{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:24:29Z","timestamp":1783445069819,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbagen.2026.130969","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:28:59Z","timestamp":1781537339000},"page":"130969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["DLGAP5-induced glycolysis reprogramming reinforces macrophage M2 polarization to impact BC progression"],"prefix":"10.1016","volume":"1870","author":[{"given":"Yanming","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbagen.2026.130969_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.bbagen.2026.130969_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/genes13060960","article-title":"The history of early breast cancer treatment","volume":"13","author":"Ben-Dror","year":"2022","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbagen.2026.130969_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2023.113386","article-title":"Clinical activity of nivolumab in combination with eribulin in HER2-negative metastatic breast cancer: a phase IB\/II study (KCSG BR18-16)","volume":"195","author":"Kim","year":"2023","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1158\/2159-8290.CD-22-0475","article-title":"The great immune escape: understanding the divergent immune response in breast cancer subtypes","volume":"13","author":"Onkar","year":"2023","journal-title":"Cancer Discov."},{"issue":"8","key":"10.1016\/j.bbagen.2026.130969_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087493","article-title":"Tumor-associated macrophage subsets: shaping polarization and targeting","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2026.130969_bb0030","article-title":"Shaping polarization of tumor-associated macrophages in cancer immunotherapy","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.bbagen.2026.130969_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-022-01645-2","article-title":"The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies","volume":"21","author":"Bai","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0045","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13046-022-02499-8","article-title":"Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis","volume":"41","author":"Qiu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.bbagen.2026.130969_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.478","article-title":"Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway","volume":"11","author":"Chen","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"8","key":"10.1016\/j.bbagen.2026.130969_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1763","article-title":"Exosomal circ-0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7\/NRF2 axis","volume":"14","author":"Zhuang","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.bbagen.2026.130969_bb0060","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41556-019-0299-0","article-title":"Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells","volume":"21","author":"Chen","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbagen.2026.130969_bb0065","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41419-022-04632-z","article-title":"Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer","volume":"13","author":"Jiang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s12935-021-02155-9","article-title":"Pan-cancer analysis of the oncogenic role of discs large homolog associated protein 5 (DLGAP5) in human tumors","volume":"21","author":"Tang","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.bbagen.2026.130969_bb0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.onc.1206129","article-title":"Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma","volume":"22","author":"Tsou","year":"2003","journal-title":"Oncogene"},{"issue":"13","key":"10.1016\/j.bbagen.2026.130969_bb0080","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1097\/CM9.0000000000001859","article-title":"DLG7\/DLGAP5 as a potential therapeutic target in gastric cancer","volume":"135","author":"Li","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbagen.2026.130969_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3217248","article-title":"ASPM, CDC20, DLGAP5, BUB1B, CDCA8, and NCAPG may serve as diagnostic and prognostic biomarkers in endometrial carcinoma","volume":"2022","author":"Zhang","year":"2022","journal-title":"Genet. Res."},{"issue":"5","key":"10.1016\/j.bbagen.2026.130969_bb0090","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20210231","article-title":"Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas","volume":"41","author":"Zhou","year":"2021","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.bbagen.2026.130969_bb0095","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10549-018-4874-z","article-title":"Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells","volume":"171","author":"Berthe","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0100","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13046-020-01676-x","article-title":"Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway","volume":"39","author":"Tao","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.bbagen.2026.130969_bb0105","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jsps.2020.06.020","article-title":"Anastatica hierochuntica (L.) methanolic and aqueous extracts exert antiproliferative effects through the induction of apoptosis in MCF-7 breast cancer cells","volume":"28","author":"Rameshbabu","year":"2020","journal-title":"Saudi Pharm. J."},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1158\/0008-5472.CAN-18-0014","article-title":"M2 macrophage-derived exosomes promote cell migration and invasion in colon cancer","volume":"79","author":"Lan","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2026.130969_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105880","article-title":"A review on the role of M2 macrophages in bladder cancer; pathophysiology and targeting","volume":"76","author":"Sharifi","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.bbagen.2026.130969_bb0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/tox.23720","article-title":"DLGAP5 knockdown inactivates the Wnt\/beta-catenin signal to repress endometrial cancer cell malignant activities","volume":"38","author":"Chen","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"5","key":"10.1016\/j.bbagen.2026.130969_bb0125","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3892\/etm.2021.10680","article-title":"Knockdown of DLGAP5 suppresses cell proliferation, induces G(2)\/M phase arrest and apoptosis in ovarian cancer","volume":"22","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbagen.2026.130969_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.892535","article-title":"NEAT1\/MALAT1\/XIST\/PKD--Hsa-Mir-101\u20133p--DLGAP5 axis as a novel diagnostic and prognostic biomarker associated with immune cell infiltration in bladder cancer","volume":"13","author":"Rao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbagen.2026.130969_bb0135","article-title":"Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbagen.2026.130969_bb0140","article-title":"Development and validation of novel biomarkers related to M2 macrophages infiltration by weighted gene co-expression network analysis in prostate cancer","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.bbagen.2026.130969_bb0145","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1007\/s00262-023-03484-6","article-title":"DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP","volume":"72","author":"Huang","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"10.1016\/j.bbagen.2026.130969_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032606","article-title":"Modulating glycolysis to improve cancer therapy","volume":"24","author":"Chelakkot","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbagen.2026.130969_bb0155","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","article-title":"Metabolism, metabolites, and macrophages in cancer","volume":"16","author":"Li","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.bbagen.2026.130969_bb0160","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41419-021-03450-z","article-title":"ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2\/PLK1\/PTEN pathway","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.bbagen.2026.130969_bb0165","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00262-023-03382-x","article-title":"Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer","volume":"72","author":"Wang","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"11","key":"10.1016\/j.bbagen.2026.130969_bb0170","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/cac2.12607","article-title":"Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma","volume":"44","author":"Cai","year":"2024","journal-title":"Cancer Commun. (Lond.)"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:44:02Z","timestamp":1783442642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416526000693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0304416526000693"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130969","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DLGAP5-induced glycolysis reprogramming reinforces macrophage M2 polarization to impact BC progression","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"130969"}}