{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:42:59Z","timestamp":1786984979231,"version":"build-2736575974"},"reference-count":85,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0A15.13"],"award-info":[{"award-number":["G.0A15.13"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["2010-00215"],"award-info":[{"award-number":["2010-00215"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["DBOF\/10\/059"],"award-info":[{"award-number":["DBOF\/10\/059"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["OT\/08\/040"],"award-info":[{"award-number":["OT\/08\/040"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["OT\/14\/100"],"award-info":[{"award-number":["OT\/14\/100"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bbalip.2017.06.004","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T17:15:53Z","timestamp":1497892553000},"page":"972-990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase"],"prefix":"10.1016","volume":"1862","author":[{"given":"Serena","family":"Mezzar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"De Schryver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanny","family":"Asselberghs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Meyhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petruta L.","family":"Morvay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Baes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.","family":"Van Veldhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbalip.2017.06.004_bb0005","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1194\/jlr.R005959","article-title":"Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism","volume":"51","author":"Van Veldhoven","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0010","series-title":"Acta Biomedica Lovaniensia","article-title":"Alpha-oxidation of 3-Methylbranched Fatty Acids: Study of the Involved Enzymes Involved in the Reaction Sequence","volume":"235","author":"Foulon","year":"2001"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0015","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/S0022-2275(20)37136-4","article-title":"Phytanic acid alpha-oxidation: decarboxylation of 2-hydroxyphytanoyl-CoA to pristanic acid in human liver","volume":"38","author":"Verhoeven","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0020","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1073\/pnas.96.18.10039","article-title":"Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids","volume":"96","author":"Foulon","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0025","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.bbamcr.2008.02.013","article-title":"Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp\/TRIP8b","volume":"1783","author":"Fransen","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0030","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/prot.20112","article-title":"Pex5p binding affinities for canonical and noncanonical PTS1 peptides","volume":"55","author":"Maynard","year":"2004","journal-title":"Proteins"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0035","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1074\/jbc.M413362200","article-title":"Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids","volume":"280","author":"Foulon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0040","doi-asserted-by":"crossref","first-page":"48562","DOI":"10.1074\/jbc.M406649200","article-title":"The human FA2H gene encodes a fatty acid 2-hydroxylase","volume":"279","author":"Alderson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BJ20041451","article-title":"A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin","volume":"388","author":"Eckhardt","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0050","first-page":"69","article-title":"Sphingosine-phosphate lyase","volume":"26","author":"Van Veldhoven","year":"1993","journal-title":"Adv. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0055","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/hmg\/9.8.1195","article-title":"Human phytanoyl-CoA hydroxylase: resolution of the gene structure and the molecular basis of Refsum's disease","volume":"9","author":"Jansen","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0060","doi-asserted-by":"crossref","first-page":"17712","DOI":"10.1073\/pnas.0806066105","article-title":"Ataxia with loss of Purkinje cells in a mouse model for Refsum disease","volume":"105","author":"Ferdinandusse","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0065","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00018-005-5603-4","article-title":"Thiamine pyrophosphate: an essential cofactor for the alpha-oxidation in mammals\u2014implications for thiamine deficiencies?","volume":"63","author":"Sniekers","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0070","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ajhg.2008.10.010","article-title":"Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia","volume":"83","author":"Edvardson","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0075","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0458-08.2008","article-title":"Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration","volume":"28","author":"Z\u00f6ller","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0080","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-540-35109-2_6","article-title":"Gene trap