{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:46:42Z","timestamp":1791406002215,"version":"4.3.3"},"reference-count":88,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"U.S. Public Health Service"},{"name":"AI087746"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.bbagen.2014.11.011","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T21:12:17Z","timestamp":1416345137000},"page":"2103-2110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["The role of immunophilins in viral infection"],"prefix":"10.1016","volume":"1850","author":[{"given":"Sam","family":"Hopkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe A.","family":"Gallay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2014.11.011_bb0005","first-page":"1456","article-title":"Cyclosporine-induced deterioration in patients with AIDS","volume":"140","author":"Phillips","year":"1989","journal-title":"CMAJ"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0010","doi-asserted-by":"crossref","first-page":"8351","DOI":"10.1073\/pnas.89.17.8351","article-title":"Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506","volume":"89","author":"Karpas","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0015","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0092-8674(93)90637-6","article-title":"Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B","volume":"73","author":"Luban","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/372359a0","article-title":"Specific incorporation of cyclophilin A into HIV-1 virions","volume":"372","author":"Franke","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/372363a0","article-title":"Functional association of cyclophilin A with HIV-1 virions","volume":"372","author":"Thali","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0030","series-title":"Antimicrob. Agents Chemother.","article-title":"Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog","volume":"38","author":"Rosenwirth","year":"1763"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0040","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1128\/JVI.69.4.2451-2461.1995","article-title":"Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions","volume":"69","author":"Billich","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0045","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0092-8674(00)81823-1","article-title":"Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid","volume":"87","author":"Gamble","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0050","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1006\/jmbi.1997.1051","article-title":"Molecular recognition in the HIV-1 capsid\/cyclophilin A complex","volume":"269","author":"Yoo","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0055","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1128\/JVI.71.3.2107-2113.1997","article-title":"The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein","volume":"71","author":"Braaten","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0060","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.1128\/JVI.71.9.7110-7113.1997","article-title":"Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions","volume":"71","author":"Dorfman","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0065","doi-asserted-by":"crossref","first-page":"10943","DOI":"10.1073\/pnas.94.20.10943","article-title":"Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence","volume":"94","author":"Bukovsky","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0070","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/emboj\/20.6.1300","article-title":"Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells","volume":"20","author":"Braaten","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0075","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1073\/pnas.0337541100","article-title":"Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells","volume":"100","author":"Kootstra","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0080","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1073\/pnas.082100499","article-title":"Catalysis of cis\/trans isomerization in native HIV-1 capsid by human cyclophilin A","volume":"99","author":"Bosco","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0085","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nm910","article-title":"Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors","volume":"9","author":"Towers","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0090","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1073\/pnas.0403364101","article-title":"TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells","volume":"101","author":"Perron","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0095","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02777","article-title":"Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1","volume":"430","author":"Sayah","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0100","doi-asserted-by":"crossref","first-page":"13324","DOI":"10.1073\/pnas.0404640101","article-title":"A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1","volume":"101","author":"Nisole","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0105","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1073\/pnas.0709003105","article-title":"Independent evolution of an antiviral TRIMCyp in rhesus macaques","volume":"105","author":"Wilson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0110","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1073\/pnas.0505659102","article-title":"Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells","volume":"102","author":"Berthoux","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0115","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1128\/AAC.01324-07","article-title":"Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent","volume":"52","author":"Ptak","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0120","doi-asserted-by":"crossref","first-page":"40293","DOI":"10.1074\/jbc.M506314200","article-title":"Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells","volume":"280","author":"Chatterji","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0125","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1128\/JVI.00325-11","article-title":"The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid","volume":"85","author":"Matreyek","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0130","doi-asserted-by":"crossref","first-page":"e1002439","DOI":"10.1371\/journal.ppat.1002439","article-title":"HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency","volume":"7","author":"Schaller","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0135","doi-asserted-by":"crossref","first-page":"e46037","DOI":"10.1371\/journal.pone.0046037","article-title":"Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration","volume":"7","author":"Di Nunzio","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0140","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/JVI.07177-11","article-title":"The host proteins transportin SR2\/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating","volume":"87","author":"Shah","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0145","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1128\/JVI.02945-13","article-title":"Contribution of PDZD8 to stabilization of the human immunodeficiency virus type 1 capsid","volume":"88","author":"Guth","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0150","doi-asserted-by":"crossref","first-page":"e1002896","DOI":"10.1371\/journal.ppat.1002896","article-title":"CPSF6 