{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:00:43Z","timestamp":1773658843117,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.bbagen.2008.11.010","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T09:40:27Z","timestamp":1230716427000},"page":"892-899","source":"Crossref","is-referenced-by-count":55,"title":["Epigenetics in hyperhomocysteinemic states. A special focus on uremia"],"prefix":"10.1016","volume":"1790","author":[{"given":"Diego","family":"Ingrosso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra F.","family":"Perna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2008.11.010_bib1","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib2","series-title":"Homocysteine in Health and Disease","first-page":"63","article-title":"S-adenosylmethionine-dependent methyltransferases","author":"Clarke","year":"2001"},{"key":"10.1016\/j.bbagen.2008.11.010_bib3","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1016\/S0021-9258(18)94346-2","article-title":"The specificity of S-adenosylmethionine derivatives in methyl transfer reactions","volume":"244","author":"Zappia","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib4","series-title":"Transmethylations","first-page":"155","article-title":"Inhibitors of S-adenosylhomocysteine hydrolase and their role in the regulation of biological methylation","author":"Cantoni","year":"1979"},{"key":"10.1016\/j.bbagen.2008.11.010_bib5","series-title":"Natural Sulfur Compounds: Novel Biochemical and Structural Aspects","first-page":"67","article-title":"The role of S-adenosylhomocysteine and Sadenosylhomocysteine hydrolase in the control of biologic methylations","author":"Cantoni","year":"1980"},{"key":"10.1016\/j.bbagen.2008.11.010_bib6","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1016\/S0021-9258(17)39845-9","article-title":"Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences","volume":"259","author":"Barber","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib7","series-title":"Biological Methylation and Drug Design. Experimental and Clinical Roles of S-adenosylmethionine","first-page":"227","article-title":"The centrality of S-adenosylhomocysteinase in the regulation of the biological utilization of S-adenosylmethionine","author":"Cantoni","year":"1986"},{"key":"10.1016\/j.bbagen.2008.11.010_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cca.2008.05.018","article-title":"Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients","volume":"395","author":"Valli","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbagen.2008.11.010_bib9","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/jn\/138.5.980","article-title":"Plasma S-adenosylhomocysteine versus homocysteine as a marker for vascular disease","volume":"138","author":"Wagner","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ajcn\/74.6.723","article-title":"Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine","volume":"74","author":"Kerins","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ajcn\/85.1.19","article-title":"Methyl balance and transmethylation fluxes in humans","volume":"85","author":"Mudd","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1026352908978","article-title":"Injury-induced enzymatic methylation of aging collagen in the extracellular matrix of blood vessels","volume":"16","author":"Weber","year":"1997","journal-title":"J. Protein. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1026300924908","article-title":"Detection and characterization of a protein isoaspartyl methyltransferase which becomes trapped in the extracellular space during blood vessel injury","volume":"16","author":"Weber","year":"1997","journal-title":"J. Protein. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrd728","article-title":"Metabonomics: a platform for studying drug toxicity and gene function","volume":"1","author":"Nicholson","year":"2002","journal-title":"Nat. Rev., Drug Discov."},{"key":"10.1016\/j.bbagen.2008.11.010_bib15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2008.11.010_bib16","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jama.299.11.1345","article-title":"Epigenetics at the epicenter of modern medicine","volume":"299","author":"Feinberg","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.bbagen.2008.11.010_bib17","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib18","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1001\/jama.299.24.2877","article-title":"Intra-individual change over time in DNA methylation with familial clustering","volume":"299","author":"Bjornsson","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.bbagen.2008.11.010_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2007.12.008","article-title":"Non-coding RNAs, epigenetics and complexity","volume":"410","author":"Costa","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.bbagen.2008.11.010_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1503\/cmaj.050774","article-title":"Epigenetics and human disease: translating basic biology into clinical applications","volume":"174","author":"Rodenhisser","year":"2006","journal-title":"CMAJ"},{"key":"10.1016\/j.bbagen.2008.11.010_bib21","first-page":"1","article-title":"DNA methylation 40 years later: its role in human health and disease","volume":"9999","author":"Scarano","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.ejhg.5201727","article-title":"Implications of abnormal epigenetic patterns for human diseases","volume":"15","author":"Santos-Rebou\u00e7as","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.bbagen.2008.11.010_bib23","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1172\/JCI116485","article-title":"Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure: evidence for high levels of the natural inhibitor S-adenosylhomocysteine","volume":"91","author":"Perna","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2008.11.010_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1568-1637(03)00011-4","article-title":"Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair","volume":"2","author":"Clarke","year":"2003","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbagen.2008.11.010_bib25","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1046\/j.1523-1755.1999.00624.x","article-title":"Homocysteine and methionine metabolism in ESRD: a stable isotope study","volume":"56","author":"Van Guldener","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2008.11.010_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/ndt\/13.3.656","article-title":"Evidence for disturbed