{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:16:50Z","timestamp":1790893010324,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.bbalip.2012.03.001","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T07:31:39Z","timestamp":1331278299000},"page":"877-883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith\u2013Lemli\u2013Opitz syndrome"],"prefix":"10.1016","volume":"1821","author":[{"given":"Libin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell G.","family":"Sheflin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned A.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Fliesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2012.03.001_bb0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/jmg.37.5.321","article-title":"The Smith\u2013Lemli\u2013Opitz syndrome","volume":"37","author":"Kelley","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1194\/jlr.R009548","article-title":"Malformation syndromes caused by disorders of cholesterol synthesis","volume":"52","author":"Porter","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-8749.1977.tb08021.x","article-title":"Smith\u2013Lemli\u2013Opitz syndrome: neuropathological and ophthalmological observations","volume":"19","author":"Fierro","year":"1977","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0020","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<501::AID-AJMG12>3.0.CO;2-J","article-title":"Eye findings in 8 children and a spontaneously aborted fetus with RSH\/Smith\u2013Lemli\u2013Opitz syndrome","volume":"80","author":"Atchaneeyasakul","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0025","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1001\/archopht.121.12.1738","article-title":"Rod photoreceptor responses in children with Smith\u2013Lemli\u2013Opitz syndrome","volume":"121","author":"Elias","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10545-007-0537-7","article-title":"Effects of cholesterol and simvastatin treatment in patients with Smith\u2013Lemli\u2013Opitz syndrome (SLOS)","volume":"30","author":"Haas","year":"2007","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1096-8628(19970131)68:3<311::AID-AJMG12>3.0.CO;2-W","article-title":"Treatment of Smith\u2013Lemli\u2013Opitz syndrome: results of a multicenter trial","volume":"68","author":"Irons","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0040","first-page":"783","article-title":"Cholesterol supplementation does not improve developmental progress in Smith\u2013Lemli\u2013Opitz syndrome","volume":"144","author":"Sikora","year":"2004","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajmg.a.33148","article-title":"Analysis of short-term behavioral effects of dietary cholesterol supplementation in Smith\u2013Lemli\u2013Opitz syndrome","volume":"152A","author":"Tierney","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bbalip.2012.03.001_bb0050","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-2275(20)33442-8","article-title":"Simvastatin. A new therapeutic approach for Smith\u2013Lemli\u2013Opitz syndrome","volume":"41","author":"Jira","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ajmg.10722","article-title":"Simvastatin treatment in the SLO syndrome: a safe approach?","volume":"113","author":"Starck","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0060","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1203\/PDR.0b013e31819ea4eb","article-title":"Effects of dietary cholesterol and simvastatin on cholesterol synthesis in Smith\u2013Lemli\u2013Opitz syndrome","volume":"65","author":"Chan","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0065","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11883-000-0022-3","article-title":"Pleiotropic effects of statins","volume":"2","author":"Farmer","year":"2000","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0070","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1021\/ja9029076","article-title":"Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes","volume":"131","author":"Xu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0075","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/ja9080265","article-title":"Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies","volume":"132","author":"Xu","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0080","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1194\/jlr.M009365","article-title":"Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith\u2013Lemli\u2013Opitz syndrome","volume":"51","author":"Korade","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0085","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1194\/jlr.M014498","article-title":"An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell\/mouse models for Smith\u2013Lemli\u2013Opitz syndrome","volume":"52","author":"Xu","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.2000.80.1.361","article-title":"Oxysterols: modulators of cholesterol metabolism and other processes","volume":"80","author":"Schroepfer","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mam.2009.02.006","article-title":"Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and\/or oncosis), oxidative and inflammatory activities, and phospholipidosis","volume":"30","author":"Vejux","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mam.2009.02.005","article-title":"Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis","volume":"30","author":"Brown","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0105","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1172\/JCI200112103","article-title":"7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith\u2013Lemli\u2013Opitz\/RSH syndrome","volume":"108","author":"Fitzky","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0110","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/hmg\/10.6.555","article-title":"Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH\/Smith\u2013Lemli\u2013Opitz syndrome","volume":"10","author":"Wassif","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1096-9926(199609)54:3<115::AID-TERA1>3.0.CO;2-2","article-title":"Inhibition of 7-dehydrocholesterol reductase by the teratogen AY9944: a rat model for Smith\u2013Lemli\u2013Opitz syndrome","volume":"54","author":"Kolf-Clauw","year":"1996","journal-title":"Teratology"},{"key":"10.1016\/j.bbalip.2012.03.001_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1172\/JCI117678","article-title":"Reproducing abnormal cholesterol biosynthesis as seen in the Smith\u2013Lemli\u2013Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats","volume":"95","author":"Xu","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0125","first-page":"1792","article-title":"Marked alteration of sterol metabolism and composition without compromising retinal development or function","volume":"40","author":"Fliesler","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0130","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/archopht.122.8.1190","article-title":"Retinal degeneration in a rodent model of Smith\u2013Lemli\u2013Opitz syndrome: electrophysiologic, biochemical, and morphologic features","volume":"122","author":"Fliesler","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1203\/pdr.0b013e318030d1cf","article-title":"Partial rescue of retinal function and sterol steady-state in a rat model of Smith\u2013Lemli\u2013Opitz syndrome","volume":"61","author":"Fliesler","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0140","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.exer.2005.08.016","article-title":"Lipid hydroperoxide formation in the retina: correlation with retinal degeneration and light damage in a rat model of Smith\u2013Lemli\u2013Opitz syndrome","volume":"82","author":"Richards","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0145","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.exer.2005.08.008","article-title":"Light-induced exacerbation of retinal degeneration