{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:29:36Z","timestamp":1777868976486,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["102129"],"award-info":[{"award-number":["102129"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","award":["1832825"],"award-info":[{"award-number":["1832825"]}],"id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","award":["DK"],"award-info":[{"award-number":["DK"]}],"id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1160925"],"award-info":[{"award-number":["1160925"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbagen.2019.129463","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T04:07:50Z","timestamp":1572667670000},"page":"129463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["ROS directly activates transforming growth factor \u03b2 type 1 receptor signalling in human vascular smooth muscle cells"],"prefix":"10.1016","volume":"1864","author":[{"given":"Raafat","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingnan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwana","family":"Afroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suowen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang T.","family":"Ta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Barras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Kamato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2019.129463_bb0005","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0165-6147(00)01678-3","article-title":"G-protein-coupled receptors and signaling networks: emerging paradigms","volume":"22","author":"Marinissen","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0010","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00018-004-4462-3","article-title":"G-protein signaling: back to the future","volume":"62","author":"Mccudden","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0015","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJM197805042981803","article-title":"Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man","volume":"298","author":"Gavras","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2019.129463_bb0020","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bbamem.2006.11.001","article-title":"Seven transmembrane receptors\u2014a brief personal retrospective","volume":"1768","author":"Lefkowitz","year":"2007","journal-title":"Biochimica. Biophysica Acta (BBA)-Biomemb."},{"key":"10.1016\/j.bbagen.2019.129463_bb0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/379557a0","article-title":"Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors","volume":"379","author":"Daub","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2019.129463_bb0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-0760(01)00190-X","article-title":"Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer","volume":"80","author":"Filardo","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0035","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","article-title":"EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF","volume":"402","author":"Prenzel","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2019.129463_bb0040","doi-asserted-by":"crossref","first-page":"26798","DOI":"10.1074\/jbc.M109.092767","article-title":"Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor","volume":"285","author":"Burch","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2019.129463_bb0045","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.2042-7158.2012.01577.x","article-title":"Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine\/threonine kinase cell surface receptors","volume":"65","author":"Kamato","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0050","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/FJC.0b013e3181ee6811","article-title":"Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-[beta] type I receptor","volume":"56","author":"Little","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180842","article-title":"RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells","volume":"12","author":"Kamato","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2019.129463_bb0060","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.lfs.2013.03.017","article-title":"GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical galphaq protein signalling pathways","volume":"92","author":"Little","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0065","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1074\/jbc.M112.400259","article-title":"Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine\/threonine kinase receptor transactivation in vascular smooth muscle cells","volume":"288","author":"Burch","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2019.129463_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12079-017-0375-9","article-title":"Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors","volume":"11","author":"Chaplin","year":"2017","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.bbagen.2019.129463_bb0075","series-title":"J Cell Commun Signal","article-title":"Mechanisms of PAR-1 mediated kinase receptor transactivation: smad linker region phosphorylation","author":"Kamato","year":"2019"},{"key":"10.1016\/j.bbagen.2019.129463_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cellsig.2015.11.003","article-title":"Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes","volume":"28","author":"Kamato","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbagen.2004.12.008","article-title":"Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells","volume":"1722","author":"Vejrazka","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2019.129463_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/106507","article-title":"Apocynin: molecular aptitudes","volume":"2008","author":"Stefanska","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbagen.2019.129463_bb0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/HYPERTENSIONAHA.107.103200","article-title":"Apocynin, NADPH oxidase, and vascular cells: a complex matter","volume":"51","author":"Touyz","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bbagen.2019.129463_bb0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/FJC.0b013e318063e820","article-title":"NADPH oxidase inhibitors: new antihypertensive agents?","volume":"50","author":"Williams","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0105","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.107.100214","article-title":"Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant","volume":"51","author":"Heumuller","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bbagen.2019.129463_bb0110","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1111\/bph.13398","article-title":"Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR-1 signalling","volume":"173","author":"Little","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pharmthera.2018.02.005","article-title":"Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis","volume":"187","author":"Afroz","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbagen.2019.129463_bb0120","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2019.129463_bb0125","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cellsig.2018.11.005","article-title":"Individual smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes","volume":"53","author":"Kamato","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0130","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.cellsig.2013.06.001","article-title":"Transforming growth factor-beta signalling: role and consequences of Smad linker region phosphorylation","volume":"25","author":"Kamato","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0135","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbagen.2019.129463_bb0140","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1582-4934.2009.00902.x","article-title":"Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo","volume":"14","author":"Ballinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbagen.2019.129463_bb0145","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1210\/en.2010-0027","article-title":"PDGF beta-receptor kinase activity and ERK1\/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL","volume":"151","author":"Getachew","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbagen.2019.129463_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cardiores.2007.05.014","article-title":"Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease","volume":"76","author":"Grande-allen","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbagen.2019.129463_bb0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MOL.0b013e32830dd7c4","article-title":"Hyperelongated biglycan: the surreptitious initiator of atherosclerosis","volume":"19","author":"Little","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0160","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/jphp.12064","article-title":"Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells","volume":"65","author":"Little","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbagen.2019.129463_bb0170","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1089\/ars.2013.5607","article-title":"NADPH oxidases in vascular pathology","volume":"20","author":"Konior","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/CS20150404","article-title":"Nox1 in cardiovascular diseases: regulation and