{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:02:37Z","timestamp":1793977357884,"version":"4.8.0"},"reference-count":135,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bbalip.2013.08.011","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T04:31:22Z","timestamp":1377577882000},"page":"422-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":238,"title":["Ceramide synthesis in the epidermis"],"prefix":"10.1016","volume":"1841","author":[{"given":"Mariona","family":"Rabionet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Gorgas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Sandhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2013.08.011_bb0005","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/BJ20111626","article-title":"Ceramide synthases at the centre of sphingolipid metabolism and biology","volume":"441","author":"Mullen","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0010","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1007\/s00018-007-7076-0","article-title":"The metabolism and function of sphingolipids and glycosphingolipids","volume":"64","author":"Lahiri","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbagen.2007.08.015","article-title":"Structure and function of glycosphingolipids and sphingolipids: recollections and future trends","volume":"1780","author":"Hakomori","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0020","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1016\/j.febslet.2006.08.039","article-title":"Epidermal sphingolipids: metabolism, function, and roles in skin disorders","volume":"580","author":"Holleran","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-2275(20)41520-2","article-title":"Lipid and protein structures in the permeability barrier of mammalian epidermis","volume":"33","author":"Downing","year":"1992","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0030","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/hmg\/ddr494","article-title":"Loss of ceramide synthase 3 causes lethal skin barrier disruption","volume":"21","author":"Jennemann","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1523-1747.2002.01846.x","article-title":"Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus","volume":"119","author":"Arikawa","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0040","doi-asserted-by":"crossref","first-page":"36624","DOI":"10.1074\/jbc.M807377200","article-title":"ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters","volume":"283","author":"Zuo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0045","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1038\/jid.2013.153","article-title":"Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length","volume":"133","author":"Eckl","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0050","doi-asserted-by":"crossref","first-page":"e1003536","DOI":"10.1371\/journal.pgen.1003536","article-title":"Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans","volume":"9","author":"Radner","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0055","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s004030050240","article-title":"Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis","volume":"289","author":"Geilen","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000056356","article-title":"Sphingolipid signaling in epidermal homeostasis. Current knowledge and new therapeutic approaches in dermatology","volume":"14","author":"Geilen","year":"2001","journal-title":"Skin Pharmacol. Appl. Ski. Physiol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0065","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1194\/jlr.M100442-JLR200","article-title":"Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress","volume":"43","author":"Uchida","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0070","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1046\/j.1523-1747.2003.12098.x","article-title":"De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes","volume":"120","author":"Uchida","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-2275(20)38005-6","article-title":"Human stratum corneum lipids: characterization and regional variations","volume":"24","author":"Lampe","year":"1983","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0080","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/jid.2011.175","article-title":"Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema","volume":"131","author":"Janssens","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","article-title":"Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?","volume":"96","author":"Imokawa","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0925-4439(93)90135-N","article-title":"Ceramide composition of the psoriatic scale","volume":"1182","author":"Motta","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/jid.2013.199","article-title":"Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model","author":"Nakajima","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0100","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1523-1747.2002.01833.x","article-title":"Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis","volume":"119","author":"Macheleidt","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00128071-200304020-00004","article-title":"Ceramides and skin function","volume":"4","author":"Coderch","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000321084","article-title":"Inherited clinical disorders of lipid metabolism","volume":"39","author":"Elias","year":"2010","journal-title":"Curr. Probl. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0115","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1172\/JCI111552","article-title":"Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis","volume":"74","author":"Elias","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1523-1747.ep12497842","article-title":"Antimicrobial activity of sphingosines","volume":"98","author":"Bibel","year":"1992","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0125","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1194\/jlr.M800014-JLR200","article-title":"Characterization of overall ceramide species in human stratum corneum","volume":"49","author":"Masukawa","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0130","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1194\/jlr.R800012-JLR200","article-title":"Biodiversity of sphingoid bases (\u201csphingosines\u201d) and related amino alcohols","volume":"49","author":"Pruett","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0135","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jchromb.2007.02.030","article-title":"Separation and mass spectrometric characterization of covalently bound skin ceramides using LC\/APCI-MS and nano-ESI-MS\/MS","volume":"852","author":"Farwanah","year":"2007","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0140","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/1523-1747.ep12323736","article-title":"Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines","volume":"105","author":"Stewart","year":"1995","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0145","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/S0022-2275(20)39952-1","article-title":"6-Hydroxy-4-sphingenine in human epidermal ceramides","volume":"35","author":"Robson","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/ac202646v","article-title":"Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry","volume":"84","author":"t'Kindt","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0155","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0022-2275(20)37950-5","article-title":"Ceramides of pig epidermis: structure determination","volume":"24","author":"Wertz","year":"1983","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0160","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1074\/jbc.273.28.17763","article-title":"Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope","volume":"273","author":"Marekov","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0165","series-title":"1-O-Acylceramides are natural components of human and mouse epidermis","author":"Rabionet","year":"2013"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20100462","article-title":"Current understanding of fatty acid biosynthesis and the acyl carrier