{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:02:51Z","timestamp":1792414971730,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbagen.2022.130097","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:10:17Z","timestamp":1643587817000},"page":"130097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition"],"prefix":"10.1016","volume":"1866","author":[{"given":"Kitti","family":"Thiankhaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2022.130097_bb0005","doi-asserted-by":"crossref","first-page":"v2","DOI":"10.1136\/jnnp.2005.082867","article-title":"Epidemiology and risk factors of dementia","volume":"76","author":"van der Flier","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbagen.2022.130097_bb0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0015","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer's disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbagen.2022.130097_bb0020","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1056\/NEJMe2103722","article-title":"Progress with treatments for Alzheimer\u2019s disease","volume":"384","author":"Levey","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0025","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.bbagen.2022.130097_bb0030","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1001\/jamainternmed.2021.4607","article-title":"Approval of aducanumab for Alzheimer disease\u2014the FDA\u2019s perspective","volume":"181","author":"Dunn","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0035","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early Alzheimer\u2019s disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0040","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1056\/NEJMp2111320","article-title":"Controversy and progress in Alzheimer\u2019s disease \u2014 FDA approval of aducanumab","volume":"385","author":"Rabinovici","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0045","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1073\/pnas.101133498","article-title":"A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A\u03b2","volume":"98","author":"Hashimoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbagen.2022.130097_bb0050","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/JME-12-0203","article-title":"The emerging role of the mitochondrial-derived peptide humanin in stress resistance","volume":"50","author":"Yen","year":"2013","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0055","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0196-9781(03)00106-2","article-title":"Identification of essential amino acids in humanin, a neuroprotective factor against Alzheimer\u2019s disease-relevant insults","volume":"24","author":"Yamagishi","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.bbagen.2022.130097_bb0060","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fendo.2014.00210","article-title":"Humanin and age-related diseases: a new link?","volume":"5","author":"Gong","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-08372-5","article-title":"The mitochondrial-derived peptides, HumaninS14G and small humanin-like peptide 2, exhibit chaperone-like activity","volume":"7","author":"Okada","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2022.130097_bb0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra040223","article-title":"Alzheimer's disease","volume":"351","author":"Cummings","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijbiomac.2011.04.003","article-title":"The biological activity of humanin analogs correlates with structure stabilities in solution","volume":"49","author":"Arakawa","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.bbagen.2022.130097_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.130024","article-title":"Humanin and Alzheimer\u2019s disease: the beginning of a new field","volume":"1866","author":"Niikura","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbagen.2022.130097_bb0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jconrel.2012.12.022","article-title":"Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin","volume":"166","author":"Park","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbagen.2022.130097_bb0090","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.peptides.2009.02.017","article-title":"Protective effect of S14G-humanin against beta-amyloid induced LTP inhibition in mouse hippocampal slices","volume":"30","author":"Zhang","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.bbagen.2022.130097_bb0095","first-page":"434","article-title":"S14G-humanin inhibits A beta 1-42 fibril formation, disaggregates preformed fibrils, and protects against A beta-induced cytotoxicity in vitro (Retraction of vol 19, pg 159, 2013)","volume":"22","author":"Hao","year":"2016"},{"key":"10.1016\/j.bbagen.2022.130097_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-32616-7","article-title":"Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans","volume":"8","author":"Yen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2022.130097_bb0105","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1096\/fj.05-3735fje","article-title":"Mitochondrial A\u03b2: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease","volume":"19","author":"Caspersen","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbagen.2022.130097_bb0110","doi-asserted-by":"crossref","first-page":"15825","DOI":"10.1074\/jbc.M413062200","article-title":"Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2\/Bax family protein BimEL","volume":"280","author":"Luciano","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2022.130097_bb0115","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0896-6273(02)00794-8","article-title":"Inflammation in neurodegenerative disease\u2014a double-edged sword","volume":"35","author":"Wyss-Coray","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbagen.2022.130097_bb0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00401-005-1038-0","article-title":"The unfolded protein response is activated in Alzheimer\u2019s disease","volume":"110","author":"Hoozemans","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0125","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1159\/000443064","article-title":"Protective effects of colivelin against Alzheimer's disease in a PDAPP mouse model","volume":"38","author":"Yin","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbagen.2022.130097_bb0130","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3233\/JAD-170307","article-title":"Colivelin ameliorates impairments in cognitive behaviors and synaptic plasticity in APP\/PS1 transgenic mice","volume":"59","author":"Wu","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbagen.2022.130097_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016259","article-title":"A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice","volume":"6","author":"Niikura","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagen.2022.130097_bb0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnagi.2013.00098","article-title":"Neprilysin and A\u03b2 clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer\u2019s disease","volume":"5","author":"Grimm","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbagen.2022.130097_bb0145","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pbb.2011.09.012","article-title":"S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe\/PS1dE9 mice","volume":"100","author":"Zhang","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbagen.2022.130097_bb0150","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3389\/fnins.2019.00788","article-title":"Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline","volume":"13","author":"Spinelli","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbagen.2022.130097_bb0155","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1002\/jcb.26452","article-title":"S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP\/PS1 transgenic mouse","volume":"119","author":"Han","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbagen.2022.130097_bb0160","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fnins.2019.00491","article-title":"Insulin and autophagy in neurodegeneration","volume":"13","author":"de