{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:25:24Z","timestamp":1792027524981,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bbagen.2020.129834","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:20:00Z","timestamp":1608866400000},"page":"129834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH"],"prefix":"10.1016","volume":"1865","author":[{"given":"Kook Hwan","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Shik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2020.129834_bb0005","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2020.129834_bb0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/cr.2018.16","article-title":"UPR(mt) regulation and output: a stress response mediated by mitochondrial-nuclear communication","volume":"28","author":"Melber","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bbagen.2020.129834_bb0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1223560","article-title":"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation","volume":"337","author":"Nargund","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbagen.2020.129834_bb0020","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The transcription factor ATF5 mediates a mammalian mitochondrial UPR","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0025","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quiros","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mito.2015.01.005","article-title":"Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response","volume":"21","author":"Michel","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbagen.2020.129834_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.3014","article-title":"Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine","volume":"19","author":"Kim","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0040","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.201607110","article-title":"Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis","volume":"216","author":"Chung","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-pharmtox-010716-104908","article-title":"Repairing mitochondrial dysfunction in disease","volume":"58","author":"Sorrentino","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0050","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1530\/JME-18-0005","article-title":"The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases","volume":"61","author":"Yi","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrm.2017.110","article-title":"The mitochondrial UPR: mechanisms, physiological functions and implications in ageing","volume":"19","author":"Shpilka","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0060","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/MCB.20.10.3742-3751.2000","article-title":"Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury","volume":"20","author":"Hsiao","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0065","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1073\/pnas.94.21.11514","article-title":"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily","volume":"94","author":"Bootcov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2020.129834_bb0070","doi-asserted-by":"crossref","first-page":"33384","DOI":"10.1074\/jbc.M101814200","article-title":"Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3","volume":"276","author":"Baek","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129834_bb0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0167-4781(97)00122-X","article-title":"PLAB, a novel placental bone morphogenetic protein","volume":"1354","author":"Hromas","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagen.2020.129834_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-1119(97)00485-X","article-title":"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta","volume":"203","author":"Lawton","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.bbagen.2020.129834_bb0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jlb.65.1.2","article-title":"MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation","volume":"65","author":"Fairlie","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0090","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1038\/s41598-018-25098-0","article-title":"Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2020.129834_bb0095","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cmet.2018.12.016","article-title":"GDF15 provides an endocrine signal of nutritional stress in mice and humans","volume":"29","author":"Patel","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbagen.2020.129834_bb0100","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2020.129834_bb0105","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jacc.2007.04.091","article-title":"Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure","volume":"50","author":"Kempf","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0110","doi-asserted-by":"crossref","first-page":"F1249","DOI":"10.1152\/ajprenal.00387.2013","article-title":"Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes","volume":"305","author":"Mazagova","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0115","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41419-018-0530-0","article-title":"Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbagen.2020.129834_bb0120","first-page":"L510","article-title":"GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis","volume":"317","author":"Zhang","year":"2019","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbagen.2020.129834_bb0125","doi-asserted-by":"crossref","first-page":"5271203","DOI":"10.1155\/2017\/5271203","article-title":"Growth differentiation Factor-15 is a predictor of mortality in critically ill patients with Sepsis","volume":"2017","author":"Buendgens","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbagen.2020.129834_bb0130","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.0530278100","article-title":"Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum","volume":"100","author":"Welsh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. 1","key":"10.1016\/j.bbagen.2020.129834_bb0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/ggi.12724","article-title":"Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders","volume":"16","author":"Fujita","year":"2016","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.bbagen.2020.129834_bb0140","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/ijo.2014.27","article-title":"NAG-1\/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism","volume":"38","author":"Chrysovergis","year":"2014","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bbagen.2020.129834_bb0145","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/liv.13587","article-title":"Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease","volume":"38","author":"Koo","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.bbagen.2020.129834_bb0150","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2164-15-91","article-title":"Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies","volume":"15","author":"Kalko","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbagen.2020.129834_bb0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mito.2014.10.006","article-title":"GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases","volume":"20","author":"Fujita","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbagen.2020.129834_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148709","article-title":"GDF-15 is elevated in children with mitochondrial diseases and is induced by mitochondrial dysfunction","volume":"11","author":"Montero","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2020.129834_bb0165","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","author":"Yatsuga","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0170","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948804","article-title":"Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress","volume":"21","author":"Ost","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbagen.2020.129834_bb0175","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2017.07.007","article-title":"mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression","volume":"26","author":"Khan","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbagen.2020.129834_bb0180","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.2337\/db17-0333","article-title":"Growth differentiation factor 15 mediates systemic glucose regulatory action of T-helper type 2 cytokines","volume":"66","author":"Lee","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.bbagen.2020.129834_bb0185","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41467-018-03998-z","article-title":"Reduced oxidative capacity in macrophages results in systemic insulin