protein","volume":"430","author":"Chan","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0175","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","article-title":"The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice","volume":"49","author":"Guillou","year":"2010","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0180","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.plipres.2006.01.004","article-title":"Fatty acid elongases in mammals: their regulation and roles in metabolism","volume":"45","author":"Jakobsson","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0185","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0190","doi-asserted-by":"crossref","first-page":"12843","DOI":"10.1073\/pnas.0802607105","article-title":"Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids","volume":"105","author":"Agbaga","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0195","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.00192-13","article-title":"Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production","volume":"33","author":"Sassa","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0200","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2008.06.007","article-title":"Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis","volume":"582","author":"Ikeda","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0205","doi-asserted-by":"crossref","first-page":"120","DOI":"10.7150\/ijbs.3.120","article-title":"Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice","volume":"3","author":"Li","year":"2007","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0210","first-page":"258","article-title":"Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4","volume":"13","author":"McMahon","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0215","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/hmg\/ddl480","article-title":"Loss of functional ELOVL4 depletes very long-chain fatty acids (> or = C28) and the unique omega-O-acylceramides in skin leading to neonatal death","volume":"16","author":"Vasireddy","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7150\/ijbs.3.111","article-title":"Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival","volume":"3","author":"Cameron","year":"2007","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0225","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1074\/jbc.M310529200","article-title":"Role for ELOVL3 and fatty acid chain length in development of hair and skin function","volume":"279","author":"Westerberg","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1471-4159.1974.tb11587.x","article-title":"The fatty acid composition of sphingolipids from bovine CNS axons and myelin","volume":"22","author":"DeVries","year":"1974","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0235","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/1523-1747.ep12471781","article-title":"Composition and morphology of epidermal cyst lipids","volume":"89","author":"Wertz","year":"1987","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0240","doi-asserted-by":"crossref","first-page":"27310","DOI":"10.1074\/jbc.M502775200","article-title":"Novel class of glycosphingolipids involved in male fertility","volume":"280","author":"Sandhoff","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0245","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-2275(20)40339-6","article-title":"Occurrence of 2-hydroxy fatty acids in animal tissues","volume":"4","author":"Kishimoto","year":"1963","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0250","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0458-08.2008","article-title":"Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration","volume":"28","author":"Zoller","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0255","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BJ20041451","article-title":"A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin","volume":"388","author":"Eckhardt","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0260","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1194\/jlr.M800158-JLR200","article-title":"Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models","volume":"49","author":"Mizutani","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0265","doi-asserted-by":"crossref","first-page":"13211","DOI":"10.1074\/jbc.M611562200","article-title":"Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation","volume":"282","author":"Uchida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0270","doi-asserted-by":"crossref","first-page":"25922","DOI":"10.1074\/jbc.M111.231977","article-title":"Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands","volume":"286","author":"Maier","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0275","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ejhg.2011.222","article-title":"Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration","volume":"20","author":"Pierson","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0280","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1074-5521(02)00139-4","article-title":"Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid","volume":"9","author":"Mukherji","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0285","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/1523-1747.ep12258532","article-title":"Epidermal metabolism in heredopathia atactica polyneuritiformis (Refsum's disease)","volume":"70","author":"Dykes","year":"1978","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0290","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/014107689108400919","article-title":"Cutaneous aspects of Refsum's disease","volume":"84","author":"Ramsay","year":"1991","journal-title":"J. R. Soc. Med."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0295","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bbalip.2011.06.006","article-title":"Phytanic acid metabolism in health and disease","volume":"1811","author":"Wanders","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0300","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/03602530701468573","article-title":"Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation","volume":"39","author":"Hsu","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0305","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1523-1747.2000.00846.x","article-title":"Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function","volume":"114","author":"Behne","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0310","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/ddi491","article-title":"Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3","volume":"15","author":"Lefevre","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0315","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jdermsci.2011.12.006","article-title":"CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development","volume":"65","author":"Sasaki","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0320","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1388-1981(03)00059-3","article-title":"Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism","volume":"1632","author":"Hanada","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0325","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.bbamcr.2013.04.010","article-title":"The complexity of sphingolipid biosynthesis in the endoplasmic reticulum","volume":"1833","author":"Tidhar","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0330","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1073\/pnas.0811269106","article-title":"Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities","volume":"106","author":"Han","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0335","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1073\/pnas.91.17.7899","article-title":"The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis","volume":"91","author":"Nagiec","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0340","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1074\/jbc.M109.092973","article-title":"Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids","volume":"285","author":"Penno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0345","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.biochi.2009.04.001","article-title":"Ceramide biosynthesis in keratinocyte and its role in skin function","volume":"91","author":"Mizutani","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0350","doi-asserted-by":"crossref","first-page":"43452","DOI":"10.1074\/jbc.M307104200","article-title":"Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors","volume":"278","author":"Riebeling","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0355","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20050291","article-title":"Mammalian