{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:30:46Z","timestamp":1793136646108,"version":"4.5.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbagen.2026.130983","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:42:38Z","timestamp":1785166958000},"page":"130983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Superparamagnetic iron oxide nanoparticles platforms: Recent trends in cancer treatment"],"prefix":"10.1016","volume":"1870","author":[{"given":"Sujan","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mita Rani","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunava","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2026.130983_bb0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/ar2000277","article-title":"Surface engineering of iron oxide nanoparticles for targeted cancer therapy","volume":"44","author":"Kievit","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bbagen.2026.130983_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117535","article-title":"Mechanistic study of cancer drug delivery: current techniques, limitations, and future prospects","volume":"290","author":"Imtiaz","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbagen.2026.130983_bb0015","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/acs.molpharmaceut.5c00411","article-title":"Smart spions for multimodal cancer theranostics: a review","volume":"22","author":"Pawar","year":"2025","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbagen.2026.130983_bb0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/pharmaceutics17040499","article-title":"Applications and efficacy of iron oxide nanoparticles in the treatment of brain tumors","volume":"17","author":"Varalli","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0025","first-page":"1","article-title":"Theranostic potential and safety assessment of epirubicin-loaded SPIONs\/PLGA-PEG nanoparticles in rabbit","author":"Kamali","year":"2025","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.bbagen.2026.130983_bb0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12032-025-02913-z","article-title":"Superparamagnetic iron oxide nanoparticles (SPIONs) in targeting brain tumors: advances and challenges","volume":"42","author":"Maheshwari","year":"2025","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0035","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1021\/nn100190v","article-title":"PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo","volume":"4","author":"Sun","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbagen.2026.130983_bb0040","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.7150\/thno.103503","article-title":"7-nm Mn0. 5 Zn0. 5Fe2O4 superparamagnetic iron oxide nanoparticle (SPION): a high-performance theranostic for MRI and hyperthermia applications","volume":"15","author":"Lee","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0045","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1016\/j.biomaterials.2009.08.042","article-title":"Magnetic resonance imaging of multifunctional pluronic stabilized iron-oxide nanoparticles in tumor-bearing mice","volume":"30","author":"Jain","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0050","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/molecules29081824","article-title":"Influence of SPION surface coating on magnetic properties and theranostic profile","volume":"29","author":"Ferreira-Filho","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bbagen.2026.130983_bb0055","series-title":"AIP Conf. Proc","first-page":"157","article-title":"Equation of state of aluminum\u2014iron oxide (Fe2O3)\u2014epoxy composite: modeling and experiment","author":"Jordan","year":"2006"},{"key":"10.1016\/j.bbagen.2026.130983_bb0060","series-title":"Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging","first-page":"265","article-title":"Superparamagnetic iron oxide and ferrite nanoparticles for MRI","author":"Vangijzegem","year":"2024"},{"key":"10.1016\/j.bbagen.2026.130983_bb0065","doi-asserted-by":"crossref","first-page":"12739","DOI":"10.1021\/ja072210i","article-title":"Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo","volume":"129","author":"Lee","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbagen.2026.130983_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123238","article-title":"Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery","volume":"320","author":"Lynn","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0075","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2217\/17435889.3.5.703","article-title":"Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats","volume":"3","author":"Longmire","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bbagen.2026.130983_bb0080","series-title":"Micro","first-page":"2","article-title":"Lipidic and inorganic nanoparticles for targeted glioblastoma multiforme therapy: Advances and strategies","author":"Musielak","year":"2025"},{"key":"10.1016\/j.bbagen.2026.130983_bb0085","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1158\/0008-5472.CAN-09-1157","article-title":"Specific targeting of brain tumors with an optical\/magnetic resonance imaging nanoprobe across the blood-brain barrier","volume":"69","author":"Veiseh","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2026.130983_bb0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpharm.2009.04.027","article-title":"Chitosan solutions and particles: evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model","volume":"376","author":"Hombach","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bbagen.2026.130983_bb0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2217\/nnm.10.74","article-title":"Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide","volume":"5","author":"Guerrero","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bbagen.2026.130983_bb0100","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s11356-009-0274-6","article-title":"Concentration of trace elements in blood and feed of homebred animals in Southern Serbia","volume":"17","author":"Popovic","year":"2010","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.bbagen.2026.130983_bb0105","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nnano.2010.58","article-title":"Tuning