{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:39:23Z","timestamp":1792395563314,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202410041"],"award-info":[{"award-number":["202410041"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbagen.2026.130993","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:25:51Z","timestamp":1787927151000},"page":"130993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone methyltransferase inhibitors prevent lens opacity in diabetic cataract rats"],"prefix":"10.1016","volume":"1870","author":[{"given":"Haoran","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagen.2026.130993_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/ICU.0b013e3282f154bd","article-title":"Cataract surgery for the developing world","volume":"19","author":"Tabin","year":"2008","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0010","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0899-9007(03)00140-0","article-title":"Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study","volume":"19","author":"Gupta","year":"2003","journal-title":"Nutrition (Burbank, Los Angeles County, Calif)"},{"key":"10.1016\/j.bbagen.2026.130993_bb0015","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.ophtha.2006.04.022","article-title":"Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi study","volume":"113","author":"Iwase","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbagen.2026.130993_bb0020","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.18240\/ijo.2022.10.05","article-title":"Age-related changes of lens thickness and density in different age phases","volume":"15","author":"Wang","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0025","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.18240\/ijo.2022.10.06","article-title":"Therapeutic potential of pupilloplasty combined with phacomulsification and intraocular lens implantation against uveitis-induced cataract","volume":"15","author":"Lu","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0030","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/sj.eye.6701964","article-title":"External factors in the development of cataract","volume":"19","author":"Robman","year":"2005","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.bbagen.2026.130993_bb0035","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2522\/ptj.20080020","article-title":"Epidemiology of diabetes and diabetes-related complications","volume":"88","author":"Deshpande","year":"2008","journal-title":"Phys. Ther."},{"key":"10.1016\/j.bbagen.2026.130993_bb0040","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.ophtha.2013.04.030","article-title":"Cataract surgery cost utility revisited in 2012: a new economic paradigm","volume":"120","author":"Brown","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbagen.2026.130993_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.14","article-title":"Cataract","volume":"1","author":"Lam","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbagen.2026.130993_bb0050","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.18240\/ijo.2023.08.02","article-title":"Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats","volume":"16","author":"Wang","year":"2023","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0026-0495(86)90180-0","article-title":"The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis","volume":"35","author":"Cheng","year":"1986","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.bbagen.2026.130993_bb0060","article-title":"Hypertension is the prominent risk factor in cataract patients","volume":"55","author":"Mylona","year":"2019","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"10.1016\/j.bbagen.2026.130993_bb0065","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1111\/aos.14565","article-title":"Changes of the tear film lipid layer thickness after cataract surgery in patients with diabetes mellitus","volume":"99","author":"Zhang","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-4835(03)00083-6","article-title":"Apoptotic cell death in the lens epithelium of rat sugar cataract","volume":"77","author":"Takamura","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2007.06.007","article-title":"Epithelial cell density in cataractous lenses of patients with diabetes: association with erythrocyte aldose reductase","volume":"85","author":"Kumamoto","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0021-5155(01)00418-X","article-title":"Immunohistochemical study of apoptosis of lens epithelial cells in human and diabetic rat cataracts","volume":"45","author":"Takamura","year":"2001","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0085","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/15672018113106660062","volume":"11","author":"Babizhayev","year":"2014","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.bbagen.2026.130993_bb0090","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrm.2016.143","article-title":"Functions of bromodomain-containing proteins and their roles in homeostasis and cancer","volume":"18","author":"Fujisawa","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0095","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/s41467-024-46649-2","article-title":"Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagen.2026.130993_bb0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-021-01373-z","article-title":"Histone citrullination: a new target for tumors","volume":"20","author":"Zhu","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbagen.2026.130993_bb0105","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/579695","article-title":"Epigenetic regulation of Werner syndrome gene in age-related cataract","volume":"2015","author":"Zhu","year":"2015","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13148-016-0229-y","article-title":"Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation","volume":"8","author":"Wang","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbagen.2026.130993_bb0115","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1167\/iovs.16-19242","article-title":"Relationship between the altered expression and epigenetics of GSTM3 and age-related cataract","volume":"57","author":"Li","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbagen.2026.130993_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/srep34704","article-title":"Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract","volume":"6","author":"Rong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2026.130993_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56414-x","article-title":"Histone acetyltransferase and polo-like kinase 3 inhibitors prevent rat