{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:11:46Z","timestamp":1782360706940,"version":"3.54.5"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbagen.2021.130066","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T20:40:25Z","timestamp":1638996025000},"page":"130066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cardio-protective role of Humanin in myocardial ischemia-reperfusion"],"prefix":"10.1016","volume":"1866","author":[{"given":"Zhenwei","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Goetzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika H.","family":"Muzumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2021.130066_bb0005","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1073\/pnas.101133498","article-title":"A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and abeta","volume":"98","author":"Hashimoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagen.2021.130066_bb0010","doi-asserted-by":"crossref","first-page":"14212","DOI":"10.1038\/s41598-018-32616-7","article-title":"Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans","volume":"8","author":"Yen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2021.130066_bb0015","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.18632\/aging.103534","article-title":"The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan","volume":"12","author":"Yen","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.bbagen.2021.130066_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006334","article-title":"Humanin: a novel central regulator of peripheral insulin action","volume":"4","author":"Muzumdar","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2021.130066_bb0025","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1152\/ajpendo.00043.2015","article-title":"Central effects of humanin on hepatic triglyceride secretion","volume":"309","author":"Gong","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0030","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/ATVBAHA.110.205997","article-title":"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice","volume":"30","author":"Muzumdar","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0035","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1755-5922.12210","article-title":"Humanin exerts cardioprotection against cardiac ischemia\/reperfusion injury through attenuation of mitochondrial dysfunction","volume":"34","author":"Thummasorn","year":"2016","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2021.130066_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12289","article-title":"High-dose humanin analogue applied during ischemia exerts cardioprotection against ischemia\/reperfusion injury by reducing mitochondrial dysfunction","volume":"35","author":"Thummasorn","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2021.130066_bb0045","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1210\/en.2015-1542","article-title":"The potent humanin analogue (HNG) protects germ cells and leucocytes while enhancing chemotherapy-induced suppression of cancer metastases in male mice","volume":"156","author":"Lue","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbagen.2021.130066_bb0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fendo.2014.00210","article-title":"Humanin and age-related diseases: a new link?","volume":"5","author":"Gong","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118679","article-title":"Humanin: a mitochondrial-derived peptide in the treatment of apoptosis-related diseases","volume":"264","author":"Hazafa","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbagen.2021.130066_bb0060","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1096\/fj.13-231092","article-title":"Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the beta cell","volume":"27","author":"Kuliawat","year":"2013","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.bbagen.2021.130066_bb0065","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","article-title":"The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance","volume":"21","author":"Lee","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbagen.2021.130066_bb0070","doi-asserted-by":"crossref","first-page":"796","DOI":"10.18632\/aging.100943","article-title":"Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers","volume":"8","author":"Cobb","year":"2016","journal-title":"Aging"},{"key":"10.1016\/j.bbagen.2021.130066_bb0075","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11306-019-1549-7","article-title":"Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment","volume":"15","author":"Mehta","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.bbagen.2021.130066_bb0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fendo.2019.00331","article-title":"Mitochondrial-derived peptides are down regulated in diabetes subjects","volume":"10","author":"Ramanjaneya","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0085","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.18632\/aging.202529","article-title":"A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide,MOTS-c","volume":"13","author":"Zempo","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.bbagen.2021.130066_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/pedi.12685","article-title":"Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance","author":"Du","year":"2018","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.bbagen.2021.130066_bb0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.atherosclerosis.2011.06.038","article-title":"Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice","volume":"219","author":"Oh","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbagen.2021.130066_bb0100","doi-asserted-by":"crossref","first-page":"H393","DOI":"10.1152\/ajpheart.00765.2012","article-title":"Circulating humanin levels are associated with preserved coronary endothelial function","volume":"304","author":"Widmer","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.redox.2018.02.021","article-title":"Cardiomyocyte hypertrophy induced by endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin","volume":"16","author":"Blasco","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0110","doi-asserted-by":"crossref","first-page":"H1127","DOI":"10.1152\/ajpheart.00685.2017","article-title":"Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice","volume":"315","author":"Qin","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0115","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1111\/jcmm.15151","article-title":"Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules","volume":"24","author":"Ren","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbagen.2021.130066_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12289","article-title":"High-dose humanin analogue applied during ischemia exerts cardioprotection against ischemia\/reperfusion injury by reducing mitochondrial dysfunction","volume":"35","author":"Thummasorn","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2021.130066_bb0125","first-page":"699","article-title":"Efficacy of a novel mitochondrial-derived peptide in a porcine model of myocardial Ischemia\/Reperfusion injury","volume":"5","author":"Sharp","year":"2020","journal-title":"JACC"},{"key":"10.1016\/j.bbagen.2021.130066_bb0130","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke Statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.bbagen.2021.130066_bb0135","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke Statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.bbagen.2021.130066_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0002-9629(15)40566-X","article-title":"Fatty acid oxidation in the reperfused ischemic heart","volume":"318","author":"Kantor","year":"1999","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.bbagen.2021.130066_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8100454","article-title":"The role of mitochondria in the mechanisms of cardiac ischemia-reperfusion injury","volume":"8","author":"Kuznetsov","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbagen.2021.130066_bb0150","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2021.130066_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007230","article-title":"Long-term mortality of older patients with acute myocardial infarction treated in US clinical practice","volume":"7","author":"Kochar","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbagen.2021.130066_bb0160","first-page":"466","article-title":"The level of circulating humanin in patients with ischemic heart disease","volume":"63","author":"Zhloba","year":"2018","journal-title":"Klin. Lab. Diagn."