payload delivery in tumour cylindroids using gold nanoparticles","volume":"5","author":"Kim","year":"2010","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2147\/NSA.S539424","article-title":"Target, treat, and track: superparamagnetic iron oxide nanoparticles (SPION) driven theranostic delivery of antimicrobials to the lungs","author":"Wyszogrodzka-Gawe\u0142","year":"2025","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.bbagen.2026.130983_bb0115","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.3390\/molecules27217416","article-title":"Plasmid-DNA delivery by covalently functionalized PEI-SPIONs as a potential \u2018Magnetofection\u2019Agent","volume":"27","author":"Stein","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbagen.2026.130983_bb0120","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1021\/mp100221h","article-title":"pH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells","volume":"7","author":"Mok","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbagen.2026.130983_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17030379","article-title":"Clinical applications of targeted nanomaterials","volume":"17","author":"Kumar","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0130","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","article-title":"Arginine-rich peptides: an abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery","volume":"276","author":"Futaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagen.2026.130983_bb0135","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/pharmaceutics15010236","article-title":"Superparamagnetic iron oxide nanoparticles (SPION): from fundamentals to state-of-the-art innovative applications for cancer therapy","volume":"15","author":"Vangijzegem","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0140","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/smll.200700784","article-title":"In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes","volume":"4","author":"Sun","year":"2008","journal-title":"Small"},{"key":"10.1016\/j.bbagen.2026.130983_bb0145","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3390\/app15063189","article-title":"Enhancement of EPR effect for passive tumor targeting: current status and future perspectives","volume":"15","author":"Vagena","year":"2025","journal-title":"Appl. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/nano12203686","article-title":"SPIONs conjugate supported anticancer drug doxorubicin\u2019s delivery: current status, challenges, and prospects","volume":"12","author":"Akhtar","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules31020236","article-title":"Peptide-functionalized iron oxide nanoparticles for cancer therapy: targeting strategies, mechanisms, and translational opportunities","volume":"31","author":"Kuskov","year":"2026","journal-title":"Molecules"},{"key":"10.1016\/j.bbagen.2026.130983_bb0160","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiol.10090050","article-title":"Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133","volume":"255","author":"Meier","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.bbagen.2026.130983_bb0165","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cis.2006.03.001","article-title":"Characterization of zero-valent iron nanoparticles","volume":"120","author":"Sun","year":"2006","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.789330","article-title":"Opportunities and challenges of nanoparticles in digestive tumours as anti-angiogenic therapies","volume":"11","author":"Yang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.7150\/ntno.91356","article-title":"Recent trends in bio-nanomaterials and non-invasive combinatorial approaches of photothermal therapy against cancer","volume":"8","author":"Beniwal","year":"2024","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0180","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1039\/D4BM00057A","article-title":"Photothermal therapy: a novel potential treatment for prostate cancer","volume":"12","author":"Dong","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0185","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3390\/ph17070932","article-title":"Photodynamic therapy in the treatment of cancer\u2014the selection of synthetic photosensitizers","volume":"17","author":"Aebisher","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbagen.2026.130983_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.oor.2024.100642","article-title":"Enhancing oral cancer treatment via photodynamic therapy: gold nanoparticle-based delivery system for 5-aminolevulinic acid (5-ALA)","volume":"11","author":"Soomro","year":"2024","journal-title":"Oral Oncology Reports"},{"key":"10.1016\/j.bbagen.2026.130983_bb0195","article-title":"Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies","volume":"5","author":"Zhao","year":"2024","journal-title":"MedComm (Beijing)"},{"key":"10.1016\/j.bbagen.2026.130983_bb0200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10544-024-00698-y","article-title":"SPIONs: superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer","volume":"26","author":"Kara","year":"2024","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.bbagen.2026.130983_bb0205","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ijbiomac.2022.09.020","article-title":"Theranostic silk sericin\/SPION nanoparticles for targeted delivery of ROR1 siRNA: synthesis, characterization, diagnosis and anticancer effect on triple-negative breast cancer","volume":"221","author":"Shirangi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0210","series-title":"Emerging Nanomaterials for Advanced Technologies","first-page":"29","article-title":"Nanoscale smart drug delivery systems and techniques of drug loading to nanoarchitectures","author":"Varalakshmi","year":"2022"},{"key":"10.1016\/j.bbagen.2026.130983_bb0215","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1021\/nn1008512","article-title":"Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma","volume":"4","author":"Kievit","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbagen.2026.130983_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202509099","article-title":"Multicore