{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:52:53Z","timestamp":1792169573111,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ9375"],"award-info":[{"award-number":["2024JJ9375"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bbagrm.2026.195186","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:33:01Z","timestamp":1790955181000},"page":"195186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caffeic acid phenethyl ester inhibits adipogenic differentiation in association with INSR suppression and AMPK activation"],"prefix":"10.1016","volume":"1869","author":[{"given":"Yan-Min","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Chang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Hao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"She-Chang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbagrm.2026.195186_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117073","article-title":"Novel insights into regulators and functional modulators of adipogenesis","volume":"177","author":"Kim","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0010","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bbrc.2005.01.067","article-title":"Inhibition of fatty acid synthase prevents preadipocyte differentiation","volume":"328","author":"Schmid","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagrm.2026.195186_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.111968","article-title":"Differential roles of insulin receptor in adipocyte progenitor cells in mice","volume":"573","author":"Yuan","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.bbagrm.2026.195186_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081799","article-title":"Muscle conditional medium reduces intramuscular adipocyte differentiation and lipid accumulation through regulating insulin signaling","volume":"18","author":"Han","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbagrm.2026.195186_bb0025","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3892\/ijmm.2013.1313","article-title":"Small-molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation","volume":"31","author":"Figarola","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbrc.2019.01.112","article-title":"A novel peptide suppresses adipogenic differentiation through activation of the AMPK pathway","volume":"510","author":"Shen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41422-020-0301-1","article-title":"Signaling networks in immunometabolism","volume":"30","author":"Saravia","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.bbagrm.2026.195186_bb0040","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.abb.2014.08.013","article-title":"Insulin inhibits AMPK activity and phosphorylates AMPK Ser485\/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle","volume":"562","author":"Valentine","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.bbagrm.2026.195186_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700701","article-title":"Caffeic acid phenethyl ester improves metabolic syndrome by activating PPAR-\u03b3 and inducing adipose tissue remodeling in diet-induced obese mice","volume":"62","author":"Kim","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"issue":"19","key":"10.1016\/j.bbagrm.2026.195186_bb0050","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1021\/jf405088f","article-title":"Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage","volume":"62","author":"Shin","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbagrm.2026.195186_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7359521","article-title":"Caffeic acid phenethyl ester regulates PPAR\u2019S levels in stem cells-derived adipocytes","volume":"2016","author":"Vanella","year":"2016","journal-title":"PPAR Res."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0060","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bbrc.2007.07.068","article-title":"CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells","volume":"361","author":"Lee","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbagrm.2026.195186_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2019.03.027","article-title":"Effect of CAPE-pNO(2) against type 2 diabetes mellitus via the AMPK\/GLUT4\/GSK3\u03b2\/PPAR\u03b1 pathway in HFD\/STZ-induced diabetic mice","volume":"853","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0070","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.bbrc.2019.01.023","article-title":"Alpha-glucosidase inhibitor 1-Deoxynojirimycin promotes beige remodeling of 3T3-L1 preadipocytes via activating AMPK","volume":"509","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5483\/BMBRep.2022-0211","article-title":"Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases","volume":"56","author":"Hwang","year":"2023","journal-title":"BMB Rep."},{"issue":"13","key":"10.1016\/j.bbagrm.2026.195186_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/nu15133006","article-title":"Dihydro-resveratrol attenuates oxidative stress, adipogenesis and insulin resistance in in vitro models and high-fat diet-induced mouse model via AMPK activation","volume":"15","author":"Lam","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbagrm.2026.195186_bb0085","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.molstruc.2019.02.071","article-title":"3D-QSAR and molecular docking studies of aminopyrimidine derivatives as novel three-targeted Lck\/Src\/KDR inhibitors","volume":"1185","author":"Xie","year":"2019","journal-title":"J. Mol. Struct."},{"issue":"2","key":"10.1016\/j.bbagrm.2026.195186_bb0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41419-022-04636-9","article-title":"Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet","volume":"13","author":"Kan","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbagrm.2026.195186_bb0095","series-title":"Studies in Natural Products Chemistry","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-443-22214-6.00008-9","article-title":"Chapter 6 - caffeic acid phenethyl ester (CAPE): an active component of propolis: a review on its therapeutic potentials","volume":"83","author":"Bar\u0131\u015f","year":"2024"},{"key":"10.1016\/j.bbagrm.2026.195186_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6007233","article-title":"Caffeic acid phenethyl ester inhibits basal lipolysis by activating PPAR-gamma and increasing lipid droplet-associated perilipin in mature rat adipocytes","volume":"2022","author":"Trang","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"9","key":"10.1016\/j.bbagrm.2026.195186_bb0105","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1248\/bpb.33.1484","article-title":"Caffeic acid phenethyl ester inhibits differentiation to adipocytes in 3T3-L1 mouse fibroblasts","volume":"33","author":"Juman","year":"2010","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0110","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1248\/bpb.34.490","article-title":"Caffeic acid phenethyl ester suppresses the production of adipocytokines, leptin, tumor necrosis factor -alpha and resistin, during differentiation to adipocytes in 3T3-L1 cells","volume":"34","author":"Juman","year":"2011","journal-title":"Biol. Pharm. Bull."