in a rat model of Smith\u2013Lemli\u2013Opitz syndrome","volume":"82","author":"Vaughan","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0150","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1194\/jlr.M018366","article-title":"Novel oxysterols observed in tissues and fluids of AY9944-treated rats - a model for Smith\u2013Lemli\u2013Opitz syndrome","volume":"52","author":"Xu","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0155","doi-asserted-by":"crossref","first-page":"33021","DOI":"10.1074\/jbc.M111.282434","article-title":"Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate","volume":"286","author":"Shinkyo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0160","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/978-1-4419-1399-9_55","article-title":"Retinal degeneration in a rat model of Smith\u2013Lemli\u2013Opitz syndrome: thinking beyond cholesterol deficiency","volume":"664","author":"Fliesler","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0165","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1194\/jlr.R010538","article-title":"The ins and outs of cholesterol in the vertebrate retina","volume":"51","author":"Fliesler","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0163-7827(83)90004-8","article-title":"Chemistry and metabolism of lipids in the vertebrate retina","volume":"22","author":"Fliesler","year":"1983","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0175","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.freeradbiomed.2007.02.023","article-title":"Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages","volume":"42","author":"Palozza","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0180","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.visres.2009.04.008","article-title":"Naturally occurring animal models with outer retina phenotypes","volume":"49","author":"Baehr","year":"2009","journal-title":"Vision Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0185","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-12-384878-9.00006-6","article-title":"Animal models of retinal disease","volume":"100","author":"Fletcher","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0190","doi-asserted-by":"crossref","first-page":"38685","DOI":"10.1074\/jbc.M105127200","article-title":"Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4","volume":"276","author":"Bodin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0195","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","article-title":"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain","volume":"96","author":"Lund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0200","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.pharmthera.2006.05.014","article-title":"Cytochrome P450s and cholesterol homeostasis","volume":"112","author":"Pikuleva","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0205","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.270.50.29739","article-title":"A novel cytochrome P450 expressed primarily in brain","volume":"270","author":"Stapleton","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0210","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1073\/pnas.94.10.4925","article-title":"Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone","volume":"94","author":"Rose","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0215","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0014-5793(93)80736-E","article-title":"In vivo biosynthesis of cholesterol in the rat retina","volume":"335","author":"Fliesler","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0220","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1006\/bbrc.1995.1715","article-title":"Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye","volume":"210","author":"Fliesler","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0225","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1023\/A:1007519321917","article-title":"Retinal structure and function in an animal model that replicates the biochemical hallmarks of desmosterolosis","volume":"25","author":"Fliesler","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0230","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11745-000-0525-y","article-title":"Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition","volume":"35","author":"Fliesler","year":"2000","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2012.03.001_bb0235","first-page":"1319","article-title":"Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0240","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1751-1097.2009.00568.x","article-title":"Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism","volume":"85","author":"Rodriguez","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0245","article-title":"DHCEO accumulation is a critical mediator of pathophysiology in a Smith\u2013Lemli\u2013Opitz syndrome model","author":"Xu","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0250","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/S0022-2275(20)37148-0","article-title":"7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque","volume":"38","author":"Brown","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0255","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1194\/jlr.R004820","article-title":"Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration","volume":"51","author":"Rodriguez","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0260","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbrc.2007.04.135","article-title":"Differential effects of cholesterol and 7-dehydrocholesterol on the ligand binding activity of the hippocampal serotonin(1A) receptor: implications in SLOS","volume":"358","author":"Singh","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0265","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.bbrc.2007.09.040","article-title":"Differential effects of cholesterol and 7-dehydrocholesterol on ligand binding of solubilized hippocampal serotonin1A receptors: implications in SLOS","volume":"363","author":"Chattopadhyay","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0270","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.bbamem.2008.03.002","article-title":"Signaling by the human serotonin(1A) receptor is impaired in cellular model of Smith\u2013Lemli\u2013Opitz syndrome","volume":"1778","author":"Paila","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2012.03.001_bb0275","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.mol.0000226123.17629.ab","article-title":"Membrane and protein interactions of oxysterols","volume":"17","author":"Massey","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0280","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mam.2009.02.004","article-title":"Interactions of oxysterols with membranes and proteins","volume":"30","author":"Olkkonen","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0285","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/exer.1998.0465","article-title":"Cholesterol oxides accumulate in human cataracts","volume":"66","author":"Girao","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbalip.2012.03.001_bb0290","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1167\/iovs.09-3443","article-title":"Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro","volume":"51","author":"Gramajo","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198112000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198112000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T09:56:46Z","timestamp":1761386206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198112000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1388198112000455"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2012.03.001","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith\u2013Lemli\u2013Opitz syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2012.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}