{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T06:38:24Z","timestamp":1771742304529,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbagen.2020.129637","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:58:05Z","timestamp":1589889485000},"page":"129637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4"],"prefix":"10.1016","volume":"1864","author":[{"given":"Yoshiyuki","family":"Osada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoshi","family":"Dohmae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siro","family":"Simizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2020.129637_bb0005","doi-asserted-by":"crossref","first-page":"13524","DOI":"10.1021\/bi00250a003","article-title":"New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us","volume":"33","author":"Hofsteenge","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2020.129637_bb0010","doi-asserted-by":"crossref","first-page":"11785","DOI":"10.1021\/bi00037a016","article-title":"The hexopyranosyl residue that ss C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is \u03b1-mannopyranose","volume":"34","author":"de Beer","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2020.129637_bb0015","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1021\/bi9610515","article-title":"Spectroscopic and protein chemical analyses demonstrate the presence of C-mannosylated tryptophan in intact human RNase 2 and its isoforms","volume":"35","author":"L\u00f6ffler","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagen.2020.129637_bb0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1091\/mbc.9.2.291","article-title":"Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor","volume":"9","author":"Doucey","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbagen.2020.129637_bb0025","doi-asserted-by":"crossref","first-page":"781","DOI":"10.18388\/abp.2000_3996","article-title":"Protein C-mannosylation: facts and questions","volume":"47","author":"Furmanek","year":"2000","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0030","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/1873-3468.12274","article-title":"C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt\/\u03b2-catenin signaling in cells","volume":"590","author":"Fujiwara","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0035","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.bbrc.2018.02.210","article-title":"Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation","volume":"498","author":"Otani","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129637_bb0040","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbrc.2017.03.085","article-title":"Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation","volume":"486","author":"Okamoto","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129637_bb0045","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bbrc.2015.10.116","article-title":"C-mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling","volume":"468","author":"Sasazawa","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129637_bb0050","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1091\/mbc.E15-06-0373","article-title":"Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells","volume":"27","author":"Niwa","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbagen.2020.129637_bb0055","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.molcel.2013.03.003","article-title":"C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats","volume":"50","author":"Buettner","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagen.2020.129637_bb0060","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1074\/jbc.M111.311084","article-title":"Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R","volume":"287","author":"Hamming","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129637_bb0065","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3892\/ijo.2014.2438","article-title":"C-mannosylation of human hyaluronidase 1: possible role for secretion and enzymatic activity","volume":"45","author":"Goto","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082243","article-title":"Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions","volume":"8","author":"Wulf-Johansson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2020.129637_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/ATVBAHA.115.306672","article-title":"MFAP4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation","volume":"36","author":"Schlosser","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0080","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1136\/thoraxjnl-2014-206609","article-title":"Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma","volume":"7","author":"Pilecki","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.bbagen.2020.129637_bb0085","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/hmg\/4.4.589","article-title":"The gene for a human microfibril-associated glycoprotein is commonly deleted in smith-magenis syndrome patients","volume":"4","author":"Zhao","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagen.2020.129637_bb0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00441-016-2374-1","article-title":"The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life","volume":"365","author":"Mili\u0107evi\u0107","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbagen.2020.129637_bb0095","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.yexcr.2005.03.005","article-title":"36-kDa microfibril-associated glycoprotein (MAGP-36) is an elastin-binding protein increased in chick aortae during development and growth","volume":"307","author":"Toyoshima","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbagen.2020.129637_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/srep00164","article-title":"Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection","volume":"1","author":"Kasamatsu","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2020.129637_bb0105","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1006\/bbrc.1994.1178","article-title":"Isolation and characterization of a 36-kDa microfibril-associated glycoprotein by the newly synthesized isoquinolinesulfonamide affinity