{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:05:09Z","timestamp":1774508709033,"version":"3.50.1"},"reference-count":87,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.bbagen.2016.03.036","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T09:22:41Z","timestamp":1459934561000},"page":"3613-3620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"PB","title":["Biochemical and biophysical methodologies open the road for effective schistosomiasis therapy and vaccination"],"prefix":"10.1016","volume":"1861","author":[{"given":"Rashika","family":"El Ridi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Tallima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Migliardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbagen.2016.03.036_bb0005","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.actatropica.2010.08.020","article-title":"From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis","volume":"120","author":"Utzinger","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bjid.2014.11.004","article-title":"Impact of human schistosomiasis in sub-Saharan Africa","volume":"19","author":"Adenowo","year":"2015","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003504","article-title":"It's time to dispel the myth of \u201casymptomatic\u201d schistosomiasis","volume":"9","author":"King","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0020","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1017\/S0031182007002971","article-title":"The schistosome in the mammalian host: understanding the mechanisms of adaptation","volume":"134","author":"Kusel","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0025","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1645\/GE-864R.1","article-title":"No overt cellular inflammation around intravascular schistosomes in vivo","volume":"92","author":"Keating","year":"2006","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0020-7519(73)90004-0","article-title":"Schistosoma mansoni: changes in the outer membrane of the tegument during development from cercaria to adult worm","volume":"3","author":"Hockley","year":"1973","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0065-308X(08)60188-8","article-title":"Ultrastructure of the tegument of Schistosoma","volume":"11","author":"Hockley","year":"1973","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/269147a0","article-title":"Blood flukes have a double outer membrane","volume":"269","author":"Mclaren","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0045","doi-asserted-by":"crossref","DOI":"10.1017\/S0031182016000184","article-title":"Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase","author":"Igetei","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1017\/S0031182000045777","article-title":"An in vitro investigation of dynamic processes occurring in the schistosome tegument, using compounds known to disrupt secretory processes","volume":"68","author":"Wilson","year":"1974","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1017\/S0031182000007071","article-title":"The Schistosoma mansoni host-interactive tegument forms from vesicle eruptions of a cyton network","volume":"122","author":"Skelly","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0065-308X(06)63003-0","article-title":"Making sense of the schistosome surface","volume":"63","author":"Skelly","year":"2006","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0065","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/bph.12898","article-title":"Structure\u2013function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control","volume":"172","author":"Leow","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0070","first-page":"137","article-title":"Host cellular components adhering to the tegument of schistosomes from cattle, buffalo, hippopotamus and lechwe","volume":"57","author":"Kruger","year":"1990","journal-title":"Onderstepoort J. Vet. Res."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0075","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3279991","article-title":"Decreased binding of cytotoxic antibody by developing Schistosoma mansoni. Evidence for a surface change independent of host antigen adsorption and membrane turnover","volume":"63","author":"Dean","year":"1977","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S0031182000076757","article-title":"Mechanisms involved in the loss of antibody-mediated adherence of macrophages to lung-stage schistosomula of Schistosoma mansoni in vitro","volume":"106","author":"Lawson","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-3024.1996.d01-6.x","article-title":"The tegument of Schistosoma mansoni: functional and immunological features","volume":"18","author":"Abath","year":"1996","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-3024.1986.tb00866.x","article-title":"Post lung-stage schistosomula of Schistosoma mansoni exhibit transient susceptibility to macrophage-mediated cytotoxicity in vitro that may relate to late phase killing in vivo","volume":"8","author":"Pearce","year":"1986","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-3024.1986.tb00835.x","article-title":"Evidence that the reduced surface antigenicity of developing Schistosoma mansoni schistosomula is due to antigen shedding rather than host molecule acquisition","volume":"8","author":"Pearce","year":"1986","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S0031182000066890","article-title":"Immune evasion by Schistosoma mansoni: loss of susceptibility to antibody or complement-dependent eosinophil attack by schistosomula cultured in medium free of macromolecules","volume":"82","author":"Dessein","year":"1981","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0105","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0169-4758(86)90130-4","article-title":"Fluorescence recovery after photobleaching: applications to parasite surface membranes","volume":"2","author":"Foley","year":"1986","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182000081671","article-title":"Changes in the organization of the surface membrane upon transformation of cercariae to schistosomula of the helminth parasite Schistosoma mansoni","volume":"96","author":"Foley","year":"1988","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0115","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.103.3.807","article-title":"The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni","volume":"103","author":"Foley","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0120","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-3024.1989.tb00680.x","article-title":"Biophysical studies of the schistosome surface and their relevance to its properties under immune and drug attack","volume":"11","author":"Kusel","year":"1989","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-4894(89)90172-0","article-title":"Schistosoma mansoni: synthesis and release of phospholipids, lysophospholipids, and neutral lipids by schistosomula","volume":"69","author":"Furlong","year":"1989","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-2275(20)39749-2","article-title":"Uptake and compartmentalization of fluorescent lipid analogs in larval Schistosoma mansoni","volume":"36","author":"Furlong","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-6851(97)00091-1","article-title":"The incorporation, modification and turnover of fatty acids in adult Schistosoma mansoni","volume":"88","author":"Brouwers","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0140","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ijpara.2015.03.011","article-title":"The tegumental surface membranes of Schistosoma mansoni are enriched in parasite-specific phospholipid species","volume":"45","author":"Retra","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0145","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1645\/GE-3122RN","article-title":"Incubation