{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:29:53Z","timestamp":1791390593414,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Collaborative Research Fund","award":["HKBU 1\/CRF\/08"],"award-info":[{"award-number":["HKBU 1\/CRF\/08"]}]},{"name":"National Science and Engineering Research Council of Canada","award":["326415-07"],"award-info":[{"award-number":["326415-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.bbagen.2012.03.010","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T22:22:38Z","timestamp":1332886958000},"page":"1092-1101","source":"Crossref","is-referenced-by-count":202,"title":["PFOS-induced hepatic steatosis, the mechanistic actions on \u03b2-oxidation and lipid transport"],"prefix":"10.1016","volume":"1820","author":[{"given":"H.T.","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.G.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.Y.","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Giesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris K.C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2012.03.010_bb0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/es802216n","article-title":"A first global production, emission, and environmental inventory for perfluorooctane sulfonate","volume":"43","author":"Paul","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0010","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0020","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1248\/bpb.29.1952","article-title":"Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice: in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase","volume":"29","author":"Kudo","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.chemosphere.2010.01.027","article-title":"Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994\u20132008 and Vietnam in 2007\u20132008","volume":"79","author":"Harada","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0030","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.chemosphere.2010.06.025","article-title":"Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population","volume":"80","author":"Ingelido","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0035","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1021\/es1043613","article-title":"Trends in exposure to polyfluoroalkyl chemicals in the U.S. population: 1999\u20132008 (dagger)","volume":"45","author":"Kato","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0040","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.ecoenv.2011.04.027","article-title":"Perfluorinated chemicals in blood of residents in Wenzhou, China","volume":"74","author":"Zhang","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2131\/jts.36.201","article-title":"Induction of apoptosis and CYP4A1 expression in Sprague\u2013Dawley rats exposed to low doses of perfluorooctane sulfonate","volume":"36","author":"Kim","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0050","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/toxsci\/kfm065","article-title":"Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity","volume":"97","author":"Martin","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0055","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.intimp.2010.08.009","article-title":"Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice","volume":"10","author":"Qazi","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0060","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.reprotox.2009.01.007","article-title":"Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid","volume":"27","author":"Rosen","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/toxsci\/kfp093","article-title":"Structure\u2013activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures","volume":"111","author":"Bjork","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/794739","article-title":"Gene expression profiling in wild-type and PPARalpha-null mice exposed to perfluorooctane sulfonate reveals PPARalpha-independent effects","volume":"2010","author":"Rosen","year":"2010","journal-title":"PPAR Res."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta\/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0009-9120(93)90015-X","article-title":"Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts","volume":"26","author":"Carr","year":"1993","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0085","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3945\/jn.109.117937","article-title":"Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content","volume":"140","author":"Machado","year":"2010","journal-title":"J. Nutr."},{"issue":"Pt 1","key":"10.1016\/j.bbagen.2012.03.010_bb0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/bj3020023","article-title":"Estimation of peroxisomal beta-oxidation in rat heart by a direct assay of acyl-CoA oxidase","volume":"302","author":"Chu","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0095","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/jn\/127.9.1814","article-title":"Rates of mitochondrial and peroxisomal beta-oxidation of palmitate change during postnatal development and food deprivation in liver, kidney and heart of pigs","volume":"127","author":"Yu","year":"1997","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0100","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/00004836-200609000-00016","article-title":"Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults","volume":"40","author":"Chen","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tox.2009.10.035","volume":"267","author":"Qazi","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0110","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1289\/ehp.6128","article-title":"Neuroendocrine effects of perfluorooctane sulfonate in rats","volume":"111","author":"Austin","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0115","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0120","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/MPG.0b013e3181fb47d3","article-title":"Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease","volume":"52","author":"Carter-Kent","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0300-483X(02)00511-5","article-title":"Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats","volume":"183","author":"Seacat","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0130","first-page":"643","article-title":"Nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systems","volume":"22","author":"Tiniakos","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0135","doi-asserted-by":"crossref","first-page":"G1333","DOI":"10.1152\/ajpgi.2001.281.6.G1333","article-title":"Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis","volume":"281","author":"Reddy","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0140","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2008.06.007","article-title":"Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression","volume":"251","author":"Bjork","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0145","first-page":"649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20","author":"Desvergne","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0150","doi-asserted-by":"crossref","first-page":"28918","DOI":"10.1074\/jbc.M910350199","article-title":"Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting","volume":"275","author":"Hashimoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0160","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-511X-9-42","article-title":"The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"9","author":"Liu","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0165","doi-asserted-by":"crossref","first-page":"G194","DOI":"10.1152\/ajpgi.00413.2005","article-title":"Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis","volume":"290","author":"Bradbury","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0170","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2012.03.010_bb0175","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0220001","article-title":"Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences","volume":"22","author":"Holden","year":"1999","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1124\/mol.53.1.14","article-title":"Peroxisome proliferator activated receptor-alpha expression in human liver","volume":"53","author":"Palmer","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbagen.2012.03.010_bb0190","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.bbalip.2011.10.016","article-title":"Roles of PPARs in NAFLD: potential therapeutic targets","volume":"1821","author":"Tailleux","year":"2012","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416512000839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416512000839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:51:45Z","timestamp":1561510305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416512000839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0304416512000839"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2012.03.010","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}