{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:15:52Z","timestamp":1791137752301,"version":"4.1.0"},"reference-count":173,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Inserm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002944","name":"INRA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"French Ministry of Higher Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LISA Carnot Institute"},{"name":"IBiSA Functional Lipidomics platform"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.bbalip.2014.09.013","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T21:15:52Z","timestamp":1411938952000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis"],"prefix":"10.1016","volume":"1851","author":[{"given":"Michel","family":"Guichardant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Calzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bernoud-Hubac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lagarde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"V\u00e9ricel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2014.09.013_bb0005","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.CIR.23.1.133","article-title":"Dietary fat ant its relation to heart attacks and strokes","volume":"23","author":"Page","year":"1961","journal-title":"Circulation"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.0954-6820.1972.tb04782.x","article-title":"Plasma lipids and lipoproteins in Greenlandic west coast Eskimos","volume":"192","author":"Bang","year":"1972","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0020","first-page":"227","article-title":"Lipid metabolism, atherogenesis, and haemostasis in Eskimos: the role of the prostaglandin-3 family","volume":"8","author":"Dyerberg","year":"1979","journal-title":"Haemostasis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0025","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1056\/NEJM198505093121901","article-title":"The inverse relation between fish consumption and 20-year mortality from coronary heart disease","volume":"312","author":"Kromhout","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0030","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(99)07072-5","article-title":"Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial","volume":"354","author":"Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0035","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1172\/JCI112261","article-title":"Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans","volume":"76","author":"von Schacky","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/bmj.328.7430.30","article-title":"Omega 3 fatty acids and cardiovascular disease\u2014fishing for a natural treatment","volume":"328","author":"Din","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archinternmed.2012.262","article-title":"Korean Meta-analysis Study Group, Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials","volume":"172","author":"Kwak","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0050","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/2012.jama.11374","article-title":"Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis","volume":"308","author":"Rizos","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0055","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1001\/jamainternmed.2013.6638","article-title":"\u03c9-3 fatty acids supplements for secondary prevention of cardiovascular disease: from \u201cno proof of effectiveness\u201d to \u201cproof of no effectiveness\u201d","volume":"173","author":"Messori","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0060","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jamainternmed.2013.12765","article-title":"Clinical trial evidence and use of fish oil supplements","author":"Grey","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0065","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1161\/CIRCULATIONAHA.110.948562","article-title":"OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction","volume":"122","author":"Rauch","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0070","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1003603","article-title":"Alpha Omega Trial Group n-3 fatty acids and cardiovascular events after myocardial infarction","volume":"363","author":"Kromhout","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0075","article-title":"Omega-3 fatty acids in cardiovascular disease\u2014an uphill battle","author":"von Schacky","year":"2014","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0080","doi-asserted-by":"crossref","first-page":"e000506","DOI":"10.1161\/JAHA.113.000506","article-title":"Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic study of atherosclerosis","volume":"2","author":"de Oliveira Otto","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0085","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/134.4.919","article-title":"Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis","volume":"134","author":"Brouwer","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0090","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3945\/ajcn.112.044040","article-title":"\u03b1-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis","volume":"96","author":"Pan","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0095","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1161\/ATVBAHA.111.226118","article-title":"Dietary alpha-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation","volume":"31","author":"Holy","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0021-9150(02)00427-6","article-title":"Dietary alpha-linolenic acid decreases c-reactive protein, serum amyloid a and interleukin-6 in dyslipidaemic patients","volume":"167","author":"Rallidis","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1079\/NRR2005113","article-title":"Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective","volume":"19","author":"Burdge","year":"2006","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0110","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3945\/jn.108.103861","article-title":"Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans","volume":"139","author":"Egert","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00075197-200203000-00002","article-title":"Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man","volume":"5","author":"Brenna","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.plefa.2009.01.004","article-title":"alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans","volume":"80","author":"Brenna","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0125","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1194\/jlr.M035139","article-title":"Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA","volume":"54","author":"Liu","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0130","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2337\/diabetes.51.4.1060","article-title":"Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures","volume":"5","author":"Wahl","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0135","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ajcn\/77.5.1140","article-title":"Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids","volume":"77","author":"James","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0140","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/mnfr.201200706","article-title":"Dietary omega-3 PUFA and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils","volume":"57","author":"Surette","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0145","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/BF02544069","article-title":"Inhibitory