{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:42:55Z","timestamp":1786984975607,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["04\/2016\/000488"],"award-info":[{"award-number":["04\/2016\/000488"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["LFA13-LSBM-57"],"award-info":[{"award-number":["LFA13-LSBM-57"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.bbagrm.2019.01.003","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T23:37:17Z","timestamp":1548805037000},"page":"184-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterization of Toxoplasma gondii Spt5 like transcription elongation factor"],"prefix":"10.1016","volume":"1862","author":[{"given":"Pallabi","family":"Mitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit S.","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Gurupwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagrm.2019.01.003_bb0005","series-title":"Toxoplasmosis in Animals and Humans","author":"Dubey","year":"2010"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1741-7007-3-26","article-title":"The transcriptome of Toxoplasma gondii","volume":"3","author":"Radke","year":"2005","journal-title":"BMC Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0015","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0092-8674(02)00655-4","article-title":"A unified theory of gene expression","volume":"108","author":"Orphanides","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0020","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molcel.2009.09.018","article-title":"\u201cCotranscriptionality\u201d: the transcription elongation complex as a nexus for nuclear transactions","volume":"36","author":"Perales","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.molcel.2009.10.019","article-title":"Progression through the RNA polymerase II CTD cycle","volume":"36","author":"Buratowski","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0030","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tplants.2013.07.001","article-title":"Emerging roles for RNA polymerase II CTD in Arabidopsis","volume":"18","author":"Hajheidari","year":"2013","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1101\/gr.652803","article-title":"The genetic core of the universal ancestor","volume":"13","author":"Harris","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0040","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1093\/nar\/gkf498","article-title":"Novel domains and orthologues of eukaryotic transcription elongation factors","volume":"30","author":"Ponting","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/genetics\/107.2.179","article-title":"Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae","volume":"107","author":"Winston","year":"1984","journal-title":"Genetics"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0050","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1101\/gad.12.3.357","article-title":"Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae","volume":"12","author":"Hartzog","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbagrm.2012.09.002","article-title":"Structural basis of transcription elongation","volume":"1829","author":"Martinez-Rucobo","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1101\/gad.12.3.343","article-title":"DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs","volume":"12","author":"Wada","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0065","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbagrm.2012.08.007","article-title":"The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation","volume":"1829","author":"Hartzog","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbagrm.2012.11.007","article-title":"Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond","volume":"1829","author":"Yamaguchi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0075","first-page":"3009","article-title":"SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat","volume":"11","author":"Swanson","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0080","doi-asserted-by":"crossref","first-page":"19639","DOI":"10.1074\/jbc.M200015200","article-title":"Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5","volume":"277","author":"Pei","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0085","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.cub.2004.08.066","article-title":"Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila","volume":"14","author":"Jennings","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molcel.2005.11.024","article-title":"P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation","volume":"21","author":"Yamada","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00279450","article-title":"Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiae","volume":"237","author":"Malone","year":"1993","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0100","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.str.2008.08.013","article-title":"Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation","volume":"16","author":"Guo","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0105","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1093\/nar\/gkq135","article-title":"Spt4\/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif","volume":"38","author":"Hirtreiter","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0110","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1074\/jbc.M109.082818","article-title":"The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair","volume":"285","author":"Ding","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0115","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.aan8552","article-title":"Structure of the complete elongation complex of RNA polymerase II with basal factors","volume":"357","author":"Ehara","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0120","doi-asserted-by":"crossref","first-page":"12707","DOI":"10.1073\/pnas.0605686103","article-title":"RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing","volume":"103","author":"Schneider","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0125","doi-asserted-by":"crossref","first-page":"18816","DOI":"10.1074\/jbc.M110.202101","article-title":"The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively","volume":"286","author":"Anderson","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0130","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1128\/MCB.00609-09","article-title":"Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex","volume":"29","author":"Liu","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0135","doi-asserted-by":"crossref","first-page":"43346","DOI":"10.1074\/jbc.M307319200","article-title":"Characterization of the