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Metab."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0370","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0926-6593(65)80173-4","article-title":"Conversion of fructose to glucose by human jejunum. Absence of galactose-to-glucose convertion","volume":"105","author":"Okermann","year":"1965","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0375","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1152\/physiolgenomics.00056.2004","article-title":"Fructose-responsive genes in the small intestine of neonatal rats","volume":"18","author":"Cui","year":"2004","journal-title":"Physiol. 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Med."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0395","doi-asserted-by":"crossref","first-page":"ra6","DOI":"10.1126\/scisignal.2001249","article-title":"Wnt signaling regulates hepatic metabolism","volume":"4","author":"Liu","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0400","first-page":"497","article-title":"Hepato-nephromegalia glykogenica (Glykogenspeicherkrankheit der Leber und Nieren)","volume":"82","author":"von Gierke","year":"1929","journal-title":"Beitr. Pathol. Anat."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0405","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-1172-6-27","article-title":"Glucose-6-phosphatase deficiency","volume":"6","author":"Froissart","year":"2011","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0410","series-title":"The Metabolic Bases of Inherited Disease","first-page":"1521","article-title":"Glycogen storage diseases","author":"Chen","year":"2000"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0415","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1093\/hmg\/ddg263","article-title":"Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter","volume":"12","author":"Chen","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0420","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1016\/j.febslet.2007.07.013","article-title":"Neutrophilia and elevated serum cytokines are implicated in glycogen storage disease type Ia","volume":"581","author":"Kima","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0425","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jhep.2007.11.014","article-title":"Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia","volume":"48","author":"Kim","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0430","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1093\/hmg\/ddp441","article-title":"Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease","volume":"18","author":"Kishnani","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0435","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/sj.ki.5002718","article-title":"The angiotensin system mediates renal fibrosis in glycogen storage disease type Ia nephropathy","volume":"73","author":"Yiu","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0440","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/labinvest.2010.38","article-title":"Oxidative stress mediates nephropathy in type Ia glycogen storage disease","volume":"90","author":"Yiu","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0445","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0306-9877(02)00199-8","article-title":"Glycogenosis type I and diabetes mellitus: a common mechanism for renal dysfunction?","volume":"59","author":"Mundy","year":"2002","journal-title":"Med. 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Dis."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0465","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1172\/JCI105230","article-title":"Studies in glycogen storage diseases. I. Intestinal glucose-6-phosphatase activity in patients with Von Gierke's disease and their parents","volume":"44","author":"Field","year":"1965","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0470","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1046\/j.1432-1327.2000.01160.x","article-title":"New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system","volume":"267","author":"van de Werve","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0475","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1172\/JCI113543","article-title":"Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity","volume":"81","author":"Efendic","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0480","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.beem.2007.09.001","article-title":"New hepatic targets for glycaemic control in diabetes","volume":"21","author":"Agius","year":"2007","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0485","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1182\/blood-2002-08-2576","article-title":"Inhibiton of microsomal glucose-6-phosphate transport In human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction In glycogen storage disease type 1b","volume":"101","author":"Leuzzi","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0490","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1021\/jf9044827","article-title":"Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract","volume":"58","author":"Henry-Vitrac","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0495","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/cbdv.201000334","article-title":"Phenolic derivatives from Ruprechtia polystachya and their inhibitory activities on the glucose-6-phosphatase system","volume":"8","author":"Bruzual De Abreua","year":"2011","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0500","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.febslet.2007.03.045","article-title":"Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallate","volume":"581","author":"Csala","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0505","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2174\/157339912800564016","article-title":"Coffee to reduce risk of type 2 diabetes? A systematic review","volume":"8","author":"Muley","year":"2012","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0510","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2007.08.006","article-title":"Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver","volume":"6","author":"Matsumoto","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0515","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1124\/mol.110.065714","article-title":"Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db\/db mice","volume":"78","author":"Nagashima","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0520","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2010.07.018","article-title":"Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db\/db