-induced pluripotent stem cell derived cardiomyocytes","volume":"121","author":"Parikh","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2026.168496_bb0685","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8237.1","article-title":"Advancing cardiovascular tissue engineering","volume":"5","author":"Truskey","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.bbadis.2026.168496_bb0690","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/stcltm\/szae014","article-title":"Advances in 3D bioprinted cardiac tissue using stem cell-derived cardiomyocytes","volume":"13","author":"Bliley","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bbadis.2026.168496_bb0695","first-page":"50","article-title":"Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration","volume":"19","author":"Kim","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104330","article-title":"Current methods for fabricating 3D cardiac engineered constructs","volume":"25","author":"Rogozinski","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bbadis.2026.168496_bb0705","article-title":"Three-dimensional poly-(\u03b5-Caprolactone) Nanofibrous scaffolds promote the maturation of human pluripotent stem cells-induced cardiomyocytes","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0710","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.908848","article-title":"A three-dimensional culture system for generating cardiac spheroids composed of cardiomyocytes, endothelial cells, smooth-muscle cells, and cardiac fibroblasts derived from human induced-pluripotent stem cells","volume":"10","author":"Kahn-Krell","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0715","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.lfs.2019.05.012","article-title":"Current research trends and challenges in tissue engineering for mending broken hearts","volume":"229","author":"Qasim","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2026.168496_bb0720","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14050269","article-title":"Recent advances in tissue-engineered cardiac scaffolds\u2014the progress and gap in mimicking native myocardium mechanical behaviors","volume":"14","author":"Baghersad","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0725","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.procir.2015.09.004","article-title":"Biomanufacturing of a chitosan\/collagen scaffold to drive adhesion and alignment of human cardiomyocyte derived from stem cells","volume":"49","author":"Benzoni","year":"2016","journal-title":"Procedia CIRP"},{"key":"10.1016\/j.bbadis.2026.168496_bb0730","article-title":"Maturation of human iPSC-derived cardiac microfiber with electrical stimulation device","volume":"13","author":"Masuda","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0735","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.actbio.2021.08.031","article-title":"Electroconductive biomaterials for cardiac tissue engineering","volume":"139","author":"Esmaeili","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0740","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200055","article-title":"Recent advances in designing electroconductive biomaterials for cardiac tissue engineering","volume":"11","author":"Ghovvati","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0745","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1385124","article-title":"Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective","volume":"12","author":"Razavi","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0750","doi-asserted-by":"crossref","DOI":"10.3390\/life12081117","article-title":"Artificial scaffolds in cardiac tissue engineering","volume":"12","author":"Roacho-P\u00e9rez","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.bbadis.2026.168496_bb0755","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.3390\/ijms21103444","article-title":"Bioresorbable polymeric scaffold in cardiovascular applications","volume":"21","author":"Toong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168496_bb0760","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41551-022-00884-4","article-title":"Metabolically driven maturation of human induced pluripotent stem cell derived cardiac microphysiological systems","volume":"6","author":"Huebsch","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bbadis.2026.168496_bb0765","doi-asserted-by":"crossref","first-page":"19071","DOI":"10.1038\/s41598-020-76052-y","article-title":"Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes","volume":"10","author":"Block","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111146","article-title":"Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes","volume":"40","author":"Afzal","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2026.168496_bb0775","doi-asserted-by":"crossref","first-page":"124","DOI":"10.7150\/thno.19441","article-title":"Engineered microenvironments for maturation of stem cell derived cardiac myocytes","volume":"8","author":"Besser","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2026.168496_bb0780","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yjmcc.2022.02.001","article-title":"The harder the climb the better the view: the impact of substrate stiffness on cardiomyocyte fate","volume":"166","author":"Querceto","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0785","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.113.003638","article-title":"Extracellular matrix\u2013mediated maturation of human pluripotent stem cell\u2013derived cardiac monolayer structure and electrophysiological function","volume":"9","author":"Herron","year":"2016","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bbadis.2026.168496_bb0790","article-title":"Engineering of mature human induced pluripotent stem cell-derived cardiomyocytes using substrates with multiscale topography","volume":"28","author":"Abadi","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0795","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41378-024-00692-7","article-title":"Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors","volume":"10","author":"Xu","year":"2024","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.bbadis.2026.168496_bb0800","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ad525d","article-title":"Microstripe pattern substrate consisting of alternating planar and nanoprotrusive regions improved hiPSC-derived cardiomyocytes\u2019 unidirectional alignment and functional properties","volume":"19","author":"Saotome","year":"2024","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bbadis.2026.168496_bb0805","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/ten.teb.2023.0080","article-title":"Induced pluripotent stem cell-derived cardiomyocytes: from regulatory status to clinical translation","volume":"30","author":"Soares","year":"2024","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bbadis.2026.168496_bb0810","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1038\/s41467-024-50224-0","article-title":"Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems","volume":"15","author":"Prondzynski","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926003625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:06:54Z","timestamp":1791954414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926003625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":162,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2027,2]]}},"alternative-id":["S0925443926003625"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168496","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"iPSC-derived cardiomyocytes for personalized medicine- promises and challenges","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"168496"}}