Schizosaccharomyces pombe Cdk9\/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis","volume":"278","author":"Pei","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0140","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1128\/MCB.20.9.2970-2983.2000","article-title":"Domains in the SPT5 protein that modulate its transcriptional regulatory properties","volume":"20","author":"Ivanov","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0145","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1128\/MCB.23.19.7005-7018.2003","article-title":"Bur1 kinase is required for efficient transcription elongation by RNA polymerase II","volume":"23","author":"Keogh","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0150","doi-asserted-by":"crossref","first-page":"12335","DOI":"10.1074\/jbc.270.21.12335","article-title":"Purification of P-TEFb, a transcription factor required for the transition into productive elongation","volume":"270","author":"Marshall","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.molcel.2017.02.023","article-title":"Spt5 plays vital roles in the control of sense and antisense transcription elongation","volume":"66","author":"Shetty","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0160","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1128\/MCB.24.14.6184-6193.2004","article-title":"mRNA capping enzyme activity is coupled to an early transcription elongation","volume":"24","author":"Kim","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0165","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1128\/MCB.23.4.1368-1378.2003","article-title":"Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins","volume":"23","author":"Lindstrom","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0170","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.chom.2011.09.004","article-title":"The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries","volume":"10","author":"Treeck","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0175","doi-asserted-by":"crossref","first-page":"35288","DOI":"10.1038\/srep35288","article-title":"Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii","volume":"6","author":"Deshmukh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0180","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.bbagrm.2018.02.004","article-title":"Cdk-related kinase 9 regulates RNA polymerase II mediated transcription in Toxoplasma gondii","volume":"1861","author":"Deshmukh","year":"2018","journal-title":"Biochim. Biophys. Acta, Gene Regul. Mech."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/mmi.13099","article-title":"Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5","volume":"98","author":"Deshmukh","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0190","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1128\/MCB.00595-14","article-title":"Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells","volume":"34","author":"Kelso","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0195","article-title":"Toxoplasma gondii proliferation require down-regulation of host Nox4 expression via activation of PI3 kinase\/Akt signaling pathway","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/BJ20150452","article-title":"Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response","volume":"470","author":"Mitra","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029998","article-title":"Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts","volume":"7","author":"Fritz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0210","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1101\/gad.844200","article-title":"High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation","volume":"14","author":"Andrulis","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0215","doi-asserted-by":"crossref","first-page":"19948","DOI":"10.1073\/pnas.0710179104","article-title":"Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking","volume":"104","author":"Tardiff","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nsmb1352","article-title":"RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes","volume":"15","author":"Glover-Cutter","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0225","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-6851(96)02814-9","article-title":"Bradyzoite-specific gene expression in Toxoplasma gondii requires minimal genomic elements","volume":"85","author":"Bohne","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0230","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nsmb.1903","article-title":"Uniform transitions of the general RNA polymerase II transcription complex","volume":"17","author":"Mayer","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbagrm.2012.08.013","article-title":"Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription","volume":"1829","author":"Heidemann","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0240","doi-asserted-by":"crossref","first-page":"22758","DOI":"10.1074\/jbc.M111.235077","article-title":"Cap-binding protein complex links pre-mRNA capping to transcription elongation and alternative splicing through positive transcription elongation factor b (P-TEFb)","volume":"286","author":"Lenasi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0245","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.febslet.2009.07.050","article-title":"The transcription elongation factors NELF, DSIF and P-TEFb control constitutive transcription in a gene-specific manner","volume":"583","author":"Fujita","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0250","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41467-018-03006-4","article-title":"Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast","volume":"9","author":"Booth","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0255","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00351735","article-title":"6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae","volume":"22","author":"Exinger","year":"1992","journal-title":"Curr. Genet."