{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:40:29Z","timestamp":1787496029484,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870824"],"award-info":[{"award-number":["31870824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31901037"],"award-info":[{"award-number":["31901037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070668"],"award-info":[{"award-number":["32070668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071431"],"award-info":[{"award-number":["32071431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101190"],"award-info":[{"award-number":["32101190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32141003"],"award-info":[{"award-number":["32141003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91839302"],"award-info":[{"award-number":["91839302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFA1304600"],"award-info":[{"award-number":["2022YFA1304600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-017"],"award-info":[{"award-number":["2019-I2M-5-017"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2022-I2M-C"],"award-info":[{"award-number":["2022-I2M-C"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["T-B-082"],"award-info":[{"award-number":["T-B-082"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bbagrm.2023.194928","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T07:04:05Z","timestamp":1679382245000},"page":"194928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis"],"prefix":"10.1016","volume":"1866","author":[{"given":"Ping","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagrm.2023.194928_bb0005","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3390\/cells10102759","article-title":"Cellular and molecular mechanisms underlying liver fibrosis regression","volume":"10","author":"Caligiuri","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0015","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3390\/cells10051097","article-title":"Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured?","volume":"10","author":"Khanam","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.matbio.2018.04.006","article-title":"Liver fibrosis: direct antifibrotic agents and targeted therapies","volume":"68\u201369","author":"Schuppan","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/liv.14390","article-title":"Collagen biology and non-invasive biomarkers of liver fibrosis","volume":"40","author":"Karsdal","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0030","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/apt.16567","article-title":"Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation","volume":"54","author":"Thiele","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0035","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/01.ATV.19.6.1506","article-title":"Complete processing of type III collagen in atherosclerotic plaques","volume":"19","author":"Bode","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004978","article-title":"The collagen family","volume":"3","author":"Ricard-Blum","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0045","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1177\/0363546519832864","article-title":"Anterior cruciate ligament tear promotes skeletal muscle myostatin expression, fibrogenic cell expansion, and a decline in muscle quality","volume":"47","author":"Peck","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0050","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jmbbm.2019.04.022","article-title":"Molecular-level collagen damage explains softening and failure of arterial tissues: a quantitative interpretation of CHP data with a novel elasto-damage model","volume":"97","author":"Marino","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0055","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1021\/acsnano.7b03150","article-title":"In situ imaging of tissue remodeling with collagen hybridizing peptides","volume":"11","author":"Hwang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MPG.0000000000002505","article-title":"Quantitative liver fibrosis using collagen hybridizing peptide to predict native liver survival in biliary atresia: a pilot study","volume":"70","author":"Jaramillo","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0065","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1021\/acsbiomaterials.9b00070","article-title":"Molecular detection and assessment of intervertebral disc degeneration via a collagen hybridizing peptide","volume":"5","author":"Xiao","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0070","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of proteomics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tcb.2021.10.002","article-title":"Mechanical communication in fibrosis progression","volume":"32","author":"Long","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101530","article-title":"The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation","volume":"298","author":"Moretti","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.matbio.2015.06.003","article-title":"The extracellular matrix: tools and insights for the \"omics\" era","volume":"49","author":"Naba","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0090","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3389\/fphar.2019.01611","article-title":"Role of TG2-mediated SERCA2 serotonylation on hypoxic pulmonary vein remodeling","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0095","first-page":"G281","article-title":"A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB","volume":"272","author":"Mirza","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/gut.21.1.63","article-title":"Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin","volume":"21","author":"Hahn","year":"1980","journal-title":"Gut"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0105","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/ar.23567","article-title":"Basement membrane type IV collagen and laminin: an overview of their biology and value as fibrosis biomarkers of liver disease","volume":"300","author":"Mak","year":"2017","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mvr.2007.05.005","article-title":"Type IV collagen-derived angiogenesis inhibitors","volume":"74","author":"Mundel","year":"2007","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0115","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/liv.14940","article-title":"Hepatic macrophages: key players in the development and progression of liver fibrosis","volume":"41","author":"Cheng","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.831","article-title":"Targeting inflammation with collagen","volume":"12","author":"Schwarz","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0125","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0168-8278(86)80486-X","article-title":"Early alcoholic liver injury. Activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the disse space","volume":"3","author":"Horn","year":"1986","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0135","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00870306","article-title":"Liver fibrosis","volume":"21","author":"Pinzani","year":"1999","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0140","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41592-022-01526-y","article-title":"Mass spectrometry-based draft of the mouse proteome","volume":"19","author":"Giansanti","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0218-2","article-title":"Mass spectrometry-based proteome profiling of extracellular vesicles and their roles in cancer biology","volume":"51","author":"Bandu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0150","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix","volume":"288","author":"Karamanos","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0155","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0160","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.semcancer.2008.03.016","article-title":"Can cancer be reversed by engineering the tumor microenvironment?","volume":"18","author":"Ingber","year":"2008","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0165","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00447.2014","article-title":"Novel insights into the function and dynamics of extracellular matrix in liver fibrosis","volume":"308","author":"Karsdal","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0170","first-page":"2520","article-title":"Anti-angiogenic cues from vascular basement membrane collagen","volume":"60","author":"Colorado","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0175","doi-asserted-by":"crossref","first-page":"12912","DOI":"10.1074\/jbc.M110.143693","article-title":"Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1\/2-mediated mechanism in primary human lung fibroblasts","volume":"286","author":"Ruiz","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0180","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41467-019-09524-z","article-title":"Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARalpha","volume":"10","author":"Liang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbagrm.2023.194928_bb0185","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cell.2019.07.021","article-title":"LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis","volume":"178","author":"Xu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbagrm.2023.194928_bb0190","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1080\/15384101.2019.1609831","article-title":"TGM2 interference regulates the angiogenesis and apoptosis of colorectal cancer via Wnt\/beta-catenin pathway","volume":"18","author":"Yang","year":"2019","journal-title":"Cell Cycle"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939923000238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939923000238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:33:43Z","timestamp":1761744823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874939923000238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1874939923000238"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagrm.2023.194928","relation":{},"ISSN":["1874-9399"],"issn-type":[{"value":"1874-9399","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagrm.2023.194928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"194928"}}