{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:04:52Z","timestamp":1788930292043,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation (NRF)","doi-asserted-by":"crossref","award":["2010-0004008"],"award-info":[{"award-number":["2010-0004008"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation (NRF)","doi-asserted-by":"crossref","award":["2012-0009853"],"award-info":[{"award-number":["2012-0009853"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.bbalip.2013.01.020","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:02:50Z","timestamp":1360022570000},"page":"1016-1026","source":"Crossref","is-referenced-by-count":52,"title":["Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia"],"prefix":"10.1016","volume":"1831","author":[{"given":"Ji-Sun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong-Oh","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Moon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin A.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinju","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Woong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2013.01.020_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signaling: lesions from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Cell Biol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0010","doi-asserted-by":"crossref","first-page":"27855","DOI":"10.1074\/jbc.R111.254359","article-title":"Many ceramides","volume":"286","author":"Hannun","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0015","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nchembio.392","article-title":"An update on sphingosine-1-phosphate and other sphingolipid mediators","volume":"6","author":"Fyrst","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-511X-9-15","article-title":"Ceramide and ceramide 1-phosphate in health and disease","volume":"9","author":"Arana","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nm977","article-title":"PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide","volume":"10","author":"Goggel","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0035","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1124\/jpet.107.131565","article-title":"Ceramide: a key signaling molecule in a guinea pig model of allergic asthmatic response and airway inflammation","volume":"324","author":"Masini","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2567.2007.02612.x","article-title":"Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis","volume":"122","author":"Sakata","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0045","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1189\/jlb.0108076","article-title":"Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide","volume":"83","author":"Sun","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0050","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.4049\/jimmunol.0902926","article-title":"Ceramide and ceramide 1-phosphate are negative regulators of TNF-\u03b1 production induced by lipopolysaccharide","volume":"185","author":"Jozefowski","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0055","doi-asserted-by":"crossref","first-page":"21103","DOI":"10.1074\/jbc.M109.080671","article-title":"Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor \u03b1 (TNF\u03b1)-converting enzyme activity and TNF\u03b1 secretion in macrophages","volume":"285","author":"Rozenova","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0060","doi-asserted-by":"crossref","first-page":"42808","DOI":"10.1074\/jbc.M111.310169","article-title":"Ceramide kinase regulates the production of tumor necrosis factor \u03b1 (TNF\u03b1) via inhibition of TNF\u03b1-converting enzyme","volume":"286","author":"Lamour","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0065","doi-asserted-by":"crossref","first-page":"44357","DOI":"10.1074\/jbc.M111.264010","article-title":"Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression","volume":"286","author":"Hankins","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0070","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1523\/JNEUROSCI.4158-11.2011","article-title":"The role of microglia in the healthy brain","volume":"31","author":"Tremblay","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00401-009-0622-0","article-title":"Microglia: biology and pathology","volume":"119","author":"Graeber","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0080","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00702-010-0428-1","article-title":"Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy","volume":"117","author":"Qian","year":"2010","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0085","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Idecola","year":"2011","journal-title":"Nat. Rev. Med."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0090","doi-asserted-by":"crossref","first-page":"e612","DOI":"10.1371\/journal.pone.0000612","article-title":"Neuronal conduction of excitation without action potentials based on ceramide production","volume":"2","author":"Fasano","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-4020-8831-5_9","article-title":"Altered lipid metabolism in brain injury and disorders","volume":"49","author":"Adibhatla","year":"2008","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0100","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/jnr.490310405","article-title":"An immortalized cell line expresses properties of activated microglial cells","volume":"31","author":"Bocchini","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2009.01.020","article-title":"Anti-inflammatory mechanism of ginseng saponins in activated microglia","volume":"209","author":"Park","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0110","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/glia.20225","article-title":"Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation","volume":"52","author":"Qin","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/jpet.111.189035","article-title":"Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice","volume":"341","author":"Park","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0120","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1074\/jbc.M110699200","article-title":"Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line","volume":"277","author":"Ogretmen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0125","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10059-011-1034-2","article-title":"C6-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides","volume":"32","author":"Choi","year":"2011","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0130","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000068491","article-title":"Ceramide 1-phosphate formation in neutrophils","volume":"109","author":"Rile","year":"2002","journal-title":"Acta Haematol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0135","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2010.01.037","article-title":"Selective transcription in response to an inflammatory stimulus","volume":"140","author":"Smale","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0140","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/tx700210j","article-title":"Oxidative stress and neurotoxicity","volume":"2","author":"Sayre","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0145","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4062\/biomolther.2012.20.2.144","article-title":"Regulation of Nrf2-mediated phase II detoxification and anti-oxidant genes","volume":"20","author":"Keum","year":"2012","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0150","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1471-4159.2008.05864.x","article-title":"The CREB\/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death","volume":"108","author":"Lee","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0155","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1471-4159.2010.07075.x","article-title":"Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A and hemeoxygenase-1 expression","volume":"115","author":"Jung","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0160","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.4049\/jimmunol.166.9.5388","article-title":"Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors","volume":"166","author":"Hsu","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0165","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1084\/jem.186.11.1831","article-title":"Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation","volume":"186","author":"Haimovitz-Friedman","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0175","doi-asserted-by":"crossref","first-page":"17606","DOI":"10.1016\/S0021-9258(17)32484-5","article-title":"Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells","volume":"269","author":"Joseph","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0180","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1462-5822.2006.00867.x","article-title":"Ceramide as a TLR4 agonist; a putative signaling intermediate between sphingolipid receptors for microbial ligands and TLR4","volume":"9","author":"Fischer","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0185","doi-asserted-by":"crossref","first-page":"37041","DOI":"10.1074\/jbc.M305213200","article-title":"Reciprocal modulation of toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase\/AKT by saturated and polyunsaturated fatty acids","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0190","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.plipres.2012.02.003","article-title":"Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs","volume":"51","author":"Im","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0195","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.4049\/jimmunol.173.6.3589","article-title":"Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-\u03baB","volume":"173","author":"Park","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0200","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/CIRCRESAHA.108.181040","article-title":"Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4 and spleen tyrosine kinase-dependent activation of NADPH oxidase","volume":"104","author":"Bae","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuropharm.2004.03.019","article-title":"A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia","volume":"47","author":"Kim","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbalip.2013.01.020_bb0210","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1084\/jem.20060845","article-title":"Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts","volume":"203","author":"Nakahira","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0215","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1194\/jlr.M300347-JLR200","article-title":"The structural requirement for ceramide activation of serine-threonine protein phosphatases","volume":"45","author":"Chalfant","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0220","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1194\/jlr.M025395","article-title":"Identification and characterization of protein phosphatase 2C activation by ceramide","volume":"53","author":"Perry","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0225","doi-asserted-by":"crossref","first-page":"13169","DOI":"10.1074\/jbc.271.22.13169","article-title":"Ceramide inactivates cellular protein kinase C alpha","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.01.020_bb0230","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1172\/JCI57144","article-title":"Ceramides as modulators of cellular and whole-body metabolism","volume":"121","author":"Bikman","year":"2011","journal-title":"J. Clin. Invest."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198113000395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198113000395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T13:29:19Z","timestamp":1644240559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198113000395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1388198113000395"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2013.01.020","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}