},{"key":"10.1016\/j.bbagen.2021.130066_bb0165","article-title":"Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans","author":"Cai","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbagen.2021.130066_bb0170","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0008-6363(99)00349-1","article-title":"Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction","volume":"45","author":"Yaoita","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbagen.2021.130066_bb0175","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with Bax activation","volume":"423","author":"Guo","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2021.130066_bb0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1027372519726","article-title":"Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes","volume":"254","author":"Kariya","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbagen.2021.130066_bb0185","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s10495-005-1191-x","article-title":"Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase","volume":"10","author":"Wang","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbagen.2021.130066_bb0190","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.metabol.2009.08.001","article-title":"The neurosurvival factor humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice","volume":"59","author":"Hoang","year":"2010","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.bbagen.2021.130066_bb0195","doi-asserted-by":"crossref","first-page":"15825","DOI":"10.1074\/jbc.M413062200","article-title":"Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2\/Bax family protein BimEL","volume":"280","author":"Luciano","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2021.130066_bb0200","doi-asserted-by":"crossref","first-page":"15815","DOI":"10.1074\/jbc.M411902200","article-title":"Humanin binds and nullifies bid activity by blocking its activation of bax and bak","volume":"280","author":"Zhai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2021.130066_bb0205","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1747-0285.2007.00576.x","article-title":"Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid","volume":"70","author":"Choi","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bbagen.2021.130066_bb0210","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2174\/0929866522666150728114955","article-title":"Humanin peptide binds to insulin-like growth factor-binding protein 3 (IGFBP3) and regulates its interaction with importin-beta","volume":"22","author":"Njomen","year":"2015","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.bbagen.2021.130066_bb0215","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.4049\/jimmunol.172.11.7078","article-title":"Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor","volume":"172","author":"Ying","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0220","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1091\/mbc.e09-02-0168","article-title":"Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha\/WSX-1\/gp130","volume":"20","author":"Hashimoto","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbagen.2021.130066_bb0225","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1016\/j.lfs.2005.03.031","article-title":"Involvement of tyrosine kinases and STAT3 in humanin-mediated neuroprotection","volume":"77","author":"Hashimoto","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.bbagen.2021.130066_bb0230","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/cdd.2008.148","article-title":"Tumour cell survival signalling by the ERK1\/2 pathway","volume":"16","author":"Balmanno","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbagen.2021.130066_bb0235","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1083\/jcb.151.3.483","article-title":"Akt regulates cell survival and apoptosis at a postmitochondrial level","volume":"151","author":"Zhou","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0240","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/DMSO.S306026","article-title":"[Gly14]-humanin ameliorates high glucose-induced apoptosis by inhibiting the expression of MicroRNA-155 in endothelial microparticles","volume":"14","author":"Shen","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.bbagen.2021.130066_bb0245","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9030563","article-title":"Oxidative stress in cell death and cardiovascular diseases","volume":"2019","author":"Xu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbagen.2021.130066_bb0250","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4330\/wjc.v10.i9.74","article-title":"Myocardial reperfusion injury and oxidative stress: therapeutic opportunities","volume":"10","author":"Gonzalez-Montero","year":"2018","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0255","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/cvr\/cvq191","article-title":"Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress","volume":"88","author":"Bachar","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbagen.2021.130066_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2013.08.055","article-title":"A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts","author":"Klein","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2021.130066_bb0265","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.201606095","article-title":"Humanin is an endogenous activator of chaperone-mediated autophagy","volume":"217","author":"Gong","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0270","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mito.2017.08.001","article-title":"Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity","volume":"38","author":"Thummasorn","year":"2018","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbagen.2021.130066_bb0275","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3892\/mmr.2020.11202","article-title":"Cytoprotective role of humanin in lens epithelial cell oxidative stressinduced injury","volume":"22","author":"Yang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbagen.2021.130066_bb0280","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2015.06.015","article-title":"Rat humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production","volume":"413","author":"Paharkova","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0285","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00223-020-00660-z","article-title":"HNGF6A inhibits oxidative stress-induced MC3T3-E1 cell apoptosis and osteoblast phenotype inhibition by targeting Circ_0001843\/miR-214 pathway","volume":"106","author":"Zhu","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbagen.2021.130066_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165150","article-title":"Humanin protects RPE cells from endoplasmic reticulum stress-induced apoptosis by upregulation of mitochondrial glutathione","volume":"11","author":"Matsunaga","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2021.130066_bb0295","doi-asserted-by":"crossref","first-page":"10832","DOI":"10.18632\/oncotarget.24396","article-title":"Humanin enhances the cellular response to stress by activation of chaperone-mediated autophagy","volume":"9","author":"Gong","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbagen.2021.130066_bb0300","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.npep.2004.11.004","article-title":"Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA","volume":"39","author":"Kariya","year":"2005","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbagen.2021.130066_bb0305","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.18632\/aging.101463","article-title":"Mitochondrial peptides modulate mitochondrial function during cellular senescence","volume":"10","author":"Kim","year":"2018","journal-title":"Aging"},{"key":"10.1016\/j.bbagen.2021.130066_bb0310","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2018.02.071","article-title":"Humanin promotes mitochondrial biogenesis in pancreatic MIN6 beta-cells","volume":"497","author":"Qin","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagen.2021.130066_bb0315","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-2999(01)00920-7","article-title":"Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat","volume":"418","author":"Zacharowski","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0320","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/01.fjc.0000211732.76668.d2","article-title":"Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics","volume":"47","author":"Sesti","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbagen.2021.130066_bb0325","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2014.07.008","article-title":"Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme a decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity","volume":"75","author":"Aksentijevic","year":"2014","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416521002257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416521002257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:14:11Z","timestamp":1759637651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416521002257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0304416521002257"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2021.130066","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardio-protective role of Humanin in myocardial ischemia-reperfusion","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2021.130066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"130066"}}