{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:05:42Z","timestamp":1791327942516,"version":"4.3.1"},"reference-count":111,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM062848"],"award-info":[{"award-number":["GM062848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RR032045"],"award-info":[{"award-number":["RR032045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DE016082"],"award-info":[{"award-number":["DE016082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007795","name":"Stowers Institute for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007795","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.bbalip.2011.04.004","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T18:58:02Z","timestamp":1303239482000},"page":"198-205","source":"Crossref","is-referenced-by-count":164,"title":["Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models"],"prefix":"10.1016","volume":"1821","author":[{"given":"Sandeep","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Koentgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Duester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2011.04.004_bb0005","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/dbio.1993.1318","article-title":"Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids","volume":"160","author":"Dersch","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0010","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0960-9822(02)00509-2","article-title":"Vitamin A-deficient quail embryos have half a hindbrain and other neural defects","volume":"6","author":"Maden","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.nutr.22.010402.102745E","article-title":"The role of vitamin A in mammalian reproduction and embryonic development","volume":"22","author":"Clagett-Dame","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0020","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(95)90202-3","article-title":"Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?","volume":"83","author":"Kastner","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg2340","article-title":"Retinoic acid in development: towards an integrated view","volume":"9","author":"Niederreither","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0030","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0035","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1242\/dev.00437","article-title":"Provitamin A conversion to retinal via the \u03b2, \u03b2-carotene-15,15\u2032-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis","volume":"130","author":"Lampert","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0040","doi-asserted-by":"crossref","first-page":"33553","DOI":"10.1074\/jbc.M706763200","article-title":"CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice","volume":"282","author":"Hessel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0045","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1093\/emboj\/18.18.4903","article-title":"Cellular retinol-binding protein I is essential for vitamin A homeostasis","volume":"18","author":"Ghyselinck","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0050","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1074\/jbc.M312410200","article-title":"Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver","volume":"279","author":"Batten","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0055","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.M507924200","article-title":"Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)","volume":"280","author":"O'Byrne","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0005-2760(93)90058-H","article-title":"Enzymes catalysing the hydrolysis of retinyl esters","volume":"1170","author":"Harrison","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0065","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1096\/fj.08-120923","article-title":"Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL","volume":"23","author":"Strom","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0070","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1074\/jbc.M112039200","article-title":"Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice","volume":"277","author":"Molotkov","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0075","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1073\/pnas.082093299","article-title":"Stimulation of retinoic acid production and growth by ubiquitously-expressed alcohol dehydrogenase Adh3","volume":"99","author":"Molotkov","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0080","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1096\/fj.06-7964com","article-title":"Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse","volume":"21","author":"Zhang","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0085","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/BJ20051988","article-title":"Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases\/reductases and aldo\u2013keto reductases with retinoids","volume":"399","author":"Gallego","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0095","doi-asserted-by":"crossref","first-page":"35621","DOI":"10.1074\/jbc.M706372200","article-title":"Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12","volume":"282","author":"Lee","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0100","doi-asserted-by":"crossref","first-page":"20764","DOI":"10.1073\/pnas.0705659105","article-title":"Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10","volume":"104","author":"Gallego","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0105","doi-asserted-by":"crossref","first-page":"51581","DOI":"10.1074\/jbc.M408830200","article-title":"Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation","volume":"279","author":"Nadauld","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0110","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cell.2010.08.030","article-title":"DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC","volume":"142","author":"Rai","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.024901","article-title":"Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system","volume":"136","author":"Strate","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2009.10.029","article-title":"Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism","volume":"338","author":"Feng","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0125","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/7788","article-title":"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development","volume":"21","author":"Niederreither","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0130","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/dev.129.9.2271","article-title":"Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice","volume":"129","author":"Mic","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0135","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1128\/MCB.23.13.4637-4648.2003","article-title":"Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina","volume":"23","author":"Fan","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0140","doi-asserted-by":"crossref","first-page":"14036","DOI":"10.1073\/pnas.2336223100","article-title":"A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment","volume":"100","author":"Dup\u00e9","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0145","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ydbio.2006.11.035","article-title":"Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone","volume":"303","author":"Molotkova","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0150","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0925-4773(00)00558-X","article-title":"Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos","volume":"101","author":"Chen","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0155","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1242\/dev.128.16.3081","article-title":"The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain","volume":"128","author":"Begemann","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0160","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1242\/dev.129.12.2851","article-title":"Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud","volume":"129","author":"Grandel","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0165","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.gep.2007.11.003","article-title":"Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts","volume":"8","author":"Pittlik","year":"2008","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0170","doi-asserted-by":"crossref","first-page":"e1000496","DOI":"10.1371\/journal.pgen.1000496","article-title":"Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes","volume":"5","author":"Canestro","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0175","doi-asserted-by":"crossref","first-page":"29922","DOI":"10.1074\/jbc.271.47.29922","article-title":"Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase","volume":"271","author":"White","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1101\/gad.851501","article-title":"The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo","volume":"15","author":"Sakai","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0185","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1101\/gad.855001","article-title":"The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures","volume":"15","author":"Abu-Abed","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0190","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(04)00062-0","article-title":"Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing limb","volume":"6","author":"Yashiro","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2006.09.045","article-title":"CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse","volume":"302","author":"Uehara","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0200","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1021\/bi00577a039","article-title":"Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver","volume":"18","author":"Frolik","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0205","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/366340a0","article-title":"The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification","volume":"366","author":"Pijnappel","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ng876","article-title":"Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development","volume":"31","author":"Niederreither","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0215","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/bdra.20709","article-title":"The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis","volume":"88","author":"Pennimpede","year":"2010","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0220","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0225","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0230","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0092-8674(92)90479-V","article-title":"9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor","volume":"68","author":"Heyman","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0235","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1006\/bbrc.1995.2872","article-title":"Endogenous retinoids in the early avian embryo","volume":"217","author":"Dong","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0240","doi-asserted-by":"crossref","first-page":"17850","DOI":"10.1074\/jbc.270.30.17850","article-title":"Plasma delivery of retinoic acid to tissues in the rat","volume":"270","author":"Kurlandsky","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/(SICI)1097-0177(199601)205:1<41::AID-AJA4>3.0.CO;2-5","article-title":"Endogenous retinoids in the zebrafish embryo and adult","volume":"205","author":"Costaridis","year":"1996","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0250","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/dbio.2000.9634","article-title":"Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid","volume":"220","author":"Ulven","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0255","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20041867","article-title":"Quantification of endogenous retinoic acid in limited biological samples by LC\/MS\/MS","volume":"388","author":"Kane","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0260","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0024-3205(96)00408-0","article-title":"Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption","volume":"59","author":"Arnhold","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0265","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1073\/pnas.1231422100","article-title":"Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis","volume":"100","author":"Mic","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0270","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: opening the X-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0275","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/371528a0","article-title":"Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding","volume":"371","author":"Kurokawa","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0280","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0092-8674(95)90075-6","article-title":"Unique response pathways are established by allosteric interactions among nuclear hormone receptors","volume":"81","author":"Forman","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0285","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1093\/emboj\/16.18.5697","article-title":"A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers","volume":"16","author":"Vivat","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0290","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1074\/jbc.273.14.8483","article-title":"Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid\u2014evidence for allosteric receptor interactions","volume":"273","author":"Thompson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0295","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1101\/gad.368706","article-title":"Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes","volume":"20","author":"Calleja","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0300","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1126\/science.290.5499.2140","article-title":"Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain","volume":"290","author":"De Urquiza","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0305","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1073\/pnas.0813143106","article-title":"A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development","volume":"106","author":"Mascrez","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0310","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1530-0277.1996.tb01946.x","article-title":"Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis","volume":"20","author":"Ang","year":"1996","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0315","doi-asserted-by":"crossref","first-page":"16796","DOI":"10.1074\/jbc.274.24.16796","article-title":"Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice: overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid","volume":"274","author":"Deltour","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0320","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1046\/j.1432-1033.2002.02935.x","article-title":"Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3","volume":"269","author":"Molotkov","year":"2002","journal-title":"FEBS J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0325","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BJ20040621","article-title":"Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation","volume":"383","author":"Molotkov","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1520-6408(1999)25:1<1::AID-DVG1>3.0.CO;2-W","article-title":"Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice","volume":"25","author":"Deltour","year":"1999","journal-title":"Dev. Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0335","doi-asserted-by":"crossref","first-page":"44083","DOI":"10.1074\/jbc.M105748200","article-title":"Molecular characterization of a mouse short chain dehydrogenase\/reductase active with all-trans-retinol in intact cells, mRDH1","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0340","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1110\/ps.26902","article-title":"Short-chain dehydrogenase\/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes","volume":"11","author":"Kallberg","year":"2002","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0345","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1167\/iovs.03-1302","article-title":"Identification of RDH10, an all-trans retinol dehydrogenase, in retinal Muller cells","volume":"45","author":"Wu","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0350","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/dvdy.21312","article-title":"Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation","volume":"236","author":"Cammas","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0355","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/cne.21707","article-title":"Dynamic expression of the retinoic acid-synthesizing enzyme retinol dehydrogenase 10 (Rdh10) in the developing mouse brain and sensory organs","volume":"508","author":"Romand","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0360","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1101\/gad.5.8.1333","article-title":"Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis","volume":"5","author":"Rossant","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0365","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/dvdy.22583","article-title":"Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing","volume":"240","author":"Cunningham","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0370","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cub.2009.04.059","article-title":"Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning","volume":"19","author":"Zhao","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0375","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s00018-007-6449-8","article-title":"Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism","volume":"64","author":"Hellgren","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0380","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1006\/bbrc.2000.3837","article-title":"Human class V alcohol dehydrogenase (ADH5): a complex transcription unit generates C-terminal multiplicity","volume":"278","author":"Str\u00f6mberg","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0385","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1242\/dev.02815","article-title":"RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1","volume":"134","author":"Chambers","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0390","doi-asserted-by":"crossref","DOI":"10.1186\/1749-8104-4-6","article-title":"Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain","volume":"4","author":"Chambers","year":"2009","journal-title":"Neural Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0395","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0925-4773(01)00561-5","article-title":"Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse","volume":"110","author":"Niederreither","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0400","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1242\/dev.112.3.693","article-title":"Aldehyde dehydrogenase is a positional marker in the retina","volume":"112","author":"McCaffery","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0405","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/(SICI)1520-6408(1999)25:4<353::AID-DVG9>3.0.CO;2-G","article-title":"Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways","volume":"25","author":"Haselbeck","year":"1999","journal-title":"Dev. Genet."