pathophysiology","volume":"130","author":"Gimenez","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbagen.2019.129463_bb0180","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","article-title":"Reciprocal regulation of TGF-beta and reactive oxygen species: A perverse cycle for fibrosis","volume":"6","author":"Liu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0185","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","article-title":"NAD (P) H oxidase 4 mediates transforming growth factor-\u03b21\u2013induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"97","author":"Cucoranu","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbagen.2019.129463_bb0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1124\/mol.62.1.58","article-title":"Inhibition of transforming growth factor (TGF)-\u03b21\u2013induced extracellular matrix with a novel inhibitor of the TGF-\u03b2 type I receptor kinase activity: SB-431542","volume":"62","author":"Laping","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1152\/ajpheart.01305.2004","article-title":"Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries","volume":"289","author":"Bailey","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0200","first-page":"H1495","article-title":"Activation of rho\/rho kinase signaling pathway by reactive oxygen species in rat aorta","volume":"287","author":"Jin","year":"2004","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bbagen.2019.129463_bb0205","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jacc.2006.06.082","article-title":"Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness","volume":"49","author":"Noma","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lfs.2018.03.004","article-title":"G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors","volume":"199","author":"Dayati","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0215","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jphp.12654","article-title":"Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis","volume":"69","author":"Sharifat","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0220","article-title":"Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-beta signalling","author":"Kamato","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0225","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/jphp.12060","article-title":"(S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells","volume":"65","author":"Kamato","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12079-018-0495-x","article-title":"Transforming growth factor-beta1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells","volume":"13","author":"Mohamed","year":"2018","journal-title":"J Cell Commun Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0235","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/jphp.13092","article-title":"Treatment of atherosclerotic plaque: perspectives on theranostics","volume":"71","author":"Zhang","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0240","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BJ20101456","article-title":"Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2","volume":"434","author":"Izumikawa","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbagen.2019.129463_bb0245","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cellsig.2016.05.002","article-title":"The role of specific smad linker region phosphorylation in TGF-beta mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle","volume":"28","author":"Rostam","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0250","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1124\/jpet.117.244483","article-title":"Flavopiridol inhibits TGF-\u03b2-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of smad2","volume":"365","author":"Rostam","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbagen.2019.129463_bb0255","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0891-5849(90)90070-Y","article-title":"Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils","volume":"8","author":"Simons","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2019.129463_bb0260","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1164\/ajrccm.150.6.7952625","article-title":"Apocynin improves the efficacy of secretory leukocyte protease inhibitor in experimental emphysema","volume":"150","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbagen.2019.129463_bb0265","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1096\/fasebj.9.2.7540156","article-title":"Free radicals and phagocytic cells","volume":"9","author":"Rosen","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.bbagen.2019.129463_bb0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00062752-200001000-00010","article-title":"Myeloperoxidase","volume":"7","author":"Winterbourn","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0275","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2005.07.011","article-title":"The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress","volume":"212","author":"Riganti","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0280","doi-asserted-by":"crossref","first-page":"17640","DOI":"10.1074\/jbc.M609450200","article-title":"Nox1 redox signaling mediates oncogenic ras-induced disruption of stress fibers and focal adhesions by down-regulating rho","volume":"282","author":"Shinohara","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2019.129463_bb0285","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/cm.20472","article-title":"Rho-kinase\/ROCK: a key regulator of the cytoskeleton and cell polarity","volume":"67","author":"Amano","year":"2010","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.bbagen.2019.129463_bb0290","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.cellsig.2013.04.009","article-title":"Signaling networks of rho GTPases in cell motility","volume":"25","author":"Hanna","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0295","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1254\/jphs.10197FP","article-title":"Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes","volume":"115","author":"Otani","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0300","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4161\/cam.5.2.14403","article-title":"Dynamics of the rho-family small GTPases in actin regulation and motility","volume":"5","author":"Spiering","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.bbagen.2019.129463_bb0305","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI27183","article-title":"Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury","volume":"116","author":"Jenkins","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2019.129463_bb0310","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.biocel.2012.01.018","article-title":"G protein coupled receptor transactivation: extending the paradigm to include serine\/threonine kinase receptors","volume":"44","author":"Burch","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0315","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00018-014-1775-0","article-title":"The expansion of GPCR transactivation-dependent signalling to include serine\/threonine kinase receptors represents a new cell signalling frontier","volume":"72","author":"Kamato","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cellsig.2018.03.009","article-title":"Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent smad linker region phosphorylation","volume":"47","author":"Talati","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbagen.2019.129463_bb0325","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejphar.2005.11.061","article-title":"Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice","volume":"531","author":"Hougee","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbagen.2019.129463_bb0330","doi-asserted-by":"crossref","first-page":"17017","DOI":"10.3390\/ijms140817017","article-title":"Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis","volume":"14","author":"Kinkade","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2019.129463_bb0335","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainres.2006.03.060","article-title":"Apocynin protects against global cerebral ischemia\u2013reperfusion-induced oxidative stress and injury in the gerbil hippocampus","volume":"1090","author":"Wang","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.bbagen.2019.129463_bb0340","first-page":"H303","article-title":"Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion lung injury","volume":"279","author":"Dodd-o","year":"2000","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bbagen.2019.129463_bb0345","first-page":"74","article-title":"Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition","volume":"6","author":"Liu","year":"2013","journal-title":"Circulation"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416519302491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416519302491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:58:39Z","timestamp":1777553919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416519302491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0304416519302491"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2019.129463","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS directly activates transforming growth factor \u03b2 type 1 receptor signalling in human vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2019.129463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129463"}}