effect of stearidonic acid (18:4 n-3) on platelet aggregation and arachidonate oxygenation","volume":"24","author":"Kockmann","year":"1989","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0150","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/jn\/134.6.1406","article-title":"Dietary echium oil increases plasma and neutrophil longchain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans","volume":"134","author":"Surette","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.plefa.2003.11.008","article-title":"The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers","volume":"70","author":"Miles","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0160","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3945\/ajcn.2009.29072","article-title":"Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety","volume":"92","author":"Lemke","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0165","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s11745-008-3215-0","article-title":"Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker","volume":"43","author":"Harris","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0170","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0006-2952(98)00334-7","article-title":"Inhibition of prostaglandin H synthase and activation of 12-lipoxygenase by 8,11,14,17-eicosatetraenoic acid in human endothelial cells and platelets","volume":"57","author":"Croset","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0175","doi-asserted-by":"crossref","first-page":"1645S","DOI":"10.1093\/ajcn\/65.5.1645S","article-title":"N-3 fatty acids and serum lipoproteins: human studies","volume":"65","author":"Harris","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0180","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ajcn\/86.2.324","article-title":"Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men","volume":"86","author":"Kelley","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2006.02.012","article-title":"Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review","volume":"189","author":"Balk","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0190","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2275(20)37258-8","article-title":"Very long-chain omega-3 fatty acids enhance chylomicron clearance in the rat","volume":"38","author":"Harris","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2007.11.008","article-title":"Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives","volume":"197","author":"Harris","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0200","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2046-4053-1-26","article-title":"Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review","volume":"1","author":"Kanji","year":"2012","journal-title":"Syst. Rev."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0205","first-page":"43","article-title":"Effect of sodium restriction and fish oil supplementation on BP and thrombotic risk factors in patients treated with ACE inhibitors","volume":"8","author":"Howe","year":"1994","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0021-9150(93)90254-R","article-title":"The effects of n-3 fatty acids on plasma lipids and lipoproteins and other cardiovascular risk factors in patients with hyperlipidemia","volume":"103","author":"Schmidt","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0215","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1161\/01.ATV.20.8.1990","article-title":"ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype","volume":"20","author":"Minihane","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0220","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/ajcn\/88.3.618","article-title":"Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study","volume":"88","author":"Caslake","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0225","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/ajcn\/71.5.1085","article-title":"Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men","volume":"71","author":"Mori","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0230","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-2275(20)39881-3","article-title":"Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages","volume":"36","author":"Suzukawa","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2337\/diacare.26.1.253","article-title":"Docosahexaenoic acid but not eicosapentaenoic acid increases LDL particle size in treated hypertensive type 2 diabetic patients","volume":"26","author":"Woodman","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0240","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/ajcn\/59.5.1060","article-title":"Effects of varying dietary fat, fish, and fish oils on blood lipids in a randomized controlled trial in men at risk of heart disease","volume":"59","author":"Mori","year":"1994","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0245","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/01.ATV.10.1.85","article-title":"Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans","volume":"10","author":"Abbey","year":"1990","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0250","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.0954-6820.1976.tb08198.x","article-title":"The composition of food consumed by Greenland Eskimos","volume":"200","author":"Bang","year":"1976","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0255","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(71)91658-8","article-title":"Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos","volume":"1","author":"Bang","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1182\/asheducation-2011.1.51","article-title":"The role of platelets in atherothrombosis","volume":"1","author":"Kaplan","year":"2011","journal-title":"Hematology"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0265","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1084\/jem.20012044","article-title":"A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation","volume":"196","author":"Massberg","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0270","first-page":"433","article-title":"Haemostatic function and platelet polyunsaturated fatty acids in Eskimos","volume":"2","author":"Dyerberg","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0275","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11745-997-0055-7","article-title":"The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans","volume":"32","author":"Nelson","year":"1997","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0280","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.ATV.2.2.87","article-title":"Polyunsaturated fatty acids, hyperlipidemia, and thrombosis","volume":"2","author":"Goodnight","year":"1982","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0285","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(80)90995-2","article-title":"Platelet-membrane fatty acids, platelet aggregation, and thromboxane formation during a mackerel diet","volume":"1","author":"Siess","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0290","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0026-0495(95)90111-6","article-title":"Effect of n-3 fatty ethyl ester supplementation on fatty acid composition of the single platelet phospholipids and on platelet