Lass6 and its related family members regulate synthesis of specific ceramides","volume":"390","author":"Mizutani","year":"2005","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0360","doi-asserted-by":"crossref","first-page":"35642","DOI":"10.1074\/jbc.M205211200","article-title":"Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1(LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells","volume":"277","author":"Venkataraman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0365","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1074\/jbc.M707386200","article-title":"Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate","volume":"283","author":"Laviad","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0370","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/BJ20060379","article-title":"LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity","volume":"398","author":"Mizutani","year":"2006","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0375","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1074\/jbc.M800870200","article-title":"Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3","volume":"283","author":"Rabionet","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0380","doi-asserted-by":"crossref","first-page":"25512","DOI":"10.1074\/jbc.M202947200","article-title":"Identification and characterization of a sphingolipid delta 4-desaturase family","volume":"277","author":"Ternes","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0385","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2007.01.002","article-title":"Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance","volume":"5","author":"Holland","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0390","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/BJ20051938","article-title":"Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5","volume":"397","author":"Enomoto","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0395","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-5793(04)00274-1","article-title":"Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation","volume":"563","author":"Mizutani","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0400","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/bj20031425","article-title":"DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine","volume":"379","author":"Omae","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0405","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/00015559850135788","article-title":"Ceramide and cholesterol composition of the skin of patients with atopic dermatitis","volume":"78","author":"Di Nardo","year":"1998","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0410","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1074\/jbc.M610304200","article-title":"Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis","volume":"282","author":"Jennemann","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0415","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1523-1747.2000.00081.x","article-title":"Permeability barrier disorder in Niemann\u2013Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis","volume":"115","author":"Schmuth","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0420","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/357407a0","article-title":"Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene","volume":"357","author":"Tybulewicz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0425","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddt264","article-title":"Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing","author":"Amen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0430","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1523-1747.2002.01836.x","article-title":"Human epidermal glucosylceramides are major precursors of stratum corneum ceramides","volume":"119","author":"Hamanaka","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0435","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0022-2275(20)32369-5","article-title":"Epidermal sphingomyelins are precursors for selected stratum corneum ceramides","volume":"41","author":"Uchida","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0440","series-title":"Stratum Corneum Ceramides: Function, Origins, and Therapeutic Applications, Skin Barrier","first-page":"43","author":"Uchida","year":"2006"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0445","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0005-2760(86)90033-0","article-title":"Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice","volume":"876","author":"Wertz","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0450","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/S0022-2275(20)42327-2","article-title":"Metabolism of linoleic acid in porcine epidermis","volume":"31","author":"Wertz","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0455","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1074\/jbc.M109.081877","article-title":"Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)","volume":"285","author":"Radner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0460","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/sj.jid.5700332","article-title":"Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin\u2013Dorfman syndrome)","volume":"126","author":"Demerjian","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0465","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/jid.2010.145","article-title":"Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman\u2013Chanarin syndrome","volume":"130","author":"Uchida","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0470","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","article-title":"Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin\u2013Dorfman syndrome","volume":"3","author":"Lass","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0475","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4161\/derm.3.2.15472","article-title":"Fat in the skin: triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease","volume":"3","author":"Radner","year":"2011","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0480","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.1074\/jbc.M311000200","article-title":"Lipopenia and skin barrier abnormalities in DGAT2-deficient mice","volume":"279","author":"Stone","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0485","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2007-8-6-r107","article-title":"Large-scale identification of human genes implicated in epidermal barrier function","volume":"8","author":"Toulza","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0490","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/BJ20120712","article-title":"A novel pathway of ceramide metabolism in Saccharomyces cerevisiae","volume":"447","author":"Voynova","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0495","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1074\/jbc.M111.251496","article-title":"Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope","volume":"286","author":"Zheng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0500","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1194\/jlr.M600001-JLR200","article-title":"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis","volume":"47","author":"Houben","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0505","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1074\/jbc.274.16.11038","article-title":"Sphingolipid activator proteins are required for epidermal permeability barrier formation","volume":"274","author":"Doering","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0510","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-5793(99)00274-4","article-title":"Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase deficient type 2 Gaucher mice","volume":"447","author":"Doering","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0515","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1172\/JCI117160","article-title":"Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease","volume":"93","author":"Holleran","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0520","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1073\/pnas.96.15.8402","article-title":"A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation","volume":"96","author":"Nemes","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0525","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1600-0625.2001.110308.x","article-title":"Basis