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0410","doi-asserted-by":"crossref","first-page":"36085","DOI":"10.1074\/jbc.M303709200","article-title":"Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid","volume":"278","author":"Molotkov","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0415","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nm1587","article-title":"Retinaldehyde represses adipogenesis and diet-induced obesity","volume":"13","author":"Ziouzenkova","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0420","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0925-4773(96)00653-3","article-title":"Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development","volume":"62","author":"Niederreither","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0425","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/dev.127.1.75","article-title":"Retinoic acid synthesis and hindbrain patterning in the mouse embryo","volume":"127","author":"Niederreither","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0430","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.01845","article-title":"Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression","volume":"132","author":"Sirbu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0435","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mod.2004.10.008","article-title":"Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation","volume":"122","author":"Molotkova","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0440","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ydbio.2006.05.019","article-title":"Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives","volume":"297","author":"Wang","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0445","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1242\/dev.006221","article-title":"Inhibition of Tgf\u03b2 signaling by endogenous retinoic acid is essential for primary lung bud induction","volume":"134","author":"Chen","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0450","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/dvdy.20256","article-title":"Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development","volume":"232","author":"Molotkov","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0455","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2005.05.035","article-title":"Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice","volume":"284","author":"Mart\u00edn","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0460","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1242\/dev.128.7.1019","article-title":"Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse","volume":"128","author":"Niederreither","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0465","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/dvdy.21570","article-title":"Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway","volume":"237","author":"Sirbu","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0470","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.1108363","article-title":"Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo","volume":"308","author":"Vermot","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0475","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ncb1374","article-title":"Retinoic acid signaling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm","volume":"8","author":"Sirbu","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0480","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/dvdy.22188","article-title":"Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction","volume":"239","author":"Zhao","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0485","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1242\/dev.040287","article-title":"Non-cell-autonomous retinoid signaling is crucial for renal development","volume":"137","author":"Rosselot","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0490","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1172\/JCI40253","article-title":"A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium","volume":"120","author":"Chen","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0495","doi-asserted-by":"crossref","first-page":"9234","DOI":"10.1073\/pnas.0910430107","article-title":"Endogenous retinoic acid regulates cardiac progenitor differentiation","volume":"107","author":"Lin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0500","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1242\/dev.054239","article-title":"Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2","volume":"138","author":"Brade","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0505","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ncomms1136","article-title":"Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signaling","volume":"2","author":"Kumar","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0510","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0925-4773(00)00352-X","article-title":"A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse","volume":"95","author":"Li","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0515","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0925-4773(00)00434-2","article-title":"RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development","volume":"97","author":"Mic","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0520","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1242\/dev.02031","article-title":"Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells","volume":"132","author":"Matt","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0525","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1242\/dev.02328","article-title":"Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning","volume":"133","author":"Molotkov","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0530","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ydbio.2010.01.027","article-title":"Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2","volume":"340","author":"Kumar","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0535","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ydbio.2008.02.030","article-title":"The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development","volume":"317","author":"Gage","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0540","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cne.20013","article-title":"Retinoic acid signaling in the brain marks formation of optic projections, maturation of the dorsal telencephalon, and function of limbic sites","volume":"470","author":"Luo","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0545","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/dev.116.1.55","article-title":"Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay","volume":"116","author":"Wagner","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.bbalip.2011.04.004_bb0550","doi-asserted-by":"crossref","first-page":"e1000609","DOI":"10.1371\/journal.pbio.1000609","article-title":"Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia","volume":"9","author":"Chatzi","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbalip.2011.04.004_bb0555","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.0014-2956.2001.02642.x","article-title":"Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes","volume":"269","author":"Szalai","year":"2002","journal-title":"FEBS J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198111000473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198111000473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T22:20:49Z","timestamp":1637533249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198111000473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":111,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1388198111000473"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2011.04.004","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}