functions","volume":"44","author":"Prisco","year":"1995","journal-title":"Metabolism"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0295","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3945\/jn.112.171249","article-title":"Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women","volume":"143","author":"Phang","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0300","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9150(99)00171-9","article-title":"The influence of low intake of n-3 fatty acids on platelets in elderly people","volume":"147","author":"V\u00e9ricel","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0305","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-0032-1333309","article-title":"Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects with cardiovascular disease","volume":"39","author":"McEwen","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0310","first-page":"CD003177","article-title":"Omega 3 fatty acids for prevention and treatment of cardiovascular disease","volume":"18","author":"Hooper","year":"2004","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0315","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2012.10.056","article-title":"Influence of omega-3 polyunsaturated fatty acid-supplementation on platelet aggregation in humans: a meta-analysis of randomized controlled trials","volume":"226","author":"Gao","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0320","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0049-3848(84)90295-0","article-title":"Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid","volume":"36","author":"Driss","year":"1984","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(90)90190-N","article-title":"Functions and tocopherol content of blood platelets from elderly people after low intake of purified eicosapentaenoic acid","volume":"57","author":"Croset","year":"1990","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0330","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/ajcn\/64.4.577","article-title":"Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols","volume":"64","author":"Brossard","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0335","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1096\/fj.09-133421","article-title":"Increasing intakes of the long chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men","volume":"23","author":"Guillot","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0340","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1093\/jn\/126.12.3032","article-title":"Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects","volume":"126","author":"Conquer","year":"1996","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0345","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1248\/bpb.23.1293","article-title":"Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation","volume":"23","author":"Akiba","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0350","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0163-7827(88)90008-2","article-title":"Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function","volume":"27","author":"Lagarde","year":"1988","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0355","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0006-291X(83)80254-X","article-title":"Thromboxane (TX)A3 is formed in human platelets after dietary eicosapentaenoic acid (20:5n-3)","volume":"116","author":"Fisher","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0360","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/bms.1200120905","article-title":"Thromboxane (TX)A3 and prostaglandin (PG)I3 are formed in man after dietary eicosapentaenoic acid: identification and quantification by capillary gas chromatography-electron impact mass spectrometry","volume":"12","author":"Fisher","year":"1985","journal-title":"Biomed. Mass Spectrom."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0365","doi-asserted-by":"crossref","first-page":"2003S","DOI":"10.1093\/ajcn\/87.6.2003S","article-title":"N-3 fatty acids and cardiovascular disease: mechanisms underlying beneficial effects","volume":"87","author":"Jung","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0370","first-page":"1055","article-title":"Prostaglandin endoperoxides and thromboxanes: role in platelets and in vascular and respiratory smooth muscle","volume":"35","author":"Samuelsson","year":"1976","journal-title":"Acta Biol. Med. Ger."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0375","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0005-2760(82)90257-0","article-title":"Interactions between prostaglandin precursors during their oxygenation by human platelets","volume":"713","author":"Boukhchache","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0380","doi-asserted-by":"crossref","first-page":"21692","DOI":"10.1016\/S0021-9258(18)45795-X","article-title":"Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2\/prostaglandin H2 receptor binding and function","volume":"265","author":"Swann","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0385","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1021\/cr2002992","article-title":"Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis","volume":"111","author":"Smith","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0390","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1160\/TH08-02-0084","article-title":"Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects","volume":"100","author":"Larson","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0395","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jacc.2009.08.039","article-title":"Treatment of aspirin-resistant patients with omega-3 fatty acids versus aspirin dose escalation","volume":"55","author":"Lev","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0400","doi-asserted-by":"crossref","first-page":"1671-1678","DOI":"10.1016\/j.jacc.2009.11.080","volume":"55","author":"Gajos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0405","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/01.ATV.13.8.1205","article-title":"Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile. The Atherosclerosis Risk in Communities (ARIC) Study","volume":"13","author":"Shahar","year":"1993","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0410","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/ATVBAHA.111.228593","article-title":"Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI clot)","volume":"31","author":"Gajos","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0415","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2010.07.004","article-title":"Docosapentaenoic acid (22:5n-3): a review of its biological effects","volume":"50","author":"Kaur","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0420","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0090-6980(98)00083-5","article-title":"Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells","volume":"57","author":"Hishinuma","year":"1999","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0425","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0952-3278(96)90010-1","article-title":"Docosapentaenoic acid (22:5n-3): metabolism and effect on prostacyclin production in endothelial cells","volume":"55","author":"B\u00e9nistant","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0430","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1194\/jlr.M047357","article-title":"Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway","volume":"55","author":"Fischer","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0435","doi-asserted-by":"crossref","first-page":"32720","DOI":"10.1074\/jbc.M110.118406","article-title":"Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of omega-3 fatty