SPION clustering within poly (amino acid) corrals for enhanced MRI contrast and drug release","volume":"21","author":"Kabil","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.bbagen.2026.130983_bb0225","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.7150\/jca.105425","article-title":"NUPR1 contributes to endocrine therapy resistance by modulating BIRC5 expression and inducing luminal B-ERBB2+ subtype-like characteristics in estrogen receptor-positive breast cancer cells","volume":"16","author":"Lee","year":"2025","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbagen.2026.130983_bb0230","series-title":"Cancer Theranostics, Second Edition","first-page":"461","article-title":"RNA Theranostics","author":"Zhou","year":"2026"},{"key":"10.1016\/j.bbagen.2026.130983_bb0235","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1016\/j.biomaterials.2010.05.061","article-title":"Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer","volume":"31","author":"Hua","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0240","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s43556-024-00239-2","article-title":"Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer","volume":"6","author":"Gu","year":"2025","journal-title":"Molecular Biomedicine"},{"key":"10.1016\/j.bbagen.2026.130983_bb0245","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1007\/s13204-023-02853-y","article-title":"Utilization of superparamagnetic iron oxide nanoparticles (SPIONs) as a vector for drug delivery","volume":"13","author":"Otieno","year":"2023","journal-title":"Appl. Nanosci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0250","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.3390\/ijms23136972","article-title":"Oleic acid protects endothelial cells from silica-coated superparamagnetic iron oxide nanoparticles (SPIONs)-induced oxidative stress and cell death","volume":"23","author":"Repar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0255","doi-asserted-by":"crossref","first-page":"115009","DOI":"10.1016\/j.ejpb.2026.115009","article-title":"Development of anti-EGFR targeted magnetic nanoparticles for doxorubicin delivery into triple negative breast cancer cells","volume":"222","author":"Lameli","year":"2026","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bbagen.2026.130983_bb0260","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ad2c54","article-title":"Fe3O4 SPIONs in cancer theranostics\u2014structure versus interactions with proteins and methods of their investigation","volume":"35","author":"Sikorski","year":"2024","journal-title":"Nanotechnology"},{"key":"10.1016\/j.bbagen.2026.130983_bb0265","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.7150\/thno.123550","article-title":"Engineering polysaccharide nanoplatforms for glioblastoma theranostics: bridging targeted therapy and advanced imaging","volume":"16","author":"Wang","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0270","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm.2108","article-title":"Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys","volume":"16","author":"Santra","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbagen.2026.130983_bb0275","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s10876-022-02327-1","article-title":"Teriflunomide loaded SPION nanoparticles induced apoptosis in MDA-MB-231 breast cancer cells","volume":"34","author":"Rabizadeh","year":"2023","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0280","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.3390\/pharmaceutics14112388","article-title":"Superparamagnetic iron oxide nanoparticles for immunotherapy of cancers through macrophages and magnetic hyperthermia","volume":"14","author":"Dias","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbagen.2026.130983_bb0285","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noz150","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012\u20132016","volume":"21","author":"Ostrom","year":"2019","journal-title":"Neuro. Oncol"},{"key":"10.1016\/j.bbagen.2026.130983_bb0290","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12668-023-01113-1","article-title":"Magnetite nanoparticle co-precipitation synthesis, characterization, and applications: mini review","volume":"13","author":"Al-Madhagi","year":"2023","journal-title":"Bionanoscience"},{"key":"10.1016\/j.bbagen.2026.130983_bb0295","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1039\/C9NR00531E","article-title":"Unravelling the growth mechanism of the co-precipitation of iron oxide nanoparticles with the aid of synchrotron X-ray diffraction in solution","volume":"11","author":"LaGrow","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.bbagen.2026.130983_bb0300","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1039\/C1CS15248C","article-title":"Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents","volume":"41","author":"Lee","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bbagen.2026.130983_bb0305","doi-asserted-by":"crossref","first-page":"12762","DOI":"10.1021\/acsnano.4c06753","article-title":"2-nitroimidazole-functionalized superparamagnetic iron oxide nanoparticles detect hypoxic regions of glioblastomas on MRI and improve radiotherapy efficacy","volume":"19","author":"Yoshino","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbagen.2026.130983_bb0310","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10948-014-2707-9","article-title":"Growth of iron oxide nanoparticles by hydrothermal process: effect of reaction parameters on the nanoparticle size","volume":"28","author":"Ozel","year":"2015","journal-title":"J. Supercond. Nov. Magn."