galactose-induced cataract","volume":"9","author":"Kanada","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagen.2026.130993_bb0130","article-title":"Histone acetyltransferase inhibition reverses opacity in rat galactose-induced cataract","volume":"17","author":"Nagaya","year":"2022","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbagen.2026.130993_bb0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nsmb.2470","article-title":"Regulation of nucleosome dynamics by histone modifications","volume":"20","author":"Zentner","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0140","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"Black","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagen.2026.130993_bb0145","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/02713683.2016.1185129","article-title":"Aberrant epigenetic alterations of glutathione-S-transferase P1 in age-related nuclear cataract","volume":"42","author":"Chen","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0150","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(05)70803-5","article-title":"Age-related cataract","volume":"365","author":"Asbell","year":"2005","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbagen.2026.130993_bb0155","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/jphp.12355","article-title":"Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens","volume":"67","author":"Abdelkader","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0160","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.aopr.2024.08.002","article-title":"Research progress on the impact of cataract surgery on corneal endothelial cells","volume":"4","author":"Yang","year":"2024","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0165","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1742-7843.2011.00756.x","article-title":"Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model","volume":"109","author":"Yanar","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0170","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2147\/CIA.S173838","article-title":"Protective effect of Anwulignan against D-galactose-induced hepatic injury through activating p38 MAPK-Nrf2-HO-1 pathway in mice","volume":"13","author":"Gao","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.bbagen.2026.130993_bb0175","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12933-024-02196-0","article-title":"Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium","volume":"23","author":"S\u00e1nchez-Ceinos","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbagen.2026.130993_bb0180","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/15592294.2019.1699991","article-title":"DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment","volume":"15","author":"Sarno","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbagen.2026.130993_bb0185","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/jcmm.17676","article-title":"PRMT5 inhibition induces pro-inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice","volume":"27","author":"Zhang","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbagen.2026.130993_bb0190","doi-asserted-by":"crossref","first-page":"21315","DOI":"10.18632\/oncotarget.15528","article-title":"Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma","volume":"8","author":"Yokoyama","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbagen.2026.130993_bb0195","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1038\/sj.ki.5000195","article-title":"The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes","volume":"69","author":"Izquierdo","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbagen.2026.130993_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7680513","article-title":"RNA-binding proteins and alternative splicing genes are coregulated in human retinal endothelial cells treated with high glucose","volume":"2022","author":"Zhao","year":"2022","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/jdi.13695","article-title":"Micro ribonucleic acid-363 regulates the phosphatidylinositol 3-kinase\/threonine protein kinase axis by targeting NOTCH1 and forkhead box C2, leading to hepatic glucose and lipids metabolism disorder in type 2 diabetes mellitus","volume":"13","author":"Peng","year":"2022","journal-title":"J. Diabetes Invest."},{"key":"10.1016\/j.bbagen.2026.130993_bb0210","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.gendis.2023.02.008","article-title":"Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases","volume":"10","author":"Liao","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbagen.2026.130993_bb0215","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jdiacomp.2016.01.001","article-title":"Strong inhibition of the polyol pathway diverts glucose flux to protein glycation leading to rapid establishment of secondary complications in diabetes mellitus","volume":"30","author":"Jagdale","year":"2016","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.bbagen.2026.130993_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13080955","article-title":"Effects of gold nanoparticles phytoreduced with rutin in an early rat model of diabetic retinopathy and cataracts","volume":"13","author":"Moldovan","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbagen.2026.130993_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2026.110905","article-title":"PIKfyve is an essential component of the endolysosomal pathway within photoreceptors and the retinal pigment epithelium","volume":"266","author":"Attia","year":"2026","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbagen.2026.130993_bb0230","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202401012","article-title":"INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis","volume":"223","author":"Saffi","year":"2024","journal-title":"J. Cell Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - General Subjects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304416526000930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:41:20Z","timestamp":1792392080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304416526000930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0304416526000930"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130993","relation":{},"ISSN":["0304-4165"],"issn-type":[{"value":"0304-4165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone methyltransferase inhibitors prevent lens opacity in diabetic cataract rats","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - General Subjects","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagen.2026.130993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130993"}}