mutagenesis","author":"Abuin","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0085","doi-asserted-by":"crossref","first-page":"14602","DOI":"10.1073\/pnas.94.26.14602","article-title":"Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells","volume":"94","author":"O'Gorman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0090","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nbd.2013.06.006","article-title":"Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation","volume":"58","author":"Verheijden","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)","volume":"29","author":"Truett","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/geno.1996.0177","article-title":"The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression","volume":"33","author":"Lennon","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0105","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1042\/bj3530673","article-title":"Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse","volume":"353","author":"Huyghe","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0110","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/glia.21027","article-title":"Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes","volume":"58","author":"Bottelbergs","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0115","doi-asserted-by":"crossref","first-page":"9064","DOI":"10.1016\/S0021-9258(17)47265-6","article-title":"Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis","volume":"259","author":"Declercq","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/abio.1996.0194","article-title":"Iodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes","volume":"237","author":"Van Veldhoven","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0125","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1083\/jcb.50.1.20d","article-title":"Tissue fractionation. Past and present","volume":"50","author":"de Duve","year":"1971","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1042\/bj0920184","article-title":"Tissue fractionation studies. 18. Resolution of mitochondrial fractions from rat liver into three distinct populations of cytoplasmic particles by means of density equilibration in various gradients","volume":"92","author":"Beaufay","year":"1964","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1194\/jlr.D044230","article-title":"RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1","volume":"55","author":"Mezzar","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0140","doi-asserted-by":"crossref","first-page":"20065","DOI":"10.1016\/S0021-9258(19)88666-0","article-title":"Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase","volume":"267","author":"Van Veldhoven","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0145","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0005-2760(97)00053-2","article-title":"2-Methylacyl-CoA racemase: a coupled assay based on the use of pristanoyl-CoA oxidase\/peroxidase and reinvestigation of its subcellular distribution in rat and human liver","volume":"1347","author":"Van Veldhoven","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0150","doi-asserted-by":"crossref","first-page":"16329","DOI":"10.1074\/jbc.M001994200","article-title":"Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids","volume":"275","author":"Baes","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1097-4644(19990301)72:3<349::AID-JCB4>3.0.CO;2-H","article-title":"Isolation of plasma membranes and Golgi apparatus from a single chicken liver homogenate","volume":"72","author":"Vleurick","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/abio.1993.1549","article-title":"Selective inactivation of eukaryotic beta-galactosidase in assays for inhibitors of HIV-1 TAT using bacterial beta-galactosidase as a reporter enzyme","volume":"215","author":"Young","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0165","doi-asserted-by":"crossref","first-page":"24670","DOI":"10.1016\/S0021-9258(18)54282-4","article-title":"Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver","volume":"266","author":"Vanhove","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0170","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1432-1033.1996.0674h.x","article-title":"Alpha-oxidation of 3-methyl-substituted fatty acids in rat liver. Production of formic acid instead of CO2, cofactor requirements, subcellular localization and formation of a 2-hydroxy-3-methylacyl-CoA intermediate","volume":"240","author":"Croes","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0175","doi-asserted-by":"crossref","first-page":"24676","DOI":"10.1016\/S0021-9258(18)54283-6","article-title":"Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase","volume":"266","author":"Van Veldhoven","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0180","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0014-5793(96)00508-X","article-title":"Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase","volume":"388","author":"Van Veldhoven","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0185","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0022-2275(20)32411-1","article-title":"Phytanoyl-CoA hydroxylase: recognition of 3-methyl-branched acyl-coAs and requirement for GTP or ATP and Mg(2+) in addition to its known hydroxylation cofactors","volume":"41","author":"Croes","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0190","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0005-2760(88)90030-6","article-title":"Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells","volume":"959","author":"Van Veldhoven","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0195","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/abio.1998.2584","article-title":"Enzymatic quantitation of cholesterol esters in lipid extracts","volume":"258","author":"Van Veldhoven","year":"1998","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0200","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s11745-006-0166-1","article-title":"Lipase-based quantitation of triacylglycerols in cellular lipid extracts: requirement for presence of detergent and prior separation by thin-layer chromatography","volume":"32","author":"Van Veldhoven","year":"1997","journal-title":"Lipids"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0205","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1523\/JNEUROSCI.4968-07.2008","article-title":"Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration","volume":"28","author":"Hulshagen","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(87)90649-X","article-title":"Inorganic and organic phosphate measurements in the nanomolar range","volume":"161","author":"Van Veldhoven","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0215","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0022-2275(20)37924-4","article-title":"Quantitative release of fatty