{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:46:53Z","timestamp":1790628413670,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":752,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"FAPEMIG (Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais, Brazil)","award":["CBB 359\/06"],"award-info":[{"award-number":["CBB 359\/06"]}]},{"name":"FAPEMIG (Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais, Brazil)","award":["CBB 1768\/08"],"award-info":[{"award-number":["CBB 1768\/08"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB815"],"award-info":[{"award-number":["SFB815"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.bbagen.2011.04.003","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T15:22:38Z","timestamp":1303658558000},"page":"683-694","source":"Crossref","is-referenced-by-count":115,"title":["Cytotoxicity and inhibition of platelet aggregation caused by an l-amino acid oxidase from Bothrops leucurus venom"],"prefix":"10.1016","volume":"1810","author":[{"given":"Gustavo B.","family":"Naumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilson","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia M.F.","family":"Gontijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Navdaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia F.","family":"de Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Eble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio F.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2011.04.003_bb0005","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1046\/j.1432-1327.2001.02042.x","article-title":"l-amino acid oxidase from Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme","volume":"268","author":"Macheroux","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02124033","article-title":"Snake venom action: are enzymes involved in it?","volume":"33","author":"Zeller","year":"1977","journal-title":"Experientia"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0015","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom l-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0020","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0041-0101(01)00133-7","article-title":"Inhibition of human platelet aggregation by l-amino acid oxidase purified from Naja naja kaouthia venom","volume":"39","author":"Sakurai","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1745-7270.2008.00372.x","article-title":"l-amino acid oxidase from Naja atra activates and binds to human platelets","volume":"40","author":"Li","year":"2008","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0030","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.bmc.2004.03.049","article-title":"Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom","volume":"12","author":"Stabeli","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0035","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0014-5793(02)03608-6","article-title":"Antimicrobial action of achacin is mediated by l-amino acid oxidase","volume":"531","author":"Ehara","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0040","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbrc.2003.08.044","article-title":"Molecular characterization of Trimeresurus stejnegeri venom l-amino acid oxidase with potential anti-HIV activity","volume":"309","author":"Zhang","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.toxicon.2008.12.004","article-title":"Antigenic, microbicidal and antiparasitic properties of an l-amino acid oxidase isolated from Bothrops jararaca snake venom","volume":"55","author":"Ciscotto","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0050","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/bi992416z","article-title":"Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with l-amino acid oxidase activity","volume":"39","author":"Torii","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0055","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s10495-006-7959-9","article-title":"Mechanism of cell death induction by l-amino acid oxidase, a major component of ophidian venom","volume":"11","author":"Ande","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0060","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/oxfordjournals.jbchem.a022287","article-title":"Comparison of the apoptotic pathways induced by l-amino acid oxidase and hydrogen peroxide","volume":"125","author":"Suhr","year":"1999","journal-title":"J Biochem Tokyo"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0065","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbrc.2006.12.217","article-title":"Molecular approches for structural characterization of Bothrops l-amino acid oxidases with antiprotozoal activity: cDNA cloning, comparative sequence analysis, and molecular modeling","volume":"355","author":"Fran\u00e7a","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0041-0101(92)90505-Y","article-title":"Biological activities of venoms from South American snakes","volume":"30","author":"Sanchez","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biochi.2005.07.008","article-title":"Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed-jararaca) snake venom","volume":"88","author":"Bello","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.abb.2007.10.002","article-title":"Structural and functional characterization of a P-III metalloproteinase, leucurolysin-B, from Bothrops leucurus venom","volume":"468","author":"Sanchez","year":"2007","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0085","series-title":"Drug Design of Zinc-Enzyme Inhibitors","first-page":"789","article-title":"P-III metalloproteinase (Leucurolysin-B) from Bothrops leucurus venom: isolation and possible inhibition","author":"Sanchez","year":"2009"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cbpa.2005.12.033","article-title":"Purification and properties of a coagulant thrombin-like enzyme from the venom of Bothrops leucurus","volume":"146A","author":"Magalhaes","year":"2007","journal-title":"Comp Biochem Physiol Mol Integrative Physiol"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0095","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.biochi.2006.10.010","article-title":"Purification and partial characterization of two phospholipases A2 from Bothrops leucurus (white-tailed-jararaca) snake venom","volume":"89","author":"Higuchi","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature London"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0105","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1073\/pnas.80.12.3734","article-title":"Permanent cell line expressing human factor VIII-related antigen established by hybridization","volume":"80","author":"Edgell","year":"1983","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0110","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1096\/fj.08-126763","article-title":"The alpha2beta1 integrin-specific antagonist rhodocetin is a cruciform, heterodimeric molecule","volume":"23","author":"Eble","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.abb.2010.01.010","article-title":"The novel metalloproteinase atroxlysin-I from Peruvian Bothrops atrox (Jerg\u00f3n) snake venom acts both on blood vessel ECM and platelets","volume":"496","author":"Sanchez","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0120","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1016\/j.bmc.2006.06.025","article-title":"Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom","volume":"14","author":"Izidoro","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0125","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/abbi.2000.2130","article-title":"Isolation, structural, and functional characterization of an apoptosis-inducing l-amino acid oxidase from leaf-nosed viper (Eristocophis macmahoni) snake venom","volume":"384","author":"Ali","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbapap.2006.01.021","article-title":"Isolation and characterization of an apoptotic and platelet aggregation inhibiting l-amino acid oxidase from Vipera berus berus (common viper) venom","volume":"1764","author":"Samel","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0135","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.cbpb.2007.11.008","article-title":"l-amino acid oxidase from Naja naja oxiana venom","volume":"149B","author":"Samel","year":"2008","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0140","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1016\/S0021-9258(18)63454-4","article-title":"Microheterogeneity of l-amino acid oxidase. Separation of multiple components by polyacrylamide gel electrofocusing","volume":"244","author":"Hayes","year":"1969","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0145","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.toxicon.2009.04.017","article-title":"Purification, characterization and biological activities of the amino acid oxidase from Bungarus fasciatus snake venom","volume":"54","author":"Wei","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0150","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0041-0101(91)90210-I","article-title":"Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudoechis australis","volume":"29","author":"Stiles","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0155","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1093\/emboj\/19.16.4204","article-title":"The structure of l-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site","volume":"19","author":"Pawelek","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0160","first-page":"249","article-title":"Purification and partial characterization of an l-amino acid oxidase from bushmaster snake (surucucu pico de jaca) Lachesis muta muta venom","volume":"24","author":"Sanchez","year":"1991","journal-title":"Brazilian J Med Biol Res"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.toxicon.2006.05.004","article-title":"l-amino acid oxidase from Vipera lebetine venom: isolation, characterization, effects on platelets and bacteria","volume":"48","author":"T\u00f5nism\u00e4gi","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0170","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.toxicon.2007.04.013","article-title":"Molecular characterization of l-amino acid oxidase from king cobra venoms","volume":"50","author":"Jin","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0175","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.toxicon.2007.07.022","article-title":"Purification, characterization and potent lung lesion activity of an l-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom","volume":"50","author":"Wei","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0180","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jmb.2006.09.032","article-title":"Crystal structure of LAAO from Calloselasma rhodostoma with an l-phenylalanine substrate insights into structure and mechanism","volume":"364","author":"Moustafa","year":"2006","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0185","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1006\/bbrc.2000.4175","article-title":"Bothrops moogeni venom kills Leishmania spp. with hidrogen peroxide generated by its l-amino acid oxidase","volume":"280","author":"Tempone","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0190","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(00)00229-6","article-title":"Molecular characterization of l-amino acid oxidase from Agkistrodon halys blomhoffii with special reference to platelet aggregation","volume":"1544","author":"Takatsuka","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0195","first-page":"336","article-title":"Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions","volume":"42","author":"Zhang","year":"2004","journal-title":"J Microbiol"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/yea.1592","article-title":"Induction of apoptosis in yeast by l-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma","volume":"25","author":"Ande","year":"2008","journal-title":"Yeast"},{"key":"10.1016\/j.bbagen.2011.04.003_bb0205","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.cdd.4400811","article-title":"Apoptosis-inducing protein, AIP, from parasite-infected fish induces apoptosis in mammalian cells by two different molecular mechanisms","volume":"8","author":"Murakawa","year":"2001","journal-title":"Cell Death Differ"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416511000808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416511000808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T23:49:41Z","timestamp":1637538581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416511000808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0304416511000808"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2011.04.003","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}