acids","volume":"285","author":"Arnold","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0440","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1515\/CCLM.2010.212","article-title":"Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins","volume":"48","author":"Hersberger","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0445","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","article-title":"Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing","volume":"192","author":"Serhan","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0450","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.20042031","article-title":"Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1","volume":"201","author":"Arita","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0455","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCRESAHA.110.223883","article-title":"Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins","volume":"107","author":"Spite","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0460","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1182\/blood-2007-11-122598","article-title":"Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes ans platelets","volume":"112","author":"Dona","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0465","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1126\/science.945611","article-title":"Thromboxanes: selective biosynthesis and distinct biological properties","volume":"193","author":"Needleman","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0470","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1073\/pnas.76.2.944","article-title":"Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties","volume":"76","author":"Needleman","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0475","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0022-2275(20)38214-6","article-title":"Eicosapentaenoic acid metabolism in brain microvessel endothelium: effect on prostaglandin formation","volume":"30","author":"Yerram","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0480","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1182\/blood-2010-11-317750","article-title":"\u039412-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice","volume":"118","author":"Hegde","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0485","doi-asserted-by":"crossref","first-page":"e63997","DOI":"10.1371\/journal.pone.0063997","article-title":"The eicosapentaenoic acid metabolite 15-deoxy-\u03b4(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPAR\u03b3-dependent mechanism","volume":"85","author":"Lefils-Lacourtablaise","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0490","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1073\/pnas.76.11.5919","article-title":"Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances","volume":"76","author":"Whitaker","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0495","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0262-1746(85)90162-3","article-title":"Dihomo-gamma-linolenic acid increases the metabolism of eicosapentaenoic acid in perfused vascular tissue","volume":"19","author":"Juan","year":"1985","journal-title":"Prostaglandins Leukot. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0500","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01990956","article-title":"Biological activity of prostaglandin E3 with regard to oedema formation in mice","volume":"35","author":"Hawkes","year":"1992","journal-title":"Agents Actions"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0505","doi-asserted-by":"crossref","first-page":"e1000177","DOI":"10.1371\/journal.pbio.1000177","article-title":"Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment","volume":"7","author":"Tull","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0510","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biochi.2009.01.008","article-title":"Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale","volume":"91","author":"Calder","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0515","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0006-2952(88)90782-4","article-title":"Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE","volume":"37","author":"Croset","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0520","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0049-3848(91)90287-7","article-title":"Lagarde M.12-HETE inhibits the binding of PGH2\/TXA2 receptor ligands in human platelets","volume":"63","author":"Fonlupt","year":"1991","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0525","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1096\/fj.08-112201","article-title":"Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators","volume":"22","author":"Merched","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0530","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1016\/j.febslet.2009.10.004","article-title":"Full characterization of PDX, a neuroprotectin\/protectin D1 isomer, which inhibits blood platelet aggregation","volume":"583","author":"Chen","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0535","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1096\/fj.10-161836","article-title":"Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation","volume":"25","author":"Chen","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0540","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11745-013-3863-6","article-title":"Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities","volume":"49","author":"Liu","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2013.11.006","article-title":"Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date","volume":"99","author":"Balas","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0550","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1194\/jlr.M000059","article-title":"Novel 14,21-dihydroxy-docosahexaenoic Acids: Structures, Formation Pathways, and Enhancement of Wound Healing","volume":"51","author":"Lu","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0555","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0009-3084(87)90071-5","article-title":"Lipid peroxides and human diseases","volume":"45","author":"Yagi","year":"1987","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0560","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0009-8981(90)90246-O","article-title":"Effect of fish oil and vitamin E supplementation on lipid peroxidation and whole blood aggregation in man","volume":"193","author":"Brown","year":"1990","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0565","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/ajcn\/58.1.98","article-title":"Dietary fish oil-induced changes in the distribution of alpha-tocopherol, retinol, and beta-carotene in plasma, red blood cells, and platelets: modulation by vitamin E","volume":"58","author":"Nair","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0570","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0021-9150(91)90107-E","article-title":"Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins","volume":"90","author":"Harats","year":"1991","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0575","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1161\/01.ATV.17.11.2576","article-title":"Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants","volume":"17","author":"Brude","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0580","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1055\/s-0038-1650399","article-title":"N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins","volume":"75","author":"Polette","year":"1996","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0585","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0006-2952(96)00734-4","article-title":"Effects