{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:28:18Z","timestamp":1789648098077,"version":"4.0.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"12","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbagrm.2013.10.003","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T01:46:01Z","timestamp":1383270361000},"page":"1266-1275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Dynamics of 1\u03b1,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes"],"prefix":"10.1016","volume":"1829","author":[{"given":"Sabine","family":"Seuter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Pehkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Heikkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-0684","authenticated-orcid":false,"given":"Carsten","family":"Carlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagrm.2013.10.003_bb0005","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2174\/156802612799436623","article-title":"Current status of vitamin D signaling and its therapeutic applications","volume":"12","author":"Carlberg","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrm1680","article-title":"Controlling nuclear receptors: the circular logic of cofactor cycles","volume":"6","author":"Perissi","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0015","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1093\/emboj\/17.17.4905","article-title":"CpG methylation, chromatin structure and gene silencing\u2014a three-way connection","volume":"17","author":"Razin","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","article-title":"Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics","volume":"3","author":"Eberharter","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0025","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1096\/fj.14.10.1455","article-title":"VDR-Alien: a novel, DNA-selective vitamin D3 receptor\u2013corepressor partnership","volume":"14","author":"Polly","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0030","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1038\/sj.onc.1207772","article-title":"Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells","volume":"23","author":"Khanim","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0035","first-page":"2557","article-title":"Epigenetic corruption of VDR signalling in malignancy","volume":"26","author":"Abedin","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0040","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/nar\/gkm913","article-title":"Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to trichostatin A and 1\u03b1,25-dihydroxyvitamin D3","volume":"36","author":"Malinen","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jsbmb.2004.03.081","article-title":"Targeting 1\u03b1,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors","volume":"89\u201390","author":"Banwell","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0050","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nrd1551","article-title":"Principles for modulation of the nuclear receptor superfamily","volume":"3","author":"Gronemeyer","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0055","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00412-010-0283-8","article-title":"Dynamics of nuclear receptor target gene regulation","volume":"119","author":"Carlberg","year":"2010","journal-title":"Chromosoma"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1756-8722-3-5","article-title":"Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents","volume":"3","author":"Tan","year":"2010","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/nar\/gks959","article-title":"Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1\u03b1,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression","volume":"41","author":"Seuter","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"Snyder, An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE-Project-Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jsbmb.2006.12.050","article-title":"Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor","volume":"103","author":"Pike","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0080","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1111\/j.1753-4887.2008.00093.x","article-title":"Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention","volume":"66","author":"Haussler","year":"2008","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0085","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gr.107920.110","article-title":"A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution","volume":"20","author":"Ramagopalan","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0090","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1093\/nar\/gkr654","article-title":"Nuclear hormone 1\u03b1,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy","volume":"39","author":"Heikkinen","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/me.2011-1109","article-title":"VDR\/RXR and TCF4\/\u03b2-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression","volume":"26","author":"Meyer","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0105","first-page":"271","article-title":"The first genome-wide view of vitamin D receptor locations and their mechanistic implications","volume":"32","author":"Carlberg","year":"2012","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.steroids.2012.10.019","article-title":"Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor","volume":"78","author":"Carlberg","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0115","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bbamcr.2010.07.009","article-title":"Primary effect of 1\u03b1,25(OH)2D3 on IL-10 expression in monocytes is short-term down-regulation","volume":"1803","author":"Matilainen","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0120","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bbamcr.2011.01.037","article-title":"Mechanism of 1\u03b1,25-dihydroxyvitamin D3-dependent repression of interleukin-12B","volume":"1813","author":"Gynther","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.2910260208","article-title":"Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)","volume":"26","author":"Tsuchiya","year":"1980","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0130","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymeth.2009.03.003","article-title":"Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)","volume":"48","author":"Giresi","year":"2009","journal-title":"Methods"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0140","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1186\/gb-2011-12-7-r67","article-title":"ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions","volume":"12","author":"Rashid","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0155","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1101\/gr.5533506","article-title":"FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin","volume":"17","author":"Giresi","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0160","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1101\/gr.121541.111","article-title":"Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity","volume":"21","author":"Song","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/361657a0","article-title":"Two nuclear signalling pathways for vitamin D","volume":"361","author":"Carlberg","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0170","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tig.2008.12.005","article-title":"Genetics and epigenetics: stability and plasticity during cellular differentiation","volume":"25","author":"Mohn","year":"2009","journal-title":"Trends Genet."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0175","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrg1920","article-title":"Spreading of silent chromatin: inaction at a distance","volume":"7","author":"Talbert","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0180","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1128\/MCB.06206-11","article-title":"Analysis of chromatin dynamics during glucocorticoid receptor activation","volume":"32","author":"Burd","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0190","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0195","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/msb.2011.73","article-title":"Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics","volume":"7","author":"Mendoza-Parra","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0200","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1101\/gr.146399.112","article-title":"Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries","volume":"23","author":"Jakobsen","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0205","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0092-8674(02)00654-2","article-title":"Cooperation between complexes that regulate chromatin structure and transcription","volume":"108","author":"Narlikar","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0210","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0215","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0092-8674(03)00934-6","article-title":"Estrogen receptor a directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter","volume":"115","author":"Metivier","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0220","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/nature05980","article-title":"Chromatin dynamics and the preservation of genetic information","volume":"447","author":"Downs","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0225","doi-asserted-by":"crossref","first-page":"8073","DOI":"10.1074\/jbc.M808090200","article-title":"Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1\u03b1,25-dihydroxyvitamin D3","volume":"284","author":"Saram\u00e4ki","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0230","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/bi982171a","article-title":"Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo","volume":"26","author":"Montecino","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0235","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1093\/hmg\/ddi378","article-title":"Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays","volume":"14","author":"Rada-Iglesias","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0240","doi-asserted-by":"crossref","first-page":"e33453","DOI":"10.1371\/journal.pone.0033453","article-title":"Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors","volume":"7","author":"Halsall","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagrm.2013.10.003_bb0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1756-8935-6-11","article-title":"The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing","volume":"6","author":"Boudadi","year":"2013","journal-title":"Epigenetics Chromatin"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939913001521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939913001521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:20:49Z","timestamp":1539217249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874939913001521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1874939913001521"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagrm.2013.10.003","relation":{},"ISSN":["1874-9399"],"issn-type":[{"value":"1874-9399","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of 1\u03b1,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagrm.2013.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}