acids from lipids by a simple hydrolysis procedure","volume":"24","author":"Aveldano","year":"1983","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0220","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/clinchem\/27.8.1352","article-title":"Direct spectrophotometry of total bile acids in serum","volume":"27","author":"Mashige","year":"1981","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0225","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbalip.2008.07.010","article-title":"Coordinate induction of PPARalpha and SREBP2 in multifunctional protein 2 deficient mice","volume":"1781","author":"Martens","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0230","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ab.2008.02.022","article-title":"Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue","volume":"376","author":"Minkler","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0235","first-page":"115","article-title":"Technical advance: a novel technique for the sensitive quantification of acyl CoA esters from plant tissues","volume":"25","author":"Larson","year":"2001","journal-title":"Plant J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0240","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.2353\/ajpath.2006.041220","article-title":"Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system","volume":"168","author":"Huyghe","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0245","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbrc.2007.03.198","article-title":"Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts","volume":"357","author":"Dirkx","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0250","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00710285","article-title":"The deficient degradation of synthetic 2- and 3-methyl-branched fatty acids in fibroblasts from patients with peroxisomal disorders","volume":"16","author":"Van Veldhoven","year":"1993","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0255","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1074\/jbc.274.5.2766","article-title":"Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-\/sterol carrier protein x-deficient mice","volume":"274","author":"Ellinghaus","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0260","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0022-2275(20)31973-8","article-title":"Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha","volume":"41","author":"Zomer","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1194\/jlr.M600050-JLR200","article-title":"Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation","volume":"48","author":"Gloerich","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0270","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1161\/hq1101.098228","article-title":"Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression","volume":"21","author":"Post","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0275","doi-asserted-by":"crossref","first-page":"G1333","DOI":"10.1152\/ajpgi.2001.281.6.G1333","article-title":"Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPARalpha, and steatohepatitis","volume":"281","author":"Reddy","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0280","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/bj3210253","article-title":"Identification and characterization of the 2-enoyl-CoA hydratases involved in peroxisomal beta-oxidation in rat liver","volume":"321","author":"Dieuaide-Noubhani","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0285","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/hep.1840090411","article-title":"Biochemical effects and zonal heterogeneity of peroxisome proliferation induced by perfluorocarboxylic acids in rat liver","volume":"9","author":"Just","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0290","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0022-2275(20)38198-0","article-title":"Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment","volume":"30","author":"Gorgas","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0295","first-page":"307","article-title":"Localization of peroxisome proliferator-activated receptor in mouse and rat-tissues and demonstration of its nuclear translocation in transfected cv-1 cells","volume":"6","author":"Huang","year":"1995","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0300","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1749-6632.1996.tb18627.x","article-title":"Zonal heterogeneity of peroxisome proliferation in rat liver","volume":"804","author":"Fahimi","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0305","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/carcin\/18.8.1491","article-title":"Hepatic zonation of the induction of cytochrome P450 IVA, peroxisomal lipid beta-oxidation enzymes and peroxisome proliferation in rats treated with dehydroepiandrosterone (DHEA). Evidence of distinct zonal and sex-specific differences","volume":"18","author":"Beier","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0310","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/bms.1200150607","article-title":"The enzymatic and mass spectrometric identification of 2-oxophytanic acid, a product of the peroxisomal oxidation of l-2-hydroxyphytanic acid","volume":"15","author":"Vamecq","year":"1988","journal-title":"Biomed. Environ. Mass Spectrom."