of fatty acids on human platelet glutathione peroxidase: possible role of oxidative stress","volume":"53","author":"Lemaitre","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0590","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1046\/j.1538-7836.2003.00076.x","article-title":"Pro- and antioxidant activities of docosahexaenoic acid on human blood platelets","volume":"1","author":"V\u00e9ricel","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0595","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.atherosclerosis.2009.07.049","article-title":"Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men","volume":"208","author":"Calzada","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0600","doi-asserted-by":"crossref","first-page":"e69415","DOI":"10.1371\/journal.pone.0069415","article-title":"4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation","volume":"8","author":"Ishikado","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0605","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2013.11.002","article-title":"Long-chain omega 3 fatty acids: molecular bases of potential antioxidant actions","volume":"90","author":"Giordano","year":"2014","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0610","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.bbrc.2009.09.013","article-title":"Docosahexaenoic acid down-regulates endothelial Nox4 through as PLA2 signaling pathway","volume":"389","author":"Richard","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0615","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1017\/S0007114508051520","article-title":"Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis","volume":"1016","author":"Mebarek","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0620","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0026-0495(99)90150-6","article-title":"Effect of dietary fish and exercise training on urinary F2-isoprostane excretion in non-insulin-dependent diabetic patients","volume":"48","author":"Mori","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0625","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0005-2760(80)90209-X","article-title":"Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids","volume":"620","author":"Benedetti","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0630","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0635","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1021\/tx00044a014","article-title":"Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal","volume":"8","author":"Nadkarni","year":"1995","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0640","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0005-2760(86)90016-0","article-title":"Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal","volume":"875","author":"J\u00fcrgens","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0645","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1021\/tx000101a","article-title":"Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation","volume":"13","author":"Lee","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0650","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1126\/science.1059501","article-title":"Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins","volume":"292","author":"Lee","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0655","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0009-2797(02)00178-3","article-title":"Covalent adduction of nucleophilic amino acids by 4-Hydroxynonenal anl and 4-oxononenal","volume":"143","author":"Doorn","year":"2003","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0660","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-2275(20)38678-8","article-title":"Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes","volume":"28","author":"Esterbauer","year":"1987","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0665","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1016\/S0021-9258(18)61395-X","article-title":"Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products","volume":"262","author":"Steinbrecher","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0670","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0022-2275(20)33458-1","article-title":"Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein","volume":"41","author":"Podrez","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0675","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1194\/jlr.M300376-JLR200","article-title":"Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids","volume":"45","author":"Yamada","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0680","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cardiores.2007.03.010","article-title":"CD36 and macrophages in atherosclerosis","volume":"75","author":"Collot-Teixeira","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0685","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0891-5849(98)00149-X","article-title":"Covalent modifications of aminophospholipids by 4-hydroxynonenal","volume":"25","author":"Guichardant","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0690","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1194\/jlr.M200450-JLR200","article-title":"Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses","volume":"44","author":"Bacot","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0695","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1194\/jlr.M600340-JLR200","article-title":"Evidence for in situ ethanolamine phospholipid adducts with hydroxy-alkenals","volume":"48","author":"Bacot","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0700","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.ATV.0000051407.42536.73","article-title":"Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions","volume":"23","author":"Hoff","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0705","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1021\/tx200207z","article-title":"Critical Insights into cardiovascular disease from basic research on the oxidation of phospholipids: the 4-hydroxyalkenal phospholipid hypothesis","volume":"24","author":"Salomon","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0710","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/ATVBAHA.110.221127","article-title":"ATVB in focus: vascular cell lineage determination and differentiation. Monocyte and macrophage dynamics during atherogenesis","volume":"31","author":"Ley","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0715","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2006.06.007","article-title":"A CD36-dependent signaling cascade is necessary for macrophage foam cell formation","volume":"4","author":"Rahaman","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0720","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1074\/jbc.274.19.13139","article-title":"Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts","volume":"274","author":"Brame","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0725","doi-asserted-by":"crossref","first-page":"30964","DOI":"10.1074\/jbc.M103768200","article-title":"Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway","volume":"276","author":"Bernoud-Hubac","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0730","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1021\/bi0257383","article-title":"Identification of oxidized derivatives of