chromatography","volume":"198","author":"Kobayashi","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129637_bb0110","doi-asserted-by":"crossref","first-page":"32234","DOI":"10.1074\/jbc.274.45.32234","article-title":"Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D","volume":"274","author":"Lausen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129637_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-3083.2006.01778.x","article-title":"Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung","volume":"64","author":"Schlosser","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0120","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0968-0004(91)90096-E","article-title":"Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif","volume":"16","author":"D\u2019Souza","year":"1991","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbagen.2020.129637_bb0125","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nri2588","article-title":"Stromal cell contributions to the homeostasis and functionality of the immune system","volume":"9","author":"Mueller","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0130","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/hep.22764","article-title":"Detection of novel biomarkers of liver cirrhosis by proteomic analysis","volume":"49","author":"M\u00f6lleken","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2020.129637_bb0135","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7150\/jca.28127","article-title":"High expression levels of AGGF1 and MFAP4 predict primary platinum-based chemoresistance and are associated with adverse prognosis in patients with serous ovarian cancer","volume":"10","author":"Zhao","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbagen.2020.129637_bb0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00592-016-0953-y","article-title":"Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus","volume":"54","author":"Blindb\u00e6k","year":"2017","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0145","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.3892\/ol.2016.4425","article-title":"N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt\/\u03b2-catenin signaling-enhancing activity","volume":"11","author":"Tsuchiya","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0150","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1016\/j.febslet.2012.08.001","article-title":"Determination of cathepsin V activity and intracellular trafficking by N-glycosylation","volume":"586","author":"Niwa","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0155","first-page":"2127","article-title":"C-mannosylation of R-spondin2 activates Wnt\/\u03b2-catenin signaling and migration activity in human tumor cells","volume":"54","author":"Mizuta","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0160","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3892\/ol.2017.6465","article-title":"Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines","volume":"14","author":"Morishita","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0165","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.1158\/0008-5472.CAN-07-1053","article-title":"Involvement of disulfide bond formation in the activation of heparanase","volume":"67","author":"Simizu","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2020.129637_bb0170","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1021\/pr201240a","article-title":"Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides","volume":"11","author":"Sherrod","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbagen.2020.129637_bb0175","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.febslet.2015.01.040","article-title":"Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling","volume":"589","author":"Komai","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0180","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1111\/cas.13693","article-title":"Integrin \u03b21 is an essential factor in vasculogenic mimicry of human cancer cells","volume":"109","author":"Kawahara","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbagen.2020.129637_bb0185","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.febslet.2012.04.007","article-title":"Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells","volume":"586","author":"Yasukagawa","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagen.2020.129637_bb0190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1091\/mbc.12.2.487","article-title":"Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals","volume":"12","author":"Anand","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbagen.2020.129637_bb0195","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.4052\/tigg.1755.1E","article-title":"C-mannosylation; previous studies and future research perspectives","volume":"30","author":"Niwa","year":"2018","journal-title":"Trends Glycosci. Glycotechnol."},{"key":"10.1016\/j.bbagen.2020.129637_bb0200","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1073\/pnas.1613165114","article-title":"Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3","volume":"114","author":"Shcherbakova","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbagen.2020.129637_bb0205","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/humu.23299","article-title":"Identification and functional analysis of an ADAMTSL1 variant associated with a complex phenotype including congenital glaucoma, craniofacial, and other systemic features in a three-generation human pedigree","volume":"38","author":"Hendee","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbagen.2020.129637_bb0210","doi-asserted-by":"crossref","first-page":"30004","DOI":"10.1074\/jbc.M109.038059","article-title":"Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1\/punctin-1 by C-mannosylation of tryptophan","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129637_bb0215","doi-asserted-by":"crossref","first-page":"13213","DOI":"10.1074\/jbc.M900553200","article-title":"Genetic variation in ANGPTL4 provides insights into protein processing and function","volume":"284","author":"Yin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129637_bb0220","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1021\/ac101555a","article-title":"Derivatization with 1-pyrenyldiazomethane enhances ionization of glycopeptides but not peptides in matrix-assisted laser desorption\/ionization mass spectrometry","volume":"82","author":"Amano","year":"2010","journal-title":"Anal. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416520301495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416520301495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:02:33Z","timestamp":1759636953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416520301495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0304416520301495"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2020.129637","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2020.129637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129637"}}