{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:36:54Z","timestamp":1791848214683,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AT007003"],"award-info":[{"award-number":["R01 AT007003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.bbalip.2015.11.007","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T20:30:25Z","timestamp":1447792225000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 \u0251-linolenic acids for FADS2 mediated \u03946-desaturation"],"prefix":"10.1016","volume":"1861","author":[{"given":"Hui Gyu","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar S.D.","family":"Kothapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"DeAllie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Brenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2015.11.007_bb0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","article-title":"Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases","volume":"24","author":"Nakamura","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0952-3278(02)00261-2","article-title":"Role of stearoyl-coenzyme a desaturase in lipid metabolism","volume":"68","author":"Miyazaki","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0015","series-title":"Expression and Nutritional Regulation of Stearoyl-CoA Desaturase Genes in the Ruminant Mammary Gland: Relationship with Milk Fatty Acid Composition","author":"Bernard","year":"2013"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF02531278","article-title":"Fatty acids of unusual double-bond positions and chain lengths found in rat skin surface lipids","volume":"3","author":"Nicolaides","year":"1968","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0025","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1194\/jlr.M200271-JLR200","article-title":"Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse","volume":"43","author":"Miyazaki","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF02533545","article-title":"Desaturation of positional and geometric isomers of monoenoic fatty acids by microsomal preparations from rat liver","volume":"15","author":"Pollard","year":"1980","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0035","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/derm.1.2.8472","article-title":"Sebaceous gland lipids","volume":"1","author":"Picardo","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0040","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1523-1747.2003.12123.x","article-title":"Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity","volume":"120","author":"Ge","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0045","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1016\/S0021-9258(17)33223-4","article-title":"Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid","volume":"251","author":"Enoch","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0050","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1194\/jlr.M025312","article-title":"A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids","volume":"53","author":"Park","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0055","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1096\/fj.15-271783","article-title":"The Fatty Acid Desaturase 2 (FADS2) Gene Product Catalyzes Delta4 Desaturation to Yield n-3 Docosahexaenoic Acid and n-6 Docosapentaenoic Acid in Human Cells","volume":"29","author":"Park","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/abio.1993.1244","article-title":"One-step lipid extraction and fatty acid methyl esters preparation from fresh plant tissues","volume":"211","author":"Garces","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0065","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1021\/ac0516584","article-title":"Acetonitrile covalent adduct chemical ionization mass spectrometry for double bond localization in non-methylene-interrupted polyene fatty acid methyl esters","volume":"78","author":"Lawrence","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0070","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/ac981387f","article-title":"Acetonitrile chemical ionization tandem mass spectrometry to locate double bonds in polyunsaturated fatty acid methyl esters","volume":"71","author":"Van Pelt","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0075","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0080","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/1346-8138.12699","article-title":"Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris","volume":"41","author":"Akaza","year":"2014","journal-title":"J. Dermatol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0003-2697(02)00037-4","article-title":"Double bond localization in minor homoallylic fatty acid methyl esters using acetonitrile chemical ionization tandem mass spectrometry","volume":"307","author":"Michaud","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0090","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1016\/j.chroma.2011.10.095","article-title":"Identification of Delta6-monounsaturated fatty acids in human hair and nail samples by gas-chromatography-mass-spectrometry using ionic-liquid coated capillary column","volume":"1218","author":"Destaillats","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0095","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1021\/tx400287u","article-title":"Hexadecenoic fatty acid isomers: a chemical biology approach for human plasma biomarker development","volume":"26","author":"Sansone","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.0022-202x.2001.01612.x","article-title":"Metabolic fate and selective utilization of major fatty acids in human sebaceous gland","volume":"118","author":"Pappas","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/derm.1.2.7811","article-title":"Epidermal surface lipids","volume":"1","author":"Pappas","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MCO.0b013e32835d2edf","article-title":"Is there something special about palmitoleate?","volume":"16","author":"Hodson","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006812","article-title":"Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK","volume":"4","author":"Scaglia","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cas.12032","article-title":"Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells","volume":"104","author":"Mauvoisin","year":"2013","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1476-511X-11-25","article-title":"Multiple roles of dihomo-gamma-linolenic acid against proliferation diseases","volume":"11","author":"Wang","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0130","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2337\/diabetes.51.4.1157","article-title":"Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death","volume":"51","author":"Stehouwer","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0135","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3945\/ajcn.114.092601","article-title":"Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the cardiovascular health study","volume":"101","author":"Ma","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0145","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/JOE-14-0581","article-title":"n-3 polyunsaturated fatty acids and insulin secretion","volume":"224","author":"Wang","year":"2015","journal-title":"J. Endocrinol."},{"issue":"Suppl 1","key":"10.1016\/j.bbalip.2015.11.007_bb0150","first-page":"S61","article-title":"Nutrition recommendations and interventions for diabetes: a position statement of the American diabetes association","volume":"31","author":"Bantle","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbalip.2015.11.007_bb0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/abio.1998.2706","article-title":"Simultaneous measurement of desaturase activities using stable isotope tracers or a nontracer method","volume":"261","author":"Su","year":"1998","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/MOL.0b013e32834d2dc5","article-title":"Recent insights into the relation of Delta5 desaturase and Delta6 desaturase activity to the development of type 2 diabetes","volume":"23","author":"Kroger","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1523-1747.2001.01378.x","article-title":"15-lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa","volume":"117","author":"Shappell","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbalip.2015.11.007_bb0170","series-title":"Sapienic Acid: Species-Specific Fatty Acid Metabolism of the Human Sebaceous Gland","author":"Prouty","year":"2015"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198115002127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198115002127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:00:53Z","timestamp":1653552053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198115002127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1388198115002127"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2015.11.007","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 \u0251-linolenic acids for FADS2 mediated \u03946-desaturation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2015.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}