{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:44:54Z","timestamp":1768635894081,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.bbagen.2013.12.026","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T03:33:55Z","timestamp":1388806435000},"page":"1747-1754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2"],"prefix":"10.1016","volume":"1840","author":[{"given":"Kerstin E.","family":"Geillinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna P.","family":"Kipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Schink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia V.","family":"R\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Spanier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannelore","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2013.12.026_bb0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jn\/135.1.19","article-title":"Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells","volume":"135","author":"Alteheld","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0010","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1128\/MCB.25.12.4914-4923.2005","article-title":"The GI-GPx gene is a target for Nrf2","volume":"25","author":"Banning","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0015","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1074\/jbc.M111.315705","article-title":"Glutathione degradation is a key determinant of glutathione homeostasis","volume":"287","author":"Baudouin-Cornu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0020","doi-asserted-by":"crossref","first-page":"e25624","DOI":"10.1371\/journal.pone.0025624","article-title":"A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans","volume":"6","author":"Benner","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02788388","article-title":"Localization of peptide transporter in nuclei and lysosomes of the pancreas","volume":"22","author":"Bockman","year":"1997","journal-title":"Int. J. Pancreatol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0030","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2133\/dmpk.DMPK-10-RG-045","article-title":"Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats","volume":"25","author":"Cang","year":"2010","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0035","first-page":"18","article-title":"Experimental strategies for the identification of DNA-binding proteins","volume":"2012","author":"Carey","year":"2012","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0040","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.03.237","article-title":"Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells","volume":"331","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0045","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbrc.2012.01.095","article-title":"Proteasome inhibition-induced p38 MAPK\/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3beta","volume":"418","author":"Choi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0050","doi-asserted-by":"crossref","first-page":"e2476","DOI":"10.1371\/journal.pone.0002476","article-title":"Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity","volume":"3","author":"Dalmasso","year":"2006","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0055","doi-asserted-by":"crossref","first-page":"23211","DOI":"10.1074\/jbc.273.36.23211","article-title":"Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter","volume":"273","author":"Doring","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0060","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1074\/jbc.M109.051714","article-title":"Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation","volume":"285","author":"Fourquet","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0065","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4161\/auto.6.1.10928","article-title":"Processing of autophagic protein LC3 by the 20S proteasome","volume":"6","author":"Gao","year":"2010","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.bbagen.2013.12.026_bb0070","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1021\/pr300385v","article-title":"Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with (15)N metabolic labeling","volume":"11","author":"Geillinger","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0075","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1158\/0008-5472.CAN-06-0139","article-title":"Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells","volume":"66","author":"Herman-Antosiewicz","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0080","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1021\/mp8001655","article-title":"Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine","volume":"5","author":"Hu","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000007736","article-title":"Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions","volume":"61","author":"Ihara","year":"2000","journal-title":"Digestion"},{"issue":"Suppl. 6","key":"10.1016\/j.bbagen.2013.12.026_bb0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/ndt\/15.suppl_6.11","article-title":"Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2","volume":"15","author":"Inui","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0095","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1365-2443.2003.00640.x","article-title":"Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles","volume":"8","author":"Itoh","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0110","doi-asserted-by":"crossref","first-page":"L478","DOI":"10.1152\/ajplung.00361.2007","article-title":"Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells","volume":"294","author":"Kode","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0115","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0120","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1158\/1535-7163.MCT-04-0290","article-title":"Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs","volume":"4","author":"Landowski","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0125","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0130","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.peptides.2011.01.019","article-title":"Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo","volume":"32","author":"Liu","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0135","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.peptides.2005.08.012","article-title":"Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents","volume":"27","author":"Lu","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0140","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1023\/A:1020436028194","article-title":"PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine","volume":"19","author":"Naruhashi","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0145","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1074\/jbc.M604267200","article-title":"Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors","volume":"282","author":"Nduati","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0150","doi-asserted-by":"crossref","first-page":"G191","DOI":"10.1152\/ajpgi.2001.281.1.G191","article-title":"Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line","volume":"281","author":"Nielsen","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0155","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1124\/jpet.103.055939","article-title":"Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten","volume":"307","author":"Pan","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0160","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.thromres.2008.01.011","article-title":"The proteasome inhibitor MG132 induces nuclear translocation of erythroid transcription factor Nrf2 and cyclooxygenase-2 expression in human vascular endothelial cells","volume":"122","author":"Sahni","year":"2008","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1158\/1535-7163.MCT-05-0293","article-title":"Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin","volume":"5","author":"Shen","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0170","first-page":"00025","article-title":"Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1","author":"Shimakura","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0175","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1474-9726.2010.00591.x","article-title":"Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity","volume":"9","author":"Spanier","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0180","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1073\/pnas.1121572109","article-title":"Keap1 degradation by autophagy for the maintenance of redox homeostasis","volume":"109","author":"Taguchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0185","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0026-0495(99)90164-6","article-title":"Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast","volume":"48","author":"Thamotharan","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0190","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.1074\/jbc.272.18.11786","article-title":"An active mechanism for completion of the final stage of protein degradation in the liver, lysosomal transport of dipeptides","volume":"272","author":"Thamotharan","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0195","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0200","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3390\/molecules13071441","article-title":"Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters","volume":"13","author":"Tsume","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0205","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejps.2003.10.002","article-title":"Effect of insulin on cephalexin uptake and transepithelial transport in the human intestinal cell line Caco-2","volume":"21","author":"Watanabe","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0210","doi-asserted-by":"crossref","first-page":"8768","DOI":"10.1021\/jf0512003","article-title":"Hydrogen peroxide induced oxidative stress damage and antioxidant enzyme response in Caco-2 human colon cells","volume":"53","author":"Wijeratne","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbagen.2013.12.026_bb0215","doi-asserted-by":"crossref","first-page":"1R","DOI":"10.1093\/glycob\/cwi041","article-title":"Lysosomal metabolism of glycoproteins","volume":"15","author":"Winchester","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.bbagen.2013.12.026_bb0220","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1124\/dmd.113.052597","article-title":"Impact of peptide transporter 1 on the intestinal absorption and pharmacokinetics of valacyclovir after oral dose escalation in wild-type and PepT1 knockout mice","volume":"41","author":"Yang","year":"2013","journal-title":"Drug Metab. Dispos."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416513005552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416513005552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T13:37:00Z","timestamp":1647869820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416513005552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0304416513005552"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2013.12.026","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2013.12.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}