{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:30:04Z","timestamp":1790695804380,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["P22838-B13"],"award-info":[{"award-number":["P22838-B13"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.bbalip.2014.03.014","type":"journal-article","created":{"date-parts":[[2014,4,6]],"date-time":"2014-04-06T09:02:20Z","timestamp":1396774940000},"page":"944-953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production"],"prefix":"10.1016","volume":"1841","author":[{"given":"Stefanie","family":"Fruhw\u00fcrth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mikula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weichhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hengstschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Stangl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2014.03.014_bb0005","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJM198911093211907","article-title":"High-density lipoprotein\u2014the clinical implications of recent studies","volume":"321","author":"Gordon","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bbalip.2014.03.014_bb0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1194\/jlr.R039297","article-title":"Cardioprotective functions of HDL","volume":"55","author":"Rye","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0015","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature06796","article-title":"Translating molecular discoveries into new therapies for atherosclerosis","volume":"451","author":"Rader","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/MOL.0b013e32832afd63","article-title":"Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins","volume":"20","author":"von Eckardstein","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0025","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0035","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1042\/BST0390495","article-title":"Regulation of the SREBP transcription factors by mTORC1","volume":"39","author":"Lewis","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0040","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0045","doi-asserted-by":"crossref","first-page":"R1046","DOI":"10.1016\/j.cub.2009.09.058","article-title":"An emerging role of mTOR in lipid biosynthesis","volume":"19","author":"Laplante","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/ajhp\/61.6.565","article-title":"Drug-related dyslipidemia after renal transplantation","volume":"61","author":"Mathis","year":"2004","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0055","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1097\/00007890-200206270-00013","article-title":"The changing causes of graft loss and death after kidney transplantation","volume":"73","author":"Howard","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0060","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1600-6143.2008.02272.x","article-title":"Mammalian target of rapamycin inhibitor dyslipidemia in kidney transplant recipients","volume":"8","author":"Kasiske","year":"2008","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0065","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI61919","article-title":"Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice","volume":"122","author":"Ai","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0070","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1034\/j.1600-6143.2003.00094.x","article-title":"Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice","volume":"3","author":"Elloso","year":"2003","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0075","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.2337\/db06-0173","article-title":"Sirolimus is associated with reduced islet engraftment and impaired beta-cell function","volume":"55","author":"Zhang","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0080","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MOL.0b013e328357ba61","article-title":"Functions of scavenger receptor class B, type I in atherosclerosis","volume":"23","author":"Mineo","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0085","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/CIRCRESAHA.108.190587","article-title":"High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1","volume":"104","author":"Rohrer","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0090","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1194\/jlr.R039479","article-title":"Regulation of signal transduction by HDL","volume":"54","author":"Mineo","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0095","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/89986","article-title":"High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase","volume":"7","author":"Yuhanna","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tcm.2007.03.005","article-title":"Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair","volume":"17","author":"Mineo","year":"2007","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0105","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1074\/jbc.M211394200","article-title":"High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases","volume":"278","author":"Mineo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0110","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0076-6879(86)28066-0","article-title":"Sequential flotation ultracentrifugation","volume":"128","author":"Schumaker","year":"1986","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0115","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2174\/138920112799095338","article-title":"Combined light and electron microscopy using diaminobenzidine photooxidation to monitor trafficking of lipids derived from lipoprotein particles","volume":"13","author":"Rohrl","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/01.ATV.1.3.177","article-title":"Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy","volume":"1","author":"Pitas","year":"1981","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0125","doi-asserted-by":"crossref","first-page":"32692","DOI":"10.1074\/jbc.274.46.32692","article-title":"Transport of lipids from high and low density lipoproteins via scavenger receptor-BI","volume":"274","author":"Stangl","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1248\/cpb.46.373","article-title":"Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore","volume":"46","author":"Kojima","year":"1998","journal-title":"Pharm. Bull."},{"issue":"4","key":"10.1016\/j.bbalip.2014.03.014_bb0135","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cmet.2013.08.002","article-title":"A Central Role for mTOR in Lipid Homeostasis","volume":"18","author":"Lamming","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"Sarbassov","year":"2006","journal-title":"Mol. Cell"},{"issue":"40","key":"10.1016\/j.bbalip.2014.03.014_bb0145","doi-asserted-by":"crossref","first-page":"16184","DOI":"10.1073\/pnas.1213343109","article-title":"Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase","volume":"109","author":"Owen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.atherosclerosis.2011.05.036","article-title":"Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism","volume":"217","author":"Leiva","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/ATVBAHA.111.238063","article-title":"The beta-chain of cell surface F(0)F(1) ATPase modulates apoA-I and HDL transcytosis through aortic endothelial cells","volume":"32","author":"Cavelier","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature01250","article-title":"Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis","volume":"421","author":"Martinez","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbalip.2014.03.014_bb0165","doi-asserted-by":"crossref","first-page":"11991","DOI":"10.1074\/jbc.M109.066621","article-title":"Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1","volume":"285","author":"Moss","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0170","doi-asserted-by":"crossref","first-page":"H2045","DOI":"10.1152\/ajpheart.01089.2002","article-title":"Sphingosine 1-phosphate and control of vascular tone","volume":"284","author":"Dantas","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/CIRCRESAHA.108.181610","article-title":"Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness","volume":"103","author":"Levkau","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.RES.0000199272.59432.5b","article-title":"High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I","volume":"98","author":"Seetharam","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0185","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cmet.2011.03.023","article-title":"Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase","volume":"13","author":"Ouimet","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2014.03.014_bb0190","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1476-5381.2008.00080.x","article-title":"Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor","volume":"156","author":"Zhao","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbalip.2014.03.014_bb0195","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MOL.0b013e328357ba61","article-title":"Functions of scavenger receptor class B, type I in atherosclerosis","volume":"23","author":"Mineo","year":"2012","journal-title":"Curr. Opin. Lipidol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198114000675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198114000675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:37:00Z","timestamp":1565339820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198114000675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1388198114000675"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2014.03.014","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2014.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}