{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:09:57Z","timestamp":1762898997835,"version":"3.40.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.bbagen.2014.02.028","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T09:03:31Z","timestamp":1394183011000},"page":"2105-2111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury"],"prefix":"10.1016","volume":"1840","author":[{"given":"Kang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofi E.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias S.J.","family":"Arn\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2014.02.028_bb0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbagen.2009.01.014","article-title":"Focus on mammalian thioredoxin reductases\u2014important selenoproteins with versatile functions","volume":"1790","author":"Arn\u00e9r","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0010","series-title":"Current Protocols in Toxicology","first-page":"7.4.1","article-title":"Measurement of thioredoxin and thioredoxin reductase","author":"Arn\u00e9r","year":"2000"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0015","doi-asserted-by":"crossref","first-page":"20096","DOI":"10.1074\/jbc.273.32.20096","article-title":"Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds","volume":"273","author":"Gromer","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/abio.1997.2373","article-title":"Determination of thioredoxin reductase activity in rat liver supernatant","volume":"253","author":"Hill","year":"1997","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/jn\/129.1.194","article-title":"Aurothioglucose inhibits murine thioredoxin reductase activity in vivo","volume":"129","author":"Smith","year":"1999","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0076-6879(02)47012-7","article-title":"High-throughput 96-well microplate assays for determining specific activities of glutathione peroxidase and thioredoxin reductase","volume":"347","author":"Smith","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0076-6879(95)52023-6","article-title":"Thioredoxin and thioredoxin reductase","volume":"252","author":"Holmgren","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0040","first-page":"2281","article-title":"Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma","volume":"60","author":"S\u00f6derberg","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0045","first-page":"575","article-title":"Tumor growth and disulfide reduction: possible dependence on protein-disulfide reductase","volume":"51","author":"Apffel","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0050","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1016\/S0021-9258(17)40204-3","article-title":"Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction","volume":"252","author":"Holmgren","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0055","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12185-011-0957-x","article-title":"Discovery of ATL: an odyssey in restrospect","volume":"94","author":"Yodoi","year":"2011","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0060","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1089\/ars.2000.2.4-687","article-title":"Thioredoxin levels in the sera of untreated viral hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic acid","volume":"2","author":"Nakashima","year":"2000","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0065","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1034\/j.1600-0676.2001.210501.x","article-title":"Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases","volume":"21","author":"Sumida","year":"2001","journal-title":"Liver"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0070","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1021\/bi00269a003","article-title":"Rat liver thioredoxin and thioredoxin reductase: purification and characterization","volume":"21","author":"Luthman","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0080","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.yrtph.2009.11.001","article-title":"Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury","volume":"56","author":"Ozer","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.taap.2007.06.013","article-title":"Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation","volume":"224","author":"Zhang","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-013-1191-5","article-title":"Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver\u2013bone axis","author":"Nussler","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0095","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00428-009-0872-1","article-title":"Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice","volume":"456","author":"Irie","year":"2010","journal-title":"Virchows Arch."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1172\/JCI103055","article-title":"Transaminase activity in human blood","volume":"34","author":"Karmen","year":"1955","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0105","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0110","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/BJ20120683","article-title":"Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase","volume":"447","author":"Peng","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0120","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1289\/ehp.95103260","article-title":"Tissue repair response as a function of dose in thioacetamide hepatotoxicity","volume":"103","author":"Mangipudy","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0125","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1124\/dmd.105.005520","article-title":"Saturation toxicokinetics of thioacetamide: role in initiation of liver injury","volume":"33","author":"Chilakapati","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2006.11.050","article-title":"Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide","volume":"230","author":"Chilakapati","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-3565(25)30789-5","article-title":"Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system","volume":"200","author":"Hunter","year":"1977","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2012.06.023","article-title":"Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries","volume":"264","author":"Yoshikawa","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0150","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.freeradbiomed.2011.11.025","article-title":"Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1","volume":"52","author":"Prigge","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0155","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0891-5849(97)00216-5","article-title":"Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability","volume":"24","author":"Rigobello","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jhep.2004.09.020","article-title":"Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice","volume":"42","author":"Okuyama","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mrgentox.2005.10.008","article-title":"Simultaneous measurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA microarrays","volume":"603","author":"Minami","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2006.09.014","article-title":"Protection against CCl4-induced injury in liver by adenovirally introduced thioredoxin gene","volume":"350","author":"Isoda","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0175","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1093\/jn\/133.9.2721","article-title":"Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element","volume":"133","author":"Hintze","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0180","doi-asserted-by":"crossref","first-page":"e6158","DOI":"10.1371\/journal.pone.0006158","article-title":"Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes","volume":"4","author":"Suvorova","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0185","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2013.05.028","article-title":"A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification","volume":"63","author":"Iverson","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0190","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/tx4001013","article-title":"Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity","volume":"26","author":"Patterson","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.toxlet.2007.12.002","article-title":"Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury","volume":"176","author":"Zhang","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1023\/A:1008032703468","article-title":"Elevated serum level of thioredoxin in patients with hepatocellular carcinoma","volume":"11","author":"Miyazaki","year":"1998","journal-title":"Biotherapy"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0205","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-2002-23201","article-title":"Elevation of serum thioredoxin levels in patients with type 2 diabetes","volume":"34","author":"Kakisaka","year":"2002","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0210","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0161-5890(01)00113-4","article-title":"Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis","volume":"38","author":"Jikimoto","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2369-11-7","article-title":"Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate","volume":"11","author":"Tsuchikura","year":"2010","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/thx.2005.053041","article-title":"Extracellular thioredoxin levels are increased in patients with acute lung injury","volume":"61","author":"Callister","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-2478(03)00006-3","article-title":"Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma","volume":"86","author":"Yamada","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0230","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00134-009-1640-z","article-title":"Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor","volume":"36","author":"Leaver","year":"2010","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0235","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.mpa.0000203958.93758.bd","article-title":"Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis","volume":"32","author":"Ohashi","year":"2006","journal-title":"Pancreas"},{"key":"10.1016\/j.bbagen.2014.02.028_bb0240","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/ars.2000.2.4-707","article-title":"Thioredoxin blood level increases after severe burn injury","volume":"2","author":"Abdiu","year":"2000","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0245","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1073\/pnas.041624998","article-title":"Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS","volume":"98","author":"Nakamura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0250","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0002-8703(03)00311-9","article-title":"Plasma thioredoxin levels and platelet aggregability in patients with acute myocardial infarction","volume":"146","author":"Miyamoto","year":"2003","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0255","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijcard.2004.01.010","article-title":"Plasma thioredoxin levels in patients with unstable angina","volume":"99","author":"Hokamaki","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/152308604771978363","article-title":"Increased plasma levels of thioredoxin in patients with coronary spastic angina","volume":"6","author":"Miyamoto","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbagen.2014.02.028_bb0265","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/ars.2011.3978","article-title":"Is serum thioredoxin-1 a useful clinical marker for malignant pleural mesothelioma?","volume":"15","author":"Maeda","year":"2011","journal-title":"Antioxid. Redox Signal."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514000890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514000890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:35:28Z","timestamp":1746146128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416514000890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0304416514000890"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.02.028","relation":{},"ISSN":["0304-4165"],"issn-type":[{"type":"print","value":"0304-4165"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}