{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:51:18Z","timestamp":1793393478715,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0900903"],"award-info":[{"award-number":["2016YFC0900903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bbagen.2021.130010","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T01:13:10Z","timestamp":1631409190000},"page":"130010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans"],"prefix":"10.1016","volume":"1866","author":[{"given":"He","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangshu","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Forno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Muzumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2021.130010_bb0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis (*)","volume":"27","author":"Galkina","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0010","doi-asserted-by":"crossref","first-page":"III27-32","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbagen.2021.130010_bb0015","first-page":"e88","article-title":"Oxidative stress: predictive marker for coronary artery disease","volume":"18","author":"Vichova","year":"2013","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0020","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1073\/pnas.101133498","article-title":"A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and abeta","volume":"98","author":"Hashimoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2021.130010_bb0025","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with bax activation","volume":"423","author":"Guo","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2021.130010_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006334","article-title":"Humanin: a novel central regulator of peripheral insulin action","volume":"4","author":"Muzumdar","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2021.130010_bb0035","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1096\/fj.13-231092","article-title":"Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the beta cell","volume":"27","author":"Kuliawat","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.bbagen.2021.130010_bb0040","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1152\/ajpendo.00043.2015","article-title":"Central effects of humanin on hepatic triglyceride secretion","volume":"309","author":"Gong","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbagen.2021.130010_bb0045","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1161\/01.STR.0000242772.94277.1f","article-title":"Humanin is a novel neuroprotective agent against stroke","volume":"37","author":"Xu","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.bbagen.2021.130010_bb0050","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.18632\/aging.103534","article-title":"The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan","volume":"12","author":"Yen","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.bbagen.2021.130010_bb0055","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/ATVBAHA.110.205997","article-title":"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice","volume":"30","author":"Muzumdar","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0060","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1096\/fj.02-0018fje","article-title":"A novel rat gene encoding a humanin-like peptide endowed with broad neuroprotective activity","volume":"16","author":"Caricasole","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.bbagen.2021.130010_bb0065","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/cvr\/cvq191","article-title":"Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress","volume":"88","author":"Bachar","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbagen.2021.130010_bb0070","first-page":"466","article-title":"The level of circulating humanin in patients with ischemic heart disease","volume":"63","author":"Zhloba","year":"2018","journal-title":"Klin. Lab. Diagn."},{"key":"10.1016\/j.bbagen.2021.130010_bb0075","first-page":"699","article-title":"Efficacy of a novel mitochondrial-derived peptide in a porcine model of myocardial ischemia\/reperfusion injury","volume":"5","author":"Sharp","year":"2020","journal-title":"JACC"},{"key":"10.1016\/j.bbagen.2021.130010_bb0080","first-page":"5","article-title":"Efficacy of a novel mitochondrial-derived peptide in a porcine model of myocardial ischemia\/reperfusion injury","author":"Thomas","year":"2020","journal-title":"JACC"},{"key":"10.1016\/j.bbagen.2021.130010_bb0085","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1755-5922.12210","article-title":"Humanin exerts cardioprotection against cardiac ischemia\/reperfusion injury through attenuation of mitochondrial dysfunction","volume":"34","author":"Thummasorn","year":"2016","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2021.130010_bb0090","first-page":"35","article-title":"High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia\/reperfusion injury by reducing mitochondrial dysfunction","author":"Thummasorn","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2021.130010_bb0095","doi-asserted-by":"crossref","first-page":"H1127","DOI":"10.1152\/ajpheart.00685.2017","article-title":"Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. american journal of physiology","volume":"315","author":"Qin","year":"2018","journal-title":"Heart Circulat. Physiol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0100","first-page":"281","article-title":"The value of detection of homoarginin level in patients with ischemic heart disease under operations of myocardium re-vascularization","volume":"63","author":"Zhloba","year":"2018","journal-title":"Klin. Lab. Diagn."},{"key":"10.1016\/j.bbagen.2021.130010_bb0105","first-page":"H634","article-title":"Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity","volume":"315","author":"Lue","year":"2018","journal-title":"Am. J. Physiol.ogy"},{"key":"10.1016\/j.bbagen.2021.130010_bb0110","doi-asserted-by":"crossref","first-page":"22039","DOI":"10.1021\/acsomega.0c01778","article-title":"Humanin ameliorates free fatty acid-induced endothelial inflammation by suppressing the NLRP3 inflammasome","volume":"5","author":"Li","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbagen.2021.130010_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/1a60b239-181f-4d5f-9a37-3d3b04949954","article-title":"Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans","volume":"7","author":"Zacharias","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2021.130010_bb0120","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1111\/jcmm.15151","article-title":"Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules","volume":"24","author":"Ren","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbagen.2021.130010_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2013.08.055","article-title":"A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts","author":"Klein","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2021.130010_bb0130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.201606095","article-title":"Humanin is an endogenous activator of chaperone-mediated autophagy","volume":"217","author":"Gong","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mito.2017.08.001","article-title":"Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity","volume":"38","author":"Thummasorn","year":"2018","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbagen.2021.130010_bb0140","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1091\/mbc.e04-06-0477","article-title":"Activation of chaperone-mediated autophagy during oxidative stress","volume":"15","author":"Kiffin","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbagen.2021.130010_bb0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bbagen.2021.130010_bb0150","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1573403X13666170426104611","article-title":"The anti-inflammatory effects of statins on coronary artery disease: an updated review of the literature","volume":"13","author":"Diamantis","year":"2017","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.bbagen.2021.130010_bb0155","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.lfs.2012.07.010","article-title":"Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice","volume":"91","author":"Zhang","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.bbagen.2021.130010_bb0160","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s11064-012-0951-6","article-title":"Neuroprotective peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide","volume":"38","author":"Zhao","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbagen.2021.130010_bb0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/sjg.SJG_318_16","article-title":"Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats","volume":"23","author":"Gultekin","year":"2017","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.bbagen.2021.130010_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7092151","article-title":"Vascular inflammation and oxidative stress: major triggers for cardiovascular disease","volume":"2019","author":"Steven","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbagen.2021.130010_bb0175","doi-asserted-by":"crossref","first-page":"673","DOI":"10.24425\/124305","article-title":"Plasma humanin as a prognostic biomarker for canine myxomatous mitral valve disease: a comparison with plasma NT-roBNP","volume":"21","author":"Mangkhang","year":"2018","journal-title":"Pol. J. Vet. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416521001690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416521001690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:13:21Z","timestamp":1759637601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416521001690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0304416521001690"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2021.130010","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2021.130010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"130010"}}