defines a conserved capsid interface that modulates HIV-1 replication","volume":"8","author":"Price","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4690-10-81","article-title":"HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358","volume":"10","author":"Bichel","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09337","article-title":"A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells","volume":"467","author":"Manel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature12769","article-title":"HIV-1 evades innate immune recognition through specific cofactor recruitment","volume":"503","author":"Rasaiyaah","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0170","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2013.11.014","article-title":"Making sense of HIV innate sensing","volume":"39","author":"Cox","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0175","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.chom.2013.08.015","article-title":"The interferon-inducible MxB protein inhibits HIV-1 infection","volume":"14","author":"Liu","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0180","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3390\/v5030981","article-title":"Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms","volume":"5","author":"Gallay","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0185","first-page":"868","article-title":"Effect of cyclosporine on proliferation of non-A, non-B hepatitis virus","volume":"20","author":"Teraoka","year":"1988","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0190","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/jhep.2003.50449","article-title":"Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes","volume":"38","author":"Watashi","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbrc.2003.11.080","article-title":"Specific inhibition of hepatitis C virus replication by cyclosporin A","volume":"313","author":"Nakagawa","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0200","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbrc.2006.03.059","article-title":"Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811","volume":"343","author":"Goto","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0205","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1128\/JVI.80.9.4510-4520.2006","article-title":"Diverse effects of cyclosporine on hepatitis C virus strain replication","volume":"80","author":"Ishii","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0210","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1053\/j.gastro.2005.06.031","article-title":"Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins","volume":"129","author":"Nakagawa","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molcel.2005.05.014","article-title":"Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase","volume":"19","author":"Watashi","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.virol.2009.10.043","article-title":"Multiple cyclophilins involved in different cellular pathways mediate HCV replication","volume":"397","author":"Gaither","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0225","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1128\/JVI.02614-07","article-title":"Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro","volume":"82","author":"Yang","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0230","doi-asserted-by":"crossref","first-page":"16998","DOI":"10.1074\/jbc.M109.007625","article-title":"The isomerase active site of cyclophilin A is critical for hepatitis C virus replication","volume":"284","author":"Chatterji","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0235","doi-asserted-by":"crossref","first-page":"e1000546","DOI":"10.1371\/journal.ppat.1000546","article-title":"Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics","volume":"5","author":"Kaul","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0240","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature12427","article-title":"Completion of the entire hepatitis C virus life cycle in genetically humanized mice","volume":"501","author":"Dorner","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0245","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1128\/AAC.00310-06","article-title":"NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon","volume":"50","author":"Ma","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0250","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/hep.21102","article-title":"The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro","volume":"43","author":"Paeshuyse","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0255","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/AAC.00660-09","article-title":"SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro","volume":"54","author":"Hopkins","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0260","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.22131","article-title":"The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus","volume":"47","author":"Flisiak","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0265","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2012.02.024","article-title":"The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection","volume":"57","author":"Hopkins","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0270","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.3390\/v4112558","article-title":"Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection","volume":"4","author":"Hopkins","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0275","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/DDDT.S30946","article-title":"Profile of alisporivir and its potential in the treatment of hepatitis C","volume":"7","author":"Gallay","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0280","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1128\/JVI.02524-06","article-title":"Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro","volume":"81","author":"Robida","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0285","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/hep.21809","article-title":"Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B","volume":"46","author":"Fernandes","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0290","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/j.1349-7006.2009.01263.x","article-title":"Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor","volume":"100","author":"Goto","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0295","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1128\/AAC.01236-09","article-title":"Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors","volume":"54","author":"Puyang","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0300","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1128\/JVI.02550-08","article-title":"Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex","volume":"83","author":"Liu","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0305","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1128\/JVI.00393-11","article-title":"Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner","volume":"85","author":"Foster","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0310","doi-asserted-by":"crossref","first-page":"12616","DOI":"10.1128\/JVI.01351-12","article-title":"Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors","volume":"86","author":"Nag","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0315","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.bcp.2008.12.019","article-title":"Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase","volume":"77","author":"Heck","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0320","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1074\/jbc.M809244200","article-title":"Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis\/trans