of Schistosoma mansoni lung-stage schistosomula in corn oil exposes their surface membrane antigenic specificities","volume":"89","author":"El Ridi","year":"2003","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0150","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How cells handle cholesterol","volume":"290","author":"Simons","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0166-6851(87)90147-2","article-title":"The phospholipid and fatty acid composition of Schistosoma mansoni and of its purified tegumental membrane","volume":"23","author":"Allan","year":"1987","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0160","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1073\/pnas.0809959106","article-title":"Effect of cholesterol on the structure of a phospholipid bilayer","volume":"106","author":"de Meyer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0165","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1021\/ar500260t","article-title":"The structural role of cholesterol in cell membranes: from condensed bilayers to lipid rafts","volume":"47","author":"Krause","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-1752-5_8","article-title":"Cholesterol depletion using methyl-\u03b2-cyclodextrin","volume":"1232","author":"Mahammad","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0175","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0021-9258(18)48480-3","article-title":"Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol","volume":"267","author":"Castanho","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0180","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cyto.990050108","article-title":"Filipin as a flow microfluorometry probe for cellular cholesterol","volume":"5","author":"Muller","year":"1984","journal-title":"Cytometry"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0185","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1645\/GE-3334","article-title":"Depletion of Schistosoma mansoni lung-stage schistosomula cholesterol by methyl-beta-cyclodextrin dramatically increases specific antibody binding to surface membrane antigens","volume":"90","author":"El Ridi","year":"2004","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0190","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1645\/GE-439R","article-title":"Methyl-beta-cyclodextrin treatment and filipin staining reveal the role of cholesterol in surface membrane antigen sequestration of Schistosoma mansoni and S. haematobium lung-stage larvae","volume":"91","author":"Tallima","year":"2005","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0195","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1017\/S0031182007003174","article-title":"Evaluation of cholesterol content and impact on antigen exposure in the outer lipid bilayer of adult schistosomes","volume":"134","author":"Tallima","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0200","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1074\/jbc.275.11.7641","article-title":"Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain","volume":"275","author":"Bernardo","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0205","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1388-1981(00)00042-1","article-title":"Physiology and pathophysiology of sphingolipid metabolism and signaling","volume":"1485","author":"Huwiler","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0210","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1074\/jbc.M102393200","article-title":"Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism","volume":"277","author":"Worgall","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0215","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1645\/GE-514R.1","article-title":"In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae","volume":"91","author":"Tallima","year":"2005","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0220","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1645\/GE-745R1.1","article-title":"Equilibrium in lung schistosomula sphingomyelin breakdown and biosynthesis allows very small molecules, but not antibody, to access proteins at the host\u2013parasite interface","volume":"92","author":"El Ridi","year":"2006","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0225","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00501395","article-title":"On the chemistry of formaldehyde fixation and its effects on immunohistochemical reactions","volume":"82","author":"Puchtler","year":"1985","journal-title":"Histochemistry"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0230","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1551929500057060","article-title":"Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do","volume":"8","author":"Kiernan","year":"2000","journal-title":"Microbiol. Today"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0235","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/1439-7633(20010202)2:2<141::AID-CBIC141>3.0.CO;2-P","article-title":"Manumycin a and its analogues are irreversible inhibitors of neutral sphingomyelinase","volume":"2","author":"Arenz","year":"2001","journal-title":"Chembiochem"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0240","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbamem.2006.06.025","article-title":"Neutral sphingomyelinases and nSMase2: bridging the gaps","volume":"1758","author":"Clarke","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0250","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0006-3495(03)74963-7","article-title":"Hydrogen-bonding propensities of sphingomyelin in solution and in a bilayer assembly: a molecular dynamics study","volume":"84","author":"Mombelli","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0255","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0009-3084(03)00003-3","article-title":"Effect of sphingomyelin versus dipalmitoyl phosphatidylcholine on the extent of lipid oxidation","volume":"123","author":"Oborina","year":"2003","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0260","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbrc.2014.02.100","article-title":"Rigidity and resistance of larval- and adult schistosomes-medium interface","volume":"446","author":"Migliardo","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0265","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12013-013-9716-3","article-title":"Is there a sphingomyelin-based hydrogen bond barrier at the mammalian host-schistosome parasite interface?","volume":"68","author":"Migliardo","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0270","series-title":"Structures Dynamics and Chemical Properties","article-title":"Organic liquids","author":"Volino","year":"1978"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0275","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1046\/j.1471-4159.1999.0730675.x","article-title":"Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death","volume":"73","author":"Yoshimura","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0280","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2011.04.003","article-title":"Enzymatic activity and immunolocalization of Schistosoma mansoni and Schistosoma haematobium neutral sphingomyelinase","volume":"178","author":"Tallima","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0290","series-title":"Parasitic Diseases \u2014 Schistosomiasis","first-page":"179","article-title":"Solving the riddle of the lung-stage schistosomula paved the way to a novel remedy and an efficacious vaccine for schistosomiasis","author":"El Ridi","year":"2013"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0295","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of Schistosoma haematobium","volume":"44","author":"Young","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0300","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1128\/AAC.00173-10","article-title":"In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium","volume":"54","author":"El