{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:29:15Z","timestamp":1786123755127,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbagen.2026.130974","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:35:14Z","timestamp":1782516914000},"page":"130974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SF3B3-dependent inclusion of STOX1 exon 3 facilitates invasion and tumor progression in colorectal cancer"],"prefix":"10.1016","volume":"1870","author":[{"given":"Lili","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aime Gael Yaya","family":"TRAORE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2026.130974_bb0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.suc.2023.11.009","article-title":"Screening for colorectal Cancer","volume":"104","author":"Jacobsson","year":"2024","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.bbagen.2026.130974_bb0010","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S2468-1253(19)30329-2","article-title":"The global challenge of colorectal cancer","volume":"4","author":"Guren","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0015","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41575-024-00934-z","article-title":"Mechanisms of metastatic colorectal cancer","volume":"21","author":"Ca\u00f1ellas-Socias","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10555-017-9726-5","article-title":"Mutations of key driver genes in colorectal cancer progression and metastasis","volume":"37","author":"Huang","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbagen.2026.130974_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-2521-7_1","article-title":"Alternative splicing in human biology and disease","volume":"2537","author":"Jutzi","year":"2022","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"10.1016\/j.bbagen.2026.130974_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110022","article-title":"Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing","volume":"37","author":"Leung","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbagen.2026.130974_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145523","article-title":"Role of promoters in regulating alternative splicing","volume":"782","author":"Kolathur","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.bbagen.2026.130974_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-023-01226-y","article-title":"Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.bbagen.2026.130974_bb0045","article-title":"The role of alternative splicing in cancer: from oncogenesis to drug resistance","volume":"53","author":"Sciarrillo","year":"2020","journal-title":"Drug Resist. Updat. Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.bbagen.2026.130974_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145262","article-title":"Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells","volume":"768","author":"Papatsirou","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.bbagen.2026.130974_bb0055","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/s41401-023-01116-4","article-title":"Truncated SCRIB isoform promotes breast cancer metastasis through HNRNP A1 mediated exon 16 skipping","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.bbagen.2026.130974_bb0060","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2013.5661","article-title":"Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene","volume":"21","author":"Doridot","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbagen.2026.130974_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70958","article-title":"STOX1 isoform a promotes proliferation and progression of hepatocellular carcinoma by dual mechanisms of transcriptionally upregulation of cyclin B1 and activation of ROS-dependent PTEN\/AKT1 Signaling","volume":"14","author":"Jiang","year":"2025","journal-title":"Cancer Med."},{"key":"10.1016\/j.bbagen.2026.130974_bb0070","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1038\/s41388-021-01905-3","article-title":"LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing","volume":"40","author":"Lin","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.bbagen.2026.130974_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167115","article-title":"Identification of splicing factors signature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC","volume":"1870","author":"Chen","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbagen.2026.130974_bb0080","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.virs.2022.12.005","article-title":"Splicing factor SF3B3, a NS5-binding protein, restricts ZIKV infection by targeting GCH1","volume":"38","author":"Chen","year":"2023","journal-title":"Virol. Sin."},{"key":"10.1016\/j.bbagen.2026.130974_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114804","article-title":"The interplay between lncRNA NR_030777 and SF3B3 in neuronal damage caused by paraquat","volume":"255","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbagen.2026.130974_bb0090","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1158\/1078-0432.CCR-16-2020","article-title":"Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer","volume":"23","author":"Chen","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbagen.2026.130974_bb0095","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1007\/s13277-016-4839-y","article-title":"Contribution of in vitro comparison of colorectal carcinoma cells from primary and metastatic lesions to elucidation of mechanisms of tumor progression and response to anticancer therapy","volume":"37","author":"Krbal","year":"2016","journal-title":"Tumour. Biol. J. Int. Soc. Oncodevelop. Biol. Med."