mice","volume":"645","author":"Tanaka","year":"2010","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/646257","article-title":"Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease","volume":"2011","author":"Specht","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0530","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/diabetes.48.3.531","article-title":"Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein","volume":"48","author":"Arden","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0535","doi-asserted-by":"crossref","first-page":"25197","DOI":"10.1074\/jbc.M101549200","article-title":"Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes","volume":"276","author":"Martin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0540","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00125-006-0185-8","article-title":"Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas","volume":"49","author":"Dogra","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0545","doi-asserted-by":"crossref","first-page":"13976","DOI":"10.1074\/jbc.M307756200","article-title":"Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP)","volume":"279","author":"Petrolonis","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0550","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s00125-006-0564-1","article-title":"Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype","volume":"50","author":"Wang","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0555","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1073\/pnas.0932778100","article-title":"Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes","volume":"100","author":"Lieberman","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0560","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nm1250","article-title":"Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide","volume":"11","author":"Han","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0565","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.4049\/jimmunol.0903931","article-title":"Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in non-obese diabetic mice","volume":"184","author":"Vincent","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0570","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.4049\/jimmunol.176.5.2781","article-title":"Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects","volume":"176","author":"Yang","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0575","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1172\/JCI29602","article-title":"Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP","volume":"116","author":"Krishnamurthy","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0580","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.2337\/db11-0220","article-title":"Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD\/ShiLtJ mice","volume":"60","author":"Oeser","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0585","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/dmrr.1251","article-title":"Multiple antigens versus single major antigen in type 1 diabetes: arguing for multiple antigens","volume":"27","author":"Di Lorenzo","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0590","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1126\/science.1156849","article-title":"A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels","volume":"320","author":"Bouatia-Naji","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0595","first-page":"2620","article-title":"Variations in the G6PC2\/ABCB11 genomic region are associated with fasting glucose levels","volume":"118","author":"Chen","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0600","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.290","article-title":"Variants in MTNR1B influence fasting glucose levels","volume":"41","author":"Prokopenko","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0605","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1007\/s00125-009-1413-9","article-title":"Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk","volume":"52","author":"Reiling","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0610","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1007\/s00125-009-1463-z","article-title":"A variant in the G6PC2\/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads","volume":"52","author":"Rose","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0615","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2337\/db08-0587","article-title":"A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro","volume":"58","author":"Dos Santos","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0620","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/db09-0374","article-title":"Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study","volume":"58","author":"Kelliny","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0625","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.2337\/db09-0228","article-title":"Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose","volume":"58","author":"Li","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0630","doi-asserted-by":"crossref","first-page":"E479","DOI":"10.1210\/jc.2010-0860","article-title":"The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia","volume":"95","author":"Heni","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0635","first-page":"E576","article-title":"Oscillations enhance the efficiency and stability of glucose disposal","volume":"250","author":"Marsh","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0640","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2337\/db10-0389","article-title":"Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels","volume":"59","author":"Bouatia-Naji","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0645","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00125-008-1241-3","article-title":"A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population","volume":"52","author":"Hu","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0650","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00125-009-1595-1","article-title":"Common variants at the GCK, GCKR, G6PC2\u2013ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations","volume":"53","author":"Takeuchi","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0655","doi-asserted-by":"crossref","first-page":"e11761","DOI":"10.1371\/journal.pone.0011761","article-title":"Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion","volume":"5","author":"Hu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0660","doi-asserted-by":"crossref","first-page":"e11428","DOI":"10.1371\/journal.pone.0011428","article-title":"Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects","volume":"5","author":"Ting Tam","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2012.12.013_bb0665","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1677\/jme.0.0290205","article-title":"Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein","volume":"29","author":"Martin","year":"2002","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0670","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1172\/JCI30443","article-title":"Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase\u2013\u03b2","volume":"117","author":"Cheung","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0675","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/jme.0.0320033","article-title":"Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein","volume":"32","author":"Boustead","year":"2004","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0680","doi-asserted-by":"crossref","first-page":"26215","DOI":"10.1074\/jbc.M402036200","article-title":"A potential new role for muscle in blood glucose homeostasis","volume":"279","author":"Shieh","year":"2004","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbagen.2012.12.013_bb0685","doi-asserted-by":"crossref","first-page":"39982","DOI":"10.1074\/jbc.M605858200","article-title":"Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)\/glucose-6-phosphatase catalytic subunit results in lowered plasma cholesterol and elevated glucagon","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. 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