{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:26:37Z","timestamp":1791606397390,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bbagen.2014.05.009","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T22:00:35Z","timestamp":1400364035000},"page":"2744-2751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells"],"prefix":"10.1016","volume":"1840","author":[{"given":"Cristiana","family":"Picco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Corzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Prestipino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2014.05.009_bb0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","article-title":"Molecular diversity of K+ channels","volume":"868","author":"Coetzee","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00039.2003","article-title":"Structure and function of Kv4-family transient potassium channels","volume":"84","author":"Birnbaum","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0015","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.febslet.2005.12.073","article-title":"A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily","volume":"580","author":"Abdel-Mottaleb","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-5793(01)02620-5","article-title":"A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain","volume":"501","author":"Vacher","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0025","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1046\/j.1432-1033.2002.03294.x","article-title":"Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus","volume":"269","author":"Vacher","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0030","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.toxicon.2004.03.023","article-title":"Definition of the alpha-KTx15 subfamily","volume":"43","author":"Vacher","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/296090a0","article-title":"Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin","volume":"296","author":"Carbone","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0040","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/bj2290739","article-title":"Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis","volume":"229","author":"Possani","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0045","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s002490000101","article-title":"Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells","volume":"29","author":"Frau","year":"2001","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s002490050112","article-title":"The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells","volume":"27","author":"Pisciotta","year":"1998","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.abb.2004.07.010","article-title":"Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+-channels (IA currents) of cerebellum granular cells","volume":"430","author":"D'Suze","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0060","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1021\/bi0519248","article-title":"Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily","volume":"45","author":"Prochnicka-Chalufour","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0065","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbagen.2008.01.012","article-title":"A positive charge at the N-terminal segment of discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells","volume":"1780","author":"Romeo","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0006-8993(84)90737-6","article-title":"Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures","volume":"290","author":"Levi","year":"1984","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.bbagen.2014.05.009_bb0075","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.mcn.2004.06.011","article-title":"Molecular physiology and modulation of somatodendritic A-type potassium channels","volume":"27","author":"Jerng","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0080","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1113\/jphysiol.2008.161620","article-title":"Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons","volume":"586","author":"Maffie","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0085","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1460-9568.2006.05020.x","article-title":"Kv4 channels sensitive to BMTx3 in rat nervous system: autoradiographic analysis of their distribution during brain ontogenesis","volume":"24","author":"Vacher","year":"2006","journal-title":"Eur. J. NeuroSci."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0090","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/bi048434k","article-title":"A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channels","volume":"44","author":"Corzo","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0100","first-page":"53","article-title":"Guide to data acquisition and analysis, in single-channel recording","volume":"3","author":"Heinemann","year":"1995","journal-title":"B. Sakmann and E. Neher. N.Y. and London, Plenum Press"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-5793(96)01388-9","article-title":"Cloning, expression and CNS distribution of Kv4.3, an A-type K+ channel alpha subunit","volume":"400","author":"Tsaur","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0110","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/jn.1998.79.2.1081","article-title":"Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain","volume":"79","author":"Serodio","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0115","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1126\/science.2476850","article-title":"Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor","volume":"245","author":"MacKinnon","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/35000592","article-title":"Modulation of A-type potassium channels by a family of calcium sensors","volume":"403","author":"An","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2014.00082","article-title":"Modulatory mechanisms and multiple functions of somatodendritic A-type K (+) channel auxiliary subunits","volume":"8","author":"Jerng","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0038205","article-title":"Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellum granule cells","volume":"7","author":"Jerng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0135","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1113\/jphysiol.2012.248831","article-title":"Dipeptidyl-peptidase-like proteins confer high-sensitivity to the scorpion toxin AmmTX3 to Kv4-medisted A-type K+ channels","volume":"591","author":"Maffie","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0165-6147(03)00080-4","article-title":"Novel interactions between K+ channels and scorpion toxins","volume":"24","author":"Rodriguez de la Vega","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbagen.2014.05.009_bb0145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0896-6273(95)90057-8","article-title":"The charybdotoxin family of K+ channel-blocking peptides","volume":"15","author":"Miller","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.bbagen.2014.05.009_bb0150","doi-asserted-by":"crossref","first-page":"15834","DOI":"10.1021\/bi051656d","article-title":"Nuclear magnetic resonance structural studies of a potassium channel\u2013charybdotoxin complex","volume":"44","author":"Yu","year":"2005","journal-title":"Biochemistry"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514001664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514001664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T15:32:22Z","timestamp":1565451142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416514001664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0304416514001664"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.05.009","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}