Ridi","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0305","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijantimicag.2011.08.019","article-title":"Efficacy and mechanism of action of arachidonic acid in the treatment of hamsters infected with Schistosoma mansoni or Schistosoma haematobium","volume":"39","author":"El Ridi","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0310","series-title":"An Overview of Tropical Diseases","first-page":"145","article-title":"Praziquantel and arachidonic acid combination \u2014 an innovative approach to the treatment of schistosomiasis","author":"Tallima","year":"2015"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0315","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4269\/ajtmh.14-0328","article-title":"Efficacy and safety of arachidonic acid for treatment of Schistosoma mansoni-infected children in Menoufiya, Egypt","volume":"91","author":"Selim","year":"2014","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0320","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4269\/ajtmh.14-0675","article-title":"Efficacy and safety of arachidonic acid for treatment of school-age children in Schistosoma mansoni high-endemicity regions","volume":"92","author":"Barakat","year":"2015","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0325","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0031182000007137","article-title":"Praziquantel-induced tegumental damage in vitro is diminished in schistosomes derived from praziquantel-resistant infections","volume":"122","author":"William","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0330","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.21238","article-title":"Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway","volume":"117","author":"Wu","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0335","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1476-4598-9-239","article-title":"Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase","volume":"9","author":"Mondal","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0340","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-4614-3381-1_20","article-title":"Withanolide D, carrying the baton of Indian rasayana herb as a lead candidate of antileukemic agent in modern medicine","volume":"749","author":"Mondal","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0345","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1472-6882-13-194","article-title":"Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells","volume":"13","author":"Park","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0350","first-page":"1672","article-title":"Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation","volume":"2014","author":"Shakor","year":"1841","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0355","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1423-0127-21-61","article-title":"Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester-induced apoptosis in C6 glioma cells","volume":"21","author":"Tseng","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0360","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.bbalip.2013.12.013","article-title":"Evolving concepts in cancer therapy through targeting sphingolipid metabolism","volume":"1841","author":"Truman","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0365","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bcp.2015.07.009","article-title":"New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase","volume":"97","author":"Romero-Ram\u00edrez","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0370","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-3024.2005.00785.x","article-title":"Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines","volume":"27","author":"Ganley-Leal","year":"2005","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001564","article-title":"Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2","volume":"6","author":"Pearson","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0380","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/pim.12118","article-title":"A multivalent chimeric vaccine composed of Schistosoma mansoni SmTSP-2 and Sm29 was able to induce protection against infection in mice","volume":"36","author":"Pinheiro","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0385","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3390\/vaccines2030654","article-title":"Schistosome vaccine adjuvants in preclinical and clinical research","volume":"2","author":"Stephenson","year":"2014","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2015.09.002","article-title":"Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates","volume":"46","author":"Sotillo","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0395","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1074\/mcp.M115.053934","article-title":"The extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis","volume":"14","author":"Cwiklinski","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0400","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1074\/mcp.M500097-MCP200","article-title":"Proteomic analysis of Schistosoma mansoni cercarial secretions","volume":"4","author":"Knudsen","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0405","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1074\/mcp.M500313-MCP200","article-title":"Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry","volume":"5","author":"Curwen","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0410","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.vaccine.2008.11.039","article-title":"Schistosoma mansoni ex vivo lung-stage larvae excretory-secretory antigens as vaccine candidates against schistosomiasis","volume":"27","author":"El Ridi","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001704","article-title":"Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis","volume":"6","author":"Riveau","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0420","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fimmu.2015.00218","article-title":"Development of the Brazilian anti schistosomiasis vaccine based on the recombinant fatty acid binding protein Sm14 plus GLA-SE adjuvant","volume":"6","author":"Tendler","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0425","article-title":"Development of a schistosomiasis vaccine","author":"Molehin","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.bbagen.2016.03.036_bb0430","doi-asserted-by":"crossref","first-page":"180","DOI":"10.14411\/fp.2008.025","article-title":"Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase is a lung-stage schistosomula surface membrane antigen","volume":"55","author":"Tallima","year":"2008","journal-title":"Folia Parasitol."},{"key":"10.1016\/j.bbagen.2016.03.036_bb0435","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fimmu.2015.00390","article-title":"Editorial: the schistosomiasis vaccine \u2014 it is time to stand up","volume":"6","author":"El Ridi","year":"2015","journal-title":"Front. Immunol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416516300952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416516300952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:11:12Z","timestamp":1655442672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416516300952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0304416516300952"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2016.03.036","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical and biophysical methodologies open the road for effective schistosomiasis therapy and vaccination","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2016.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}