{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:17:34Z","timestamp":1789406254805,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.bbaexp.2005.05.010","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T16:19:55Z","timestamp":1119975595000},"page":"22-30","source":"Crossref","is-referenced-by-count":27,"title":["Discovery and characterization of new epididymis-specific beta-defensins in mice"],"prefix":"10.1016","volume":"1730","author":[{"given":"Jenni","family":"Jalkanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilpo","family":"Huhtaniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbaexp.2005.05.010_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1439-0272.1995.tb01093.x","article-title":"The apical mitochondria-rich cells of the mammalian epididymis","volume":"27","author":"Martinez-Garcia","year":"1995","journal-title":"Andrologia"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib2","series-title":"The Physiology of Reproduction","first-page":"999","article-title":"Efferent ducts, epididymis, and vas deferens: structure, functions, and their regulation","author":"Robaire","year":"1988"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib3","first-page":"303","article-title":"Maturation, transport and fate of spermatozoa in the epididymis","volume":"vol. 5","author":"Bedford","year":"1975"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib4","first-page":"1254","article-title":"Physiology of the male reproduction: the testis, epididymis, and ductus deferens","volume":"vol. 2","author":"Schlegel","year":"1997"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib5","series-title":"Essential Medical Physiology","first-page":"631","article-title":"Hormonal control of reproduction in the male","author":"Goodman","year":"1998"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib6","series-title":"Handbook of Andrology","first-page":"18","article-title":"What does the epididymis do and how does it do it?","author":"Hinton","year":"1995"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib7","first-page":"319","article-title":"Endocrine control of the development and maintenance of sperm fertilizing ability in the epididymis","volume":"vol. 5","author":"Orgebin-Crist","year":"1975"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/j.1939-4640.2002.tb02295.x","article-title":"Host defense proteins of the male reproductive tract","volume":"23","author":"Hall","year":"2002","journal-title":"J. Androl."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib9","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1056545","article-title":"An antimicrobial peptide gene found in the male reproductive system of rats","volume":"291","author":"Li","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1095\/biolreprod.102.004564","article-title":"Novel antimicrobial peptide of human epididymal duct origin","volume":"67","author":"von Horsten","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib11","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1095\/biolreprod64.4.1072","article-title":"Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes","volume":"64","author":"Frohlich","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib12","first-page":"670","article-title":"Sexually transmitted diseases: the classic diseases","volume":"vol. 2","author":"Berger","year":"1997"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1464-410x.2001.02216.x","article-title":"Acute epididymitis","volume":"87","author":"Luzzi","year":"2001","journal-title":"BJU Int."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1095\/biolreprod.102.005983","article-title":"Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis","volume":"68","author":"Rao","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib15","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1095\/biolreprod.103.018606","article-title":"Secreted epididymal glycoprotein 2D6 that binds to the sperm's plasma membrane is a member of the beta-defensin superfamily of pore-forming glycopeptides","volume":"69","author":"Zanich","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/molbev\/msg060","article-title":"Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family","volume":"20","author":"Morrison","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib17","doi-asserted-by":"crossref","first-page":"12421","DOI":"10.1074\/jbc.M307697200","article-title":"Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ","author":"Zaballos","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib18","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1095\/biolreprod.103.016105","article-title":"ESP13.2, a member of the beta-defensin family, is a macaque sperm surface-coating protein involved in the capacitation process","volume":"69","author":"Yudin","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1095\/biolreprod61.4.965","article-title":"The novel epididymal secretory protein ESP13.2 in Macaca fascicularis","volume":"61","author":"Perry","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib20","doi-asserted-by":"crossref","first-page":"31510","DOI":"10.1074\/jbc.M104149200","article-title":"A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle","volume":"276","author":"Yamaguchi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0952-7915(01)00303-X","article-title":"Defensins of vertebrate animals","volume":"14","author":"Lehrer","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0609.1990.tb00339.x","article-title":"Defensins","volume":"44","author":"Ganz","year":"1990","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib23","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.7886453","article-title":"Epithelial antibiotics induced at sites of inflammation","volume":"267","author":"Schonwetter","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib24","doi-asserted-by":"crossref","first-page":"F39","DOI":"10.1097\/00002030-200311070-00001","article-title":"Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication","volume":"17","author":"Quinones-Mateu","year":"2003","journal-title":"Aids"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib25","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/en.141.3.1245","article-title":"HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human","volume":"141","author":"Hamil","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0091-6749(99)70004-7","article-title":"Defensins: key players or bystanders in infection, injury, and repair in the lung?","volume":"104","author":"van Wetering","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1357-2725(99)00013-8","article-title":"Human beta-defensin-2","volume":"31","author":"Schroder","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib28","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1210\/me.2003-0008","article-title":"Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis","volume":"17","author":"Penttinen","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ar.1092090207","article-title":"Regional differences of the proximal part of mouse epididymis: morphological and histochemical characterization","volume":"209","author":"Abou-Haila","year":"1984","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib31","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1073\/pnas.042692699","article-title":"Discovery of five conserved beta-defensin gene clusters using a computational search strategy","volume":"99","author":"Schutte","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib32","doi-asserted-by":"crossref","first-page":"32911","DOI":"10.1074\/jbc.M006098200","article-title":"The structure of human beta-defensin-2 shows evidence of higher order oligomerization","volume":"275","author":"Hoover","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib33","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1210\/en.142.10.4529","article-title":"Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human","volume":"142","author":"Liu","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1095\/biolreprod65.2.575","article-title":"Epididymal specificity and androgen regulation of rat EP2","volume":"65","author":"Ibrahim","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1095\/biolreprod.102.008953","volume":"68","author":"Palladino","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib36","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1530\/acta.0.0890780","article-title":"Developmental patterns of plasma and testicular testosterone in mice from birth to adulthood","volume":"89","author":"Jean-Faucher","year":"1978","journal-title":"Acta Endocrinol. (Copenh)"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-1119(99)00136-5","article-title":"A 450-kb contig of defensin genes on human chromosome 8p23","volume":"233","author":"Linzmeier","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.bbaexp.2005.05.010_bib38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/bj20030225","article-title":"Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli","volume":"372","author":"Yenugu","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbaexp.2005.05.010_bib39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb1127","article-title":"An epididymis-specific beta-defensin is important for the initiation of sperm maturation","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat. Cell Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167478105001363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167478105001363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T11:12:15Z","timestamp":1706353935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167478105001363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0167478105001363"],"URL":"https:\/\/doi.org\/10.1016\/j.bbaexp.2005.05.010","relation":{},"ISSN":["0167-4781"],"issn-type":[{"value":"0167-4781","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}