neuroketals","volume":"41","author":"Bernoud-Hubac","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0735","doi-asserted-by":"crossref","first-page":"18170","DOI":"10.1074\/jbc.M110.213470","article-title":"Phosphatidylethanolamines modified by \u03b3-ketoaldehyde (\u03b3KA) induce endoplasmic reticulum stress and endothelial activation","volume":"286","author":"Guo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0740","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.freeradbiomed.2012.07.077","article-title":"Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation","volume":"53","author":"Guo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0745","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1194\/jlr.M001040","article-title":"Isoketals form cytotoxic phosphatidylethanolamine adducts in cells","volume":"51","author":"Sullivan","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0750","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.freeradbiomed.2004.07.031","article-title":"Covalent binding of isoketals to ethanolamine phospholipids","volume":"37","author":"Bernoud-Hubac","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0755","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbalip.2009.02.003","article-title":"Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation","volume":"1791","author":"Bernoud-Hubac","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0760","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1388-1981(00)00038-X","article-title":"Isolevuglandin\u2013protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway","volume":"1485","author":"Salomon","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0765","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.04.037","article-title":"Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis","volume":"49","author":"Stavrovskaya","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0770","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1074\/jbc.271.25.14916","article-title":"Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms","volume":"271","author":"Pratico","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0775","doi-asserted-by":"crossref","first-page":"14092","DOI":"10.1074\/jbc.M601035200","article-title":"Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid","volume":"81","author":"Gao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0780","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1194\/jlr.R800037-JLR200","article-title":"Isoprostanes","volume":"50","author":"Roberts","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0785","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1074\/jbc.273.22.13605","article-title":"Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid","volume":"273","author":"Roberts","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0790","doi-asserted-by":"crossref","first-page":"e89393","DOI":"10.1371\/journal.pone.0089393","article-title":"Lipid profiling following Intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention","volume":"9","author":"Gladine","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0795","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00216-012-6226-x","article-title":"Quantitative profiling of oxylipins through comprehensive LC-MS\/MS analysis: application in cardiac surgery","volume":"404","author":"Strassburg","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0800","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jchromb.2013.06.014","article-title":"LC-MS\/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites","volume":"932","author":"Le Faouder","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0805","first-page":"1415","article-title":"Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS\/MS","volume":"2012","author":"Giera","year":"1821","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0810","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0003-2697(85)90525-1","article-title":"Quantitative determination of the lipid peroxidation product 4-hydroxynonenal by high-performance chromatography","volume":"150","author":"Lang","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0815","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","article-title":"Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal","volume":"186","author":"Esterbauer","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0820","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1046\/j.1471-4159.2003.01628.x","article-title":"Mitochondrial oxidation of 4-hydroxy-2-nonenal in rat cerebral cortex","volume":"84","author":"Murphy","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0825","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0021-9673(97)01161-8","article-title":"High-performance liquid chromatographic peak identification of 2,4-dinitrophenylhydrazine derivatives of lipid peroxidation aldehydes by photodiode array detection","volume":"798","author":"Cordis","year":"1998","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0830","first-page":"116","volume":"1043","author":"Van Kuijk","year":"1990"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0835","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/tx060199e","article-title":"Lipidomic analysis for lipid peroxidation-derived aldehydes using gas chromatography\u2013mass spectrometry","volume":"20","author":"Kawai","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0840","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/bst0320139","article-title":"Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids","volume":"32","author":"Guichardant","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0845","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1016\/j.febslet.2007.04.048","article-title":"The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell","volume":"581","author":"Zarrouki","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0850","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11745-008-3199-9","article-title":"Structural characterization of alpha, beta-unsaturated aldehydes by gc\/miss dependent upon ionization methods","volume":"43","author":"Long","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2014.09.013_bb0855","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1194\/jlr.M026179","article-title":"Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells","volume":"53","author":"Awada","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0860","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1021\/ac300695p","article-title":"Shotgun lipidomics analysis of 4-hydroxyalkenal species directly from lipid extracts after one-step in situ derivatization","volume":"84","author":"Wang","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbalip.2014.09.013_bb0865","series-title":"Apoptosis Methods in Pharmacology and Toxicology: Methods in Biological Oxidative Stress","first-page":"117","article-title":"Analysis of neuroketals protein adducts by liquid chromatography electrospray ionization tandem mass spectrometry","author":"Bernoud-Hubac","year":"2003"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198114001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198114001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T04:35:22Z","timestamp":1650256522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198114001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":173,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1388198114001917"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2014.09.013","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2014.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}