},{"key":"10.1016\/j.bbagen.2026.130983_bb0315","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1111\/acer.14910","article-title":"Alcohol solution strength preference predicts compulsive-like drinking behavior in rats","volume":"46","author":"Foo","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbagen.2026.130983_bb0320","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.2147\/IJN.S218488","article-title":"Functionalization of T lymphocytes with citrate-coated superparamagnetic iron oxide nanoparticles for magnetically controlled immune therapy","author":"M\u00fchlberger","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bbagen.2026.130983_bb0325","series-title":"Functionalization of Primary Human T Cells with Superparamagnetic Iron Oxide Nanoparticles for Site-Directed Immunotherapy of Solid Tumors","author":"Pfister","year":"2025"},{"key":"10.1016\/j.bbagen.2026.130983_bb0330","article-title":"Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism","volume":"6","author":"Pfister","year":"2025","journal-title":"MedComm (Beijing)"},{"key":"10.1016\/j.bbagen.2026.130983_bb0335","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/acsnano.8b07141","article-title":"Magnetic nanoclusters armed with responsive PD-1 antibody synergistically improved adoptive T-cell therapy for solid tumors","volume":"13","author":"Nie","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbagen.2026.130983_bb0340","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202520493","article-title":"In vivo generation and manipulation of CAR-T-mimicking cells via magnetic bispecific nano-antibody for solid tumor therapy","volume":"38","author":"Zhu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bbagen.2026.130983_bb0345","doi-asserted-by":"crossref","first-page":"2414368","DOI":"10.1002\/adfm.202414368","article-title":"In vivo monitoring and magnetically-enhanced delivery of CAR T-cells to solid tumor","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bbagen.2026.130983_bb0350","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/nano9020170","article-title":"T 1-weight magnetic resonance imaging performances of iron oxide nanoparticles modified with a natural protein macromolecule and an artificial macromolecule","volume":"9","author":"Tao","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0355","series-title":"Biomedical Nanomagnetics","first-page":"615","article-title":"Quantitative \u201chot-spot\u201d imaging of transplanted stem cells using superparamagnetic tracers and magnetic particle imaging","author":"Bulte","year":"2015"},{"key":"10.1016\/j.bbagen.2026.130983_bb0360","doi-asserted-by":"crossref","first-page":"315","DOI":"10.18383\/j.tom.2020.00043","article-title":"A perspective on cell tracking with magnetic particle imaging","volume":"6","author":"Sehl","year":"2020","journal-title":"Tomography"},{"key":"10.1016\/j.bbagen.2026.130983_bb0365","doi-asserted-by":"crossref","DOI":"10.1007\/s11307-022-01738-w","article-title":"Magnetic particle imaging is a sensitive in vivo imaging modality for the detection of dendritic cell migration","volume":"24","author":"Gevaert","year":"2022","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0370","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/acs.nanolett.7b03829","article-title":"Janus iron oxides@ semiconducting polymer nanoparticle tracer for cell tracking by magnetic particle imaging","volume":"18","author":"Song","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.bbagen.2026.130983_bb0375","first-page":"2020","article-title":"Development of magnetic particle imaging (MPI) for cell tracking and detection","author":"Melo","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbagen.2026.130983_bb0380","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.3390\/cells11182892","article-title":"Cell tracking by magnetic particle imaging: methodology for labeling THP-1 monocytes with magnetic nanoparticles for cellular imaging","volume":"11","author":"Remmo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbagen.2026.130983_bb0385","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1038\/s41598-024-54784-5","article-title":"Counting cells in motion by quantitative real-time magnetic particle imaging","volume":"14","author":"Remmo","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2026.130983_bb0390","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/mrm.28987","article-title":"Magnetic microspheres can be used for magnetic particle imaging of cancer cells arrested in the mouse brain","volume":"87","author":"Melo","year":"2022","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.bbagen.2026.130983_bb0395","doi-asserted-by":"crossref","first-page":"8070","DOI":"10.3390\/ijms16048070","article-title":"Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery","volume":"16","author":"Estelrich","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0400","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2010.05.006","article-title":"Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy","volume":"63","author":"Mahmoudi","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbagen.2026.130983_bb0405","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jmmm.2005.01.064","article-title":"Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system","volume":"293","author":"Neuberger","year":"2005","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.bbagen.2026.130983_bb0410","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1517\/17425247.2014.924501","article-title":"Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges","volume":"11","author":"Laurent","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.bbagen.2026.130983_bb0415","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.biomaterials.2007.08.050","article-title":"Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors","volume":"29","author":"Chertok","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbagen.2026.130983_bb0420","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.3390\/cancers14235978","article-title":"In vitro setup for determination of nanoparticle-mediated magnetic cell and drug accumulation in tumor spheroids under flow conditions","volume":"14","author":"Behr","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbagen.2026.130983_bb0425","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/IJN.S125002","article-title":"Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery","volume":"13","author":"Kumar","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bbagen.2026.130983_bb0430","article-title":"Anti-proliferative activity of poloxamer cobalt ferrite nanoparticles against human prostate cancer (DU-145) cells: in-vitro study","author":"Oroskhani","year":"2024","journal-title":"IET Nanobiotechnol. 