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Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0355","doi-asserted-by":"crossref","first-page":"13741","DOI":"10.1021\/bi00250a027","article-title":"Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction","volume":"33","author":"Palczewski","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0360","doi-asserted-by":"crossref","first-page":"18822","DOI":"10.1074\/jbc.M501757200","article-title":"Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo","volume":"280","author":"Maeda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0365","doi-asserted-by":"crossref","first-page":"45537","DOI":"10.1074\/jbc.M208882200","article-title":"Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina","volume":"277","author":"Haeseleer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0370","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1021\/bi050226k","volume":"44","author":"Belyaeva","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0375","doi-asserted-by":"crossref","first-page":"37697","DOI":"10.1074\/jbc.M608375200","article-title":"Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice","volume":"281","author":"Maeda","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0380","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1128\/MCB.01486-06","article-title":"Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function","volume":"27","author":"Kurth","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0385","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ng1394","article-title":"Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy","volume":"36","author":"Janecke","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0390","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1086\/424889","article-title":"Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis","volume":"75","author":"Perrault","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0395","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.1073\/pnas.0707477104","article-title":"Redundant and unique roles of retinol dehydrogenases in the mouse retina","volume":"104","author":"Maeda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0400","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1523\/JNEUROSCI.18-21-08936.1998","article-title":"The major cell populations of the mouse retina","volume":"18","author":"Jeon","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0405","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/1096-9861(20001002)425:4<545::AID-CNE6>3.0.CO;2-3","article-title":"Spatial and temporal expression of short, long\/medium, or both opsins in human fetal cones","volume":"425","author":"Xiao","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0410","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/j.visres.2007.04.005","article-title":"Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations","volume":"47","author":"Sun","year":"2007","journal-title":"Vision Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0415","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1167\/iovs.06-0628","article-title":"The phenotype of early-onset retinal degeneration in persons with RDH12 mutations","volume":"48","author":"Schuster","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0420","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2009.08.005","article-title":"Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells","volume":"48","author":"Marchette","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0425","doi-asserted-by":"crossref","first-page":"21790","DOI":"10.1074\/jbc.273.34.21790","article-title":"Molecular characterization of a novel short-chain dehydrogenase\/reductase that reduces all-trans-retinal","volume":"273","author":"Haeseleer","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0430","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1074\/jbc.270.3.1107","article-title":"The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases","volume":"270","author":"Simon","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0435","doi-asserted-by":"crossref","first-page":"9667","DOI":"10.1074\/jbc.M109.063941","article-title":"Importance of membrane structural integrity for RPE65 retinoid isomerization activity","volume":"285","author":"Golczak","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0440","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/9707","article-title":"Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus","volume":"22","author":"Yamamoto","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0445","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01569200","article-title":"Fundus albipunctatus: a clinical study of the fundus lesions, the physiologic deficit, and the vitamin A metabolism","volume":"43","author":"Marmor","year":"1977","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0450","first-page":"3925","article-title":"A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene","volume":"41","author":"Nakamura","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0455","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1017\/S0952523800175029","article-title":"Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man","volume":"17","author":"Cideciyan","year":"2000","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0460","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1128\/MCB.20.12.4275-4287.2000","article-title":"Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters","volume":"20","author":"Driessen","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0465","doi-asserted-by":"crossref","first-page":"32456","DOI":"10.1074\/jbc.M104949200","article-title":"Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus","volume":"276","author":"Jang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0470","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1074\/jbc.274.13.8577","article-title":"Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein","volume":"274","author":"Stecher","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0475","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1074\/jbc.M109.027458","article-title":"RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization","volume":"285","author":"Redmond","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0480","first-page":"1611","article-title":"Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase\/reductase family highly expressed in normal and neoplastic prostate epithelium","volume":"61","author":"Lin","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0485","doi-asserted-by":"crossref","first-page":"32380","DOI":"10.1074\/jbc.M304969200","article-title":"Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins","volume":"278","author":"Kasus-Jacobi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0490","doi-asserted-by":"crossref","first-page":"20413","DOI":"10.1074\/jbc.M413789200","article-title":"Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo","volume":"280","author":"Kasus-Jacobi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0495","doi-asserted-by":"crossref","first-page":"28909","DOI":"10.1074\/jbc.M202588200","article-title":"Evidence that the human gene for prostate short-chain dehydrogenase\/reductase (PSDR1) encodes a novel retinal reductase (RalR1)","volume":"277","author":"Kedishvili","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0500","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1021\/bi035288u","article-title":"Properties of short-chain dehydrogenase\/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines","volume":"42","author":"Belyaeva","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0505","doi-asserted-by":"crossref","first-page":"8694","DOI":"10.1074\/jbc.M413172200","article-title":"Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo","volume":"280","author":"Kim","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0510","first-page":"3365","article-title":"Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase\/reductase from the RPE","volume":"43","author":"Wu","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0515","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1167\/iovs.03-1302","article-title":"Identification of RDH10, an all-trans retinol dehydrogenase, in retinal Muller cells","volume":"45","author":"Wu","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0520","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-5793(03)01089-5","article-title":"Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene","volume":"554","author":"Picozzi","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0525","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0530","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1167\/iovs.09-3797","article-title":"The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins","volume":"50","author":"Farjo","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0535","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1742-4658.2007.06184.x","article-title":"Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase\/reductase with a retinaldehyde reductase activity","volume":"275","author":"Belyaeva","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0540","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0014-4835(91)90112-R","article-title":"Monoclonal