Mello","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbagen.2022.130097_bb0165","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1007\/s00018-008-8112-4","article-title":"Amyloid \u03b2-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin","volume":"65","author":"Malito","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbagen.2022.130097_bb0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbagen.2022.130097_bb0180","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s12264-014-1479-3","article-title":"Humanin attenuates alzheimer-like cognitive deficits and pathological changes induced by amyloid \u03b2-peptide in rats","volume":"30","author":"Chai","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbagen.2022.130097_bb0185","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hipo.22202","article-title":"The neuroprotection of rattin against amyloid \u03b2 peptide in spatial memory and synaptic plasticity of rats","volume":"24","author":"Wang","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbagen.2022.130097_bb0190","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.peptides.2008.06.019","article-title":"The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues","volume":"29","author":"Kune\u0161ov\u00e1","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.bbagen.2022.130097_bb0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.npep.2017.10.002","article-title":"Humanin affects object recognition and gliosis in short-term cuprizone-treated mice","volume":"66","author":"Murakami","year":"2017","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbagen.2022.130097_bb0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.npep.2016.10.008","article-title":"Humanin ameliorates diazepam-induced memory deficit in mice","volume":"62","author":"Murakami","year":"2017","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbagen.2022.130097_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15295","article-title":"Tau association with synaptic vesicles causes presynaptic dysfunction","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagen.2022.130097_bb0210","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1177\/0963689719853540","article-title":"Protective effect of hyperbaric oxygen therapy on cognitive function in patients with vascular dementia","volume":"28","author":"Xu","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbagen.2022.130097_bb0215","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbagen.2022.130097_bb0220","article-title":"Post-stroke cognitive impairment: epidemiology, mechanisms and management","volume":"2","author":"Sun","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bbagen.2022.130097_bb0225","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/jcp.29955","article-title":"The effects of hyperbaric oxygen therapy on the brain with middle cerebral artery occlusion","volume":"236","author":"Thiankhaw","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0230","first-page":"S3","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.bbagen.2022.130097_bb0235","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0240","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.14037","article-title":"Brain aging and neurodegeneration: from a mitochondrial point of view","volume":"143","author":"Grimm","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbagen.2022.130097_bb0245","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.3389\/fcell.2020.615461","article-title":"Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities","volume":"8","author":"Prasuhn","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0250","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1086\/373937","article-title":"Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease","volume":"72","author":"Van Der Walt","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbagen.2022.130097_bb0255","doi-asserted-by":"crossref","first-page":"S838","DOI":"10.1093\/geroni\/igz038.3088","article-title":"Mitochondrial-derived peptide, SHLP2, a novel protective factor in Parkinson\u2019s disease","volume":"3","author":"Kim","year":"2019","journal-title":"Innov. Aging"},{"key":"10.1016\/j.bbagen.2022.130097_bb0260","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/sj.ejhg.5201425","article-title":"Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians","volume":"13","author":"Ghezzi","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.bbagen.2022.130097_bb0265","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4103\/0366-6999.159348","article-title":"Mitochondrial DNA haplogroups and the risk of sporadic Parkinson's disease in Han Chinese","volume":"128","author":"Chen","year":"2015","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbagen.2022.130097_bb0270","first-page":"AMD41","article-title":"Perspective on AMD pathobiology: a bioenergetic crisis in the RPE","volume":"59","author":"Fisher","year":"2018"},{"key":"10.1016\/j.bbagen.2022.130097_bb0275","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/cells9051102","article-title":"Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD","volume":"9","author":"Nashine","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbagen.2022.130097_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101663","article-title":"Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: implications for age-related macular degeneration","volume":"37","author":"Sreekumar","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-33290-5","article-title":"Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration","volume":"8","author":"Nashine","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2022.130097_bb0290","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbagen.2022.130097_bb0295","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbagen.2022.130097_bb0300","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/ATVBAHA.110.205997","article-title":"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice","volume":"30","author":"Muzumdar","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0305","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12289","article-title":"High-dose humanin analogue applied during ischemia exerts cardioprotection against ischemia\/reperfusion injury by reducing mitochondrial dysfunction","volume":"35","author":"Thummasorn","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbagen.2022.130097_bb0310","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.carpath.2005.03.006","article-title":"Myocardial ischemia and reperfusion injury","volume":"14","author":"Buja","year":"2005","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0315","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12035-012-8344-z","article-title":"Molecular mechanisms of ischemia\u2013reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation","volume":"47","author":"Sanderson","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0320","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1113\/EP085749","article-title":"Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia\u2013reperfusion injury model","volume":"101","author":"Kumfu","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbagen.2022.130097_bb0325","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3233\/JAD-170708","article-title":"Humanin exerts neuroprotection during cardiac ischemia-reperfusion injury","volume":"61","author":"Kumfu","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbagen.2022.130097_bb0330","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fnagi.2019.00123","article-title":"Humanin, a mitochondrial-derived peptide released by astrocytes, prevents synapse loss in hippocampal neurons","volume":"11","author":"Z\u00e1rate","year":"2019","journal-title":"Front. Aging Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416522000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416522000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:14:46Z","timestamp":1759637686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416522000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0304416522000150"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2022.130097","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2022.130097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"130097"}}