2024"},{"key":"10.1016\/j.bbagen.2026.130983_bb0435","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.3390\/cancers17243905","article-title":"A theoretical framework for ligand-functionalised magnetic lipid nanoparticles in glioblastoma therapy","volume":"17","author":"Buist","year":"2025","journal-title":"Cancers (Basel)."},{"key":"10.1016\/j.bbagen.2026.130983_bb0440","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/jcbfm.1995.27","article-title":"Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain","volume":"15","author":"Kondo","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbagen.2026.130983_bb0445","doi-asserted-by":"crossref","first-page":"1226044","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0450","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF01907940","article-title":"The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart","volume":"77","author":"Meerson","year":"1982","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0455","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/1097-0142(19890715)64:2<422::AID-CNCR2820640214>3.0.CO;2-2","article-title":"Increased lipid peroxidation in malignant tissues of patients with colorectal cancer","volume":"64","author":"Otamiri","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.bbagen.2026.130983_bb0460","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0891-5849(91)90074-D","article-title":"The possible role of lipid peroxidation in breast cancer risk","volume":"10","author":"Boyd","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2026.130983_bb0465","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbagen.2026.130983_bb0470","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12943-021-01466-9","article-title":"CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma","volume":"21","author":"Chen","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbagen.2026.130983_bb0475","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0480","doi-asserted-by":"crossref","first-page":"9014","DOI":"10.3390\/ijms23169014","article-title":"Combination RSL3 treatment sensitizes ferroptosis-and EGFR-inhibition-resistant HNSCCs to cetuximab","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbagen.2026.130983_bb0485","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2026.130983_bb0490","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","article-title":"The development of the concept of ferroptosis","volume":"133","author":"Hirschhorn","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbagen.2026.130983_bb0495","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature05859","article-title":"RAS\u2013RAF\u2013MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbagen.2026.130983_bb0500","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbagen.2026.130983_bb0505","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1166\/jbn.2016.2298","article-title":"Doxorubicin-conjugated heparin-coated superparamagnetic iron oxide nanoparticles for combined anticancer drug delivery and magnetic resonance imaging","volume":"12","author":"Yang","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bbagen.2026.130983_bb0510","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2147\/NSA.S550828","article-title":"Nanoparticle-mediated ferroptosis for cancer therapy: mechanisms and therapeutic strategies","author":"Szwed","year":"2025","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.bbagen.2026.130983_bb0515","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0971-6203.121198","article-title":"Superparamagnetic iron oxide-C595: potential MR imaging contrast agents for ovarian cancer detection","volume":"38","author":"Shahbazi-Gahrouei","year":"2013","journal-title":"J. Med. Phys."},{"key":"10.1016\/j.bbagen.2026.130983_bb0520","first-page":"17020","article-title":"Mesoporous \u03b3-iron oxide nanoparticles for magnetically triggered release of doxorubicin and hyperthermia treatment","volume":"22","author":"Benyettou","year":"2016","journal-title":"Chemistry (Weinheim an der Bergstrasse, Germany)"},{"key":"10.1016\/j.bbagen.2026.130983_bb0525","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/nl8029114","article-title":"Targeted gold nanoparticles enable molecular CT imaging of cancer","volume":"8","author":"Popovtzer","year":"2008","journal-title":"Nano Lett."},{"key":"10.1016\/j.bbagen.2026.130983_bb0530","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1002\/celc.201800339","article-title":"Graphene-oxide-loaded superparamagnetic iron oxide nanoparticles for ultrasensitive electrocatalytic detection of MicroRNA","volume":"5","author":"Islam","year":"2018","journal-title":"ChemElectroChem"},{"key":"10.1016\/j.bbagen.2026.130983_bb0535","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13048-016-0230-2","article-title":"Folic acid-targeted iron oxide nanoparticles as contrast agents for magnetic resonance imaging of human ovarian cancer","volume":"9","author":"Zhang","year":"2016","journal-title":"J. Ovarian Res."},{"issue":"5_Supplement_2","key":"10.1016\/j.bbagen.2026.130983_bb0540","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.OVARIAN23-B045","article-title":"Abstract B045: in vivo ovarian cancer detection using folate receptor-\u03b1 targeted iron oxide nanoparticles","volume":"84","author":"Zhang","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagen.2026.130983_bb0545","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1039\/D3NA01064C","article-title":"Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials","volume":"6","author":"Lapusan","year":"2024","journal-title":"Nanoscale Adv."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:13:26Z","timestamp":1786119206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416526000838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":109,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0304416526000838"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130983","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superparamagnetic iron oxide nanoparticles platforms: Recent trends in cancer treatment","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130983"}}