},{"issue":"18","key":"10.1016\/j.bbagrm.2026.195186_bb0115","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e25458","article-title":"Equisetin inhibits adiposity through AMPK-dependent regulation of brown adipocyte differentiation","volume":"10","author":"Zhong","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030503","article-title":"L-Fucose suppresses lipid accumulation via the AMPK pathway in 3T3-L1 adipocytes","volume":"15","author":"Nakao","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbagrm.2026.195186_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1645587","article-title":"Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells","volume":"16","author":"Luo","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.bbagrm.2026.195186_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070135","article-title":"Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1\/AMPK pathway","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032108","article-title":"Inhibition effect of adipogenesis and lipogenesis via activation of AMPK in preadipocytes treated with Canavalia gladiata extract","volume":"24","author":"Hong","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bbagrm.2026.195186_bb0145","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbagrm.2026.195186_bb0150","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s42003-024-06418-9","article-title":"Dorsomorphin inhibits AMPK, upregulates Wnt and Foxo genes and promotes the activation of dormant follicles","volume":"7","author":"Madsen","year":"2024","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41418-024-01283-9","article-title":"AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death","volume":"31","author":"Jia","year":"2024","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0160","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/1744-7917.12795","article-title":"Galactose-NlGr11 inhibits AMPK phosphorylation by activating the PI3K-AKT-PKF-ATP signaling cascade via insulin receptor and G\u03b2\u03b3","volume":"28","author":"Chen","year":"2021","journal-title":"Insect Sci."},{"issue":"1","key":"10.1016\/j.bbagrm.2026.195186_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00109-023-02395-4","article-title":"Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR\/PI3K\/AKT\/AMPK pathway","volume":"102","author":"Zhang","year":"2024","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"12","key":"10.1016\/j.bbagrm.2026.195186_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315037","article-title":"CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer","volume":"19","author":"Fang","year":"2024","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbagrm.2026.195186_bb0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1179\/136485911X12987676649700","article-title":"A guide to the Simulium damnosum complex (Diptera: Simuliidae) in Nigeria, with a cytotaxonomic key for the identification of the sibling species","volume":"105","author":"Post","year":"2011","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"8","key":"10.1016\/j.bbagrm.2026.195186_bb0185","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.2337\/db16-0212","article-title":"Differential roles of insulin and IGF-1 receptors in adipose tissue development and function","volume":"65","author":"Boucher","year":"2016","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bbagrm.2026.195186_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27031222","article-title":"Insulin signaling in Alzheimer\u2019s disease: association with brain insulin resistance","volume":"27","author":"Pliszka","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbagrm.2026.195186_bb0195","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/s42255-025-01349-z","article-title":"The insulin signalling network","volume":"7","author":"Burchfield","year":"2025","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.bbagrm.2026.195186_bb0200","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/BJ20131344","article-title":"Phosphorylation by Akt within the ST loop of AMPK-\u03b11 down-regulates its activation in tumour cells","volume":"459","author":"Hawley","year":"2014","journal-title":"Biochem. J."},{"issue":"7716","key":"10.1016\/j.bbagrm.2026.195186_bb0205","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-018-0353-2","article-title":"Accumulation of succinate controls activation of adipose tissue thermogenesis","volume":"560","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bbagrm.2026.195186_bb0210","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.3382\/ps.2014-04027","article-title":"Folate supplementation modifies CCAAT\/enhancer-binding protein alpha methylation to mediate differentiation of preadipocytes in chickens","volume":"93","author":"Yu","year":"2014","journal-title":"Poult. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939926000520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874939926000520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:15:45Z","timestamp":1792167345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874939926000520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S1874939926000520"],"URL":"https:\/\/doi.org\/10.1016\/j.bbagrm.2026.195186","relation":{},"ISSN":["1874-9399"],"issn-type":[{"value":"1874-9399","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caffeic acid phenethyl ester inhibits adipogenic differentiation in association with INSR suppression and AMPK activation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbagrm.2026.195186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"195186"}}