S-adenosylmethionine:S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions?","volume":"13","author":"Loehrer","year":"1998","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbagen.2008.11.010_bib27","doi-asserted-by":"crossref","first-page":"25506","DOI":"10.1074\/jbc.M504815200","article-title":"Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia","volume":"280","author":"Devlin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib28","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/jn\/132.8.2157","article-title":"In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific","volume":"132","author":"Choumenkovitch","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib29","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/jn\/131.11.2811","article-title":"Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine B-synthase heterozygous mice","volume":"131","author":"Caudill","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib30","doi-asserted-by":"crossref","first-page":"29318","DOI":"10.1074\/jbc.M002725200","article-title":"Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation","volume":"275","author":"Yi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jn\/128.7.1204","article-title":"Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women","volume":"128","author":"Jacob","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib32","first-page":"849","article-title":"Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene","volume":"9","author":"Stern","year":"2000","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbagen.2008.11.010_bib33","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2008.11.010_bib34","doi-asserted-by":"crossref","first-page":"25380","DOI":"10.1074\/jbc.272.40.25380","article-title":"Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine","volume":"272","author":"Wang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib35","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1182\/blood.V99.3.939","article-title":"Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition","volume":"99","author":"Wang","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbagen.2008.11.010_bib36","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood-2007-06-096701","article-title":"Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene","volume":"110","author":"Jamaluddin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbagen.2008.11.010_bib37","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1515\/CCLM.2007.350","article-title":"Hyperhomocysteinemia, DNA methylation, and vascular disease","volume":"45","author":"Jamaluddin","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib38","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1161\/01.ATV.19.9.2171","article-title":"Local hypomethylation in atherosclerosis found in rabbit ec-sod gene","volume":"19","author":"Laukkanen","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1191\/1358863x02vm418oa","article-title":"DNA hypomethylation and methyltransferase expression in atherosclerotic lesions","volume":"7","author":"Hiltunen","year":"2002","journal-title":"Vasc. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/01.CIR.0000134487.51510.97","article-title":"Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice","volume":"110","author":"Zhou","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbagen.2008.11.010_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2008.11.010_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jn\/138.2.311","article-title":"Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in Apolipoprotein E-deficient mice fed high dietary methionine","volume":"138","author":"Liu","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib43","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/ajcn\/86.6.1581","article-title":"S-adenosylhomocysteine \u2014 a better indicator of vascular disease than homocysteine?","volume":"86","author":"Wagner","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib44","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1373\/49.8.1292","article-title":"Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease","volume":"49","author":"Castro","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib45","doi-asserted-by":"crossref","first-page":"29147","DOI":"10.1074\/jbc.M403618200","article-title":"DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E","volume":"279","author":"Lund","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jn\/135.1.5","article-title":"Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?","volume":"135","author":"Zaina","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib47","doi-asserted-by":"crossref","unstructured":"J. Zhou, G.H. Werstuck, S. Lhot\u00e1k, Y.Y. Shi, V. Tedesco, B. Trigatti, J. Dickhout, A.K. Majors, P. DiBello, D.W. Jacobsen, R.C. Austin, Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL\/6J mice, FASEB J. doi: 10.1096\/fj.07-105353.","DOI":"10.1096\/fj.07-105353"},{"key":"10.1016\/j.bbagen.2008.11.010_bib48","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0008-6363(99)00153-4","article-title":"Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system","volume":"43","author":"Post","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbagen.2008.11.010_bib49","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1073\/pnas.0400658101","article-title":"S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism","volume":"101","author":"Baric","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbagen.2008.11.010_bib50","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s10545-006-0240-0","article-title":"S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man","volume":"29","author":"Buist","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbagen.2008.11.010_bib51","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1093\/jn\/133.9.2907","article-title":"Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats","volume":"133","author":"Davis","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/carcin\/24.1.81","article-title":"The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon","volume":"24","author":"Sohn","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbagen.2008.11.010_bib53","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/jn\/133.4.1206","article-title":"Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific","volume":"133","author":"Choi","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2008.11.010_bib54","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.108.171082","article-title":"Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation","volume":"102","author":"Chang","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbagen.2008.11.010_bib55","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"Bonaa","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib56","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib57","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial","volume":"299","author":"Albert","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.bbagen.2008.11.010_bib58","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1161\/CIRCULATIONAHA.105.570846","article-title":"Improvement in stroke mortality in Canada and the United States, 1990 to 2002","volume":"113","author":"Yang","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbagen.2008.11.010_bib59","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bbagen.2008.11.010_bib60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1525-139X.2007.00345.x","article-title":"It is important to lower homocysteine in dialysis patients","volume":"20","author":"Zoccali","year":"2007","journal-title":"Semin. Dial."