isomerase activity of cyclophilins A and B","volume":"284","author":"Hanoulle","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0325","doi-asserted-by":"crossref","first-page":"e1001118","DOI":"10.1371\/journal.ppat.1001118","article-title":"A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0330","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1128\/JVI.06641-11","article-title":"A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility","volume":"86","author":"Gris\u00e9","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0335","doi-asserted-by":"crossref","first-page":"20441","DOI":"10.1074\/jbc.M110.182436","article-title":"Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A","volume":"286","author":"Verdegem","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0340","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/v4123303","article-title":"Subtype specific differences in NS5A domain II reveals involvement of proline at position 310 in cyclosporine susceptibility of hepatitis C virus","volume":"4","author":"Ansari","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0345","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jhep.2010.01.041","article-title":"HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors","volume":"53","author":"Chatterji","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0350","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/AAC.01627-10","article-title":"Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family","volume":"55","author":"Gregory","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0355","doi-asserted-by":"crossref","first-page":"e13687","DOI":"10.1371\/journal.pone.0013687","article-title":"DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A","volume":"5","author":"Coelmont","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0360","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1128\/AAC.00919-12","article-title":"Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir","volume":"56","author":"Garcia-Rivera","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0365","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1743-422X-8-329","article-title":"Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion","volume":"8","author":"Anderson","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0370","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.3390\/v6072826","article-title":"Membranous replication factories induced by plus-strand RNA viruses","volume":"6","author":"Romero-Brey","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0375","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1053\/j.gastro.2014.01.055","article-title":"Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation","volume":"146","author":"Madan","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0380","article-title":"Alisporivir specifically eliminates HCV-created double membrane vesicles in infected hepatocytes by disrupting CypA-NS5A interactions","author":"Chatterji","year":"2014"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0385","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1128\/JVI.02555-09","article-title":"Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection","volume":"84","author":"Tian","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0390","article-title":"Bioengineering and semisynthesis combined to generate an optimized natural product cyclophilin inhibitor for treatment of chronic HBV, HCV and HIV infection","author":"Hansson","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0395","doi-asserted-by":"crossref","first-page":"A11","DOI":"10.1136\/gutjnl-2012-302514a.25","article-title":"Alisporivir inhibition of cellular cyclophilins disrupts hepatitis B virus (HBV) replication and this effect is further enhanced in combination with direct antiviral targeting HBV-DNA polymerase in vitro","volume":"61","author":"Chokshi","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0400","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.virusres.2014.02.010","article-title":"Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir","volume":"184","author":"Carbajo-Lozoya","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0405","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1099\/vir.0.034983-0","article-title":"Cyclosporin A inhibits the replication of diverse coronaviruses","volume":"92","author":"de Wilde","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0410","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1128\/JVI.00261-07","article-title":"Cyclosporine inhibits mouse cytomegalovirus infection via a cyclophilin-dependent pathway specifically in neural stem\/progenitor cells","volume":"81","author":"Kawasaki","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0415","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1099\/vir.0.037309-0","article-title":"Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation","volume":"93","author":"Keyes","year":"2012","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0420","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.virol.2011.01.011","article-title":"Involvement of cyclophilin B in the replication of Japanese encephalitis virus","volume":"412","author":"Kambara","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0425","doi-asserted-by":"crossref","first-page":"e1000524","DOI":"10.1371\/journal.ppat.1000524","article-title":"Target cell cyclophilins facilitate human papillomavirus type 16 infection","volume":"5","author":"Bienkowska-Haba","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0430","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1099\/vir.0.19074-0","article-title":"Requirement for cyclophilin A for the replication of vesicular stomatitis virus New Jersey serotype","volume":"84","author":"Bose","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbagen.2014.11.011_bb0435","doi-asserted-by":"crossref","first-page":"e31063","DOI":"10.1371\/journal.pone.0031063","article-title":"Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0440","doi-asserted-by":"crossref","first-page":"e37277","DOI":"10.1371\/journal.pone.0037277","article-title":"Cyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2014.11.011_bb0445","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1128\/AAC.00189-09","article-title":"Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein","volume":"53","author":"Qing","year":"2009","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514003882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416514003882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:29:29Z","timestamp":1598488169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416514003882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":88,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0304416514003882"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.11.011","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of immunophilins in viral infection","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2014.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}