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0260","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.biochem.66.1.117","article-title":"Basic mechanisms of transcript elongation and its regulation","volume":"66","author":"Uptain","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0265","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpara.2008.10.002","article-title":"New eukaryotic systematics: a phylogenetic perspective of developmental gene expression in the Apicomplexa","volume":"39","author":"Gissot","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0270","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/blood-2006-05-020735","article-title":"Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia","volume":"109","author":"Byrd","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0275","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/01.cco.0000432528.88101.1a","article-title":"Targeting transcription factors: promising new strategies for cancer therapy","volume":"25","author":"Yeh","year":"2013","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0280","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.resmic.2010.09.002","article-title":"Cycling through transcription with the RNA polymerase F\/E (RPB4\/7) complex: structure, function and evolution of archaeal RNA polymerase","volume":"162","author":"Grohmann","year":"2011","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0285","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1093\/nar\/gku096","article-title":"The transcript elongation factor SPT4\/SPT5 is involved in auxin-related gene expression in Arabidopsis","volume":"42","author":"Durr","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0290","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/370075a0","article-title":"Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation","volume":"370","author":"O'Brien","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0295","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1101\/gad.824700","article-title":"Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription","volume":"14","author":"Komarnitsky","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0300","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1097-2765(03)00492-1","article-title":"Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3\u2032 end processing","volume":"13","author":"Ahn","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0305","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1101\/gad.231274.113","article-title":"3\u2032 end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells","volume":"28","author":"Davidson","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0310","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/nar\/gki274","article-title":"Molecular characterization of Drosophila NELF","volume":"33","author":"Wu","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0315","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S1097-2765(00)80091-X","article-title":"Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast","volume":"1","author":"Keaveney","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0320","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.molcel.2010.11.005","article-title":"Splicing-dependent RNA polymerase pausing in yeast","volume":"40","author":"Alexander","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0325","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrg3293","article-title":"Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans","volume":"13","author":"Adelman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0330","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1101\/gr.204578.116","article-title":"Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast","volume":"26","author":"Booth","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0335","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41586-018-0440-4","article-title":"Structure of activated transcription complex Pol II-DSIF-PAF-SPT6","volume":"560","author":"Vos","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0340","first-page":"2078","article-title":"Control of formation of two distinct classes of RNA polymerase II elongation complexes","volume":"12","author":"Marshall","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0345","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molcel.2006.06.014","article-title":"Controlling the elongation phase of transcription with P-TEFb","volume":"23","author":"Peterlin","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0350","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ncomms1846","article-title":"Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition","volume":"3","author":"Czudnochowski","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0355","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1073\/pnas.0806302106","article-title":"Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5","volume":"106","author":"Zhou","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0360","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbagrm.2012.08.008","article-title":"Transcription-associated histone modifications and cryptic transcription","volume":"1829","author":"Smolle","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0365","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1073\/pnas.0401493101","article-title":"Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II","volume":"101","author":"Mandal","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0370","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2009.02.001","article-title":"Pre-mRNA processing reaches back to transcription and ahead to translation","volume":"136","author":"Moore","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0375","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4161\/rna.7.2.11057","article-title":"P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms","volume":"7","author":"Lenasi","year":"2010","journal-title":"RNA Biol."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0380","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.celrep.2012.08.041","article-title":"DSIF restricts NF-kappaB signaling by coordinating elongation with mRNA processing of negative feedback genes","volume":"2","author":"Diamant","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbagrm.2019.01.003_bb0385","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1128\/MCB.01117-15","article-title":"Analysis of subcellular RNA fractions revealed a transcription-independent effect of tumor necrosis factor alpha on splicing, mediated by Spt5","volume":"36","author":"Diamant","year":"2016","journal-title":"Mol. Cell. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939918304310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939918304310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:07:39Z","timestamp":1778828859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874939918304310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1874939918304310"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagrm.2019.01.003","relation":{},"ISSN":["1874-9399"],"issn-type":[{"value":"1874-9399","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Toxoplasma gondii Spt5 like transcription elongation factor","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagrm.2019.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}