},{"key":"10.1016\/j.bbagen.2008.11.010_bib61","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.ki.5000096","article-title":"Impact of malnutrition\u2013inflammation on the association between homocysteine and mortality","volume":"69","author":"Ducloux","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2008.11.010_bib62","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1046\/j.1523-1755.2000.00018.x","article-title":"Hyperhomocysteinemia, nutritional status, and cardiovascular disease in hemodialysis patients","volume":"57","author":"Suliman","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2008.11.010_bib63","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1093\/hmg\/ddi100","article-title":"The impact of metabolism on DNA methylation","volume":"14","author":"Ulrey","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2008.11.010_bib64","first-page":"315","article-title":"Detection of DNA methylation in eucaryotic cells","volume":"45","author":"Sulewska","year":"2007","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib65","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(03)13372-7","article-title":"Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia","volume":"361","author":"Ingrosso","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bbagen.2008.11.010_bib66","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1515\/CCLM.2005.181","article-title":"Hyperhomocysteinemia and macromolecule modifications in uremic patients","volume":"43","author":"Perna","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib67","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2796.2007.01777.x","article-title":"impact of inflammation on epigenetic DNA methylation \u2014 a novel risk factor for cardiovascular disease ?","volume":"261","author":"Stenvinkel","year":"2007","journal-title":"J. Inter. Med."},{"key":"10.1016\/j.bbagen.2008.11.010_bib68","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1521-6616(03)00224-9","article-title":"DNA methylation in the immune system","volume":"109","author":"Teitell","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib69","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0002-9440(10)63511-0","article-title":"Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation","volume":"163","author":"Kang","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbagen.2008.11.010_bib70","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ijc.1394","article-title":"p16(INK4a) promoter hypermethylation of non-tumorous tissue adjacent to gastric cancer is correlated with glandular atrophy and chronic inflammation","volume":"93","author":"Jang","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbagen.2008.11.010_bib71","doi-asserted-by":"crossref","first-page":"39508","DOI":"10.1074\/jbc.C100343200","article-title":"Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells","volume":"276","author":"Hodge","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2008.11.010_bib72","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1158\/0008-5472.CAN-04-3589","article-title":"Interleukin 6 supports the maintenance of p53 tumor suppressor gene promotor methylation","volume":"65","author":"Hodge","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2008.11.010_bib73","first-page":"1","article-title":"Association between global leukocyte DNA methylation, renal function, carotid intima media thickness and plasma homocysteine in patients with stage 2\u20134 chronic kidney disease","author":"Nanayakkara","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbagen.2008.11.010_bib74","first-page":"297","article-title":"Plasma homocysteine and microvascular complications in type 1 diabetes","volume":"10","author":"Vaccaro","year":"2000","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.bbagen.2008.11.010_bib75","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.2337\/diacare.23.7.1026","article-title":"Plasma homocysteine and its determinants in diabetic retinopathy","volume":"23","author":"Vaccaro","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbagen.2008.11.010_bib76","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1046\/j.1523-1755.1998.00918.x","article-title":"Major determinants of hyperhomocysteinemia in peritoneal dialysis patients","volume":"53","author":"Vychtil","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2008.11.010_bib77","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1074\/jbc.M308140200","article-title":"Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements","volume":"279","author":"Di Leva","year":"2004","journal-title":"J. Biol. Chem.,"},{"key":"10.1016\/j.bbagen.2008.11.010_bib78","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1261\/rna.351707","article-title":"The imprinted H19 noncoding RNA is a primary microRNA precursor","volume":"13","author":"Cai","year":"2007","journal-title":"RNA"},{"key":"10.1016\/j.bbagen.2008.11.010_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddn163","article-title":"Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer","author":"Ito","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2008.11.010_bib80","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/ndt\/gfh746","article-title":"Methylation of CpG islands; potential relevance for hypertension and kidney disease","volume":"20","author":"Frey","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbagen.2008.11.010_bib81","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/ndt\/gfn056","article-title":"Epigenetics \u2014 a helpful tool to better understand processes in clinical nephrology?","volume":"23","author":"Stenvinkel","year":"2008","journal-title":"Nephrol. Dial. Transplant."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416508002687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416508002687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T04:02:51Z","timestamp":1632888171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416508002687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0304416508002687"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2008.11.010","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}