for the permeability barrier abnormality in lamellar ichthyosis","volume":"11","author":"Elias","year":"2002","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0530","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2007.06.031","article-title":"A molecular caliper mechanism for determining very long-chain fatty acid length","volume":"130","author":"Denic","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0535","doi-asserted-by":"crossref","first-page":"e67317","DOI":"10.1371\/journal.pone.0067317","article-title":"Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation","volume":"8","author":"Mizutani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0540","series-title":"Ceramide Synthase 3 and its Essential Role in Skin Barrier Function and Male Fertility, Dissertation","author":"Rabionet","year":"2011"},{"issue":"Pt 3","key":"10.1016\/j.bbalip.2013.08.011_bb0545","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1042\/bj2900751","article-title":"The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver","volume":"290","author":"Hirschberg","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0550","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbalip.2005.04.001","article-title":"Molecular mechanisms and regulation of ceramide transport","volume":"1734","author":"Perry","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt 2","key":"10.1016\/j.bbalip.2013.08.011_bb0555","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/bj2800295","article-title":"Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver","volume":"280","author":"Futerman","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0560","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbalip.2009.01.006","article-title":"CERT-mediated trafficking of ceramide","volume":"1791","author":"Hanada","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0565","doi-asserted-by":"crossref","first-page":"16682","DOI":"10.1074\/jbc.M800799200","article-title":"Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation","volume":"283","author":"Charruyer","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0570","series-title":"The Epidermal Lamellar Body as a Multifunctional Secretory Organelle, Skin Barrier","first-page":"261","author":"Elias","year":"2006"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0575","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.0022-202X.2004.22515.x","article-title":"Epidermal lamellar granules transport different cargoes as distinct aggregates","volume":"122","author":"Ishida-Yamamoto","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0580","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1172\/JCI24834","article-title":"Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer","volume":"115","author":"Akiyama","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0585","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1086\/429844","article-title":"Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis","volume":"76","author":"Kelsell","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0590","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1194\/jlr.M006445","article-title":"Regulation of ABCG1 expression in human keratinocytes and murine epidermis","volume":"51","author":"Jiang","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0595","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/jid.2012.100","article-title":"GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier","volume":"132","author":"Tarutani","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0600","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1074\/mcp.M700334-MCP200","article-title":"Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking\/secretion","volume":"7","author":"Raymond","year":"2008","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0605","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrm1664","article-title":"CLIPs and CLASPs and cellular dynamics","volume":"6","author":"Galjart","year":"2005","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0610","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1523-1747.2003.12359.x","article-title":"Barrier function of the skin: \u201cla raison d'etre\u201d of the epidermis","volume":"121","author":"Madison","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0615","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1086\/432556","article-title":"A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma","volume":"77","author":"Sprecher","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0620","first-page":"610","article-title":"CEDNIK syndrome results from loss-of-function mutations in SNAP29","volume":"164","author":"Fuchs-Telem","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0625","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1242\/dmm.007146","article-title":"Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis","volume":"4","author":"Li","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0630","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jid.2012.250","article-title":"Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation","volume":"133","author":"Krieg","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0635","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0005-2760(89)90289-0","article-title":"Free sphingosines in porcine epidermis","volume":"1002","author":"Wertz","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2013.08.011_bb0640","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.jid.5700046","article-title":"Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing","volume":"126","author":"Man","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0645","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/sj.jid.5701026","article-title":"Deficiency of PPARbeta\/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation","volume":"128","author":"Man","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0650","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1046\/j.0022-202x.2001.01555.x","article-title":"Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures","volume":"117","author":"Uchida","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0655","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/jid.2008.380","article-title":"Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation","volume":"129","author":"Oda","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0660","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/jid.2013.39","article-title":"Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles","volume":"133","author":"Borkowski","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0665","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1515\/BC.2007.046","article-title":"Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1\u2212\/\u2212) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation","volume":"388","author":"Binczek","year":"2007","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0670","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/jid.2011.301","article-title":"TCF\/Lef1-mediated control of lipid metabolism regulates skin barrier function","volume":"132","author":"Fehrenschild","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbalip.2013.08.011_bb0675","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/jid.2012.358","article-title":"Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development","volume":"133","author":"Wang","year":"2013","journal-title":"J. Investig. Dermatol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198113001716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198113001716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T17:51:49Z","timestamp":1646416309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198113001716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":135,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1388198113001716"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2013.08.011","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ceramide synthesis in the epidermis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2013.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}