resistance","volume":"9","author":"Jung","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagen.2020.129834_bb0190","doi-asserted-by":"crossref","first-page":"e12943","DOI":"10.1111\/acel.12943","article-title":"mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism","volume":"18","author":"Tang","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbagen.2020.129834_bb0195","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/thoraxjnl-2017-211440","article-title":"Growth\/differentiation factor 15 causes TGFbeta-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension","volume":"74","author":"Garfield","year":"2019","journal-title":"Thorax"},{"key":"10.1016\/j.bbagen.2020.129834_bb0200","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nm1677","article-title":"Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1","volume":"13","author":"Johnen","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0205","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jcsm.12077","article-title":"MAP3K11\/GDF15 axis is a critical driver of cancer cachexia","volume":"7","author":"Lerner","year":"2016","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bbagen.2020.129834_bb0210","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0215","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbagen.2020.129834_bb0220","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0225","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrd3976","article-title":"Targeting the unfolded protein response in disease","volume":"12","author":"Hetz","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbagen.2020.129834_bb0230","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0235","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/carcin\/bgq008","article-title":"The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1\/MIC-1\/PTGF-beta)","volume":"31","author":"Yang","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbagen.2020.129834_bb0240","doi-asserted-by":"crossref","first-page":"19841","DOI":"10.1074\/jbc.M111.330639","article-title":"Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1","volume":"287","author":"Park","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2020.129834_bb0245","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bbrc.2017.08.096","article-title":"Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice","volume":"498","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129834_bb0250","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.redox.2018.01.013","article-title":"Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid beta-oxidation and ketogenesis via activating XBP1 signaling in liver","volume":"16","author":"Zhang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0255","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/13693780701874507","article-title":"Expression of genes in normal human monocytes in response to Aspergillus fumigatus","volume":"46","author":"Rodland","year":"2008","journal-title":"Med. Mycol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0260","doi-asserted-by":"crossref","first-page":"e19967","DOI":"10.1371\/journal.pone.0019967","article-title":"Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes","volume":"6","author":"Si","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2020.129834_bb0265","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-017-00902-5","article-title":"Growth differentiation Factor-15 deficiency augments inflammatory response and exacerbates septic heart and renal injury induced by lipopolysaccharide","volume":"7","author":"Abulizi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2020.129834_bb0270","doi-asserted-by":"crossref","first-page":"15080","DOI":"10.1038\/nrdp.2015.80","article-title":"Nonalcoholic fatty liver disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbagen.2020.129834_bb0275","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0280","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagen.2020.129834_bb0285","doi-asserted-by":"crossref","first-page":"5170402","DOI":"10.1155\/2016\/5170402","article-title":"Pathogenesis of nonalcoholic steatohepatitis: interactions between liver parenchymal and nonparenchymal cells","volume":"2016","author":"Magee","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbagen.2020.129834_bb0290","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagen.2020.129834_bb0295","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbagen.2020.129834_bb0300","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fendo.2018.00485","article-title":"Pathogenesis of nonalcoholic steatohepatitis and hormone-based therapeutic approaches","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbagen.2020.129834_bb0305","first-page":"1756","article-title":"GDF15 prevents LPS and Dgalactosamineinduced in fl ammation and acute liver injury in mice","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0310","article-title":"Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2020.129834_bb0315","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5009\/gnl16049","article-title":"Growth differentiation factor 15 predicts chronic liver disease severity","volume":"11","author":"Lee","year":"2017","journal-title":"Gut Liver"},{"key":"10.1016\/j.bbagen.2020.129834_bb0320","doi-asserted-by":"crossref","first-page":"17238","DOI":"10.1038\/s41598-017-17574-w","article-title":"GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury","volume":"7","author":"Chung","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2020.129834_bb0325","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2018.04.061","article-title":"CST3 and GDF15 ameliorate renal fibrosis by inhibiting fibroblast growth and activation","volume":"500","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2020.129834_bb0330","doi-asserted-by":"crossref","first-page":"112010","DOI":"10.1016\/j.yexcr.2020.112010","article-title":"Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts","volume":"391","author":"Takenouchi","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbagen.2020.129834_bb0335","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1038\/nrdp.2017.34","article-title":"Obesity","volume":"3","author":"Gonzalez-Muniesa","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbagen.2020.129834_bb0340","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbagen.2020.129834_bb0345","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCRESAHA.110.225698","article-title":"Endoplasmic reticulum stress and inflammation in obesity and diabetes","volume":"107","author":"Hummasti","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbagen.2020.129834_bb0350","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4093\/dmj.2018.0221","article-title":"Mitochondrial dysfunction in adipocytes as a primary cause of adipose tissue inflammation","volume":"43","author":"Woo","year":"2019","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.bbagen.2020.129834_bb0355","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates","author":"Mullican","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0360","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","author":"Yang","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0365","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","author":"Emmerson","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2020.129834_bb0370","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature24042","article-title":"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15","volume":"550","author":"Hsu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2020.129834_bb0375","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2020.129834_bb0380","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2019.12.004","article-title":"GDF15 induces anorexia through nausea and Emesis","volume":"31","author":"Borner","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbagen.2020.129834_bb0385","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood-2016-01-696617","article-title":"GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5\/TGF-\u03b2RII heterodimer","volume":"128","author":"Artz","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbagen.2020.129834_bb0390","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1172\/JCI91561","article-title":"NF-\u03baB regulates GDF-15 to suppress macrophage surveillance during early tumor development","volume":"127","author":"Ratnam","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2020.129834_bb0395","doi-asserted-by":"crossref","first-page":"8278039","DOI":"10.1155\/2018\/8278039","article-title":"CRP stimulates GDF15 expression in endothelial cells through p53","volume":"2018","author":"Kim","year":"2018","journal-title":"Mediat. Inflamm."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416520303457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416520303457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:06:19Z","timestamp":1759637179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416520303457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0304416520303457"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2020.129834","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2020.129834","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129834"}}