antibodies which recognize endoplasmic reticulum in the retinal pigment epithelium","volume":"53","author":"Sagara","year":"1991","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0545","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/jnr.490340406","article-title":"A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina","volume":"34","author":"Hamel","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0550","doi-asserted-by":"crossref","first-page":"15751","DOI":"10.1016\/S0021-9258(18)82319-5","article-title":"Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro","volume":"268","author":"Hamel","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0555","doi-asserted-by":"crossref","first-page":"14978","DOI":"10.1016\/S0021-9258(18)98574-1","article-title":"Identification and partial characterization of a retinal pigment epithelial membrane receptor for plasma retinol-binding protein","volume":"266","author":"Bavik","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0560","doi-asserted-by":"crossref","first-page":"20540","DOI":"10.1016\/S0021-9258(20)80759-5","article-title":"The retinal pigment epithelial membrane receptor for plasma retinol-binding protein. Isolation and cDNA cloning of the 63-kDa protein","volume":"268","author":"Bavik","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0565","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1126\/science.276.5320.1872","article-title":"Specific oxidative cleavage of carotenoids by VP14 of maize","volume":"276","author":"Schwartz","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0570","doi-asserted-by":"crossref","first-page":"12235","DOI":"10.1073\/pnas.94.22.12235","article-title":"Genetic control of abscisic acid biosynthesis in maize","volume":"94","author":"Tan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0575","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ng1097-194","article-title":"Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy","volume":"17","author":"Gu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0580","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng1097-139","article-title":"Mutations in RPE65 cause Leber's congenital amaurosis","volume":"17","author":"Marlhens","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0585","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/3813","article-title":"Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle","volume":"20","author":"Redmond","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0590","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-5793(98)01459-8","article-title":"Lack of effect of RPE65 removal on the enzymatic processing of all-trans-retinol into 11-cis-retinol in vitro","volume":"440","author":"Choo","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0595","doi-asserted-by":"crossref","first-page":"11824","DOI":"10.1021\/bi035227w","article-title":"RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters","volume":"42","author":"Gollapalli","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0600","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cell.2004.05.016","article-title":"A palmitoylation switch mechanism in the regulation of the visual cycle","volume":"117","author":"Xue","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0605","doi-asserted-by":"crossref","first-page":"14463","DOI":"10.1021\/bi0510779","article-title":"Specificity of binding of all-trans-retinyl ester to RPE65","volume":"44","author":"Maiti","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0610","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1074\/jbc.M310042200","article-title":"Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells","volume":"279","author":"Mata","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0615","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1111\/j.1742-4658.2009.07021.x","article-title":"Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane","volume":"276","author":"Nikolaeva","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0620","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1360-1385(03)00053-0","article-title":"Carotenoid oxygenases: cleave it or leave it","volume":"8","author":"Giuliano","year":"2003","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0625","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00018-006-6176-6","article-title":"Structural and biological aspects of carotenoid cleavage","volume":"63","author":"Kloer","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0630","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1271\/bbb1961.53.2757","article-title":"Purification and some properties of lignostilbene-alpha-beta-dioxygenase responsible for the C-Alpha-C-Beta cleavage of a diarylpropane type lignin model-compound from pseudomonas Sp Tmy 1009","volume":"53","author":"Kamoda","year":"1989","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0635","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1271\/bbb.57.926","article-title":"Cloning, expression, and sequence-analysis of a lignostilbene-alpha, beta-dioxygenase gene from pseudomonas-paucimobilis Tmy 1009","volume":"57","author":"Kamoda","year":"1993","journal-title":"Biosci. Biotechnol. 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Acad. Sci. USA"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0655","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/geno.1994.1212","article-title":"The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3","volume":"20","author":"Hamel","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0660","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/hmg\/4.4.641","article-title":"Molecular characterization of the human gene encoding an abundant 61kDa protein specific to the retinal pigment epithelium","volume":"4","author":"Nicoletti","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0665","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-4781(98)00221-8","article-title":"Cloning and localization of RPE65 mRNA in salamander cone photoreceptor cells1","volume":"1443","author":"Ma","year":"1998","journal-title":"Biochim. Biophys. 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Am. Chem. Soc."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0770","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1074\/jbc.M508903200","article-title":"RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle","volume":"281","author":"Moiseyev","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0775","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1002\/chem.200701344","article-title":"Reaction mechanism of apocarotenoid oxygenase (ACO): a DFT study","volume":"14","author":"Borowski","year":"2008","journal-title":"Chemistry"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0780","first-page":"1151","article-title":"RPE65 surface epitopes, protein interactions, and expression in rod- and cone-dominant species","volume":"11","author":"Hemati","year":"2005","journal-title":"Mol. 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Eye Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0800","first-page":"425","article-title":"Gene therapy for vision loss \u2014 recent developments","volume":"10","author":"Stieger","year":"2010","journal-title":"Discov. Med."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0805","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1001\/jama.2010.1412","article-title":"Seeing is believing: gene therapy shows promise for ocular disorders","volume":"304","author":"Friedrich","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.bbalip.2011.03.005_bb0810","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1172\/JCI42258","article-title":"Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies","volume":"120","author":"den Hollander","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0815","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.preteyeres.2010.04.002","article-title":"Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy","volume":"29","author":"Cideciyan","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0820","first-page":"125","article-title":"Recent breakthroughs in gene therapy for inherited retinal degeneration","volume":"8","author":"Revere","year":"2009","journal-title":"Discov. Med."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0825","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0501-92","article-title":"Gene therapy restores vision in a canine model of childhood blindness","volume":"28","author":"Acland","year":"2001","journal-title":"Nat. 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Ther."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0835","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1371\/journal.pmed.0020333","article-title":"Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis","volume":"2","author":"Batten","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbalip.2011.03.005_bb0840","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1089\/hum.2006.17.845","article-title":"Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis","volume":"17","author":"Jacobson","year":"2006","journal-title":"Hum. 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