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Genet."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib86","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/hmg\/9.19.2811","article-title":"Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila","volume":"9","author":"Chan","year":"2000","journal-title":"Hum. Mol. 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Biol."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib112","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2008.05.008_bib113","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1568-1637(01)00006-X","article-title":"The proteasome in brain aging","volume":"1","author":"Keller","year":"2002","journal-title":"Age. Res. Rev."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib114","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. 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Neurosci."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib118","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0361-9230(01)00611-6","article-title":"Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease","volume":"56","author":"Morton","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib119","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagrm.2008.05.008_bib120","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","article-title":"Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. 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