},{"key":"10.1016\/j.bbagen.2026.130974_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110658","article-title":"The SW480 cell line as a model of resident and migrating colon cancer stem cells","volume":"27","author":"Verhagen","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bbagen.2026.130974_bb0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00726-002-0333-5","article-title":"Polyamine metabolism in primary human colon adenocarcinoma cells (SW480) and their lymph node metastatic derivatives (SW620)","volume":"24","author":"Duranton","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbagen.2026.130974_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.canlet.2019.05.025","article-title":"AKT and ERK dual inhibitors: the way forward?","volume":"459","author":"Cao","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbagen.2026.130974_bb0115","doi-asserted-by":"crossref","unstructured":"Parchem JG, Kanasaki K, Lee SB, Kanasaki M, Yang JL, Xu Y, et al. STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects. JCI Insight n.d.;6:e141588. Doi: https:\/\/doi.org\/10.1172\/jci.insight.141588.","DOI":"10.1172\/jci.insight.141588"},{"key":"10.1016\/j.bbagen.2026.130974_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148742","article-title":"Preeclampsia and STOX1 (storkhead-box protein 1): molecular evaluation of STOX1 in preeclampsia","volume":"927","author":"Akin","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.bbagen.2026.130974_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2019.106568","article-title":"Stox1 induced the proliferation and cell cycle arrest in pulmonary artery smooth muscle cells via AKT signaling pathway","volume":"120","author":"Xu","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0130","doi-asserted-by":"crossref","unstructured":"Li Z, Zhou G, Jiang L, Xiang H, Cao Y. Effect of STOX1 on Rrecurrent Sspontaneous Aabortion by Rregulating Ttrophoblast Ccell Pproliferation and Mmigration Vvia the PI3K\/AKT Ssignaling Ppathway n.d. Doi: https:\/\/doi.org\/10.1002\/jcb.28112.","DOI":"10.1002\/jcb.28112"},{"key":"10.1016\/j.bbagen.2026.130974_bb0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/cpr.12174","article-title":"Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway","volume":"48","author":"Nie","year":"2015","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbagen.2026.130974_bb0140","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1515\/biol-2021-0119","article-title":"Downregulation of STOX1 is a novel prognostic biomarker for glioma patients","volume":"16","author":"Jin","year":"2021","journal-title":"Open Life Sci."},{"key":"10.1016\/j.bbagen.2026.130974_bb0145","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ng1541","article-title":"Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family","volume":"37","author":"van Dijk","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbagen.2026.130974_bb0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jri.2009.05.001","article-title":"Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia","volume":"82","author":"Rigourd","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0155","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1080\/14728222.2016.1253682","article-title":"Targeting STOX1 in the therapy of preeclampsia","volume":"20","author":"Vaiman","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbagen.2026.130974_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101086","article-title":"Molecular mechanisms of trophoblast dysfunction mediated by imbalance between STOX1 isoforms","volume":"23","author":"Ducat","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.bbagen.2026.130974_bb0165","doi-asserted-by":"crossref","first-page":"23717","DOI":"10.1038\/s41598-025-07731-x","article-title":"Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4\u03b1-dependent alterations of coagulation cascades in mice","volume":"15","author":"Collinot","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2026.130974_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415927","article-title":"Modeling preeclampsia in vitro: polymorphic variants of STOX1-a\/B genes can downregulate CD24 in trophoblast cell lines","volume":"23","author":"Sammar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2026.130974_bb0175","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2012.09.017","article-title":"STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer\u2019s disease","volume":"528","author":"van Abel","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbagen.2026.130974_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102406","article-title":"Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia\/IUGR consequences","volume":"55","author":"Chatre","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.633937","article-title":"Urothelial Cancer associated 1 (UCA1) and miR-193 are two non-coding RNAs involved in trophoblast fusion and placental diseases","volume":"9","author":"Apicella","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbagen.2026.130974_bb0190","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3233\/JAD-2010-1265","article-title":"The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer\u2019s disease","volume":"19","author":"van Dijk","year":"2010","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.bbagen.2026.130974_bb0195","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-024-03053-4","article-title":"SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis","volume":"43","author":"Xu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbagen.2026.130974_bb0200","first-page":"536","article-title":"Dysregulation and therapeutic targeting of RNA splicing in cancer","volume":"3","author":"Stanley","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbagen.2026.130974_bb0205","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0140-6736(20)30164-1","article-title":"Small molecules, big impact: 20 years of targeted therapy in oncology","volume":"395","author":"Bedard","year":"2020","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.bbagen.2026.130974_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9062004","article-title":"Antisense oligonucleotides: an emerging area in drug discovery and development","volume":"9","author":"Dhuri","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbagen.2026.130974_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102351","article-title":"Mechanistic insights into ASO-RNA complexation: advancing antisense oligonucleotide design strategies","volume":"35","author":"H\u00f6rberg","year":"2024","journal-title":"Mol Ther Nucleic Acids"}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:12:31Z","timestamp":1786119151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416526000747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0304416526000747"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130974","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SF3B3-dependent inclusion of STOX1 exon 3 facilitates invasion and tumor progression in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130974"}}