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0315","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1194\/jlr.M300121-JLR200","article-title":"Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease","volume":"44","author":"Wierzbicki","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0320","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1742-4658.2010.07947.x","article-title":"Fatty acid omega-oxidation as a rescue pathway for fatty acid oxidation disorders in humans","volume":"278","author":"Wanders","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0325","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.exger.2006.02.013","article-title":"A study of the cytotoxicity of branched-chain phytanic acid with mitochondria and rat brain astrocytes","volume":"41","author":"Sch\u00f6nfeld","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0330","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.nbd.2009.08.005","article-title":"The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes","volume":"36","author":"R\u00f6nicke","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0335","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1101\/gad.12.8.1189","article-title":"Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2\/sterol carrier protein-x gene function","volume":"12","author":"Seedorf","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0340","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/hmg\/ddh107","article-title":"A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids","volume":"13","author":"Savolainen","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0345","doi-asserted-by":"crossref","first-page":"G939","DOI":"10.1152\/ajpgi.00308.2006","article-title":"Effect of SCP-x gene ablation on branched-chain fatty acid metabolism","volume":"292","author":"Atshaves","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0350","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ymgme.2009.12.005","article-title":"A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeleton","volume":"99","author":"Braverman","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0355","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1042\/BST0350881","article-title":"Peroxisomal disorders affecting phytanic acid alpha-oxidation: a review","volume":"35","author":"Wierzbicki","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0360","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1194\/jlr.M400337-JLR200","article-title":"A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways","volume":"46","author":"Gloerich","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0365","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1124\/dmd.106.013839","article-title":"Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha","volume":"35","author":"Ng","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0370","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.1840200229","article-title":"Zonal heterogeneity of peroxisomal enzymes in rat liver: differential induction by three divergent hypolipidemic drugs","volume":"20","author":"Lindauer","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0375","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1210\/endo.139.12.6384","article-title":"Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression","volume":"139","author":"Kelly","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0380","doi-asserted-by":"crossref","first-page":"9562","DOI":"10.1074\/jbc.M110132200","article-title":"Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes","volume":"277","author":"Nakatani","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0385","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1007\/s00018-007-7357-7","article-title":"Phytanic acid impairs mitochondrial respiration through protonophoric action","volume":"64","author":"Komen","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0390","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1074\/jbc.M513198200","article-title":"Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria","volume":"281","author":"Sch\u00f6nfeld","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0395","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/clinchem\/29.3.434","article-title":"2,6-Dimethyloctanedioic acid\u2014a metabolite of phytanic acid in Refsum's disease","volume":"29","author":"Greter","year":"1983","journal-title":"Clin. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.bbalip.2017.06.004_bb0400","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF01811502","article-title":"3-Methyladipate excretion in animals fed a phytol supplement with reference to Refsum's disease","volume":"8","author":"Krywawych","year":"1985","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0405","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1388-1981(99)00126-2","article-title":"Phytanic acid alpha-oxidation: identification of 2-hydroxyphytanoyl-CoA lyase in rat liver and its localisation in peroxisomes","volume":"1440","author":"Jansen","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbalip.2017.06.004_bb0410","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1083\/jcb.61.1.213","article-title":"Analytical study of microsomes and isolated subcellular membranes from rat liver. 3. Subfractionation of the microsomal fraction by isopycnic and differential centrifugation in density gradients","volume":"61","author":"Beaufay","year":"1974","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0415","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/hmg\/ddu448","article-title":"A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3","volume":"24","author":"Ferdinandusse","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0420","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/mgme.2001.3279","article-title":"Straight-chain acyl-CoA oxidase knockout mouse accumulates extremely long chain fatty acids from alpha-linolenic acid: evidence for runaway carousel-type enzyme kinetics in peroxisomal beta-oxidation diseases","volume":"75","author":"Infante","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbalip.2017.06.004_bb0425","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.1073\/pnas.1118349109","article-title":"2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy","volume":"109","author":"Teres","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198117301087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388198117301087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T14:12:17Z","timestamp":1657548737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388198117301087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1388198117301087"],"URL":"https:\/\/doi.org\/10.1016\/j.bbalip.2017.06.004","relation":{},"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbalip.2017.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}