{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:42:54Z","timestamp":1757310174686},"reference-count":51,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"Austrian Science Fund","award":["F3003","P24005","W901 DK"],"award-info":[{"award-number":["F3003","P24005","W901 DK"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.bbalip.2013.07.004","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T06:00:29Z","timestamp":1373868029000},"page":"1600-1608","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cardiac oxidative stress in a mouse model of neutral lipid storage disease"],"prefix":"10.1016","volume":"1831","author":[{"given":"Astrid","family":"Schrammel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Mussbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenter","family":"Haemmerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Stessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"W\u00f6lkart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Zechner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2013.07.004_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2009.03.011","article-title":"As a matter of fat","volume":"10","author":"Brookheart","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0010","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cardiores.2006.03.016","article-title":"NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure","volume":"71","author":"Murdoch","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0015","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI21968","article-title":"Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load","volume":"115","author":"Takimoto","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0020","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.0000144303.24894.1C","article-title":"Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?","volume":"110","author":"Engberding","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0025","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.freeradbiomed.2008.11.020","article-title":"Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: involvement of mitochondrial and NAD(P)H oxidase systems","volume":"46","author":"Feillet-Coudray","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0030","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s00125-006-0229-0","article-title":"Cardiac contractile dysfunction in Lep\/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch","volume":"49","author":"Li","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0035","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0040","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0045","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0050","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1123965","article-title":"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase","volume":"312","author":"Haemmerle","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0055","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1476-5381.2011.01490.x","article-title":"Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARalpha agonist","volume":"165","author":"W\u00f6lkart","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0060","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/MCB.06470-11","article-title":"Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction","volume":"32","author":"Kienesberger","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0065","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1194\/jlr.M001073","article-title":"Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids","volume":"51","author":"Schoiswohl","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1165\/ajrcmb.25.2.4235","article-title":"Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin","volume":"25","author":"Oury","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0075","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/hh1701.096037","article-title":"Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(\u2212) and systolic blood pressure in mice","volume":"89","author":"Rey","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0080","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1074\/jbc.273.4.2015","article-title":"Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems","volume":"273","author":"Li","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0085","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0028-3908(94)90024-8","article-title":"Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole","volume":"33","author":"Mayer","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0090","series-title":"Meth Enzym Anal","first-page":"379","article-title":"Guanylate cyclase. GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2","author":"Schultz","year":"1984"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(89)90536-0","article-title":"Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells","volume":"170","author":"Schmidt","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0105","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","article-title":"Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction","volume":"110","author":"Sharma","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCHEARTFAILURE.112.971168","article-title":"Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis","volume":"6","author":"Yu","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0115","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1002\/j.1460-2075.1996.tb01078.x","article-title":"Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme","volume":"15","author":"Friebe","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0120","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/01.RES.87.11.999","article-title":"Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide\/cGMP signaling and endothelial dysfunction","volume":"87","author":"Oelze","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2005.01.014","article-title":"Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes","volume":"511","author":"Bitar","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0130","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI200314172","article-title":"Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension","volume":"111","author":"Landmesser","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0135","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/ATVBAHA.107.160754","article-title":"Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus","volume":"28","author":"Sasaki","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0140","doi-asserted-by":"crossref","first-page":"23471","DOI":"10.1016\/S0021-9258(17)31540-5","article-title":"Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo","volume":"269","author":"Faulkner","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0145","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0014-5793(96)00087-7","article-title":"Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger","volume":"381","author":"Szabo","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0150","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0735-1097(03)00471-6","article-title":"Increased myocardial NADPH oxidase activity in human heart failure","volume":"41","author":"Heymes","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0160","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1016\/S0021-9258(17)41797-2","article-title":"Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages","volume":"269","author":"Sato","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0165","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0170","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1172\/JCI200317592","article-title":"Critical role of galectin-3 in phagocytosis by macrophages","volume":"112","author":"Sano","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0175","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.165.4.2156","article-title":"Human galectin-3 is a novel chemoattractant for monocytes and macrophages","volume":"165","author":"Sano","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0180","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.yjmcc.2011.05.017","article-title":"Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure","volume":"51","author":"Moens","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.freeradbiomed.2004.11.004","article-title":"Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide\u2014a role for GFRP?","volume":"38","author":"Kalivendi","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0190","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nm.2439","article-title":"ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1","volume":"17","author":"Haemmerle","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0195","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvn001","article-title":"Cardiac hypertrophy is enhanced in PPAR alpha\u2212\/\u2212 mice in response to chronic pressure overload","volume":"78","author":"Smeets","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0200","first-page":"H93","article-title":"Role of oxidative stress in cardiac dysfunction of PPARalpha\u2212\/\u2212 mice","volume":"293","author":"Guellich","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0205","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1582-4934.2006.tb00304.x","article-title":"Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells","volume":"10","author":"Moe","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.0408230","article-title":"Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC","volume":"87","author":"Kilpatrick","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pharmthera.2009.08.001","article-title":"Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO* and beyond","volume":"124","author":"Ritchie","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0220","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/10715769309145868","article-title":"The reaction of no with superoxide","volume":"18","author":"Huie","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0225","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1021\/bi00184a036","article-title":"Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states","volume":"33","author":"Stone","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2013.07.004_bb0230","doi-asserted-by":"crossref","first-page":"23852","DOI":"10.1074\/jbc.M111.328708","article-title":"Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation","volume":"287","author":"Kuramoto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0235","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cardiores.2007.06.027","article-title":"Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage","volume":"76","author":"Ding","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0240","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.freeradbiomed.2008.09.042","article-title":"Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy","volume":"46","author":"Batinic-Haberle","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0245","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jpba.2008.08.005","article-title":"Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic\/therapeutic purposes","volume":"48","author":"Reboucas","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0250","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1139\/Y10-063","article-title":"Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species","volume":"88","author":"Liu","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbalip.2013.07.004_bb0255","first-page":"H2223","article-title":"The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet","volume":"295","author":"Chess","year":"2008","journal-title":"Am. J. Physiol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819811300142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138819811300142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T23:58:04Z","timestamp":1646092684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138819811300142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S138819811300142X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2013.07.004","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac oxidative stress in a mouse model of neutral lipid storage disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2013.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}